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PMC:7068984 / 19557-21843 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
702 275-279 Gene denotes ACE2 Gene:59272
703 493-497 Gene denotes TLR7 Gene:51284
704 499-503 Gene denotes TLR8 Gene:51311
705 509-513 Gene denotes TLR9 Gene:54106
706 619-624 Gene denotes RIG-I Gene:23586
707 651-693 Gene denotes melanoma differentiation-associated gene 5 Gene:64135
708 695-699 Gene denotes MDA5 Gene:64135
709 728-751 Gene denotes cyclic GMP-AMP synthase Gene:115004
710 892-929 Gene denotes TIR-domain-containing adaptor protein Gene:114609
711 940-945 Gene denotes IFN-β Gene:3439
712 947-951 Gene denotes TRIF Gene:148022
713 998-1002 Gene denotes MAVS Gene:57506
714 1013-1051 Gene denotes stimulator of interferon genes protein Gene:340061
715 1134-1139 Gene denotes MyD88 Gene:4615
716 1214-1219 Gene denotes NF-κB Gene:4790
717 1225-1255 Gene denotes interferon regulatory factor 3 Gene:3661
718 1257-1261 Gene denotes IRF3 Gene:3661
719 1305-1310 Gene denotes IFN-α Gene:3439
720 1679-1683 Gene denotes IL-1 Gene:3552
721 1685-1689 Gene denotes IL-2 Gene:3558
722 1691-1695 Gene denotes IL-4 Gene:3565
723 1697-1701 Gene denotes IL-7 Gene:3574
724 1703-1708 Gene denotes IL-10 Gene:3586
725 1717-1722 Gene denotes IL-13 Gene:3596
726 1724-1729 Gene denotes IL-17 Gene:3605
727 1731-1735 Gene denotes GCSF Gene:1440
728 1737-1773 Gene denotes macrophage colony-stimulating factor Gene:1435
729 1775-1779 Gene denotes MCSF Gene:1435
730 1782-1787 Gene denotes IP-10 Gene:3627
731 1789-1794 Gene denotes MCP-1 Gene:6347
732 1796-1802 Gene denotes MIP-1α Gene:6348
733 1804-1828 Gene denotes hepatocyte growth factor Gene:3082
734 1830-1833 Gene denotes HGF Gene:3082
735 1836-1841 Gene denotes IFN-γ Gene:3458
736 1846-1851 Gene denotes TNF-α Gene:7124
737 753-757 Gene denotes cGAS Gene:115004
738 236-247 Species denotes Coronavirus Tax:11118
739 1659-1667 Species denotes patients Tax:9606
740 2277-2285 Species denotes patients Tax:9606
741 1053-1058 Gene denotes STING Gene:340061
742 104-118 Disease denotes CoV infections MESH:D018352
743 1650-1658 Disease denotes COVID-19 MESH:C000657245
744 1896-1914 Disease denotes COVID-19 pneumonia MESH:C000657245
745 1942-1950 Disease denotes COVID-19 MESH:C000657245
746 2014-2025 Disease denotes lung injury MESH:D055370
747 2268-2276 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T118 224-232 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T119 266-271 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T120 326-329 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T121 526-529 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T122 534-537 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T123 545-553 Body_part denotes endosome http://purl.org/sig/ont/fma/fma67180
T124 574-577 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T125 611-615 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T126 632-641 Body_part denotes cytosolic http://purl.org/sig/ont/fma/fma66836
T127 687-691 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T128 809-812 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T129 817-820 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T130 828-837 Body_part denotes cytoplasm http://purl.org/sig/ont/fma/fma66835
T131 922-929 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T132 989-996 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T133 1044-1051 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T134 1348-1357 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T135 1377-1381 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T136 1592-1598 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T137 1599-1608 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T138 1613-1623 Body_part denotes chemokines http://purl.org/sig/ont/fma/fma241981
T139 1679-1683 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T140 1679-1681 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T141 1685-1689 Body_part denotes IL-2 http://purl.org/sig/ont/fma/fma84051
T142 1685-1687 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T143 1691-1693 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T144 1697-1699 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T145 1703-1705 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T146 1710-1715 Body_part denotes IL-12 http://purl.org/sig/ont/fma/fma86579
T147 1710-1712 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T148 1717-1719 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T149 1724-1726 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T150 1737-1747 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T151 1804-1814 Body_part denotes hepatocyte http://purl.org/sig/ont/fma/fma14515
T152 2014-2018 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T153 2084-2090 Body_part denotes mucosa http://purl.org/sig/ont/fma/fma85355
T154 2116-2121 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T155 2185-2193 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T156 2207-2211 Body_part denotes body http://purl.org/sig/ont/fma/fma256135

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T24 2014-2018 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T25 2084-2090 Body_part denotes mucosa http://purl.obolibrary.org/obo/UBERON_0000344

