PMC:7068984 / 22485-27503
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
805 | 297-310 | Gene | denotes | neuraminidase | Gene:4758 |
806 | 1433-1438 | Gene | denotes | TNF-α | Gene:7124 |
807 | 1443-1447 | Gene | denotes | IL-6 | Gene:3569 |
808 | 70-78 | Species | denotes | SARS-CoV | Tax:694009 |
809 | 83-91 | Species | denotes | MERS-CoV | Tax:1335626 |
810 | 446-461 | Species | denotes | influenza virus | Tax:11308 |
811 | 721-726 | Species | denotes | mouse | Tax:10090 |
812 | 1670-1678 | Species | denotes | SARS-CoV | Tax:694009 |
813 | 1886-1896 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
814 | 168-179 | Species | denotes | coronavirus | Tax:11118 |
815 | 323-334 | Chemical | denotes | oseltamivir | MESH:D053139 |
816 | 336-345 | Chemical | denotes | peramivir | MESH:C414210 |
817 | 347-356 | Chemical | denotes | zanamivir | MESH:D053243 |
818 | 364-375 | Chemical | denotes | ganciclovir | MESH:D015774 |
819 | 377-386 | Chemical | denotes | acyclovir | MESH:D000212 |
820 | 392-401 | Chemical | denotes | ribavirin | MESH:D012254 |
821 | 414-432 | Chemical | denotes | methylprednisolone | MESH:D008775 |
822 | 509-519 | Chemical | denotes | Remdesivir | MESH:C000606551 |
823 | 521-528 | Chemical | denotes | GS-5734 | MESH:C000606551 |
824 | 556-565 | Chemical | denotes | adenosine | MESH:D000241 |
825 | 734-744 | Chemical | denotes | remdesivir | MESH:C000606551 |
826 | 850-860 | Chemical | denotes | Remdesivir | MESH:C000606551 |
827 | 937-948 | Chemical | denotes | Chloroquine | MESH:D002738 |
828 | 1010-1021 | Chemical | denotes | Chloroquine | MESH:D002738 |
829 | 1196-1207 | Chemical | denotes | Chloroquine | MESH:D002738 |
830 | 1353-1364 | Chemical | denotes | chloroquine | MESH:D002738 |
831 | 1599-1610 | Chemical | denotes | chloroquine | MESH:D002738 |
832 | 1804-1814 | Chemical | denotes | remdesivir | MESH:C000606551 |
833 | 1819-1830 | Chemical | denotes | chloroquine | MESH:D002738 |
834 | 479-487 | Disease | denotes | COVID-19 | MESH:C000657245 |
835 | 909-917 | Disease | denotes | COVID-19 | MESH:C000657245 |
836 | 1000-1008 | Disease | denotes | COVID-19 | MESH:C000657245 |
837 | 1045-1052 | Disease | denotes | malaria | MESH:D008288 |
838 | 1132-1148 | Disease | denotes | viral infections | MESH:D001102 |
839 | 1307-1325 | Disease | denotes | SARS-CoV infection | MESH:C000657245 |
840 | 1534-1549 | Disease | denotes | viral infection | MESH:D001102 |
841 | 1745-1753 | Disease | denotes | COVID-19 | MESH:C000657245 |
842 | 1754-1763 | Disease | denotes | infection | MESH:D007239 |
843 | 1772-1774 | CellLine | denotes | E6 | CVCL:4582 |
869 | 3476-3487 | Gene | denotes | cathepsin B | Gene:1508 |
870 | 3750-3763 | Gene | denotes | Neuraminidase | Gene:4758 |
871 | 3811-3824 | Gene | denotes | neuraminidase | Gene:4758 |
872 | 2916-2921 | Species | denotes | HIV-1 | Tax:11676 |
873 | 3300-3305 | Species | denotes | Ebola | Tax:1570291 |
874 | 3531-3536 | Species | denotes | Ebola | Tax:1570291 |
875 | 3692-3703 | Species | denotes | DNA viruses | Tax:2080735 |
876 | 3907-3924 | Species | denotes | Influenza viruses | Tax:11308 |
877 | 4151-4162 | Species | denotes | Herpesvirus | Tax:39059 |
878 | 4444-4449 | Species | denotes | Ebola | Tax:1570291 |
879 | 4463-4467 | Species | denotes | H1N1 | Tax:114727 |
880 | 4751-4756 | Species | denotes | human | Tax:9606 |
881 | 4764-4777 | Species | denotes | coronaviruses | Tax:11118 |
882 | 3514-3523 | Species | denotes | Influenza | Tax:11309 |
883 | 4451-4460 | Species | denotes | influenza | Tax:11309 |
884 | 3007-3010 | Species | denotes | HIV | Tax:12721 |
885 | 2865-2884 | Chemical | denotes | Lopinavir/Ritonavir | MESH:C558899 |
886 | 3076-3087 | Chemical | denotes | Chloroquine | MESH:D002738 |
887 | 3089-3103 | Chemical | denotes | -aminoquinolin | |
888 | 3217-3227 | Chemical | denotes | Remdesivir | MESH:C000606551 |
889 | 3398-3404 | Chemical | denotes | serine | MESH:D012694 |
890 | 3011-3015 | Disease | denotes | AIDS | MESH:D000163 |
891 | 3168-3175 | Disease | denotes | Malaria | MESH:D008288 |
892 | 3177-3195 | Disease | denotes | autoimmune disease | MESH:D001327 |
893 | 4180-4238 | Disease | denotes | cytomegalovirus AIDS-associated cytomegalovirus infections | MESH:D003586 |
