PMC:7054935 / 883-2247 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"47","span":{"begin":72,"end":82},"obj":"Species"},{"id":"48","span":{"begin":113,"end":119},"obj":"Species"},{"id":"49","span":{"begin":142,"end":147},"obj":"Species"},{"id":"50","span":{"begin":148,"end":158},"obj":"Species"},{"id":"51","span":{"begin":218,"end":221},"obj":"Species"},{"id":"52","span":{"begin":290,"end":300},"obj":"Species"},{"id":"53","span":{"begin":331,"end":336},"obj":"Species"},{"id":"54","span":{"begin":337,"end":345},"obj":"Species"},{"id":"55","span":{"begin":389,"end":392},"obj":"Species"},{"id":"56","span":{"begin":578,"end":583},"obj":"Species"},{"id":"57","span":{"begin":584,"end":594},"obj":"Species"},{"id":"58","span":{"begin":614,"end":617},"obj":"Species"},{"id":"59","span":{"begin":754,"end":758},"obj":"Species"},{"id":"60","span":{"begin":794,"end":797},"obj":"Species"},{"id":"61","span":{"begin":825,"end":835},"obj":"Species"},{"id":"62","span":{"begin":990,"end":1000},"obj":"Species"},{"id":"63","span":{"begin":1089,"end":1095},"obj":"Species"},{"id":"64","span":{"begin":1125,"end":1129},"obj":"Species"},{"id":"65","span":{"begin":1154,"end":1159},"obj":"Species"},{"id":"66","span":{"begin":1160,"end":1170},"obj":"Species"},{"id":"67","span":{"begin":1220,"end":1224},"obj":"Species"},{"id":"68","span":{"begin":1244,"end":1254},"obj":"Species"},{"id":"69","span":{"begin":455,"end":457},"obj":"Chemical"}],"attributes":[{"id":"A47","pred":"tao:has_database_id","subj":"47","obj":"Tax:2697049"},{"id":"A48","pred":"tao:has_database_id","subj":"48","obj":"Tax:9606"},{"id":"A49","pred":"tao:has_database_id","subj":"49","obj":"Tax:9606"},{"id":"A50","pred":"tao:has_database_id","subj":"50","obj":"Tax:2697049"},{"id":"A51","pred":"tao:has_database_id","subj":"51","obj":"Tax:11118"},{"id":"A52","pred":"tao:has_database_id","subj":"52","obj":"Tax:2697049"},{"id":"A53","pred":"tao:has_database_id","subj":"53","obj":"Tax:9606"},{"id":"A54","pred":"tao:has_database_id","subj":"54","obj":"Tax:694009"},{"id":"A55","pred":"tao:has_database_id","subj":"55","obj":"Tax:11118"},{"id":"A56","pred":"tao:has_database_id","subj":"56","obj":"Tax:9606"},{"id":"A57","pred":"tao:has_database_id","subj":"57","obj":"Tax:2697049"},{"id":"A58","pred":"tao:has_database_id","subj":"58","obj":"Tax:11118"},{"id":"A59","pred":"tao:has_database_id","subj":"59","obj":"Tax:11118"},{"id":"A60","pred":"tao:has_database_id","subj":"60","obj":"Tax:11118"},{"id":"A61","pred":"tao:has_database_id","subj":"61","obj":"Tax:2697049"},{"id":"A62","pred":"tao:has_database_id","subj":"62","obj":"Tax:2697049"},{"id":"A63","pred":"tao:has_database_id","subj":"63","obj":"Tax:9606"},{"id":"A64","pred":"tao:has_database_id","subj":"64","obj":"Tax:11118"},{"id":"A65","pred":"tao:has_database_id","subj":"65","obj":"Tax:9606"},{"id":"A66","pred":"tao:has_database_id","subj":"66","obj":"Tax:2697049"},{"id":"A67","pred":"tao:has_database_id","subj":"67","obj":"Tax:11118"},{"id":"A68","pred":"tao:has_database_id","subj":"68","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Currently, there are speculations, rumours and conspiracy theories that SARS-CoV-2 is of laboratory origin. Some people have alleged that the human SARS-CoV-2 was leaked directly from a laboratory in Wuhan where a bat CoV (RaTG13) was recently reported, which shared ∼96% homology with the SARS-CoV-2 [4]. However, as we know, the human SARS-CoV and intermediate host palm civet SARS-like CoV shared 99.8% homology, with a total of 202 single-nucleotide (nt) variations (SNVs) identified across the genome [6]. Given that there are greater than 1,100 nt differences between the human SARS-CoV-2 and the bat RaTG13-CoV [4], which are distributed throughout the genome in a naturally occurring pattern following the evolutionary characteristics typical of CoVs, it is highly unlikely that RaTG13 CoV is the immediate source of SARS-CoV-2. The absence of a logical targeted pattern in the new viral sequences and a close relative in a wildlife species (bats) are the most revealing signs that SARS-CoV-2 evolved by natural evolution. A search for an intermediate animal host between bats and humans is needed to identify animal CoVs more closely related to human SARS-CoV-2. There is speculation that pangolins might carry CoVs closely related to SARS-CoV-2, but the data to substantiate this is not yet published (https://www.nature.com/articles/d41586-020-00364-2)."