PMC:7055038 / 5779-8641 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7055038","sourcedb":"PMC","sourceid":"7055038","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7055038","text":"Genome sequence analysis\nComparing the two genome sequences with a non-redundant selection of representatives from all known CoV families by alignment [10] and phylogenetic tree (Figure 1A) [11] shows that they belong to the SARS family of betacoronaviruses and while related to SARS-CoV (80% genome identity), they were most closely related to SARS-like bat CoV from China (88% identity) as closest known sequence at the time of emergence.\nFigure 1 Phylogenetic trees of Thai sequences in context of all coronavirus families (A) and structural mapping of mutations in the spike glycoprotein between SARS CoV (PDB:6CG [12]) and the current SARS-CoV-2 using YASARA [20] (B)\nCoV: coronavirus; MERS: Middle East respiratory syndrome coronavirus; SARS: severe acute respiratory syndrome.\nPanel A: blue: SARS-CoV-2; red: SARS; purple: MERS; green: common cold.\nPanel B: cyan: ACE2 human host receptor; grey: CoV spike glycoprotein trimer (PDB:6ACG); red: mutations between SARS-CoV vs SARS-CoV-2.\nThe phylogenetic tree was created from whole genome alignment with MAFFT using the neighbour-joining method with maximum composite likelihood (MCL) model, uniform site rates and 500 bootstrap tests using MEGA X. Structural mapping of mutations in the spike glycoprotein between SARS CoV and the two cases of the SARS-CoV-2 reported here shows only 76% identity at the protein level (Figure 1B). This surface protein is critical for ACE2 host receptor interaction and is also a target of the immune response [12,13]. Given several mutations in the binding interface, it may differ in host cell binding efficiency compared with SARS-CoV which could result in differences in virulence and transmission potential [14,15].\nThe genomes of the two separate cases of coronavirus disease 2019 (COVID-19) are identical over the full length of close to 30 kb and are furthermore identical to five other sequences (four from Wuhan and one from Zhejiang); together these sequences form the largest cluster of identical cases within the early outbreak, comprising a core of at least indirectly linked cases (Figure 2). Within-outbreak sequence divergence is generally low with 0–9 nt differences over the whole genome and mutations unique to individual strains are possibly related to quality differences of the samples and noise of the methods used for sequencing.\nFigure 2 Within-outbreak SARS-CoV-2 sequence divergence and clusters, China and Thailand, January 2020\nNumber of pair-wise nt differences across whole genomes colour-coded from zero (green) to nine (red). Blue: Thai sample names. Orange: samples with sequences identical to each other and the Thai sequences.\nWe gratefully acknowledge the authors, the originating and submitting laboratories for their sequence and metadata shared through GISAID, on which this research is based (as listed in Supplementary Table 1).","divisions":[{"label":"title","span":{"begin":0,"end":24}},{"label":"p","span":{"begin":25,"end":440}},{"label":"figure","span":{"begin":441,"end":1204}},{"label":"label","span":{"begin":441,"end":449}},{"label":"caption","span":{"begin":451,"end":673}},{"label":"p","span":{"begin":451,"end":673}},{"label":"p","span":{"begin":674,"end":784}},{"label":"p","span":{"begin":785,"end":856}},{"label":"p","span":{"begin":857,"end":992}},{"label":"p","span":{"begin":993,"end":1204}},{"label":"p","span":{"begin":1205,"end":1710}},{"label":"p","span":{"begin":1711,"end":2344}},{"label":"label","span":{"begin":2345,"end":2353}},{"label":"caption","span":{"begin":2355,"end":2448}},{"label":"p","span":