899 | 4788-4820 | Disease | denotes | HIV Human immunodeficiency virus | MESH:D015658 |
900 | 4822-4862 | Disease | denotes | AIDS Acquired immune deficiency syndrome | MESH:D000163 |
901 | 4864-4902 | Disease | denotes | SARS Severe acute respiratory syndrome | MESH:D045169 |
902 | 4904-4941 | Disease | denotes | MERS Middle East respiratory syndrome | MESH:D018352 |
903 | 4943-4964 | Disease | denotes | HCV Hepatitis C virus | MESH:D006526 |
921 | 2022-2050 | Species | denotes | human immunodeficiency virus | Tax:12721 |
922 | 2092-2100 | Species | denotes | MERS-CoV | Tax:1335626 |
923 | 2110-2118 | Species | denotes | SARS-CoV | Tax:694009 |
924 | 2124-2132 | Species | denotes | patients | Tax:9606 |
925 | 2155-2168 | Species | denotes | β-coronavirus | Tax:694002 |
926 | 2195-2202 | Species | denotes | patient | Tax:9606 |
927 | 2052-2055 | Species | denotes | HIV | Tax:12721 |
928 | 1968-1977 | Chemical | denotes | lopinavir | MESH:D061466 |
929 | 1982-1991 | Chemical | denotes | ritonavir | MESH:D019438 |
930 | 2242-2261 | Chemical | denotes | lopinavir/ritonavir | MESH:C558899 |
931 | 2404-2423 | Chemical | denotes | lopinavir/ritonavir | MESH:C558899 |
932 | 2667-2679 | Chemical | denotes | nitazoxanide | MESH:C041747 |
933 | 2681-2692 | Chemical | denotes | favipiravir | MESH:C462182 |
934 | 2694-2704 | Chemical | denotes | nafamostat | MESH:C032855 |
935 | 2007-2016 | Disease | denotes | infection | MESH:D007239 |
936 | 2186-2194 | Disease | denotes | COVID-19 | MESH:C000657245 |
937 | 2549-2558 | Disease | denotes | pneumonia | MESH:D011014 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T159 | 566-576 | Body_part | denotes | nucleotide | http://purl.org/sig/ont/fma/fma82740 |
T160 | 652-655 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T161 | 707-711 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T162 | 817-821 | Body_part | denotes | ExoN | http://purl.org/sig/ont/fma/fma84120 |
T163 | 1443-1445 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T164 | 1775-1780 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T165 | 2052-2055 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T166 | 2296-2298 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T167 | 2463-2470 | Body_part | denotes | Capsule | http://purl.org/sig/ont/fma/fma85272 |
T168 | 2916-2919 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T169 | 2935-2942 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T170 | 3007-3010 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
T171 | 3115-3124 | Body_part | denotes | endosomal | http://purl.org/sig/ont/fma/fma67180 |
T172 | 3238-3248 | Body_part | denotes | Nucleotide | http://purl.org/sig/ont/fma/fma82740 |
T173 | 3335-3338 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T174 | 3398-3404 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
T175 | 3636-3640 | Body_part | denotes | mRNA | http://purl.org/sig/ont/fma/fma67122 |
T176 | 3684-3687 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T177 | 3692-3695 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
T178 | 3866-3870 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T179 | 4006-4013 | Body_part | denotes | guanine | http://purl.org/sig/ont/fma/fma82775 |
T180 | 4305-4308 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T181 | 4423-4426 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T182 | 4430-4433 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
T183 | 4788-4791 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T26 | 2463-2470 | Body_part | denotes | Capsule | http://purl.obolibrary.org/obo/UBERON_0003893 |
LitCovid_AGAC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
p13997s9 | 1631-1644 | MPA | denotes | glycosylation |
p14001s18 | 2226-2235 | NegReg | denotes | decreased |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T158 | 70-78 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T159 | 446-455 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
T160 | 479-487 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T161 | 521-523 | Disease | denotes | GS | http://purl.obolibrary.org/obo/MONDO_0005773 |
T162 | 909-917 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T163 | 1000-1008 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T164 | 1045-1052 | Disease | denotes | malaria | http://purl.obolibrary.org/obo/MONDO_0005136 |