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T193","span":{"begin":825,"end":835},"obj":"SP_7"},{"id":"T192","span":{"begin":890,"end":895},"obj":"NCBITaxon:10239"},{"id":"T210","span":{"begin":72,"end":82},"obj":"SP_7"},{"id":"T209","span":{"begin":113,"end":119},"obj":"NCBITaxon:9606"},{"id":"T208","span":{"begin":142,"end":147},"obj":"SP_6;NCBITaxon:9606"},{"id":"T207","span":{"begin":148,"end":158},"obj":"SP_7"},{"id":"T206","span":{"begin":214,"end":217},"obj":"SP_2"},{"id":"T205","span":{"begin":272,"end":280},"obj":"SO:0000853"},{"id":"T204","span":{"begin":290,"end":300},"obj":"SP_7"},{"id":"T203","span":{"begin":331,"end":336},"obj":"SP_6;NCBITaxon:9606"},{"id":"T202","span":{"begin":337,"end":345},"obj":"SP_10"},{"id":"T201","span":{"begin":368,"end":378},"obj":"SP_5"},{"id":"T200","span":{"begin":379,"end":383},"obj":"SP_10"},{"id":"T199","span":{"begin":406,"end":414},"obj":"SO:0000853"},{"id":"T198","span":{"begin":499,"end":505},"obj":"SO:0001026"},{"id":"T197","span":{"begin":578,"end":583},"obj":"SP_6;NCBITaxon:9606"},{"id":"T196","span":{"begin":584,"end":594},"obj":"SP_7"},{"id":"T195","span":{"begin":603,"end":606},"obj":"SP_2"},{"id":"T194","span":{"begin":660,"end":666},"obj":"SO:0001026"},{"id":"T191","span":{"begin":941,"end":948},"obj":"NCBITaxon:species"},{"id":"T190","span":{"begin":950,"end":954},"obj":"SP_2;NCBITaxon:9397"},{"id":"T189","span":{"begin":990,"end":1000},"obj":"SP_7"},{"id":"T188","span":{"begin":1060,"end":1066},"obj":"NCBITaxon:33208"},{"id":"T187","span":{"begin":1080,"end":1084},"obj":"SP_2;NCBITaxon:6960"},{"id":"T186","span":{"begin":1089,"end":1095},"obj":"NCBITaxon:9606"},{"id":"T185","span":{"begin":1118,"end":1124},"obj":"NCBITaxon:33208"},{"id":"T184","span":{"begin":1154,"end":1159},"obj":"SP_6;NCBITaxon:9606"},{"id":"T183","span":{"begin":1160,"end":1164},"obj":"PR:000014459;SP_7"},{"id":"T182","span":{"begin":1164,"end":1170},"obj":"SP_7"},{"id":"T181","span":{"begin":1198,"end":1207},"obj":"SP_1"},{"id":"T180","span":{"begin":1244,"end":1254},"obj":"SP_7"}],"text":"Currently, there are speculations, rumours and conspiracy theories that SARS-CoV-2 is of laboratory origin. Some people have alleged that the human SARS-CoV-2 was leaked directly from a laboratory in Wuhan where a bat CoV (RaTG13) was recently reported, which shared ∼96% homology with the SARS-CoV-2 [4]. However, as we know, the human SARS-CoV and intermediate host palm civet SARS-like CoV shared 99.8% homology, with a total of 202 single-nucleotide (nt) variations (SNVs) identified across the genome [6]. Given that there are greater than 1,100 nt differences between the human SARS-CoV-2 and the bat RaTG13-CoV [4], which are distributed throughout the genome in a naturally occurring pattern following the evolutionary characteristics typical of CoVs, it is highly unlikely that RaTG13 CoV is the immediate source of SARS-CoV-2. The absence of a logical targeted pattern in the new viral sequences and a close relative in a wildlife species (bats) are the most revealing signs that SARS-CoV-2 evolved by natural evolution. A search for an intermediate animal host between bats and humans is needed to identify animal CoVs more closely related to human SARS-CoV-2. There is speculation that pangolins might carry CoVs closely related to SARS-CoV-2, but the data to substantiate this is not yet published (https://www.nature.com/articles/d41586-020-00364-2)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T2","span":{"begin":368,"end":372},"obj":"Body_part"},{"id":"T3","span":{"begin":443,"end":453},"obj":"Body_part"},{"id":"T4","span":{"begin":455,"end":457},"obj":"Body_part"},{"id":"T5","span":{"begin":499,"end":505},"obj":"Body_part"},{"id":"T6","span":{"begin":551,"end":553},"obj":"Body_part"},{"id":"T7","span":{"begin":660,"end":666},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma24920"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma82740"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma82740"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma82740"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma84116"}],"text":"Currently, there are speculations, rumours and conspiracy theories that SARS-CoV-2 is of laboratory origin. Some people have alleged that the human SARS-CoV-2 was leaked directly from a laboratory in Wuhan where a bat CoV (RaTG13) was recently reported, which shared ∼96% homology with the SARS-CoV-2 [4]. However, as we know, the human SARS-CoV and intermediate host palm civet SARS-like CoV shared 99.8% homology, with a total of 202 single-nucleotide (nt) variations (SNVs) identified across the genome [6]. Given that there are greater than 1,100 nt differences between the human SARS-CoV-2 and the bat RaTG13-CoV [4], which are distributed throughout the genome in a naturally occurring pattern following the evolutionary characteristics typical of CoVs, it is highly unlikely that RaTG13 CoV is the immediate source of SARS-CoV-2. The absence of a logical targeted pattern in the new viral sequences and a close relative in a wildlife species (bats) are the most revealing signs that SARS-CoV-2 evolved by natural evolution. A search for an intermediate animal host between bats and humans is needed to identify animal CoVs more closely related to human SARS-CoV-2. There is speculation that pangolins might carry CoVs closely related to SARS-CoV-2, but the data to substantiate this is not yet published (https://www.nature.com/articles/d41586-020-00364-2)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T16","span":{"begin":72,"end":80},"obj":"Disease"},{"id":"T17","span":{"begin":72,"end":76},"obj":"Disease"},{"id":"T18","span":{"begin":148,"end":156},"obj":"Disease"},{"id":"T19","span":{"begin":148,"end":152},"obj":"Disease"},{"id":"T20","span":{"begin":290,"end":298},"obj":"Disease"},{"id":"T21","span":{"begin":290,"end":294},"obj":"Disease"},{"id":"T22","span":{"begin":337,"end":345},"obj":"Disease"},{"id":"T23","span":{"begin":337,"end":341},"obj":"Disease"},{"id":"T24","span":{"begin":379,"end":383},"obj":"Disease"},{"id":"T25","span":{"begin":584,"end":592},"obj":"Disease"},{"id":"T26","span":{"begin":584,"end":588},"obj":"Disease"},{"id":"T27","span":{"begin":825,"end":833},"obj":"Disease"},{"id":"T28","span":{"begin":825,"end":829},"obj":"Disease"},{"id":"T29","span":{"begin":990,"end":998},"obj":"Disease"},{"id":"T30","span":{"begin":990,"end":994},"obj":"Disease"},{"id":"T31","span":{"begin":1160,"end":1168},"obj":"Disease"},{"id":"T32","span":{"begin":1160,"end":1164},"obj":"Disease"},{"id":"T33","span":{"begin":1244,"end":1252},"obj":"Disease"},{"id":"T34","span":{"begin":1244,"end":1248},"obj":"Disease"}],"attributes":[{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A21","pred":"mondo_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A22","pred":"mondo_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A23","pred":"mondo_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A24","pred":"mondo_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A25","pred":"mondo_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A26","pred":"mondo_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A27","pred":"mondo_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A28","pred":"mondo_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A29","pred":"mondo_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A30","pred":"mondo_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A31","pred":"mondo_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A32","pred":"mondo_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A33","pred":"mondo_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A34","pred":"mondo_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Currently, there are speculations, rumours and