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PMC:7068984 / 22485-27503 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
805 297-310 Gene denotes neuraminidase Gene:4758
806 1433-1438 Gene denotes TNF-α Gene:7124
807 1443-1447 Gene denotes IL-6 Gene:3569
808 70-78 Species denotes SARS-CoV Tax:694009
809 83-91 Species denotes MERS-CoV Tax:1335626
810 446-461 Species denotes influenza virus Tax:11308
811 721-726 Species denotes mouse Tax:10090
812 1670-1678 Species denotes SARS-CoV Tax:694009
813 1886-1896 Species denotes SARS-CoV-2 Tax:2697049
814 168-179 Species denotes coronavirus Tax:11118
815 323-334 Chemical denotes oseltamivir MESH:D053139
816 336-345 Chemical denotes peramivir MESH:C414210
817 347-356 Chemical denotes zanamivir MESH:D053243
818 364-375 Chemical denotes ganciclovir MESH:D015774
819 377-386 Chemical denotes acyclovir MESH:D000212
820 392-401 Chemical denotes ribavirin MESH:D012254
821 414-432 Chemical denotes methylprednisolone MESH:D008775
822 509-519 Chemical denotes Remdesivir MESH:C000606551
823 521-528 Chemical denotes GS-5734 MESH:C000606551
824 556-565 Chemical denotes adenosine MESH:D000241
825 734-744 Chemical denotes remdesivir MESH:C000606551
826 850-860 Chemical denotes Remdesivir MESH:C000606551
827 937-948 Chemical denotes Chloroquine MESH:D002738
828 1010-1021 Chemical denotes Chloroquine MESH:D002738
829 1196-1207 Chemical denotes Chloroquine MESH:D002738
830 1353-1364 Chemical denotes chloroquine MESH:D002738
831 1599-1610 Chemical denotes chloroquine MESH:D002738
832 1804-1814 Chemical denotes remdesivir MESH:C000606551
833 1819-1830 Chemical denotes chloroquine MESH:D002738
834 479-487 Disease denotes COVID-19 MESH:C000657245
835 909-917 Disease denotes COVID-19 MESH:C000657245
836 1000-1008 Disease denotes COVID-19 MESH:C000657245
837 1045-1052 Disease denotes malaria MESH:D008288
838 1132-1148 Disease denotes viral infections MESH:D001102
839 1307-1325 Disease denotes SARS-CoV infection MESH:C000657245
840 1534-1549 Disease denotes viral infection MESH:D001102
841 1745-1753 Disease denotes COVID-19 MESH:C000657245
842 1754-1763 Disease denotes infection MESH:D007239
843 1772-1774 CellLine denotes E6 CVCL:4582
869 3476-3487 Gene denotes cathepsin B Gene:1508
870 3750-3763 Gene denotes Neuraminidase Gene:4758
871 3811-3824 Gene denotes neuraminidase Gene:4758
872 2916-2921 Species denotes HIV-1 Tax:11676
873 3300-3305 Species denotes Ebola Tax:1570291
874 3531-3536 Species denotes Ebola Tax:1570291
875 3692-3703 Species denotes DNA viruses Tax:2080735
876 3907-3924 Species denotes Influenza viruses Tax:11308
877 4151-4162 Species denotes Herpesvirus Tax:39059
878 4444-4449 Species denotes Ebola Tax:1570291
879 4463-4467 Species denotes H1N1 Tax:114727
880 4751-4756 Species denotes human Tax:9606
881 4764-4777 Species denotes coronaviruses Tax:11118
882 3514-3523 Species denotes Influenza Tax:11309
883 4451-4460 Species denotes influenza Tax:11309
884 3007-3010 Species denotes HIV Tax:12721
885 2865-2884 Chemical denotes Lopinavir/Ritonavir MESH:C558899
886 3076-3087 Chemical denotes Chloroquine MESH:D002738
887 3089-3103 Chemical denotes -aminoquinolin
888 3217-3227 Chemical denotes Remdesivir MESH:C000606551
889 3398-3404 Chemical denotes serine MESH:D012694
890 3011-3015 Disease denotes AIDS MESH:D000163
891 3168-3175 Disease denotes Malaria MESH:D008288
892 3177-3195 Disease denotes autoimmune disease MESH:D001327
893 4180-4238 Disease denotes cytomegalovirus AIDS-associated cytomegalovirus infections MESH:D003586
899 4788-4820 Disease denotes HIV Human immunodeficiency virus MESH:D015658
900 4822-4862 Disease denotes AIDS Acquired immune deficiency syndrome MESH:D000163
901 4864-4902 Disease denotes SARS Severe acute respiratory syndrome MESH:D045169
902 4904-4941 Disease denotes MERS Middle East respiratory syndrome MESH:D018352
903 4943-4964 Disease denotes HCV Hepatitis C virus MESH:D006526
921 2022-2050 Species denotes human immunodeficiency virus Tax:12721
922 2092-2100 Species denotes MERS-CoV Tax:1335626
923 2110-2118 Species denotes SARS-CoV Tax:694009
924 2124-2132 Species denotes patients Tax:9606
925 2155-2168 Species denotes β-coronavirus Tax:694002
926 2195-2202 Species denotes patient Tax:9606
927 2052-2055 Species denotes HIV Tax:12721
928 1968-1977 Chemical denotes lopinavir MESH:D061466
929 1982-1991 Chemical denotes ritonavir MESH:D019438
930 2242-2261 Chemical denotes lopinavir/ritonavir MESH:C558899
931 2404-2423 Chemical denotes lopinavir/ritonavir MESH:C558899
932 2667-2679 Chemical denotes nitazoxanide MESH:C041747
933 2681-2692 Chemical denotes favipiravir MESH:C462182
934 2694-2704 Chemical denotes nafamostat MESH:C032855
935 2007-2016 Disease denotes infection MESH:D007239
936 2186-2194 Disease denotes COVID-19 MESH:C000657245
937 2549-2558 Disease denotes pneumonia MESH:D011014

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T159 566-576 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T160 652-655 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T161 707-711 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T162 817-821 Body_part denotes ExoN http://purl.org/sig/ont/fma/fma84120
T163 1443-1445 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T164 1775-1780 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T165 2052-2055 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T166 2296-2298 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T167 2463-2470 Body_part denotes Capsule http://purl.org/sig/ont/fma/fma85272