T165 | 1132-1148 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
T166 | 1307-1325 | Disease | denotes | SARS-CoV infection | http://purl.obolibrary.org/obo/MONDO_0005091 |
T167 | 1316-1325 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T168 | 1534-1549 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
T169 | 1540-1549 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T170 | 1670-1678 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T171 | 1745-1753 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T172 | 1754-1763 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T173 | 1886-1894 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T174 | 2007-2016 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T175 | 2028-2044 | Disease | denotes | immunodeficiency | http://purl.obolibrary.org/obo/MONDO_0021094 |
T176 | 2110-2118 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T177 | 2186-2194 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T178 | 2549-2558 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
T179 | 2970-2980 | Disease | denotes | infectious | http://purl.obolibrary.org/obo/MONDO_0005550 |
T180 | 3011-3015 | Disease | denotes | AIDS | http://purl.obolibrary.org/obo/MONDO_0012268 |
T181 | 3017-3021 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T182 | 3168-3175 | Disease | denotes | Malaria | http://purl.obolibrary.org/obo/MONDO_0005136 |
T183 | 3177-3195 | Disease | denotes | autoimmune disease | http://purl.obolibrary.org/obo/MONDO_0007179 |
T184 | 3229-3231 | Disease | denotes | GS | http://purl.obolibrary.org/obo/MONDO_0005773 |
T185 | 3300-3305 | Disease | denotes | Ebola | http://purl.obolibrary.org/obo/MONDO_0005737 |
T186 | 3307-3311 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T187 | 3514-3523 | Disease | denotes | Influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
T188 | 3531-3536 | Disease | denotes | Ebola | http://purl.obolibrary.org/obo/MONDO_0005737 |
T189 | 3710-3714 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T190 | 3907-3916 | Disease | denotes | Influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
T191 | 4196-4200 | Disease | denotes | AIDS | http://purl.obolibrary.org/obo/MONDO_0012268 |
T192 | 4212-4238 | Disease | denotes | cytomegalovirus infections | http://purl.obolibrary.org/obo/MONDO_0005132 |
T193 | 4444-4449 | Disease | denotes | Ebola | http://purl.obolibrary.org/obo/MONDO_0005737 |
T194 | 4451-4468 | Disease | denotes | influenza A(H1N1) | http://purl.obolibrary.org/obo/MONDO_0005460 |
T195 | 4451-4460 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
T196 | 4798-4814 | Disease | denotes | immunodeficiency | http://purl.obolibrary.org/obo/MONDO_0021094 |
T197 | 4822-4826 | Disease | denotes | AIDS | http://purl.obolibrary.org/obo/MONDO_0012268 |
T198 | 4827-4862 | Disease | denotes | Acquired immune deficiency syndrome | http://purl.obolibrary.org/obo/MONDO_0012268 |
T199 | 4864-4868 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T200 | 4869-4902 | Disease | denotes | Severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
T201 | 4947-4958 | Disease | denotes | Hepatitis C | http://purl.obolibrary.org/obo/MONDO_0005231 |
T202 | 4947-4956 | Disease | denotes | Hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
T203 | 4970-4984 | Disease | denotes | Herpes simplex | http://purl.obolibrary.org/obo/MONDO_0004609 |
T204 | 4996-5005 | Disease | denotes | Varicella | http://purl.obolibrary.org/obo/MONDO_0005700 |
T205 | 5006-5012 | Disease | denotes | zoster | http://purl.obolibrary.org/obo/MONDO_0005609 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T218 | 456-461 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T219 | 533-534 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T220 | 627-635 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
T221 | 656-663 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T222 | 707-716 | http://purl.obolibrary.org/obo/CLO_0000031 | denotes | cell line |
T223 | 721-726 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
T224 | 835-843 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
