PMC:7073332 / 19836-20855 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7073332","sourcedb":"PMC","sourceid":"7073332","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7073332","text":"a Network-predicted evidence and gene set enrichment analysis (GSEA) scores for 16 potential repurposable drugs for HCoVs. The overall connectivity of the top drug candidates to the HCoV-associated proteins was examined. Most of these drugs indirectly target HCoV-associated proteins via the human protein–protein interaction networks. All the drug–target-HCoV-associated protein connections were examined, and those proteins with at least five connections are shown. The box heights for the proteins indicate the number of connections. GSEA scores for eight drugs were not available (NA) due to the lack of transcriptome profiles for the drugs. b–e Inferred mechanism-of-action networks for four selected drugs: b toremifene (first-generation nonsteroidal-selective estrogen receptor modulator), c irbesartan (an angiotensin receptor blocker), d mercaptopurine (an antimetabolite antineoplastic agent with immunosuppressant properties), and e melatonin (a biogenic amine for treating circadian rhythm sleep disorders).","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"474","span":{"begin":767,"end":784},"obj":"Gene"},{"id":"475","span":{"begin":292,"end":297},"obj":"Species"},{"id":"476","span":{"begin":182,"end":186},"obj":"Species"},{"id":"477","span":{"begin":259,"end":263},"obj":"Species"},{"id":"478","span":{"begin":356,"end":360},"obj":"Species"},{"id":"479","span":{"begin":537,"end":541},"obj":"Chemical"},{"id":"480","span":{"begin":715,"end":725},"obj":"Chemical"},{"id":"481","span":{"begin":799,"end":809},"obj":"Chemical"},{"id":"482","span":{"begin":847,"end":861},"obj":"Chemical"},{"id":"483","span":{"begin":944,"end":953},"obj":"Chemical"},{"id":"484","span":{"begin":966,"end":971},"obj":"Chemical"},{"id":"485","span":{"begin":995,"end":1017},"obj":"Disease"}],"attributes":[{"id":"A474","pred":"tao:has_database_id","subj":"474","obj":"Gene:2099"},{"id":"A475","pred":"tao:has_database_id","subj":"475","obj":"Tax:9606"},{"id":"A476","pred":"tao:has_database_id","subj":"476","obj":"Tax:694448"},{"id":"A477","pred":"tao:has_database_id","subj":"477","obj":"Tax:694448"},{"id":"A478","pred":"tao:has_database_id","subj":"478","obj":"Tax:694448"},{"id":"A480","pred":"tao:has_database_id","subj":"480","obj":"MESH:D017312"},{"id":"A481","pred":"tao:has_database_id","subj":"481","obj":"MESH:D000077405"},{"id":"A482","pred":"tao:has_database_id","subj":"482","obj":"MESH:D015122"},{"id":"A483","pred":"tao:has_database_id","subj":"483","obj":"MESH:D008550"},{"id":"A484","pred":"tao:has_database_id","subj":"484","obj":"MESH:D000588"},{"id":"A485","pred":"tao:has_database_id","subj":"485","obj":"MESH:D012893"},{"subj":"474","pred":"source","obj":"LitCovid-PubTator"},{"subj":"475","pred":"source","obj":"LitCovid-PubTator"},{"subj":"476","pred":"source","obj":"LitCovid-PubTator"},{"subj":"477","pred":"source","obj":"LitCovid-PubTator"},{"subj":"478","pred":"source","obj":"LitCovid-PubTator"},{"subj":"479","pred":"source","obj":"LitCovid-PubTator"},{"subj":"480","pred":"source","obj":"LitCovid-PubTator"},{"subj":"481","pred":"source","obj":"LitCovid-PubTator"},{"subj":"482","pred":"source","obj":"LitCovid-PubTator"},{"subj":"483","pred":"source","obj":"LitCovid-PubTator"},{"subj":"484","pred":"source","obj":"LitCovid-PubTator"},{"subj":"485","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T99","span":{"begin":33,"end":37},"obj":"Body_part"},{"id":"T100","span":{"begin":198,"end":206},"obj":"Body_part"},{"id":"T101","span":{"begin":275,"end":283},"obj":"Body_part"},{"id":"T102","span":{"begin":298,"end":305},"obj":"Body_part"},{"id":"T103","span":{"begin":306,"end":313},"obj":"Body_part"},{"id":"T104","span":{"begin":372,"end":379},"obj":"Body_part"},{"id":"T105","span":{"begin":417,"end":425},"obj":"Body_part"},{"id":"T106","span":{"begin":492,"end":500},"obj":"Body_part"},{"id":"T107","span":{"begin":767,"end":775},"obj":"Body_part"},{"id":"T108","span":{"begin":944,"end":953},"obj":"Body_part"},{"id":"T109","span":{"begin":957,"end":971},"obj":"Body_part"}],"attributes":[{"id":"A99","pred":"fma_id","subj":"T99","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A100","pred":"fma_id","subj":"T100","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A101","pred":"fma_id","subj":"T101","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A102","pred":"fma_id","subj":"T102","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A103","pred":"fma_id","subj":"T103","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A104","pred":"fma_id","subj":"T104","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A105","pred":"fma_id","subj":"T105","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