T168 2916-2919 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T169 2935-2942 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T170 3007-3010 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T171 3115-3124 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T172 3238-3248 Body_part denotes Nucleotide http://purl.org/sig/ont/fma/fma82740
T173 3335-3338 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T174 3398-3404 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T175 3636-3640 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T176 3684-3687 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T177 3692-3695 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T178 3866-3870 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T179 4006-4013 Body_part denotes guanine http://purl.org/sig/ont/fma/fma82775
T180 4305-4308 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T181 4423-4426 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T182 4430-4433 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T183 4788-4791 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T26 2463-2470 Body_part denotes Capsule http://purl.obolibrary.org/obo/UBERON_0003893

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p13997s9 1631-1644 MPA denotes glycosylation
p14001s18 2226-2235 NegReg denotes decreased

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T158 70-78 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T159 446-455 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T160 479-487 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T161 521-523 Disease denotes GS http://purl.obolibrary.org/obo/MONDO_0005773
T162 909-917 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T163 1000-1008 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T164 1045-1052 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T165 1132-1148 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T166 1307-1325 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T167 1316-1325 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T168 1534-1549 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T169 1540-1549 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T170 1670-1678 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T171 1745-1753 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T172 1754-1763 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T173 1886-1894 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T174 2007-2016 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T175 2028-2044 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T176 2110-2118 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T177 2186-2194 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T178 2549-2558 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T179 2970-2980 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T180 3011-3015 Disease denotes AIDS http://purl.obolibrary.org/obo/MONDO_0012268
T181 3017-3021 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T182 3168-3175 Disease denotes Malaria http://purl.obolibrary.org/obo/MONDO_0005136
T183 3177-3195 Disease denotes autoimmune disease http://purl.obolibrary.org/obo/MONDO_0007179
T184 3229-3231 Disease denotes GS http://purl.obolibrary.org/obo/MONDO_0005773
T185 3300-3305 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T186 3307-3311 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T187 3514-3523 Disease denotes Influenza http://purl.obolibrary.org/obo/MONDO_0005812
T188 3531-3536 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T189 3710-3714 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T190 3907-3916 Disease denotes Influenza http://purl.obolibrary.org/obo/MONDO_0005812
T191 4196-4200 Disease denotes AIDS http://purl.obolibrary.org/obo/MONDO_0012268
T192 4212-4238 Disease denotes cytomegalovirus infections http://purl.obolibrary.org/obo/MONDO_0005132
T193 4444-4449 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T194 4451-4468 Disease denotes influenza A(H1N1) http://purl.obolibrary.org/obo/MONDO_0005460
T195 4451-4460 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T196 4798-4814 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T197 4822-4826 Disease denotes AIDS http://purl.obolibrary.org/obo/MONDO_0012268
T198 4827-4862 Disease denotes Acquired immune deficiency syndrome http://purl.obolibrary.org/obo/MONDO_0012268
T199 4864-4868 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T200 4869-4902 Disease denotes Severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T201 4947-4958 Disease denotes Hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T202 4947-4956 Disease denotes Hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T203 4970-4984 Disease denotes Herpes simplex http://purl.obolibrary.org/obo/MONDO_0004609
T204 4996-5005 Disease denotes Varicella http://purl.obolibrary.org/obo/MONDO_0005700
T205 5006-5012 Disease denotes zoster http://purl.obolibrary.org/obo/MONDO_0005609

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T218 456-461 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T219 533-534 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T220 627-635 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T221 656-663 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T222 707-716 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell line