T225 | 861-864 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T226 | 952-953 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T227 | 1022-1025 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T228 | 1079-1080 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T229 | 1269-1276 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T230 | 1288-1289 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T231 | 1365-1368 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T232 | 1466-1467 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T233 | 1767-1780 | http://purl.obolibrary.org/obo/CLO_0051719 | denotes | Vero E6 cells |
T234 | 1787-1788 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T235 | 2022-2027 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T236 | 2045-2050 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T237 | 2137-2140 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T238 | 2184-2185 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T239 | 2479-2480 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T240 | 3283-3288 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T241 | 3319-3320 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T242 | 3339-3346 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T243 | 3433-3441 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T244 | 3486-3487 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T245 | 3503-3513 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
T246 | 3642-3643 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T247 | 3659-3667 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
T248 | 3696-3703 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T249 | 3725-3727 | http://purl.obolibrary.org/obo/CLO_0001527 | denotes | 94 |
T250 | 3789-3797 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
T251 | 3866-3870 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T252 | 3917-3924 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T253 | 3925-3930 | http://purl.obolibrary.org/obo/CLO_0001625 | denotes | A [95 |
T254 | 3986-3987 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T255 | 4461-4462 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T256 | 4605-4606 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T257 | 4699-4707 | http://purl.obolibrary.org/obo/NCBITaxon_2 | denotes | bacteria |
T258 | 4709-4716 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T259 | 4717-4718 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T260 | 4733-4740 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T261 | 4751-4756 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T262 | 4757-4763 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animal |
T263 | 4779-4782 | http://purl.obolibrary.org/obo/CLO_0054060 | denotes | 102 |
T264 | 4792-4797 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | Human |
T265 | 4815-4820 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T266 | 4959-4964 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T267 | 4985-4990 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T268 | 5013-5018 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T119 | 196-201 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T120 | 215-229 | Chemical | denotes | corticosteroid | http://purl.obolibrary.org/obo/CHEBI_50858 |
T121 | 297-321 | Chemical | denotes | neuraminidase inhibitors | http://purl.obolibrary.org/obo/CHEBI_52425 |
T122 | 311-321 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
T123 | 323-334 | Chemical | denotes | oseltamivir | http://purl.obolibrary.org/obo/CHEBI_7798 |
T124 | 336-345 | Chemical | denotes | peramivir | http://purl.obolibrary.org/obo/CHEBI_85196|http://purl.obolibrary.org/obo/CHEBI_85202 |
T126 | 347-356 | Chemical | denotes | zanamivir | http://purl.obolibrary.org/obo/CHEBI_50663 |
T127 | 364-375 | Chemical | denotes | ganciclovir | http://purl.obolibrary.org/obo/CHEBI_465284 |
T128 | 377-386 | Chemical | denotes | acyclovir | http://purl.obolibrary.org/obo/CHEBI_2453 |
T129 | 392-401 | Chemical | denotes | ribavirin | http://purl.obolibrary.org/obo/CHEBI_63580 |
T130 | 414-432 | Chemical | denotes | methylprednisolone | http://purl.obolibrary.org/obo/CHEBI_6888 |
T131 | 521-528 | Chemical | denotes | GS-5734 | http://purl.obolibrary.org/obo/CHEBI_145994 |
T132 | 521-523 | Chemical | denotes | GS | http://purl.obolibrary.org/obo/CHEBI_73516 |
