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PMC:7073332 / 19836-20855 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
474 767-784 Gene denotes estrogen receptor Gene:2099
475 292-297 Species denotes human Tax:9606
476 182-186 Species denotes HCoV Tax:694448
477 259-263 Species denotes HCoV Tax:694448
478 356-360 Species denotes HCoV Tax:694448
479 537-541 Chemical denotes GSEA
480 715-725 Chemical denotes toremifene MESH:D017312
481 799-809 Chemical denotes irbesartan MESH:D000077405
482 847-861 Chemical denotes mercaptopurine MESH:D015122
483 944-953 Chemical denotes melatonin MESH:D008550
484 966-971 Chemical denotes amine MESH:D000588
485 995-1017 Disease denotes rhythm sleep disorders MESH:D012893

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T99 33-37 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T100 198-206 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T101 275-283 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T102 298-305 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T103 306-313 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T104 372-379 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T105 417-425 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T106 492-500 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T107 767-775 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T108 944-953 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T109 957-971 Body_part denotes biogenic amine http://purl.org/sig/ont/fma/fma67161

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T71 985-1017 Disease denotes circadian rhythm sleep disorders http://purl.obolibrary.org/obo/MONDO_0024361
T72 1002-1017 Disease denotes sleep disorders http://purl.obolibrary.org/obo/MONDO_0003406

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T138 0-1 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T139 33-37 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T140 292-305 http://purl.obolibrary.org/obo/PR_000029067 denotes human protein
T141 646-647 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T142 713-714 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T143 767-784 http://purl.obolibrary.org/obo/PR_000007204 denotes estrogen receptor
T144 955-956 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T198 106-111 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T199 159-163 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T200 198-206 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T201 235-240 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T202 275-283 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T203 298-305 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T204 306-313 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T205 344-348 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T206 372-379 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T207 417-425 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T208 492-500 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T209 559-564 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T210 585-587 Chemical denotes NA http://purl.obolibrary.org/obo/CHEBI_33696
T211 639-644 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T212 706-711 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T213 715-725 Chemical denotes toremifene http://purl.obolibrary.org/obo/CHEBI_9635
T214 767-794 Chemical denotes estrogen receptor modulator http://purl.obolibrary.org/obo/CHEBI_50739
T215 767-775 Chemical denotes estrogen http://purl.obolibrary.org/obo/CHEBI_50114
T216 776-794 Chemical denotes receptor modulator http://purl.obolibrary.org/obo/CHEBI_90710
T217 799-809 Chemical denotes irbesartan http://purl.obolibrary.org/obo/CHEBI_5959
T218 814-825 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T219 847-861 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T220 866-880 Chemical denotes antimetabolite http://purl.obolibrary.org/obo/CHEBI_35221
T221 881-901 Chemical denotes antineoplastic agent http://purl.obolibrary.org/obo/CHEBI_35610
T222 907-924 Chemical denotes immunosuppressant http://purl.obolibrary.org/obo/CHEBI_35705
T223 944-953 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T224 966-971 Chemical denotes amine http://purl.obolibrary.org/obo/CHEBI_32952

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T24 985-1001 http://purl.obolibrary.org/obo/GO_0007623 denotes circadian rhythm
T25 995-1001 http://purl.obolibrary.org/obo/GO_0048511 denotes rhythm
T26 1002-1007 http://purl.obolibrary.org/obo/GO_0030431 denotes sleep

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T120 0-122 Sentence denotes a Network-predicted evidence and gene set enrichment analysis (GSEA) scores for 16 potential repurposable drugs for HCoVs.
T121 123-220 Sentence denotes The overall connectivity of the top drug candidates to the HCoV-associated proteins was examined.
T122 221-335 Sentence denotes Most of these drugs indirectly target HCoV-associated proteins via the human protein–protein interaction networks.
T123 336-467 Sentence denotes All the drug–target-HCoV-associated protein connections were examined, and those proteins with at least five connections are shown.
T124 468-536 Sentence denotes The box heights for the proteins indicate the number of connections.
T125 537-1019 Sentence denotes GSEA scores for eight drugs were not available (NA) due to the lack of transcriptome profiles for the drugs. b–e Inferred mechanism-of-action networks for four selected drugs: b toremifene (first-generation nonsteroidal-selective estrogen receptor modulator), c irbesartan (an angiotensin receptor blocker), d mercaptopurine (an antimetabolite antineoplastic agent with immunosuppressant properties), and e melatonin (a biogenic amine for treating circadian rhythm sleep disorders).