T223 721-726 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T224 835-843 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T225 861-864 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T226 952-953 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T227 1022-1025 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T228 1079-1080 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T229 1269-1276 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T230 1288-1289 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T231 1365-1368 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T232 1466-1467 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T233 1767-1780 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T234 1787-1788 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T235 2022-2027 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T236 2045-2050 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T237 2137-2140 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T238 2184-2185 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T239 2479-2480 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T240 3283-3288 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T241 3319-3320 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T242 3339-3346 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T243 3433-3441 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T244 3486-3487 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T245 3503-3513 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T246 3642-3643 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T247 3659-3667 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T248 3696-3703 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T249 3725-3727 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T250 3789-3797 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T251 3866-3870 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T252 3917-3924 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T253 3925-3930 http://purl.obolibrary.org/obo/CLO_0001625 denotes A [95
T254 3986-3987 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T255 4461-4462 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T256 4605-4606 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T257 4699-4707 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T258 4709-4716 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T259 4717-4718 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T260 4733-4740 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T261 4751-4756 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T262 4757-4763 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T263 4779-4782 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T264 4792-4797 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T265 4815-4820 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T266 4959-4964 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T267 4985-4990 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T268 5013-5018 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T119 196-201 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T120 215-229 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T121 297-321 Chemical denotes neuraminidase inhibitors http://purl.obolibrary.org/obo/CHEBI_52425
T122 311-321 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T123 323-334 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T124 336-345 Chemical denotes peramivir http://purl.obolibrary.org/obo/CHEBI_85196|http://purl.obolibrary.org/obo/CHEBI_85202
T126 347-356 Chemical denotes zanamivir http://purl.obolibrary.org/obo/CHEBI_50663
T127 364-375 Chemical denotes ganciclovir http://purl.obolibrary.org/obo/CHEBI_465284
T128 377-386 Chemical denotes acyclovir http://purl.obolibrary.org/obo/CHEBI_2453
T129 392-401 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T130 414-432 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T131 521-528 Chemical denotes GS-5734 http://purl.obolibrary.org/obo/CHEBI_145994
T132 521-523 Chemical denotes GS http://purl.obolibrary.org/obo/CHEBI_73516
T133 538-543 Chemical denotes cyano http://purl.obolibrary.org/obo/CHEBI_48819
T134 556-565 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T135 566-576 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T136 584-591 Chemical denotes prodrug http://purl.obolibrary.org/obo/CHEBI_50266
T137 617-626 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T138 734-744 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T139 937-948 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T140 965-969 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T141 1010-1021 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T142 1196-1207 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T143 1353-1364 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T144 1443-1445 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T146 1483-1502 Chemical denotes autophagy inhibitor http://purl.obolibrary.org/obo/CHEBI_88230
T147 1493-1502 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T148 1599-1610 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T149 1804-1814 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T150 1819-1830 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T151 1948-1967 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T153 1957-1967 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T154 1968-1991 Chemical denotes lopinavir and ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T155 1968-1977 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T156 1982-1991 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T157 2242-2261 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T158 2242-2251 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T159 2252-2261 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T160 2263-2270 Chemical denotes Kaletra http://purl.obolibrary.org/obo/CHEBI_145924