{"begin":2355,"end":2448}},{"label":"p","span":{"begin":2449,"end":2654}}],"tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"110","span":{"begin":125,"end":128},"obj":"Species"},{"id":"111","span":{"begin":240,"end":257},"obj":"Species"},{"id":"112","span":{"begin":279,"end":287},"obj":"Species"},{"id":"113","span":{"begin":359,"end":362},"obj":"Species"},{"id":"117","span":{"begin":506,"end":517},"obj":"Species"},{"id":"118","span":{"begin":601,"end":609},"obj":"Species"},{"id":"119","span":{"begin":641,"end":651},"obj":"Species"},{"id":"125","span":{"begin":674,"end":677},"obj":"Species"},{"id":"126","span":{"begin":679,"end":690},"obj":"Species"},{"id":"127","span":{"begin":698,"end":742},"obj":"Species"},{"id":"128","span":{"begin":692,"end":696},"obj":"Disease"},{"id":"129","span":{"begin":750,"end":783},"obj":"Disease"},{"id":"133","span":{"begin":800,"end":810},"obj":"Species"},{"id":"134","span":{"begin":831,"end":835},"obj":"Disease"},{"id":"135","span":{"begin":851,"end":855},"obj":"Disease"},{"id":"141","span":{"begin":872,"end":876},"obj":"Gene"},{"id":"142","span":{"begin":877,"end":882},"obj":"Species"},{"id":"143","span":{"begin":904,"end":907},"obj":"Species"},{"id":"144","span":{"begin":969,"end":977},"obj":"Species"},{"id":"145","span":{"begin":981,"end":991},"obj":"Species"},{"id":"150","span":{"begin":1425,"end":1429},"obj":"Gene"},{"id":"151","span":{"begin":1271,"end":1279},"obj":"Species"},{"id":"152","span":{"begin":1305,"end":1315},"obj":"Species"},{"id":"153","span":{"begin":1619,"end":1627},"obj":"Species"},{"id":"157","span":{"begin":1879,"end":1894},"obj":"Species"},{"id":"158","span":{"begin":1752,"end":1776},"obj":"Disease"},{"id":"159","span":{"begin":1778,"end":1786},"obj":"Disease"},{"id":"161","span":{"begin":2371,"end":2381},"obj":"Species"}],"attributes":[{"id":"A110","pred":"tao:has_database_id","subj":"110","obj":"Tax:11118"},{"id":"A111","pred":"tao:has_database_id","subj":"111","obj":"Tax:694002"},{"id":"A112","pred":"tao:has_database_id","subj":"112","obj":"Tax:694009"},{"id":"A113","pred":"tao:has_database_id","subj":"113","obj":"Tax:11118"},{"id":"A117","pred":"tao:has_database_id","subj":"117","obj":"Tax:11118"},{"id":"A118","pred":"tao:has_database_id","subj":"118","obj":"Tax:694009"},{"id":"A119","pred":"tao:has_database_id","subj":"119","obj":"Tax:2697049"},{"id":"A125","pred":"tao:has_database_id","subj":"125","obj":"Tax:11118"},{"id":"A126","pred":"tao:has_database_id","subj":"126","obj":"Tax:11118"},{"id":"A127","pred":"tao:has_database_id","subj":"127","obj":"Tax:1335626"},{"id":"A128","pred":"tao:has_database_id","subj":"128","obj":"MESH:D018352"},{"id":"A129","pred":"tao:has_database_id","subj":"129","obj":"MESH:D045169"},{"id":"A133","pred":"tao:has_database_id","subj":"133","obj":"Tax:2697049"},{"id":"A134","pred":"tao:has_database_id","subj":"134","obj":"MESH:D018352"},{"id":"A135","pred":"tao:has_database_id","subj":"135","obj":"MESH:D000067390"},{"id":"A141","pred":"tao:has_database_id","subj":"141","obj":"Gene:59272"},{"id":"A142","pred":"tao:has_database_id","subj":"142","obj":"Tax:9606"},{"id":"A143","pred":"tao:has_database_id","subj":"143","obj":"Tax:11118"},{"id":"A144","pred":"tao:has_database_id","subj":"144","obj":"Tax:694009"},{"id":"A145","pred":"tao:has_database_id","subj":"145","obj":"Tax:2697049"},{"id":"A150","pred":"tao:has_database_id","subj":"150","obj":"Gene:59272"},{"id":"A151","pred":"tao:has_database_id","subj":"151","obj":"Tax:694009"},{"id":"A152","pred":"tao:has_database_id","subj":"152","obj":"Tax:2697049"},{"id":"A153","pred":"tao:has_database_id","subj":"153","obj":"Tax:694009"},{"id":"A157","pred":"tao:has_database_id","subj":"157","obj":"Tax:28384"},{"id":"A158","pred":"tao:has_database_id","subj":"158