PMC:7067204 / 15748-16947 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7067204","sourcedb":"PMC","sourceid":"7067204","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7067204","text":"Comparison of protein sequences of A. Spike globular head S1, and B. S1 receptor-binding domain (RBD) subunit. Multiple alignment of Spike S1 amino acid sequences of 2019-nCoV HKU-SZ-005b (accession number MN975262), bat SARS-like coronavirus isolates bat-SL-CoVZXC21, bat-SL-CoVZXC45, bat-SL-CoV-YNLF_31C, bat-SL-CoV-YNLF_34C and bat SL-CoV HKU3-1 (accession number MG772934.1 and MG772933.1, KP886808, KP886809 and DQ022305, respectively), human SARS coronavirus GZ02 and Tor2 (accession number AY390556 and AY274119, respectively) and Paguma SARS-CoV (accession number AY515512) was performed and displayed using CLUSTAL 2.1 and BOXSHADE 3.21, respectively. The black background represents the identity while the grey background represents the similarity of the amino acid sequences. Orange box indicates the region of signal peptide, while green and blue boxes indicate the core domain and receptor binding domain respectively. Sequences of RBD, highlighted in (A) were used for comparison. External subdomain variable region of 2019-nCoV HKU-SZ-005b was predicted by comparison of amino acid similarity and published structural analysis [17]. Purple box indicates the external subdomain region.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"804","span":{"begin":693,"end":696},"obj":"Gene"},{"id":"805","span":{"begin":474,"end":477},"obj":"Gene"},{"id":"806","span":{"begin":331,"end":334},"obj":"Gene"},{"id":"807","span":{"begin":307,"end":310},"obj":"Gene"},{"id":"808","span":{"begin":286,"end":289},"obj":"Gene"},{"id":"809","span":{"begin":269,"end":272},"obj":"Gene"},{"id":"810","span":{"begin":252,"end":255},"obj":"Gene"},{"id":"811","span":{"begin":1169,"end":1172},"obj":"Gene"},{"id":"812","span":{"begin":874,"end":877},"obj":"Gene"},{"id":"813","span":{"begin":808,"end":811},"obj":"Gene"},{"id":"814","span":{"begin":761,"end":764},"obj":"Gene"},{"id":"815","span":{"begin":661,"end":664},"obj":"Gene"},{"id":"816","span":{"begin":133,"end":138},"obj":"Gene"},{"id":"817","span":{"begin":38,"end":43},"obj":"Gene"},{"id":"818","span":{"begin":1083,"end":1085},"obj":"Gene"},{"id":"819","span":{"begin":1030,"end":1032},"obj":"Gene"},{"id":"820","span":{"begin":819,"end":821},"obj":"Gene"},{"id":"821","span":{"begin":758,"end":760},"obj":"Gene"},{"id":"822","span":{"begin":163,"end":165},"obj":"Gene"},{"id":"823","span":{"begin":130,"end":132},"obj":"Gene"},{"id":"824","span":{"begin":32,"end":34},"obj":"Gene"},{"id":"825","span":{"begin":11,"end":13},"obj":"Gene"},{"id":"826","span":{"begin":166,"end":175},"obj":"Species"},{"id":"827","span":{"begin":217,"end":242},"obj":"Species"},{"id":"828","span":{"begin":293,"end":296},"obj":"Species"},{"id":"829","span":{"begin":314,"end":317},"obj":"Species"},{"id":"830","span":{"begin":338,"end":341},"obj":"Species"},{"id":"831","span":{"begin":448,"end":469},"obj":"Species"},{"id":"832","span":{"begin":545,"end":553},"obj":"Species"},{"id":"833","span":{"begin":1033,"end":1042},"obj":"Species"},{"id":"834","span":{"begin":342,"end":346},"obj":"Species"},{"id":"835","span":{"begin":206,"end":214},"obj":"CellLine"}],"attributes":[{"id":"A804","pred":"tao:has_database_id","subj":"804","obj":"Gene:25085"},{"id":"A805","pred":"tao:has_database_id","subj":"805","obj":"Gene:6097"},{"id":"A806","pred":"tao:has_database_id","subj":"806","obj":"Gene:570"},{"id":"A807","pred":"tao:has_database_id","subj":"807","obj":"Gene:570"},{"id":"A808","pred":"tao:has_database_id","subj":"808","obj":"Gene:570"},{"id":"A809","pred":"tao:has_database_id","subj":"809","obj":"Gene:570"},{"id":"A810","pred":"tao:has_database_id","subj":"810","obj":"Gene:570"},{"id":"A811","pred":"tao:has_database_id","subj":"811","obj":"Gene:25085"},{"id":"A812","pred":"tao:has_database_id","subj":"812","obj":"Gene:25085"},{"id":"A813","pred":"tao:has_database_id","subj":"813","obj":"Gene:25085"},{"id":"A814","pred":"tao:has_database_id","subj":"814","obj":"Gene:25085"},{"id":"A815","pred":"tao:has_database_id","subj":"815","obj":"Gene:25085"},{"id":"A816","pred":"tao:has_database