T161 2296-2298 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T163 2375-2383 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T164 2404-2423 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T165 2404-2413 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T166 2414-2423 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T167 2425-2432 Chemical denotes Kaletra http://purl.obolibrary.org/obo/CHEBI_145924
T168 2436-2443 Chemical denotes arbidol http://purl.obolibrary.org/obo/CHEBI_134730
T169 2501-2509 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T170 2643-2658 Chemical denotes antiviral drugs http://purl.obolibrary.org/obo/CHEBI_36044
T171 2643-2652 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T172 2653-2658 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T173 2681-2692 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T174 2694-2704 Chemical denotes nafamostat http://purl.obolibrary.org/obo/CHEBI_135466
T175 2769-2784 Chemical denotes antiviral drugs http://purl.obolibrary.org/obo/CHEBI_36044
T176 2769-2778 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T177 2779-2784 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T178 2798-2804 Chemical denotes Action http://purl.obolibrary.org/obo/CHEBI_5133
T179 2865-2874 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T180 2894-2904 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T181 2935-2942 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T182 3076-3087 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T183 3147-3167 Chemical denotes autophagy inhibitors http://purl.obolibrary.org/obo/CHEBI_88230
T184 3157-3167 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T185 3229-3236 Chemical denotes GS-5734 http://purl.obolibrary.org/obo/CHEBI_145994
T186 3229-3231 Chemical denotes GS http://purl.obolibrary.org/obo/CHEBI_73516
T187 3238-3248 Chemical denotes Nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T188 3258-3265 Chemical denotes prodrug http://purl.obolibrary.org/obo/CHEBI_50266
T189 3398-3423 Chemical denotes serine protease inhibitor http://purl.obolibrary.org/obo/CHEBI_64926
T190 3398-3404 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T191 3405-3423 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T193 3414-3423 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T194 3489-3502 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T195 3575-3584 Chemical denotes guanosine http://purl.obolibrary.org/obo/CHEBI_16750
T196 3585-3595 Chemical denotes nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T197 3692-3695 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T198 3738-3749 Chemical denotes Oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T199 3750-3773 Chemical denotes Neuraminidase inhibitor http://purl.obolibrary.org/obo/CHEBI_52425
T200 3764-3773 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T201 3968-3978 Chemical denotes Nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T202 4006-4013 Chemical denotes guanine http://purl.obolibrary.org/obo/CHEBI_16235
T203 4097-4108 Chemical denotes Ganciclovir http://purl.obolibrary.org/obo/CHEBI_465284
T204 4109-4119 Chemical denotes Nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T205 4134-4143 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T206 4273-4278 Chemical denotes T-705 http://purl.obolibrary.org/obo/CHEBI_134722
T207 4280-4290 Chemical denotes Nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T208 4305-4329 Chemical denotes RNA polymerase inhibitor http://purl.obolibrary.org/obo/CHEBI_37416
T209 4320-4329 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T210 4430-4433 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T39 1132-1148 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T40 1483-1492 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T41 1483-1492 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T42 1534-1549 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T43 1631-1644 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T44 3147-3156 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T45 3147-3156 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T46 3433-3448 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T47 3489-3513 http://purl.obolibrary.org/obo/GO_0050819 denotes anticoagulant activities
T48 3617-3626 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T49 3844-3851 http://purl.obolibrary.org/obo/GO_0007114 denotes budding
T50 3872-3889 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T51 3872-3889 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T52 4377-4389 http://purl.obolibrary.org/obo/GO_0000003 denotes reproduction
T53 4430-4443 http://purl.obolibrary.org/obo/GO_0071897 denotes DNA synthesis
T54 4434-4443 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T55 4576-4582 http://purl.obolibrary.org/obo/GO_0040007 denotes growth

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T149 0-20 Sentence denotes Antiviral treatments
T150 21-185 Sentence denotes Based on the experience of fighting the epidemic SARS-CoV and MERS-CoV previously, we may learn some lessons for some treatment strategies against coronavirus [74].
T151 186-508 Sentence denotes Antiviral drugs and systemic corticosteroid treatment commonly used in clinical practice previously, including neuraminidase inhibitors (oseltamivir, peramivir, zanamivir, etc), ganciclovir, acyclovir, and ribavirin, as well as methylprednisolone [46, 75] for influenza virus, are invalid for COVID-19 and not recommended.