T133 | 538-543 | Chemical | denotes | cyano | http://purl.obolibrary.org/obo/CHEBI_48819 |
T134 | 556-565 | Chemical | denotes | adenosine | http://purl.obolibrary.org/obo/CHEBI_16335 |
T135 | 566-576 | Chemical | denotes | nucleotide | http://purl.obolibrary.org/obo/CHEBI_36976 |
T136 | 584-591 | Chemical | denotes | prodrug | http://purl.obolibrary.org/obo/CHEBI_50266 |
T137 | 617-626 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T138 | 734-744 | Chemical | denotes | remdesivir | http://purl.obolibrary.org/obo/CHEBI_145994 |
T139 | 937-948 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T140 | 965-969 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T141 | 1010-1021 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T142 | 1196-1207 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T143 | 1353-1364 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T144 | 1443-1445 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T146 | 1483-1502 | Chemical | denotes | autophagy inhibitor | http://purl.obolibrary.org/obo/CHEBI_88230 |
T147 | 1493-1502 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
T148 | 1599-1610 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T149 | 1804-1814 | Chemical | denotes | remdesivir | http://purl.obolibrary.org/obo/CHEBI_145994 |
T150 | 1819-1830 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T151 | 1948-1967 | Chemical | denotes | protease inhibitors | http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258 |
T153 | 1957-1967 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
T154 | 1968-1991 | Chemical | denotes | lopinavir and ritonavir | http://purl.obolibrary.org/obo/CHEBI_145924 |
T155 | 1968-1977 | Chemical | denotes | lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
T156 | 1982-1991 | Chemical | denotes | ritonavir | http://purl.obolibrary.org/obo/CHEBI_45409 |
T157 | 2242-2261 | Chemical | denotes | lopinavir/ritonavir | http://purl.obolibrary.org/obo/CHEBI_145924 |
T158 | 2242-2251 | Chemical | denotes | lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
T159 | 2252-2261 | Chemical | denotes | ritonavir | http://purl.obolibrary.org/obo/CHEBI_45409 |
T160 | 2263-2270 | Chemical | denotes | Kaletra | http://purl.obolibrary.org/obo/CHEBI_145924 |
T161 | 2296-2298 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T163 | 2375-2383 | Chemical | denotes | medicine | http://purl.obolibrary.org/obo/CHEBI_23888 |
T164 | 2404-2423 | Chemical | denotes | lopinavir/ritonavir | http://purl.obolibrary.org/obo/CHEBI_145924 |
T165 | 2404-2413 | Chemical | denotes | lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
T166 | 2414-2423 | Chemical | denotes | ritonavir | http://purl.obolibrary.org/obo/CHEBI_45409 |
T167 | 2425-2432 | Chemical | denotes | Kaletra | http://purl.obolibrary.org/obo/CHEBI_145924 |
T168 | 2436-2443 | Chemical | denotes | arbidol | http://purl.obolibrary.org/obo/CHEBI_134730 |
T169 | 2501-2509 | Chemical | denotes | medicine | http://purl.obolibrary.org/obo/CHEBI_23888 |
T170 | 2643-2658 | Chemical | denotes | antiviral drugs | http://purl.obolibrary.org/obo/CHEBI_36044 |
T171 | 2643-2652 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T172 | 2653-2658 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T173 | 2681-2692 | Chemical | denotes | favipiravir | http://purl.obolibrary.org/obo/CHEBI_134722 |
T174 | 2694-2704 | Chemical | denotes | nafamostat | http://purl.obolibrary.org/obo/CHEBI_135466 |
T175 | 2769-2784 | Chemical | denotes | antiviral drugs | http://purl.obolibrary.org/obo/CHEBI_36044 |
T176 | 2769-2778 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T177 | 2779-2784 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
T178 | 2798-2804 | Chemical | denotes | Action | http://purl.obolibrary.org/obo/CHEBI_5133 |
T179 | 2865-2874 | Chemical | denotes | Lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
T180 | 2894-2904 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
T181 | 2935-2942 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T182 | 3076-3087 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
T183 | 3147-3167 | Chemical | denotes | autophagy inhibitors | http://purl.obolibrary.org/obo/CHEBI_88230 |
T184 | 3157-3167 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