_id","subj":"816","obj":"Gene:43740568"},{"id":"A817","pred":"tao:has_database_id","subj":"817","obj":"Gene:43740568"},{"id":"A818","pred":"tao:has_database_id","subj":"818","obj":"Gene:6688"},{"id":"A819","pred":"tao:has_database_id","subj":"819","obj":"Gene:6688"},{"id":"A820","pred":"tao:has_database_id","subj":"820","obj":"Gene:6688"},{"id":"A821","pred":"tao:has_database_id","subj":"821","obj":"Gene:6688"},{"id":"A822","pred":"tao:has_database_id","subj":"822","obj":"Gene:6688"},{"id":"A823","pred":"tao:has_database_id","subj":"823","obj":"Gene:6688"},{"id":"A824","pred":"tao:has_database_id","subj":"824","obj":"Gene:6688"},{"id":"A825","pred":"tao:has_database_id","subj":"825","obj":"Gene:6688"},{"id":"A826","pred":"tao:has_database_id","subj":"826","obj":"Tax:2697049"},{"id":"A827","pred":"tao:has_database_id","subj":"827","obj":"Tax:1508227"},{"id":"A828","pred":"tao:has_database_id","subj":"828","obj":"Tax:11118"},{"id":"A829","pred":"tao:has_database_id","subj":"829","obj":"Tax:11118"},{"id":"A830","pred":"tao:has_database_id","subj":"830","obj":"Tax:11118"},{"id":"A831","pred":"tao:has_database_id","subj":"831","obj":"Tax:256753"},{"id":"A832","pred":"tao:has_database_id","subj":"832","obj":"Tax:694009"},{"id":"A833","pred":"tao:has_database_id","subj":"833","obj":"Tax:2697049"},{"id":"A834","pred":"tao:has_database_id","subj":"834","obj":"Tax:290028"},{"id":"A835","pred":"tao:has_database_id","subj":"835","obj":"CVCL:U508"},{"subj":"804","pred":"source","obj":"LitCovid-PubTator"},{"subj":"805","pred":"source","obj":"LitCovid-PubTator"},{"subj":"806","pred":"source","obj":"LitCovid-PubTator"},{"subj":"807","pred":"source","obj":"LitCovid-PubTator"},{"subj":"808","pred":"source","obj":"LitCovid-PubTator"},{"subj":"809","pred":"source","obj":"LitCovid-PubTator"},{"subj":"810","pred":"source","obj":"LitCovid-PubTator"},{"subj":"811","pred":"source","obj":"LitCovid-PubTator"},{"subj":"812","pred":"source","obj":"LitCovid-PubTator"},{"subj":"813","pred":"source","obj":"LitCovid-PubTator"},{"subj":"814","pred":"source","obj":"LitCovid-PubTator"},{"subj":"815","pred":"source","obj":"LitCovid-PubTator"},{"subj":"816","pred":"source","obj":"LitCovid-PubTator"},{"subj":"817","pred":"source","obj":"LitCovid-PubTator"},{"subj":"818","pred":"source","obj":"LitCovid-PubTator"},{"subj":"819","pred":"source","obj":"LitCovid-PubTator"},{"subj":"820","pred":"source","obj":"LitCovid-PubTator"},{"subj":"821","pred":"source","obj":"LitCovid-PubTator"},{"subj":"822","pred":"source","obj":"LitCovid-PubTator"},{"subj":"823","pred":"source","obj":"LitCovid-PubTator"},{"subj":"824","pred":"source","obj":"LitCovid-PubTator"},{"subj":"825","pred":"source","obj":"LitCovid-PubTator"},{"subj":"826","pred":"source","obj":"LitCovid-PubTator"},{"subj":"827","pred":"source","obj":"LitCovid-PubTator"},{"subj":"828","pred":"source","obj":"LitCovid-PubTator"},{"subj":"829","pred":"source","obj":"LitCovid-PubTator"},{"subj":"830","pred":"source","obj":"LitCovid-PubTator"},{"subj":"831","pred":"source","obj":"LitCovid-PubTator"},{"subj":"832","pred":"source","obj":"LitCovid-PubTator"},{"subj":"833","pred":"source","obj":"LitCovid-PubTator"},{"subj":"834","pred":"source","obj":"LitCovid-PubTator"},{"subj":"835","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T76","span":{"begin":14,"end":21},"obj":"Body_part"},{"id":"T77","span":{"begin":53,"end":57},"obj":"Body_part"},{"id":"T78","span":{"begin":142,"end":152},"obj":"Body_part"},{"id":"T79","span":{"begin":765,"end":775},"obj":"Body_part"},{"id":"T80","span":{"begin":1086,"end":1096},"obj":"Body_part"}],"attributes":[{"id":"A76","pred":"fma_id","subj":"T76","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A77","pred":"fma_id","subj":"T77","obj":"http://purl.org/sig/ont/fma/fma7154"},{"id":"A78","pred":"fma_id","subj":"T78","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A79","pred":"fma_id","subj":"T79","obj":"http://purl.org/sig/ont/fma/fma82739"},{"id":"A80","pred":"fma_id","subj":"T80","obj":"http://purl.org/sig/ont/fma/fma82739"},{"subj":"T76","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T77","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T16","span":{"begin":53,"end":57},"obj":"Body_part"}],"attributes":[{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0000033"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T72","span":{"begin":221,"end":225},"obj":"Disease"},{"id":"T73","span":{"begin":448,"end":452},"obj":"Disease"},{"id":"T74","span":{"begin":545,"end":553},"obj":"Disease"}],"attributes":[{"id":"A72","pred":"mondo_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A73","pred":"mondo_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A74","pred":"mondo_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T73","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T177","span":{"begin":35,"end":36},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T178","span":{"begin":53,"end":57},"obj":"http://purl.obolibrary.org/obo/UBERON_0000033"},{"id":"T179","span":{"begin":53,"end":57},"obj":"http://www.ebi.ac.uk/efo/EFO_0000964"},{"id":"T180","span":{"begin":58,"end":60},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T181","span":{"begin":66,"end":67},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T182","span":{"begin":69,"end":71},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T183","span":{"begin":139,"end":141},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T184","span":{"begin":217,"end":220},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9397"},{"id":"T185","span":{"begin":252,"end":255},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9397"},{"id":"T186","span":{"begin":269,"end":272},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9397"},{"id":"T187","span":{"begin":286,"end":289},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9397"},{"id":"T188","span":{"begin":307,"end":310},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9397"},{"id":"T189","span":{"begin":331,"end":334},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9397"},{"id":"T190","span":{"begin":442,"end":447},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T191","span":{"begin":822,"end":828},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T192","span":{"begin":829,"end":836},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T193","span":{"begin":966,"end":967},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T177","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T178","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T179","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T180","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T181","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T182","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T183","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T184","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T185","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T186","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T187","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T188","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T189","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T190","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T191","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T192","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T193","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T96","span":{"begin":14,"end":21},"obj":"Chemical"},{"id":"T97","span":{"begin":142,"end":152},"obj":"Chemical"},{"id":"T98","span":{"begin":142,"end":147},"obj":"Chemical"},{"id":"T99","span":{"begin":148,"end":152},"obj":"Chemical"},{"id":"T100","span":{"begin":256,"end":258},"obj":"Chemical"},{"id":"T101","span":{"begin":273,"end":275},"obj":"Chemical"},{"id":"T102","span":{"begin":290,"end":292},"obj":"Chemical"},{"id":"T103","span":{"begin":311,"end":313},"obj":"Chemical"},{"id":"T104","span":{"begin":335,"end":337},"obj":"Chemical"},{"id":"T105","span":{"begin":765,"end":775},"obj":"Chemical"},{"id":"T106","span":{"begin":765,"end":770},"obj":"Chemical"},{"id":"T107","span":{"begin":771,"end":775},"obj":"Chemical"},{"id":"T108","span":{"begin":829,"end":836},"obj":"Chemical"},{"id":"T109","span":{"begin":1086,"end":1096},"obj":"Chemical"},{"id":"T110","span":{"begin":1086,"end":1091},"obj":"Chemical"},{"id":"T111","span":{"begin":1092,"end":1096},"obj":"Chemical"}],"attributes":[{"id":"A96","pred":"chebi_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A97","pred":"chebi_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A98","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A99","pred":"chebi_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A100","pred":"chebi_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/CHEBI_74815"},{"id":"A101","pred":"chebi_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/CHEBI_74815"},{"id":"A102","pred":"chebi_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/CHEBI_74815"},{"id":"A103","pred":"chebi_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/CHEBI_74815"},{"id":"A104","pred":"chebi_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/CHEBI_74815"},{"id":"A105","pred":"chebi_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A106","pred":"chebi_id","subj":"T106","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A107","pred":"chebi_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A108","pred":"chebi_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A109","pred":"chebi_id","subj":"T109","obj":"http://purl.obolibrary.org/obo/CHEBI_33709"},{"id":"A110","pred":"chebi_id","subj":"T110","obj":"http://purl.obolibrary.org/obo/CHEBI_46882"},{"id":"A111","pred":"chebi_id","subj":"T111","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"subj":"T96","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T97","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T98","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T99","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T100","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T101","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T102","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T103","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T104","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T105","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T106","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T107","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T108","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T109","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T110","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T111","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T172","span":{"begin":0,"end":37},"obj":"Sentence"},{"id":"T173","span":{"begin":38,"end":68},"obj":"Sentence"},{"id":"T174","span":{"begin":69,"end":110},"obj":"Sentence"},{"id":"T175","span":{"begin":111,"end":660},"obj":"Sentence"},{"id":"T176","span":{"begin":661,"end":786},"obj":"Sentence"},{"id":"T177","span":{"begin":787,"end":931},"obj":"Sentence"},{"id":"T178","span":{"begin":932,"end":994},"obj":"Sentence"},{"id":"T179","span":{"begin":995,"end":1147},"obj":"Sentence"},{"id":"T180","span":{"begin":1148,"end":1199},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T172","pred":"source","obj":"LitCovid-sentences"},{"subj":"T173","pred":"source","obj":"LitCovid-sentences"},{"subj":"T174","pred":"source","obj":"LitCovid-sentences"},{"subj":"T175","pred":"source","obj":"LitCovid-sentences"},{"subj":"T176","pred":"source","obj":"LitCovid-sentences"},{"subj":"T177","pred":"source","obj":"LitCovid-sentences"},{"subj":"T178","pred":"source","obj":"LitCovid-sentences"},{"subj":"T179","pred":"source","obj":"LitCovid-sentences"},{"subj":"T180","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"31987001-25211075-27754486","span":{"begin":1143,"end":1145},"obj":"25211075"}],"attributes":[{"subj":"31987001-25211075-27754486","pred":"source","obj":"2_test"}]},{"project":"MyTest","denotations":[{"id":"31987001-25211075-27754486","span":{"begin":1143,"end":1145},"obj":"25211075"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"31987001-25211075-27754486","pred":"source","obj":"MyTest"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ec93d0","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#93eaec"},{"id":"LitCovid-PD-UBERON","color":"#ecd393"},{"id":"LitCovid-PD-MONDO","color":"#b993ec"},{"id":"LitCovid-PD-CLO","color":"#93ec9f"},{"id":"LitCovid-PD-CHEBI","color":"#ec93a0"},{"id":"LitCovid-sentences","color":"#93baec"},{"id":"2_test","color":"#d4ec93"},{"id":"MyTest","color":"#ea93ec"}]}]}}