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PMC:7073332 / 28199-29388 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
792 55-64 Species denotes 2019-nCoV Tax:2697049
793 65-75 Species denotes SARS-CoV-2 Tax:2697049
803 909-926 Gene denotes estrogen receptor Gene:2099
804 463-476 Gene denotes Drugs A and B
805 368-373 Species denotes human Tax:9606
806 113-117 Species denotes HCoV Tax:694448
807 305-309 Species denotes HCoV Tax:694448
808 493-497 Species denotes HCoV Tax:694448
809 846-852 Disease denotes tumors MESH:D009369
810 993-1010 Disease denotes polycystic kidney MESH:D007690
811 1070-1092 Disease denotes rhythm sleep disorders MESH:D012893

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T140 129-136 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T141 797-800 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T142 909-917 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T143 1004-1010 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T144 1019-1028 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T145 1032-1046 Body_part denotes biogenic amine http://purl.org/sig/ont/fma/fma67161

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T7 1004-1010 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T121 65-73 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T122 846-852 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T123 1060-1092 Disease denotes circadian rhythm sleep disorders http://purl.obolibrary.org/obo/MONDO_0024361
T124 1077-1092 Disease denotes sleep disorders http://purl.obolibrary.org/obo/MONDO_0003406

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T205 77-78 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T206 368-373 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T207 469-470 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T208 475-476 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T209 482-483 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T210 580-581 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T211 591-595 http://purl.obolibrary.org/obo/CLO_0001869 denotes B. b
T212 683-684 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T213 696-697 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T214 909-926 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T215 1004-1010 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T216 1004-1010 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T217 1004-1010 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T218 1030-1031 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T313 33-37 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T314 129-136 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T315 160-164 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T316 192-196 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T317 286-291 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T318 664-668 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T319 685-694 Chemical denotes sirolimus http://purl.obolibrary.org/obo/CHEBI_9168
T320 705-722 Chemical denotes immunosuppressant http://purl.obolibrary.org/obo/CHEBI_35705
T321 733-743 Chemical denotes antifungal http://purl.obolibrary.org/obo/CHEBI_35718
T322 748-762 Chemical denotes antineoplastic http://purl.obolibrary.org/obo/CHEBI_35610
T323 811-820 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T324 857-867 Chemical denotes toremifene http://purl.obolibrary.org/obo/CHEBI_9635
T325 909-936 Chemical denotes estrogen receptor modulator http://purl.obolibrary.org/obo/CHEBI_50739
T326 909-917 Chemical denotes estrogen http://purl.obolibrary.org/obo/CHEBI_50114
T327 918-936 Chemical denotes receptor modulator http://purl.obolibrary.org/obo/CHEBI_90710
T328 943-949 Chemical denotes emodin http://purl.obolibrary.org/obo/CHEBI_42223|http://purl.obolibrary.org/obo/CHEBI_77659
T330 967-971 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T331 1019-1028 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T332 1041-1046 Chemical denotes amine http://purl.obolibrary.org/obo/CHEBI_32952
T333 1099-1113 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T334 1118-1132 Chemical denotes antimetabolite http://purl.obolibrary.org/obo/CHEBI_35221
T335 1133-1153 Chemical denotes antineoplastic agent http://purl.obolibrary.org/obo/CHEBI_35610
T336 1159-1176 Chemical denotes immunosuppressant http://purl.obolibrary.org/obo/CHEBI_35705

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T39 797-810 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T40 801-810 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T41 1060-1076 http://purl.obolibrary.org/obo/GO_0007623 denotes circadian rhythm
T42 1070-1076 http://purl.obolibrary.org/obo/GO_0048511 denotes rhythm
T43 1077-1082 http://purl.obolibrary.org/obo/GO_0030431 denotes sleep

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T21 993-1010 Phenotype denotes polycystic kidney http://purl.obolibrary.org/obo/HP_0000113

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T173 77-178 Sentence denotes a The possible exposure mode of the HCoV-associated protein module to the pairwise drug combinations.
T174 179-394 Sentence denotes An effective drug combination will be captured by the “Complementary Exposure” pattern: the targets of the drugs both hit the HCoV–host subnetwork, but target separate neighborhoods in the human interactome network.
T175 395-498 Sentence denotes ZCA and ZCB denote the network proximity (Z-score) between targets (Drugs A and B) and a specific HCoV.
T176 499-1189 Sentence denotes SAB denotes separation score (see Materials and methods) of targets between Drug A and Drug B. b–d Inferred mechanism-of-action networks for three selected pairwise drug combinations: b sirolimus (a potent immunosuppressant with both antifungal and antineoplastic properties) plus dactinomycin (an RNA synthesis inhibitor for treatment of various tumors), c toremifene (first-generation nonsteroidal-selective estrogen receptor modulator) plus emodin (an experimental drug for the treatment of polycystic kidney), and d melatonin (a biogenic amine for treating circadian rhythm sleep disorders) plus mercaptopurine (an antimetabolite antineoplastic agent with immunosuppressant properties).