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T146 108-118 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T147 651-659 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105
T148 1650-1658 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T149 1896-1904 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T150 1905-1914 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T151 1942-1950 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T152 2019-2025 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T153 2268-2276 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T183 266-271 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T184 295-303 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T185 611-615 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T186 687-691 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T187 853-863 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T188 978-988 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T189 1038-1043 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T190 1156-1166 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T191 1211-1212 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T192 1218-1219 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T193 1285-1303 http://purl.obolibrary.org/obo/PR_000024990 denotes type I Interferons
T194 1319-1320 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T195 1371-1376 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T196 1377-1381 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T197 1403-1404 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T198 1458-1463 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T199 1499-1500 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T200 1537-1542 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T201 1586-1587 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T202 1592-1598 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T203 1685-1689 http://purl.obolibrary.org/obo/PR_000001379 denotes IL-2
T204 1731-1735 http://purl.obolibrary.org/obo/PR_000005932 denotes GCSF
T205 1830-1833 http://purl.obolibrary.org/obo/CLO_0003740 denotes HGF
T206 1853-1855 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T207 1996-2002 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T208 2014-2018 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T209 2014-2018 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T210 2045-2050 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T211 2084-2090 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa
T212 2116-2121 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T213 2134-2135 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T76 224-232 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T77 534-537 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T78 596-600 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T79 728-742 Chemical denotes cyclic GMP-AMP http://purl.obolibrary.org/obo/CHEBI_71580
T80 735-738 Chemical denotes GMP http://purl.obolibrary.org/obo/CHEBI_17345|http://purl.obolibrary.org/obo/CHEBI_58115
T82 739-742 Chemical denotes AMP http://purl.obolibrary.org/obo/CHEBI_16027|http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_456215
T85 817-820 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T86 922-929 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T87 968-977 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T88 989-996 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T89 1027-1037 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T90 1044-1051 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T91 1096-1105 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T92 1125-1133 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T93 1214-1216 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T96 1225-1235 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T97 1679-1681 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T99 1685-1687 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T101 1691-1693 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T103 1697-1699 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T105 1703-1705 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T107 1710-1712 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T109 1717-1719 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T111 1724-1726 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T113 1782-1787 Chemical denotes IP-10 http://purl.obolibrary.org/obo/CHEBI_138157
T114 1782-1784 Chemical denotes IP http://purl.obolibrary.org/obo/CHEBI_74076
T115 1789-1792 Chemical denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T27 5-20 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T28 45-60 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T29 186-201 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T30 853-863 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T31 978-988 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T32 1174-1194 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factor
T33 1174-1187 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T34 1470-1485 http://purl.obolibrary.org/obo/GO_0045087 denotes Innate immunity
T35 1509-1519 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T36 1815-1821 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T37 1961-1982 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T38 2146-2162 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T132 0-40 Sentence denotes Host immune response and immunopathology
T133 41-217 Sentence denotes The immune response is vital for the control and resolution of CoV infections, while it can also lead to immunopathogenesis, associated with the immune response out of control.
T134 218-330 Sentence denotes The S proteins of Coronavirus binds to the host cells by ACE2, fusing to the membrane and release the viral RNA.
T135 331-455 Sentence denotes The viral RNAs, as pathogen-associated molecular patterns (PAMPs), are detected by the pattern recognition receptors (PRRs).
T136 456-563 Sentence denotes Usually, Toll-like receptor (TLR) 3, TLR7, TLR8, and TLR9 sense viral RNA and DNA in the endosome [60, 61].
T137 564-838 Sentence denotes The viral RNA receptor retinoic-acid inducible gene I (RIG-I) [62], cytosolic receptor melanoma differentiation-associated gene 5 (MDA5) and nucleotidyltransferase cyclic GMP-AMP synthase (cGAS) [63] are responsible for the recognition of viral RNA and DNA in the cytoplasm.
T138 839-1363 Sentence denotes These complex signalling recruit adaptors, including TIR-domain-containing adaptor protein including IFN-β (TRIF), mitochondrial antiviral-signalling protein (MAVS) [64] and stimulator of interferon genes protein (STING) [65] to trigger downstream cascades molecules, involving adaptor molecule MyD88 and lead to the activation of the transcription factor nuclear factor-κB (NF-κB) and interferon regulatory factor 3 (IRF3) and the production of type I Interferons (IFN-α /β) and a series of pro-inflammatory cytokines [66].
T139 1364-1469 Sentence denotes Hence, virus-cell interactions produce a diverse set of immune mediators against the invading virus [67].
T140 1470-1585 Sentence denotes Innate immunity is needed in a precise regulation to eliminate the virus, otherwise will result in immunopathology.
T141 1586-1865 Sentence denotes A few plasma cytokines and chemokines were observed ascended in COVID-19 patients, including IL-1, IL-2, IL-4, IL-7, IL-10, IL-12, IL-13, IL-17, GCSF, macrophage colony-stimulating factor (MCSF), IP-10, MCP-1, MIP-1α, hepatocyte growth factor (HGF), IFN-γ and TNF-α [48, 68, 69].
T142 1866-2026 Sentence denotes Of note, an anatomy report of COVID-19 pneumonia corpse [70] indicated that COVID-19 caused an inflammatory response in the lower airway and led to lung injury.
T143 2027-2286 Sentence denotes Collectively, the virus particles invade the respiratory mucosa firstly and infect other cells, triggering a series of immune responses and the production of cytokine storm in the body, which may be associated with the critical condition of COVID-19 patients.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T44 651-659 Phenotype denotes melanoma http://purl.obolibrary.org/obo/HP_0002861
T45 1905-1914 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T46 2185-2199 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041

2_test

Id Subject Object Predicate Lexical cue
32169119-11607032-70132230 555-557 11607032 denotes 60
32169119-24655297-70132231 559-561 24655297 denotes 61
32169119-24968321-70132232 627-629 24968321 denotes 62
32169119-23258412-70132233 760-762 23258412 denotes 63
32169119-16125763-70132234 1005-1007 16125763 denotes 64
32169119-18724357-70132235 1061-1063 18724357 denotes 65
32169119-20404851-70132236 1359-1361 20404851 denotes 66
32169119-19120477-70132237 1465-1467 19120477 denotes 67
32169119-31986264-70132238 1853-1855 31986264 denotes 48
32169119-32114747-70132239 1857-1859 32114747 denotes 68