T185 | 3229-3236 | Chemical | denotes | GS-5734 | http://purl.obolibrary.org/obo/CHEBI_145994 |
T186 | 3229-3231 | Chemical | denotes | GS | http://purl.obolibrary.org/obo/CHEBI_73516 |
T187 | 3238-3248 | Chemical | denotes | Nucleotide | http://purl.obolibrary.org/obo/CHEBI_36976 |
T188 | 3258-3265 | Chemical | denotes | prodrug | http://purl.obolibrary.org/obo/CHEBI_50266 |
T189 | 3398-3423 | Chemical | denotes | serine protease inhibitor | http://purl.obolibrary.org/obo/CHEBI_64926 |
T190 | 3398-3404 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
T191 | 3405-3423 | Chemical | denotes | protease inhibitor | http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258 |
T193 | 3414-3423 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
T194 | 3489-3502 | Chemical | denotes | anticoagulant | http://purl.obolibrary.org/obo/CHEBI_50249 |
T195 | 3575-3584 | Chemical | denotes | guanosine | http://purl.obolibrary.org/obo/CHEBI_16750 |
T196 | 3585-3595 | Chemical | denotes | nucleoside | http://purl.obolibrary.org/obo/CHEBI_33838 |
T197 | 3692-3695 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
T198 | 3738-3749 | Chemical | denotes | Oseltamivir | http://purl.obolibrary.org/obo/CHEBI_7798 |
T199 | 3750-3773 | Chemical | denotes | Neuraminidase inhibitor | http://purl.obolibrary.org/obo/CHEBI_52425 |
T200 | 3764-3773 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
T201 | 3968-3978 | Chemical | denotes | Nucleoside | http://purl.obolibrary.org/obo/CHEBI_33838 |
T202 | 4006-4013 | Chemical | denotes | guanine | http://purl.obolibrary.org/obo/CHEBI_16235 |
T203 | 4097-4108 | Chemical | denotes | Ganciclovir | http://purl.obolibrary.org/obo/CHEBI_465284 |
T204 | 4109-4119 | Chemical | denotes | Nucleoside | http://purl.obolibrary.org/obo/CHEBI_33838 |
T205 | 4134-4143 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
T206 | 4273-4278 | Chemical | denotes | T-705 | http://purl.obolibrary.org/obo/CHEBI_134722 |
T207 | 4280-4290 | Chemical | denotes | Nucleoside | http://purl.obolibrary.org/obo/CHEBI_33838 |
T208 | 4305-4329 | Chemical | denotes | RNA polymerase inhibitor | http://purl.obolibrary.org/obo/CHEBI_37416 |
T209 | 4320-4329 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
T210 | 4430-4433 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T39 | 1132-1148 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infections |
T40 | 1483-1492 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
T41 | 1483-1492 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
T42 | 1534-1549 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
T43 | 1631-1644 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
T44 | 3147-3156 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
T45 | 3147-3156 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
T46 | 3433-3448 | http://purl.obolibrary.org/obo/GO_0061025 | denotes | membrane fusion |
T47 | 3489-3513 | http://purl.obolibrary.org/obo/GO_0050819 | denotes | anticoagulant activities |
T48 | 3617-3626 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
T49 | 3844-3851 | http://purl.obolibrary.org/obo/GO_0007114 | denotes | budding |
T50 | 3872-3889 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
T51 | 3872-3889 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
T52 | 4377-4389 | http://purl.obolibrary.org/obo/GO_0000003 | denotes | reproduction |
T53 | 4430-4443 | http://purl.obolibrary.org/obo/GO_0071897 | denotes | DNA synthesis |
T54 | 4434-4443 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
T55 | 4576-4582 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T149 | 0-20 | Sentence | denotes | Antiviral treatments |
T150 | 21-185 | Sentence | denotes | Based on the experience of fighting the epidemic SARS-CoV and MERS-CoV previously, we may learn some lessons for some treatment strategies against coronavirus [74]. |
T151 | 186-508 | Sentence | denotes | Antiviral drugs and systemic corticosteroid treatment commonly used in clinical practice previously, including neuraminidase inhibitors (oseltamivir, peramivir, zanamivir, etc), ganciclovir, acyclovir, and ribavirin, as well as methylprednisolone [46, 75] for influenza virus, are invalid for COVID-19 and not recommended. |
