PMC:7054964 / 5883-7576 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7054964","sourcedb":"PMC","sourceid":"7054964","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7054964","text":"Fortunately, two cases with detectable virus both in blood and anal swab cohort were recorded. Patient 1 (Figure 2(A)) was admitted to ICU after enrollment evaluation and was highly suspected infection with 2019-nCoV because of his recent travelling from Wuhan and of confirmed pneumonia by radiographic diagnosis with 5-day fever and 1-day continuous dry coughing. He was then confirmed to be infected by the 2019-nCoV virus on illness day 6 by CDC. High concentrations of the viral RNA were detected in the pharyngeal swabs on illness days 5 (Ct = 17 + 25), 7, 8 (Ct = 25 + 26), and 11 (Ct = 15 + 25). In the blood, no viral RNA was detected on day 5 but the sample on day 6 gave a weak positive signal (Ct = Neg+39), and then the signal was gone again on day 8. On day 9, a low level of viral RNA (Ct = 36 + 41) was detected again in the blood. On day 12, the blood lost signal again. A high concentration of virus RNA (Ct = 23 + 27) was detected in the anal sample on day 13, on the day the 2019-nCoV virus was not detected in the pharyngeal swab. Unfortunately, he was transferred out to another hospital after an emergency expert consultation.\nFigure 2. Diagram of viral detection in patient 1 (A) and 2 (B) with both detectable virus RNA in blood and anal swab. Illness day represents the patients with clear clinical symptoms such as fever, dry-coughing is labelled over the first line. ICU, CDC confirmed, and transfer indicates that the patient is in the ICU ward, CDC confirmation of viral positive, and transfer of patient out from ICU ward to another hospital to receive a higher level of medical care, respectively. 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