conspiracy theories that SARS-CoV-2 is of laboratory origin. Some people have alleged that the human SARS-CoV-2 was leaked directly from a laboratory in Wuhan where a bat CoV (RaTG13) was recently reported, which shared ∼96% homology with the SARS-CoV-2 [4]. However, as we know, the human SARS-CoV and intermediate host palm civet SARS-like CoV shared 99.8% homology, with a total of 202 single-nucleotide (nt) variations (SNVs) identified across the genome [6]. Given that there are greater than 1,100 nt differences between the human SARS-CoV-2 and the bat RaTG13-CoV [4], which are distributed throughout the genome in a naturally occurring pattern following the evolutionary characteristics typical of CoVs, it is highly unlikely that RaTG13 CoV is the immediate source of SARS-CoV-2. The absence of a logical targeted pattern in the new viral sequences and a close relative in a wildlife species (bats) are the most revealing signs that SARS-CoV-2 evolved by natural evolution. A search for an intermediate animal host between bats and humans is needed to identify animal CoVs more closely related to human SARS-CoV-2. There is speculation that pangolins might carry CoVs closely related to SARS-CoV-2, but the data to substantiate this is not yet published (https://www.nature.com/articles/d41586-020-00364-2)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T8","span":{"begin":142,"end":147},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T9","span":{"begin":184,"end":185},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T10","span":{"begin":212,"end":213},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T11","span":{"begin":214,"end":217},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9397"},{"id":"T12","span":{"begin":331,"end":336},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T13","span":{"begin":421,"end":422},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T14","span":{"begin":578,"end":583},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T15","span":{"begin":603,"end":606},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9397"},{"id":"T16","span":{"begin":670,"end":671},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T17","span":{"begin":852,"end":853},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T18","span":{"begin":910,"end":911},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T19","span":{"begin":930,"end":931},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T20","span":{"begin":950,"end":954},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9397"},{"id":"T21","span":{"begin":1031,"end":1032},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T22","span":{"begin":1060,"end":1066},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T23","span":{"begin":1080,"end":1084},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9397"},{"id":"T24","span":{"begin":1089,"end":1095},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T25","span":{"begin":1118,"end":1124},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T26","span":{"begin":1154,"end":1159},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}],"text":"Currently, there are speculations, rumours and conspiracy theories that SARS-CoV-2 is of laboratory origin. Some people have alleged that the human SARS-CoV-2 was leaked directly from a laboratory in Wuhan where a bat CoV (RaTG13) was recently reported, which shared ∼96% homology with the SARS-CoV-2 [4]. However, as we know, the human SARS-CoV and intermediate host palm civet SARS-like CoV shared 99.8% homology, with a total of 202 single-nucleotide (nt) variations (SNVs) identified across the genome [6]. Given that there are greater than 1,100 nt differences between the human SARS-CoV-2 and the bat RaTG13-CoV [4], which are distributed throughout the genome in a naturally occurring pattern following the evolutionary characteristics typical of CoVs, it is highly unlikely that RaTG13 CoV is the immediate source of SARS-CoV-2. The absence of a logical targeted pattern in the new viral sequences and a close relative in a wildlife species (bats) are the most revealing signs that SARS-CoV-2 evolved by natural evolution. A search for an intermediate animal host between bats and humans is needed to identify animal CoVs more closely related to human SARS-CoV-2. There is speculation that pangolins might carry CoVs closely related to SARS-CoV-2, but the data to substantiate this is not yet published (https://www.nature.com/articles/d41586-020-00364-2)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T2","span":{"begin":443,"end":453},"obj":"Chemical"},{"id":"T3","span":{"begin":455,"end":457},"obj":"Chemical"},{"id":"T4","span":{"begin":551,"end":553},"obj":"Chemical"}],"attributes":[{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_36976"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_36976"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_36976"}],"text":"Currently, there are speculations, rumours and conspiracy theories that SARS-CoV-2 is of laboratory origin. Some people have alleged that the human SARS-CoV-2 was leaked directly from a laboratory in Wuhan where a bat CoV (RaTG13) was recently reported, which shared ∼96% homology with the SARS-CoV-2 [4]. However, as we know, the human SARS-CoV and intermediate host palm civet SARS-like CoV shared 99.8% homology, with a total of 202 single-nucleotide (nt) variations (SNVs) identified across the genome [6]. Given that there are greater than 1,100 nt differences between the human SARS-CoV-2 and the bat RaTG13-CoV [4], which are distributed throughout the genome in a naturally occurring pattern following the evolutionary characteristics typical of CoVs, it is highly unlikely that RaTG13 CoV is the immediate source of SARS-CoV-2. The absence of a logical targeted pattern in the new viral sequences and a close relative in a wildlife species (bats) are the most revealing signs that SARS-CoV-2 evolved by natural evolution. A search for an intermediate animal host between bats and humans is needed to identify animal CoVs more closely related to human SARS-CoV-2. There is speculation that pangolins might carry CoVs closely related to SARS-CoV-2, but the data to substantiate this is not yet published (https://www.nature.com/articles/d41586-020-00364-2)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T10","span":{"begin":0,"end":107},"obj":"Sentence"},{"id":"T11","span":{"begin":108,"end":305},"obj":"Sentence"},{"id":"T12","span":{"begin":306,"end":510},"obj":"Sentence"},{"id":"T13","span":{"begin":511,"end":836},"obj":"Sentence"},{"id":"T14","span":{"begin":837,"end":1030},"obj":"Sentence"},{"id":"T15","span":{"begin":1031,"end":1171},"obj":"Sentence"},{"id":"T16","span":{"begin":1172,"end":1364},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Currently, there are speculations, rumours and conspiracy theories that SARS-CoV-2 is of laboratory origin. Some people have alleged that the human SARS-CoV-2 was leaked directly from a laboratory in Wuhan where a bat CoV (RaTG13) was recently reported, which shared ∼96% homology with the SARS-CoV-2 [4]. However, as we know, the human SARS-CoV and intermediate host palm civet SARS-like CoV shared 99.8% homology, with a total of 202 single-nucleotide (nt) variations (SNVs) identified across the genome [6]. Given that there are greater than 1,100 nt differences between the human SARS-CoV-2 and the bat RaTG13-CoV [4], which are distributed throughout the genome in a naturally occurring pattern following the evolutionary characteristics typical of CoVs, it is highly unlikely that RaTG13 CoV is the immediate source of SARS-CoV-2. The absence of a logical targeted pattern in the new viral sequences and a close relative in a wildlife species (bats) are the most revealing signs that SARS-CoV-2 evolved by natural evolution. A search for an intermediate animal host between bats and humans is needed to identify animal CoVs more closely related to human SARS-CoV-2. There is speculation that pangolins might carry CoVs closely related to SARS-CoV-2, but the data to substantiate this is not yet published (https://www.nature.com/articles/d41586-020-00364-2)."}