T152 509-664 Sentence denotes Remdesivir (GS-5734) is a 1′-cyano-substituted adenosine nucleotide analog prodrug and shows broad-spectrum antiviral activity against several RNA viruses.
T153 665-849 Sentence denotes Based on the data collected from in vitro cell line and mouse model, remdesivir could interfere with the NSP12 polymerase even in the setting of intact ExoN proofreading activity [76].
T154 850-936 Sentence denotes Remdesivir has been reported to treat the first US case of COVID-19 successfully [77].
T155 937-1009 Sentence denotes Chloroquine is a repurposed drug with great potential to treat COVID-19.
T156 1010-1149 Sentence denotes Chloroquine has been used to treat malaria for many years [78], with a mechanism that is not well understood against some viral infections.
T157 1150-1195 Sentence denotes Several possible mechanisms are investigated:
T158 1196-1342 Sentence denotes Chloroquine can inhibit pH-dependent steps of the replication of several viruses [79], with a potent effect on SARS-CoV infection and spread [80].
T159 1343-1448 Sentence denotes Moreover, chloroquine has immunomodulatory effects, suppressing the production/release of TNF-α and IL-6.
T160 1449-1566 Sentence denotes It also works as a novel class of autophagy inhibitor [81], which may interfere with viral infection and replication.
T161 1567-1786 Sentence denotes Several studies have found that chloroquine interfered with the glycosylation of cellular receptors of SARS-CoV [80] and functioned at both entry and at post-entry stages of the COVID-19 infection in Vero E6 cells [82].
T162 1787-1906 Sentence denotes A combination of remdesivir and chloroquine was proven to effectively inhibit the recently emerged SARS-CoV-2 in vitro.
T163 1907-2133 Sentence denotes Scientists previously confirmed that the protease inhibitors lopinavir and ritonavir, used to treat infection with human immunodeficiency virus (HIV) [83], could improve the outcome of MERS-CoV [84] and SARS-CoV [85] patients.
T164 2134-2320 Sentence denotes It has reported that β-coronavirus viral loads of a COVID-19 patient in Korea significantly decreased after lopinavir/ritonavir (Kaletra®, AbbVie, North Chicago, IL, USA) treatment [86].
T165 2321-2742 Sentence denotes Additionally, clinicians combined Chinese and Western medicine treatment including lopinavir/ritonavir (Kaletra®), arbidol, and Shufeng Jiedu Capsule (SFJDC, a traditional Chinese medicine) and gained significant improvement in pneumonia associated symptoms in Shanghai Public Health Clinical Center, China [87].The other antiviral drugs include nitazoxanide, favipiravir, nafamostat, and so on (See Table 1 for details).
T166 2743-2784 Sentence denotes Table 1 Common and potent antiviral drugs
T167 2785-2855 Sentence denotes Status Drugs Action mode Anti-infective mechanism Target diseases Ref.
T168 2856-3035 Sentence denotes Approved Lopinavir/Ritonavir Protease inhibitors Inhibiting HIV-1 protease for protein cleavage, resulting in non-infectious, immature viral particles HIV/AIDS, SARS, MERS [83–85]
T169 3036-3203 Sentence denotes Approved, Investigational, Vet approved Chloroquine 9-aminoquinolin Increasing endosomal pH, immunomodulating, autophagy inhibitors Malaria, autoimmune disease [79–82]
T170 3204-3317 Sentence denotes Experimental Remdesivir (GS-5734) Nucleotide analogue prodrug Interfering with virus post-entry Ebola, SARS, MERS
T171 3318-3360 Sentence denotes (A wide array of RNA viruses) [76, 88, 89]
T172 3361-3545 Sentence denotes Investigational Nafamostat Synthetic serine protease inhibitor Prevents membrane fusion by reducing the release of cathepsin B; anticoagulant activities Influenza, MERS, Ebola [90, 91]
T173 3546-3728 Sentence denotes Approved Ribavirin Synthetic guanosine nucleoside Interfering with the synthesis of viral mRNA (a broad-spectrum activity against several RNA and DNA viruses) HCV, SARS, MERS [92–94]