","obj":"MESH:C000657245"},{"id":"A159","pred":"tao:has_database_id","subj":"159","obj":"MESH:C000657245"},{"id":"A161","pred":"tao:has_database_id","subj":"161","obj":"Tax:2697049"},{"subj":"110","pred":"source","obj":"LitCovid-PubTator"},{"subj":"111","pred":"source","obj":"LitCovid-PubTator"},{"subj":"112","pred":"source","obj":"LitCovid-PubTator"},{"subj":"113","pred":"source","obj":"LitCovid-PubTator"},{"subj":"117","pred":"source","obj":"LitCovid-PubTator"},{"subj":"118","pred":"source","obj":"LitCovid-PubTator"},{"subj":"119","pred":"source","obj":"LitCovid-PubTator"},{"subj":"125","pred":"source","obj":"LitCovid-PubTator"},{"subj":"126","pred":"source","obj":"LitCovid-PubTator"},{"subj":"127","pred":"source","obj":"LitCovid-PubTator"},{"subj":"128","pred":"source","obj":"LitCovid-PubTator"},{"subj":"129","pred":"source","obj":"LitCovid-PubTator"},{"subj":"133","pred":"source","obj":"LitCovid-PubTator"},{"subj":"134","pred":"source","obj":"LitCovid-PubTator"},{"subj":"135","pred":"source","obj":"LitCovid-PubTator"},{"subj":"141","pred":"source","obj":"LitCovid-PubTator"},{"subj":"142","pred":"source","obj":"LitCovid-PubTator"},{"subj":"143","pred":"source","obj":"LitCovid-PubTator"},{"subj":"144","pred":"source","obj":"LitCovid-PubTator"},{"subj":"145","pred":"source","obj":"LitCovid-PubTator"},{"subj":"150","pred":"source","obj":"LitCovid-PubTator"},{"subj":"151","pred":"source","obj":"LitCovid-PubTator"},{"subj":"152","pred":"source","obj":"LitCovid-PubTator"},{"subj":"153","pred":"source","obj":"LitCovid-PubTator"},{"subj":"157","pred":"source","obj":"LitCovid-PubTator"},{"subj":"158","pred":"source","obj":"LitCovid-PubTator"},{"subj":"159","pred":"source","obj":"LitCovid-PubTator"},{"subj":"161","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T25","span":{"begin":0,"end":6},"obj":"Body_part"},{"id":"T26","span":{"begin":43,"end":49},"obj":"Body_part"},{"id":"T27","span":{"begin":293,"end":299},"obj":"Body_part"},{"id":"T28","span":{"begin":580,"end":592},"obj":"Body_part"},{"id":"T29","span":{"begin":914,"end":926},"obj":"Body_part"},{"id":"T30","span":{"begin":1038,"end":1044},"obj":"Body_part"},{"id":"T31","span":{"begin":1136,"end":1139},"obj":"Body_part"},{"id":"T32","span":{"begin":1250,"end":1262},"obj":"Body_part"},{"id":"T33","span":{"begin":1361,"end":1368},"obj":"Body_part"},{"id":"T34","span":{"begin":1401,"end":1408},"obj":"Body_part"},{"id":"T35","span":{"begin":1581,"end":1585},"obj":"Body_part"},{"id":"T36","span":{"begin":1715,"end":1722},"obj":"Body_part"},{"id":"T37","span":{"begin":2190,"end":2196},"obj":"Body_part"},{"id":"T38","span":{"begin":2497,"end":2504},"obj":"Body_part"}],"attributes":[{"id":"A25","pred":"fma_id","subj":"T25","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A26","pred":"fma_id","subj":"T26","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A28","pred":"fma_id","subj":"T28","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A29","pred":"fma_id","subj":"T29","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma305650"},{"id":"A32","pred":"fma_id","subj":"T32","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A33","pred":"fma_id","subj":"T33","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A34","pred":"fma_id","subj":"T34","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A35","pred":"fma_id","subj":"T35","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A36","pred":"fma_id","subj":"T36","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A37","pred":"fma_id","subj":"T37","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A38","pred":"fma_id","subj":"T38","obj":"http://purl.org/sig/ont/fma/fma84116"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid_AGAC","denotations":[{"id":"p9941s12","span":