
PMC:7060195 / 3871-5297
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
99 | 676-677 | Gene | denotes | E | Gene:43740570 |
100 | 680-688 | Gene | denotes | membrane | Gene:43740571 |
101 | 690-691 | Gene | denotes | M | Gene:43740571 |
102 | 708-709 | Gene | denotes | N | Gene:43740575 |
103 | 716-721 | Gene | denotes | spike | Gene:43740568 |
104 | 723-724 | Gene | denotes | S | Gene:43740568 |
105 | 820-823 | Gene | denotes | CD4 | Gene:920 |
106 | 825-828 | Gene | denotes | CD8 | Gene:925 |
107 | 694-706 | Gene | denotes | nucleocapsid | Gene:43740575 |
108 | 24-34 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
109 | 273-283 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
110 | 305-313 | Species | denotes | SARS-CoV | Tax:694009 |
111 | 318-373 | Species | denotes | Middle East respiratory syndrome coronavirus (MERS-CoV) | Tax:1335626 |
112 | 617-627 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
113 | 977-986 | Disease | denotes | hepatitis | MESH:D056486 |
114 | 77-87 | CellLine | denotes | MN908947.3 | CVCL:U508 |
115 | 89-99 | CellLine | denotes | MN975262.1 | CVCL:U508 |
116 | 114-124 | CellLine | denotes | MN997409.1 | CVCL:U508 |
117 | 126-136 | CellLine | denotes | MN985325.1 | CVCL:U508 |
118 | 138-148 | CellLine | denotes | MN988669.1 | CVCL:U508 |
119 | 150-160 | CellLine | denotes | MN988668.1 | CVCL:U508 |
120 | 162-172 | CellLine | denotes | MN994468.1 | CVCL:U508 |
121 | 174-184 | CellLine | denotes | MN994467.1 | CVCL:U508 |
122 | 186-196 | CellLine | denotes | MN988713.1 | CVCL:U508 |
123 | 202-212 | CellLine | denotes | MN938384.1 | CVCL:U508 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T7 | 35-42 | Body_part | denotes | genomes | http://purl.org/sig/ont/fma/fma84116 |
T8 | 422-425 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T9 | 439-445 | Body_part | denotes | genome | http://purl.org/sig/ont/fma/fma84116 |
T10 | 464-475 | Body_part | denotes | nucleotides | http://purl.org/sig/ont/fma/fma82740 |
T11 | 648-656 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T12 | 739-747 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T13 | 832-836 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T14 | 1091-1094 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
T15 | 1099-1103 | Body_part | denotes | mRNA | http://purl.org/sig/ont/fma/fma67122 |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T8 | 977-986 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T23 | 24-32 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T24 | 273-281 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T25 | 305-313 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T26 | 617-625 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T27 | 977-988 | Disease | denotes | hepatitis B | http://purl.obolibrary.org/obo/MONDO_0005344 |
T28 | 977-986 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T24 | 243-248 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T25 | 426-431 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T26 | 437-438 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T27 | 608-609 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T28 | 628-631 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T29 | 680-688 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T30 | 820-823 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
T31 | 825-828 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
T32 | 830-836 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T-cell |
T33 | 987-988 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T34 | 1066-1072 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T9 | 464-475 | Chemical | denotes | nucleotides | http://purl.obolibrary.org/obo/CHEBI_36976 |
T10 | 648-656 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T11 | 739-747 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
T12 | 761-769 | Chemical | denotes | antigens | http://purl.obolibrary.org/obo/CHEBI_59132 |
T13 | 921-930 | Chemical | denotes | adjuvants | http://purl.obolibrary.org/obo/CHEBI_60809 |
T14 | 997-1004 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
T15 | 1091-1094 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
T16 | 1364-1372 | Chemical | denotes | antigens | http://purl.obolibrary.org/obo/CHEBI_59132 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T7 | 546-555 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T29 | 0-272 | Sentence | denotes | Accumulated releases of SARS-CoV-2 genomes such as GenBank accession numbers MN908947.3, MN975262.1, NC_045512.2, MN997409.1, MN985325.1, MN988669.1, MN988668.1, MN994468.1, MN994467.1, MN988713.1, and MN938384.1 facilitate the development of virus-based subunit vaccines. |
T30 | 273-607 | Sentence | denotes | SARS-CoV-2, which is similar to SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), is an enveloped, single- and positive-stranded RNA virus with a genome comprising 29,891 nucleotides, which encode the 12 putative open reading frames responsible for the synthesis of viral structural and nonstructural proteins7,10. |
T31 | 608-728 | Sentence | denotes | A mature SARS-CoV-2 has four structural proteins, namely, envelope (E), membrane (M), nucleocapsid (N), and spike (S)10. |
T32 | 729-850 | Sentence | denotes | All these proteins may serve as antigens to stimulate neutralizing antibodies and increase CD4+/CD8+ T-cell responses8,9. |
T33 | 851-1086 | Sentence | denotes | However, subunit vaccines require multiple booster shots and suitable adjuvants to work, and certain subunit vaccines such as hepatitis B surface antigen, PreS1, and PreS2 may fail to yield protective response when tested clinically11. |
T34 | 1087-1205 | Sentence | denotes | The DNA and mRNA vaccines that are easier to design and proceed into clinical trials very quickly remain experimental. |
T35 | 1206-1303 | Sentence | denotes | The viral vector-based vaccines could also be quickly constructed and used without an adjuvant12. |
T36 | 1304-1426 | Sentence | denotes | However, development of such vaccines might not start until antigens containing the neutralizing epitopes are identified8. |