A106","pred":"fma_id","subj":"T106","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A107","pred":"fma_id","subj":"T107","obj":"http://purl.org/sig/ont/fma/fma83376"},{"id":"A108","pred":"fma_id","subj":"T108","obj":"http://purl.org/sig/ont/fma/fma74644"},{"id":"A109","pred":"fma_id","subj":"T109","obj":"http://purl.org/sig/ont/fma/fma67161"},{"subj":"T99","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T100","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T101","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T102","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T103","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T104","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T105","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T106","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T107","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T108","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T109","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T71","span":{"begin":985,"end":1017},"obj":"Disease"},{"id":"T72","span":{"begin":1002,"end":1017},"obj":"Disease"}],"attributes":[{"id":"A71","pred":"mondo_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/MONDO_0024361"},{"id":"A72","pred":"mondo_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/MONDO_0003406"},{"subj":"T71","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T138","span":{"begin":0,"end":1},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T139","span":{"begin":33,"end":37},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T140","span":{"begin":292,"end":305},"obj":"http://purl.obolibrary.org/obo/PR_000029067"},{"id":"T141","span":{"begin":646,"end":647},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T142","span":{"begin":713,"end":714},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T143","span":{"begin":767,"end":784},"obj":"http://purl.obolibrary.org/obo/PR_000007204"},{"id":"T144","span":{"begin":955,"end":956},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T138","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T139","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T140","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T141","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T142","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T143","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T144","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T198","span":{"begin":106,"end":111},"obj":"Chemical"},{"id":"T199","span":{"begin":159,"end":163},"obj":"Chemical"},{"id":"T200","span":{"begin":198,"end":206},"obj":"Chemical"},{"id":"T201","span":{"begin":235,"end":240},"obj":"Chemical"},{"id":"T202","span":{"begin":275,"end":283},"obj":"Chemical"},{"id":"T203","span":{"begin":298,"end":305},"obj":"Chemical"},{"id":"T204","span":{"begin":306,"end":313},"obj":"Chemical"},{"id":"T205","span":{"begin":344,"end":348},"obj":"Chemical"},{"id":"T206","span":{"begin":372,"end":379},"obj":"Chemical"},{"id":"T207","span":{"begin":417,"end":425},"obj":"Chemical"},{"id":"T208","span":{"begin":492,"end":500},"obj":"Chemical"},{"id":"T209","span":{"begin":559,"end":564},"obj":"Chemical"},{"id":"T210","span":{"begin":585,"end":587},"obj":"Chemical"},{"id":"T211","span":{"begin":639,"end":644},"obj":"Chemical"},{"id":"T212","span":{"begin":706,"end":711},"obj":"Chemical"},{"id":"T213","span":{"begin":715,"end":725},"obj":"Chemical"},{"id":"T214","span":{"begin":767,"end":794},"obj":"Chemical"},{"id":"T215","span":{"begin":767,"end":775},"obj":"Chemical"},{"id":"T216","span":{"begin":776,"end":794},"obj":"Chemical"},{"id":"T217","span":{"begin":799,"end":809},"obj":"Chemical"},{"id":"T218","span":{"begin":814,"end":825},"obj":"Chemical"},{"id":"T219","span":{"begin":847,"end":861},"obj":"Chemical"},{"id":"T220","span":{"begin":866,"end":880},"obj":"Chemical"},{"id":"T221","span":{"begin":881,"end":901},"obj":"Chemical"},{"id":"T222","span":{"begin":907,"end":924},"obj":"Chemical"},{"id":"T223","span":{"begin":944,"end":953},"obj":"Chemical"},{"id":"T224","span":{"begin":966,"end":971},"obj":"Chemical"}],"attributes":[{"id":"A198","pred":"chebi_id","subj":"T198","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A199","pred":"chebi_id","subj":"T199","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A200","pred":"chebi_id","subj":"T200","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A201","pred":"chebi_id","subj":"T201","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A202","pred":"chebi_id","subj":"T202","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A203","pred":"chebi_id","subj":"T203","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A204","pred":"chebi_id","subj":"T204","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A205","pred":"chebi_