PMC:7060195 / 446-1642 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7060195","sourcedb":"PMC","sourceid":"7060195","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7060195","text":"An outbreak of 2019-novel coronavirus (SARS-CoV-2) that causes atypical pneumonia (COVID-19) has raged in China since mid-December 2019 and has spread to 26 countries (February 20, 2020). The epidemic was identified by the first four cases confirmed on December 29, 2019 and was traced to the Huanan Seafood Wholesale Market, Wuhan city, Hubei Province, China1. A total of 75,465 cases with SARS-CoV-2 infections have been confirmed up to date (February 20, 2020), and 2,236 people have died in China2. COVID-19 spreads rapidly by human-to-human transmission with a median incubation period of 3.0 days (range, 0 to 24.0), and the time from symptom onset to developing pneumonia is 4.0 days (range, 2.0 to 7.0)3. Respiratory droplets and direct contact are conventional transmission routes for SARS-CoV-2, and fecal-to-oral transmission might also have a role3. Fever, dry cough, and fatigue are common symptoms at onset of COVID-194. Most patients have lymphopenia and bilateral ground-glass opacity changes on chest CT scans4,5. No specific antiviral treatments or vaccines are available because it is a new emerging viral disease. Development of SARS-CoV-2-based vaccines is urgently 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