{"begin":1576,"end":1604},"obj":"MPA"},{"id":"p9941s27","span":{"begin":1665,"end":1674},"obj":"MPA"},{"id":"p9941s29","span":{"begin":1679,"end":1701},"obj":"MPA"}],"attributes":[{"subj":"p9941s12","pred":"source","obj":"LitCovid_AGAC"},{"subj":"p9941s27","pred":"source","obj":"LitCovid_AGAC"},{"subj":"p9941s29","pred":"source","obj":"LitCovid_AGAC"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T29","span":{"begin":225,"end":229},"obj":"Disease"},{"id":"T30","span":{"begin":279,"end":287},"obj":"Disease"},{"id":"T31","span":{"begin":279,"end":283},"obj":"Disease"},{"id":"T32","span":{"begin":345,"end":349},"obj":"Disease"},{"id":"T33","span":{"begin":601,"end":605},"obj":"Disease"},{"id":"T34","span":{"begin":641,"end":649},"obj":"Disease"},{"id":"T35","span":{"begin":641,"end":645},"obj":"Disease"},{"id":"T36","span":{"begin":744,"end":748},"obj":"Disease"},{"id":"T37","span":{"begin":750,"end":783},"obj":"Disease"},{"id":"T38","span":{"begin":800,"end":808},"obj":"Disease"},{"id":"T39","span":{"begin":800,"end":804},"obj":"Disease"},{"id":"T40","span":{"begin":817,"end":821},"obj":"Disease"},{"id":"T41","span":{"begin":844,"end":855},"obj":"Disease"},{"id":"T42","span":{"begin":969,"end":977},"obj":"Disease"},{"id":"T43","span":{"begin":969,"end":973},"obj":"Disease"},{"id":"T44","span":{"begin":981,"end":989},"obj":"Disease"},{"id":"T45","span":{"begin":981,"end":985},"obj":"Disease"},{"id":"T46","span":{"begin":1271,"end":1275},"obj":"Disease"},{"id":"T47","span":{"begin":1305,"end":1313},"obj":"Disease"},{"id":"T48","span":{"begin":1305,"end":1309},"obj":"Disease"},{"id":"T49","span":{"begin":1619,"end":1627},"obj":"Disease"},{"id":"T50","span":{"begin":1619,"end":1623},"obj":"Disease"},{"id":"T51","span":{"begin":1752,"end":1776},"obj":"Disease"},{"id":"T52","span":{"begin":1778,"end":1786},"obj":"Disease"},{"id":"T53","span":{"begin":2371,"end":2379},"obj":"Disease"},{"id":"T54","span":{"begin":2371,"end":2375},"obj":"Disease"}],"attributes":[{"id":"A29","pred":"mondo_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A30","pred":"mondo_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A31","pred":"mondo_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A32","pred":"mondo_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A33","pred":"mondo_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A34","pred":"mondo_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A35","pred":"mondo_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A36","pred":"mondo_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A37","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A38","pred":"mondo_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A41","pred":"mondo_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/MONDO_0005709"},{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A44","pred":"mondo_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A45","pred":"mondo_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A48","pred":"mondo_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A50","pred":"mondo_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A51","pred":"mondo_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A52","pred":"mondo_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A53","pred":"mondo_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A54","pred":"mondo_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T54","span":{"begin":65,"end":66},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T55","span":{"begin":191,"end":193},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T56","span":{"begin":355,"end":358},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9397"},{"id":"T57","span":{"begin":528,"end":529},