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A206","pred":"chebi_id","subj":"T206","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A207","pred":"chebi_id","subj":"T207","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A208","pred":"chebi_id","subj":"T208","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A209","pred":"chebi_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A210","pred":"chebi_id","subj":"T210","obj":"http://purl.obolibrary.org/obo/CHEBI_33696"},{"id":"A211","pred":"chebi_id","subj":"T211","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A212","pred":"chebi_id","subj":"T212","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A213","pred":"chebi_id","subj":"T213","obj":"http://purl.obolibrary.org/obo/CHEBI_9635"},{"id":"A214","pred":"chebi_id","subj":"T214","obj":"http://purl.obolibrary.org/obo/CHEBI_50739"},{"id":"A215","pred":"chebi_id","subj":"T215","obj":"http://purl.obolibrary.org/obo/CHEBI_50114"},{"id":"A216","pred":"chebi_id","subj":"T216","obj":"http://purl.obolibrary.org/obo/CHEBI_90710"},{"id":"A217","pred":"chebi_id","subj":"T217","obj":"http://purl.obolibrary.org/obo/CHEBI_5959"},{"id":"A218","pred":"chebi_id","subj":"T218","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A219","pred":"chebi_id","subj":"T219","obj":"http://purl.obolibrary.org/obo/CHEBI_50667"},{"id":"A220","pred":"chebi_id","subj":"T220","obj":"http://purl.obolibrary.org/obo/CHEBI_35221"},{"id":"A221","pred":"chebi_id","subj":"T221","obj":"http://purl.obolibrary.org/obo/CHEBI_35610"},{"id":"A222","pred":"chebi_id","subj":"T222","obj":"http://purl.obolibrary.org/obo/CHEBI_35705"},{"id":"A223","pred":"chebi_id","subj":"T223","obj":"http://purl.obolibrary.org/obo/CHEBI_16796"},{"id":"A224","pred":"chebi_id","subj":"T224","obj":"http://purl.obolibrary.org/obo/CHEBI_32952"},{"subj":"T198","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T199","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T200","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T201","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T202","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T203","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T204","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T205","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T206","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T207","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T208","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T209","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T210","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T211","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T212","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T213","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T214","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T215","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T216","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T217","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T218","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T219","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T220","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T221","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T222","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T223","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T224","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T24","span":{"begin":985,"end":1001},"obj":"http://purl.obolibrary.org/obo/GO_0007623"},{"id":"T25","span":{"begin":995,"end":1001},"obj":"http://purl.obolibrary.org/obo/GO_0048511"},{"id":"T26","span":{"begin":1002,"end":1007},"obj":"http://purl.obolibrary.org/obo/GO_0030431"}],"attributes":[{"subj":"T24","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T120","span":{"begin":0,"end":122},"obj":"Sentence"},{"id":"T121","span":{"begin":123,"end":220},"obj":"Sentence"},{"id":"T122","span":{"begin":221,"end":335},"obj":"Sentence"},{"id":"T123","span":{"begin":336,"end":467},"obj":"Sentence"},{"id":"T124","span":{"begin":468,"end":536},"obj":"Sentence"},{"id":"T125","span":{"begin":537,"end":1019},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T120","pred":"source","obj":"LitCovid-sentences"},{"subj":"T121","pred":"source","obj":"LitCovid-sentences"},{"subj":"T122","pred":"source","obj":"LitCovid-sentences"},{"subj":"T123","pred":"source","obj":"LitCovid-sentences"},{"subj":"T124","pred":"source","obj":"LitCovid-sentences"},{"subj":"T125","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#93dcec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ece293"},{"id":"LitCovid-PD-MONDO","color":"#c893ec"},{"id":"LitCovid-PD-CLO","color":"#93ecae"},{"id":"LitCovid-PD-CHEBI","color":"#ec9493"},{"id":"LitCovid-PD-GO-BP","color":"#93abec"},{"id":"LitCovid-sentences","color":"#c6ec93"}]}]}}