T152 | 509-664 | Sentence | denotes | Remdesivir (GS-5734) is a 1′-cyano-substituted adenosine nucleotide analog prodrug and shows broad-spectrum antiviral activity against several RNA viruses. |
T153 | 665-849 | Sentence | denotes | Based on the data collected from in vitro cell line and mouse model, remdesivir could interfere with the NSP12 polymerase even in the setting of intact ExoN proofreading activity [76]. |
T154 | 850-936 | Sentence | denotes | Remdesivir has been reported to treat the first US case of COVID-19 successfully [77]. |
T155 | 937-1009 | Sentence | denotes | Chloroquine is a repurposed drug with great potential to treat COVID-19. |
T156 | 1010-1149 | Sentence | denotes | Chloroquine has been used to treat malaria for many years [78], with a mechanism that is not well understood against some viral infections. |
T157 | 1150-1195 | Sentence | denotes | Several possible mechanisms are investigated: |
T158 | 1196-1342 | Sentence | denotes | Chloroquine can inhibit pH-dependent steps of the replication of several viruses [79], with a potent effect on SARS-CoV infection and spread [80]. |
T159 | 1343-1448 | Sentence | denotes | Moreover, chloroquine has immunomodulatory effects, suppressing the production/release of TNF-α and IL-6. |
T160 | 1449-1566 | Sentence | denotes | It also works as a novel class of autophagy inhibitor [81], which may interfere with viral infection and replication. |
T161 | 1567-1786 | Sentence | denotes | Several studies have found that chloroquine interfered with the glycosylation of cellular receptors of SARS-CoV [80] and functioned at both entry and at post-entry stages of the COVID-19 infection in Vero E6 cells [82]. |
T162 | 1787-1906 | Sentence | denotes | A combination of remdesivir and chloroquine was proven to effectively inhibit the recently emerged SARS-CoV-2 in vitro. |
T163 | 1907-2133 | Sentence | denotes | Scientists previously confirmed that the protease inhibitors lopinavir and ritonavir, used to treat infection with human immunodeficiency virus (HIV) [83], could improve the outcome of MERS-CoV [84] and SARS-CoV [85] patients. |
T164 | 2134-2320 | Sentence | denotes | It has reported that β-coronavirus viral loads of a COVID-19 patient in Korea significantly decreased after lopinavir/ritonavir (Kaletra®, AbbVie, North Chicago, IL, USA) treatment [86]. |
T165 | 2321-2742 | Sentence | denotes | Additionally, clinicians combined Chinese and Western medicine treatment including lopinavir/ritonavir (Kaletra®), arbidol, and Shufeng Jiedu Capsule (SFJDC, a traditional Chinese medicine) and gained significant improvement in pneumonia associated symptoms in Shanghai Public Health Clinical Center, China [87].The other antiviral drugs include nitazoxanide, favipiravir, nafamostat, and so on (See Table 1 for details). |
T166 | 2743-2784 | Sentence | denotes | Table 1 Common and potent antiviral drugs |
T167 | 2785-2855 | Sentence | denotes | Status Drugs Action mode Anti-infective mechanism Target diseases Ref. |
T168 | 2856-3035 | Sentence | denotes | Approved Lopinavir/Ritonavir Protease inhibitors Inhibiting HIV-1 protease for protein cleavage, resulting in non-infectious, immature viral particles HIV/AIDS, SARS, MERS [83–85] |
T169 | 3036-3203 | Sentence | denotes | Approved, Investigational, Vet approved Chloroquine 9-aminoquinolin Increasing endosomal pH, immunomodulating, autophagy inhibitors Malaria, autoimmune disease [79–82] |
T170 | 3204-3317 | Sentence | denotes | Experimental Remdesivir (GS-5734) Nucleotide analogue prodrug Interfering with virus post-entry Ebola, SARS, MERS |
T171 | 3318-3360 | Sentence | denotes | (A wide array of RNA viruses) [76, 88, 89] |
T172 | 3361-3545 | Sentence | denotes | Investigational Nafamostat Synthetic serine protease inhibitor Prevents membrane fusion by reducing the release of cathepsin B; anticoagulant activities Influenza, MERS, Ebola [90, 91] |
T173 | 3546-3728 | Sentence | denotes | Approved Ribavirin Synthetic guanosine nucleoside Interfering with the synthesis of viral mRNA (a broad-spectrum activity against several RNA and DNA viruses) HCV, SARS, MERS [92–94] |
T174 | 3729-3935 | Sentence | denotes | Approved Oseltamivir Neuraminidase inhibitor Inhibiting the activity of the viral neuraminidase enzyme, preventing budding from the host cell, viral replication, and infectivity Influenza viruses A [95, 96] |