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T58","span":{"begin":671,"end":672},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T59","span":{"begin":791,"end":792},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T60","span":{"begin":863,"end":864},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T61","span":{"begin":877,"end":882},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T62","span":{"begin":1185,"end":1190},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T63","span":{"begin":1468,"end":1469},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T64","span":{"begin":1581,"end":1585},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T65","span":{"begin":1838,"end":1840},"obj":"http://purl.obolibrary.org/obo/CLO_0007074"},{"id":"T66","span":{"begin":1838,"end":1840},"obj":"http://purl.obolibrary.org/obo/CLO_0051988"},{"id":"T67","span":{"begin":2043,"end":2044},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T54","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T62","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T63","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T67","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T3","span":{"begin":580,"end":592},"obj":"Chemical"},{"id":"T4","span":{"begin":914,"end":926},"obj":"Chemical"},{"id":"T5","span":{"begin":1197,"end":1201},"obj":"Chemical"},{"id":"T6","span":{"begin":1250,"end":1262},"obj":"Chemical"},{"id":"T7","span":{"begin":1361,"end":1368},"obj":"Chemical"},{"id":"T8","span":{"begin":1401,"end":1408},"obj":"Chemical"}],"attributes":[{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_6617"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T4","span":{"begin":1484,"end":1499},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T5","span":{"begin":1665,"end":1674},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T6","span":{"begin":1665,"end":1674},"obj":"http://purl.obolibrary.org/obo/GO_0009405"}],"attributes":[{"subj":"T4","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"2_test","denotations":[{"id":"32127124-29506019-29320639","span":{"begin":152,"end":154},"obj":"29506019"},{"id":"32127124-29722887-29320640","span":{"begin":191,"end":193},"obj":"29722887"},{"id":"32127124-30102747-29320641","span":{"begin":620,"end":622},"obj":"30102747"},{"id":"32127124-24996895-29320642","span":{"begin":666,"end":668},"obj":"24996895"},{"id":"32127124-30102747-29320643","span":{"begin":1501,"end":1503},"obj":"30102747"},{"id":"32127124-19198616-29320644","span":{"begin":1504,"end":1506},"obj":"19198616"},{"id":"32127124-32015507-29320645","span":{"begin":1703,"end":1705},"obj":"32015507"},{"id":"32127124-31996437-29320646","span":{"begin":1706,"end":1708},"obj":"31996437"}],"attributes":[{"subj":"32127124-29506019-29320639","pred":"source","obj":"2_test"},{"subj":"32127124-29722887-29320640","pred":"source","obj":"2_test"},{"subj":"32127124-30102747-29320641","pred":"source","obj":"2_test"},{"subj":"32127124-24996895-29320642","pred":"source","obj":"2_test"},{"subj":"32127124-30102747-29320643","pred":"source","obj":"2_test"},{"subj":"32127124-19198616-29320644","pred":"source","obj":"2_test"},{"subj":"32127124-32015507-29320645","pred":"source","obj":"2_test"},{"subj":"32127124-31996437-29320646","pred":"source","obj":"2_test"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T54","span":{"begin":0,"end":24},"obj":"Sentence"},{"id":"T55","span":{"begin":25,"end":440},"obj":"Sentence"},{"id":"T56","span":{"begin":441,"end":673},"obj":"Sentence"},{"id":"T57","span":{"begin":674,"end":697},"obj":"Sentence"},{"id":"T58","span":{"begin":698,"end":784},"obj":"Sentence"},{"id":"T59","span":{"begin":785,"end":856},"obj":"Sentence"},{"id":"T60","span":{"begin":857,"end":903},"obj":"Sentence"},{"id":"T