T174 3729-3935 Sentence denotes Approved Oseltamivir Neuraminidase inhibitor Inhibiting the activity of the viral neuraminidase enzyme, preventing budding from the host cell, viral replication, and infectivity Influenza viruses A [95, 96]
T175 3936-4070 Sentence denotes Approved Penciclovir/ Acyclovir Nucleoside analog A synthetic acyclic guanine derivative, resulting in chain termination HSV, VZV [97]
T176 4071-4243 Sentence denotes Approved, Investigational Ganciclovir Nucleoside analog Potent inhibitor of the Herpesvirus family including cytomegalovirus AIDS-associated cytomegalovirus infections [98]
T177 4244-4298 Sentence denotes Investigational Favipiravir (T-705) Nucleoside analog:
T178 4299-4477 Sentence denotes Viral RNA polymerase inhibitor Acting on viral genetic copying to prevent its reproduction, without affecting host cellular RNA or DNA synthesis Ebola, influenza A(H1N1) [99–101]
T179 4478-4787 Sentence denotes Approved, Investigational, Vet approved Nitazoxanide Antiprotozoal agent Modulating the survival, growth, and proliferation of a range of extracellular and intracellular protozoa, helminths, anaerobic and microaerophilic bacteria, viruses A wide range of viruses including human/animal coronaviruses [102–104]
T180 4788-5018 Sentence denotes HIV Human immunodeficiency virus, AIDS Acquired immune deficiency syndrome, SARS Severe acute respiratory syndrome, MERS Middle East respiratory syndrome, HCV Hepatitis C virus, HSV Herpes simplex virus, VZV Varicella-zoster virus

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T49 2028-2044 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T50 2549-2558 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T51 3177-3195 Phenotype denotes autoimmune disease http://purl.obolibrary.org/obo/HP_0002960
T52 4798-4814 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T53 4836-4853 Phenotype denotes immune deficiency http://purl.obolibrary.org/obo/HP_0002721
T54 4947-4956 Phenotype denotes Hepatitis http://purl.obolibrary.org/obo/HP_0012115

2_test

Id Subject Object Predicate Lexical cue
32169119-26868298-70132240 181-183 26868298 denotes 74
32169119-29511076-70132241 845-847 29511076 denotes 76
32169119-32004427-70132242 932-934 32004427 denotes 77
32169119-30396013-70132243 1069-1071 30396013 denotes 78
32169119-14592603-70132244 1278-1280 14592603 denotes 79
32169119-16115318-70132245 1338-1340 16115318 denotes 80
32169119-25727221-70132246 1504-1506 25727221 denotes 81
32169119-16115318-70132247 1680-1682 16115318 denotes 80
32169119-32020029-70132248 1782-1784 32020029 denotes 82
32169119-12662125-70132249 2058-2060 12662125 denotes 83
32169119-31900204-70132250 2102-2104 31900204 denotes 84
32169119-14985565-70132251 2120-2122 14985565 denotes 85
32169119-32056407-70132252 2316-2318 32056407 denotes 86
32169119-12662125-70132253 3029-3031 12662125 denotes 83
32169119-31900204-70132253 3029-3031 31900204 denotes 83
32169119-14985565-70132253 3029-3031 14985565 denotes 83
32169119-14592603-70132254 3197-3199 14592603 denotes 79
32169119-16115318-70132254 3197-3199 16115318 denotes 79
32169119-25727221-70132254 3197-3199 25727221 denotes 79
32169119-32020029-70132254 3197-3199 32020029 denotes 79
32169119-29511076-70132255 3349-3351 29511076 denotes 76
32169119-30987343-70132256 3353-3355 30987343 denotes 88
32169119-31142680-70132257 3357-3359 31142680 denotes 89
32169119-18220789-70132258 3538-3540 18220789 denotes 90
32169119-26346967-70132259 3542-3544 26346967 denotes 91
32169119-30215672-70132260 3722-3724 30215672 denotes 92
32169119-15018130-70132260 3722-3724 15018130 denotes 92
32169119-24811411-70132261 3932-3934 24811411 denotes 96
32169119-29896665-70132262 4067-4069 29896665 denotes 97
32169119-29678260-70132263 4240-4242 29678260 denotes 98
32169119-24084488-70132264 4470-4472 24084488 denotes 99
32169119-25108173-70132265 4779-4782 25108173 denotes 102
32169119-25451075-70132265 4779-4782 25451075 denotes 102
32169119-27095301-70132265 4779-4782 27095301 denotes 102