PMC:7048180 / 8507-9569
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T32 | 31-39 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T33 | 295-303 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T34 | 322-327 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T35 | 388-396 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T36 | 433-440 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T37 | 801-809 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T2 | 322-327 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T44 | 13-21 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T45 | 346-350 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T46 | 953-961 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T51 | 155-156 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T52 | 166-169 | http://purl.obolibrary.org/obo/CLO_0009946 | denotes | kon |
| T53 | 184-188 | http://purl.obolibrary.org/obo/CLO_0007875 | denotes | Ms−1 |
| T54 | 184-188 | http://purl.obolibrary.org/obo/CLO_0050048 | denotes | Ms−1 |
| T55 | 184-188 | http://purl.obolibrary.org/obo/CLO_0052410 | denotes | Ms−1 |
| T56 | 224-227 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | s−1 |
| T57 | 260-264 | http://purl.obolibrary.org/obo/CLO_0001692 | denotes | a KD |
| T58 | 322-327 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T59 | 322-327 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T60 | 331-332 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T61 | 541-546 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T62 | 614-622 | http://purl.obolibrary.org/obo/CLO_0007225 | denotes | labelled |
| T63 | 675-680 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T64 | 731-735 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | test |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T47 | 262-264 | Chemical | denotes | KD | http://purl.obolibrary.org/obo/CHEBI_73601 |
| T48 | 433-440 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T49 | 689-697 | Chemical | denotes | solution | http://purl.obolibrary.org/obo/CHEBI_75958 |
| T50 | 988-995 | Chemical | denotes | epitope | http://purl.obolibrary.org/obo/CHEBI_53000 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T52 | 0-142 | Sentence | denotes | Notably, one SARS-CoV-specific antibody, CR3022, was found to bind potently with 2019-nCoV RBD as determined by ELISA and BLI (Figure 1(e,f)). |
| T53 | 143-289 | Sentence | denotes | It followed a fast-on (kon of 1.84 × 105 Ms−1) and slow-off (koff of 1.16 × 10−3 s−1) binding kinetics, resulting in a KD of 6.3 nM (Figure 1(f)). |
| T54 | 290-445 | Sentence | denotes | This antibody was isolated from blood of a convalescent SARS patient and did not compete with the antibody CR3014 for binding to recombinant S protein [5]. |
| T55 | 446-585 | Sentence | denotes | To further elucidate the binding epitopes of CR3022, we measured the competition of CR3022 and human ACE2 for the binding to 2019-nCoV RBD. |
| T56 | 586-771 | Sentence | denotes | The streptavidin biosensors labelled with biotinylated 2019-nCoV RBD were saturated with human ACE2 in solution, followed by the addition of the test antibodies in the presence of ACE2. |
| T57 | 772-889 | Sentence | denotes | As shown in Figure 1(g), the antibody CR3022 did not show any competition with ACE2 for the binding to 2019-nCoV RBD. |
| T58 | 890-1062 | Sentence | denotes | These results suggest that CR3022, distinct from the other two SARS-CoV antibodies, recognizes an epitope that does not overlap with the ACE2 binding site of 2019-nCoV RBD. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 317 | 547-551 | Gene | denotes | ACE2 | Gene:59272 |
| 318 | 681-685 | Gene | denotes | ACE2 | Gene:59272 |
| 319 | 766-770 | Gene | denotes | ACE2 | Gene:59272 |
| 320 | 851-855 | Gene | denotes | ACE2 | Gene:59272 |
| 321 | 1027-1031 | Gene | denotes | ACE2 | Gene:59272 |
| 322 | 81-90 | Species | denotes | 2019-nCoV | Tax:2697049 |
| 323 | 351-358 | Species | denotes | patient | Tax:9606 |
| 324 | 541-546 | Species | denotes | human | Tax:9606 |
| 325 | 571-580 | Species | denotes | 2019-nCoV | Tax:2697049 |
| 326 | 641-650 | Species | denotes | 2019-nCoV | Tax:2697049 |
| 327 | 675-680 | Species | denotes | human | Tax:9606 |
| 328 | 875-884 | Species | denotes | 2019-nCoV | Tax:2697049 |
| 329 | 1048-1057 | Species | denotes | 2019-nCoV | Tax:2697049 |
| 330 | 13-21 | Species | denotes | SARS-CoV | Tax:694009 |
| 331 | 953-961 | Species | denotes | SARS-CoV | Tax:694009 |
| 332 | 41-47 | Chemical | denotes | CR3022 | |
| 333 | 397-403 | Chemical | denotes | CR3014 | |
| 334 | 491-497 | Chemical | denotes | CR3022 | |
| 335 | 530-536 | Chemical | denotes | CR3022 | |
| 336 | 810-816 | Chemical | denotes | CR3022 | |
| 337 | 917-923 | Chemical | denotes | CR3022 |