61","span":{"begin":904,"end":992},"obj":"Sentence"},{"id":"T62","span":{"begin":993,"end":1204},"obj":"Sentence"},{"id":"T63","span":{"begin":1205,"end":1387},"obj":"Sentence"},{"id":"T64","span":{"begin":1388,"end":1508},"obj":"Sentence"},{"id":"T65","span":{"begin":1509,"end":1710},"obj":"Sentence"},{"id":"T66","span":{"begin":1711,"end":2097},"obj":"Sentence"},{"id":"T67","span":{"begin":2098,"end":2344},"obj":"Sentence"},{"id":"T68","span":{"begin":2345,"end":2448},"obj":"Sentence"},{"id":"T69","span":{"begin":2449,"end":2550},"obj":"Sentence"},{"id":"T70","span":{"begin":2551,"end":2556},"obj":"Sentence"},{"id":"T71","span":{"begin":2557,"end":2575},"obj":"Sentence"},{"id":"T72","span":{"begin":2576,"end":2654},"obj":"Sentence"},{"id":"T73","span":{"begin":2655,"end":2862},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T54","pred":"source","obj":"LitCovid-sentences"},{"subj":"T55","pred":"source","obj":"LitCovid-sentences"},{"subj":"T56","pred":"source","obj":"LitCovid-sentences"},{"subj":"T57","pred":"source","obj":"LitCovid-sentences"},{"subj":"T58","pred":"source","obj":"LitCovid-sentences"},{"subj":"T59","pred":"source","obj":"LitCovid-sentences"},{"subj":"T60","pred":"source","obj":"LitCovid-sentences"},{"subj":"T61","pred":"source","obj":"LitCovid-sentences"},{"subj":"T62","pred":"source","obj":"LitCovid-sentences"},{"subj":"T63","pred":"source","obj":"LitCovid-sentences"},{"subj":"T64","pred":"source","obj":"LitCovid-sentences"},{"subj":"T65","pred":"source","obj":"LitCovid-sentences"},{"subj":"T66","pred":"source","obj":"LitCovid-sentences"},{"subj":"T67","pred":"source","obj":"LitCovid-sentences"},{"subj":"T68","pred":"source","obj":"LitCovid-sentences"},{"subj":"T69","pred":"source","obj":"LitCovid-sentences"},{"subj":"T70","pred":"source","obj":"LitCovid-sentences"},{"subj":"T71","pred":"source","obj":"LitCovid-sentences"},{"subj":"T72","pred":"source","obj":"LitCovid-sentences"},{"subj":"T73","pred":"source","obj":"LitCovid-sentences"}]},{"project":"MyTest","denotations":[{"id":"32127124-29506019-29320639","span":{"begin":152,"end":154},"obj":"29506019"},{"id":"32127124-29722887-29320640","span":{"begin":191,"end":193},"obj":"29722887"},{"id":"32127124-30102747-29320641","span":{"begin":620,"end":622},"obj":"30102747"},{"id":"32127124-24996895-29320642","span":{"begin":666,"end":668},"obj":"24996895"},{"id":"32127124-30102747-29320643","span":{"begin":1501,"end":1503},"obj":"30102747"},{"id":"32127124-19198616-29320644","span":{"begin":1504,"end":1506},"obj":"19198616"},{"id":"32127124-32015507-29320645","span":{"begin":1703,"end":1705},"obj":"32015507"},{"id":"32127124-31996437-29320646","span":{"begin":1706,"end":1708},"obj":"31996437"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"32127124-29506019-29320639","pred":"source","obj":"MyTest"},{"subj":"32127124-29722887-29320640","pred":"source","obj":"MyTest"},{"subj":"32127124-30102747-29320641","pred":"source","obj":"MyTest"},{"subj":"32127124-24996895-29320642","pred":"source","obj":"MyTest"},{"subj":"32127124-30102747-29320643","pred":"source","obj":"MyTest"},{"subj":"32127124-19198616-29320644","pred":"source","obj":"MyTest"},{"subj":"32127124-32015507-29320645","pred":"source","obj":"MyTest"},{"subj":"32127124-31996437-29320646","pred":"source","obj":"MyTest"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ec93e0","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecde"},{"id":"LitCovid_AGAC","color":"#ecc493"},{"id":"LitCovid-PD-MONDO","color":"#a993ec"},{"id":"LitCovid-PD-CLO","color":"#96ec93"},{"id":"LitCovid-PD-CHEBI","color":"#ec93b0"},{"id":"LitCovid-PD-GO-BP","color":"#93caec"},{"id":"2_test","color":"#e4ec93"},{"id":"LitCovid-sentences","color":"#da93ec"},{"id":"MyTest","color":"#93ecc0"}]}]}}