T175 | 3936-4070 | Sentence | denotes | Approved Penciclovir/ Acyclovir Nucleoside analog A synthetic acyclic guanine derivative, resulting in chain termination HSV, VZV [97] |
T176 | 4071-4243 | Sentence | denotes | Approved, Investigational Ganciclovir Nucleoside analog Potent inhibitor of the Herpesvirus family including cytomegalovirus AIDS-associated cytomegalovirus infections [98] |
T177 | 4244-4298 | Sentence | denotes | Investigational Favipiravir (T-705) Nucleoside analog: |
T178 | 4299-4477 | Sentence | denotes | Viral RNA polymerase inhibitor Acting on viral genetic copying to prevent its reproduction, without affecting host cellular RNA or DNA synthesis Ebola, influenza A(H1N1) [99–101] |
T179 | 4478-4787 | Sentence | denotes | Approved, Investigational, Vet approved Nitazoxanide Antiprotozoal agent Modulating the survival, growth, and proliferation of a range of extracellular and intracellular protozoa, helminths, anaerobic and microaerophilic bacteria, viruses A wide range of viruses including human/animal coronaviruses [102–104] |
T180 | 4788-5018 | Sentence | denotes | HIV Human immunodeficiency virus, AIDS Acquired immune deficiency syndrome, SARS Severe acute respiratory syndrome, MERS Middle East respiratory syndrome, HCV Hepatitis C virus, HSV Herpes simplex virus, VZV Varicella-zoster virus |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T49 | 2028-2044 | Phenotype | denotes | immunodeficiency | http://purl.obolibrary.org/obo/HP_0002721 |
T50 | 2549-2558 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
T51 | 3177-3195 | Phenotype | denotes | autoimmune disease | http://purl.obolibrary.org/obo/HP_0002960 |
T52 | 4798-4814 | Phenotype | denotes | immunodeficiency | http://purl.obolibrary.org/obo/HP_0002721 |
T53 | 4836-4853 | Phenotype | denotes | immune deficiency | http://purl.obolibrary.org/obo/HP_0002721 |
T54 | 4947-4956 | Phenotype | denotes | Hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32169119-26868298-70132240 | 181-183 | 26868298 | denotes | 74 |
32169119-29511076-70132241 | 845-847 | 29511076 | denotes | 76 |
32169119-32004427-70132242 | 932-934 | 32004427 | denotes | 77 |
32169119-30396013-70132243 | 1069-1071 | 30396013 | denotes | 78 |
32169119-14592603-70132244 | 1278-1280 | 14592603 | denotes | 79 |
32169119-16115318-70132245 | 1338-1340 | 16115318 | denotes | 80 |
32169119-25727221-70132246 | 1504-1506 | 25727221 | denotes | 81 |
32169119-16115318-70132247 | 1680-1682 | 16115318 | denotes | 80 |
32169119-32020029-70132248 | 1782-1784 | 32020029 | denotes | 82 |
32169119-12662125-70132249 | 2058-2060 | 12662125 | denotes | 83 |
32169119-31900204-70132250 | 2102-2104 | 31900204 | denotes | 84 |
32169119-14985565-70132251 | 2120-2122 | 14985565 | denotes | 85 |
32169119-32056407-70132252 | 2316-2318 | 32056407 | denotes | 86 |
32169119-12662125-70132253 | 3029-3031 | 12662125 | denotes | 83 |
32169119-31900204-70132253 | 3029-3031 | 31900204 | denotes | 83 |
32169119-14985565-70132253 | 3029-3031 | 14985565 | denotes | 83 |
32169119-14592603-70132254 | 3197-3199 | 14592603 | denotes | 79 |
32169119-16115318-70132254 | 3197-3199 | 16115318 | denotes | 79 |
32169119-25727221-70132254 | 3197-3199 | 25727221 | denotes | 79 |
32169119-32020029-70132254 | 3197-3199 | 32020029 | denotes | 79 |
32169119-29511076-70132255 | 3349-3351 | 29511076 | denotes | 76 |
32169119-30987343-70132256 | 3353-3355 | 30987343 | denotes | 88 |
32169119-31142680-70132257 | 3357-3359 | 31142680 | denotes | 89 |
32169119-18220789-70132258 | 3538-3540 | 18220789 | denotes | 90 |
32169119-26346967-70132259 | 3542-3544 | 26346967 | denotes | 91 |
32169119-30215672-70132260 | 3722-3724 | 30215672 | denotes | 92 |
32169119-15018130-70132260 | 3722-3724 | 15018130 | denotes | 92 |
32169119-24811411-70132261 | 3932-3934 | 24811411 | denotes | 96 |
32169119-29896665-70132262 | 4067-4069 | 29896665 | denotes | 97 |
32169119-29678260-70132263 | 4240-4242 | 29678260 | denotes | 98 |
32169119-24084488-70132264 | 4470-4472 | 24084488 | denotes | 99 |
32169119-25108173-70132265 | 4779-4782 | 25108173 | denotes | 102 |
32169119-25451075-70132265 | 4779-4782 | 25451075 | denotes | 102 |
32169119-27095301-70132265 | 4779-4782 | 27095301 | denotes | 102 |