PMC:7048180
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T1 | 47-54 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T2 | 103-111 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T3 | 630-637 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T4 | 836-844 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T5 | 1393-1400 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T6 | 2638-2645 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T7 | 2707-2719 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
T8 | 2767-2783 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
T9 | 2778-2783 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T10 | 2804-2816 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
T11 | 2804-2808 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T12 | 2897-2907 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
T13 | 2970-2977 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T14 | 3698-3706 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T15 | 4207-4215 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T16 | 4563-4571 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T17 | 4737-4744 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T18 | 4921-4933 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
T19 | 4943-4950 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T20 | 5230-5237 | Body_part | denotes | Protein | http://purl.org/sig/ont/fma/fma67257 |
T21 | 6004-6011 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T22 | 6463-6468 | Body_part | denotes | helix | http://purl.org/sig/ont/fma/fma60992 |
T23 | 6568-6576 | Body_part | denotes | arginine | http://purl.org/sig/ont/fma/fma82763 |
T24 | 6787-6793 | Body_part | denotes | lysine | http://purl.org/sig/ont/fma/fma82758 |
T25 | 6833-6839 | Body_part | denotes | valine | http://purl.org/sig/ont/fma/fma82766 |
T26 | 6992-6999 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T27 | 7379-7386 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T28 | 7544-7551 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T29 | 7830-7838 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T30 | 8154-8162 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T31 | 8210-8218 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T32 | 8538-8546 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T33 | 8802-8810 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T34 | 8829-8834 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
T35 | 8895-8903 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T36 | 8940-8947 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T37 | 9308-9316 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
T38 | 10036-10043 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
T39 | 10203-10211 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 6463-6468 | Body_part | denotes | helix | http://purl.obolibrary.org/obo/UBERON_0002488 |
T2 | 8829-8834 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid_AGAC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
p8111s23 | 6647-6656 | NegReg | denotes | abolished |
p8111s25 | 6661-6667 | MPA | denotes | strong |
p8111s26 | 6668-6686 | MPA | denotes | polar interactions |
p8111s33 | 6707-6715 | NegReg | denotes | decrease |
p8111s36 | 6723-6747 | Interaction | denotes | binding affinity between |
p8112s39 | 6937-6952 | MPA | denotes | binding ability |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 60-64 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T2 | 288-298 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
T3 | 527-535 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T4 | 589-593 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T5 | 801-809 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T6 | 1193-1213 | Disease | denotes | 2019-nCoV infections | http://purl.obolibrary.org/obo/MONDO_0100096 |
T7 | 1254-1262 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T8 | 1353-1361 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T9 | 1445-1453 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T10 | 1884-1897 | Disease | denotes | infections in | http://purl.obolibrary.org/obo/MONDO_0005550 |
T11 | 2140-2159 | Disease | denotes | 2019-nCoV infection | http://purl.obolibrary.org/obo/MONDO_0100096 |
T12 | 2150-2159 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T13 | 2346-2379 | Disease | denotes | severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
T14 | 2432-2436 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T15 | 2548-2552 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T16 | 2566-2574 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T17 | 2653-2661 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T18 | 3103-3111 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T19 | 3184-3192 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T20 | 3468-3476 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T21 | 3583-3591 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T22 | 3640-3648 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T23 | 3840-3848 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T24 | 3909-3911 | Disease | denotes | VL | http://purl.obolibrary.org/obo/MONDO_0024555 |
T25 | 4047-4049 | Disease | denotes | VL | http://purl.obolibrary.org/obo/MONDO_0024555 |
T26 | 4085-4093 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T27 | 4343-4351 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T28 | 4379-4387 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T29 | 4477-4485 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T30 | 4696-4704 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T31 | 5168-5176 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T32 | 5274-5282 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T33 | 5366-5374 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T34 | 5444-5452 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T35 | 5461-5469 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T36 | 5551-5559 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T37 | 6189-6197 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T38 | 6472-6480 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T39 | 6586-6594 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T40 | 6849-6857 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T41 | 7057-7065 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T42 | 7364-7372 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T43 | 7626-7634 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T44 | 8520-8528 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T45 | 8853-8857 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T46 | 9460-9468 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T47 | 9616-9624 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T48 | 9893-9901 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T49 | 9996-10004 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T50 | 10261-10269 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T51 | 10456-10464 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T52 | 10727-10747 | Disease | denotes | 2019-nCoV infections | http://purl.obolibrary.org/obo/MONDO_0100096 |
T53 | 10812-10820 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 58-59 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T2 | 86-91 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T3 | 233-236 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T4 | 282-287 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T5 | 329-330 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T6 | 349-354 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T7 | 799-800 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T8 | 819-824 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T9 | 1468-1471 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T10 | 1472-1473 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T11 | 1676-1677 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T12 | 1823-1826 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T13 | 1839-1840 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T14 | 1878-1883 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T15 | 1931-1934 | http://purl.obolibrary.org/obo/CLO_0054061 | denotes | 132 |
T16 | 2268-2269 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
T17 | 2333-2336 | http://purl.obolibrary.org/obo/NCBITaxon_9397 | denotes | bat |
T18 | 2340-2345 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T19 | 2428-2431 | http://purl.obolibrary.org/obo/NCBITaxon_9397 | denotes | bat |
T20 | 2473-2474 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T21 | 2499-2500 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T22 | 2684-2685 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T23 | 2749-2754 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T24 | 2767-2777 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
T25 | 2778-2783 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T26 | 2804-2808 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T27 | 3217-3222 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T28 | 3226-3227 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T29 | 3498-3499 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
T30 | 3683-3684 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T31 | 3878-3879 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T32 | 4224-4226 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
T33 | 4877-4878 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T34 | 5025-5031 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
T35 | 5117-5118 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
T36 | 5874-5875 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T37 | 5876-5879 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 1:1 |
T38 | 6110-6115 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T39 | 6492-6493 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T40 | 6520-6521 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T41 | 6705-6706 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T42 | 6785-6786 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T43 | 7035-7036 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T44 | 7128-7133 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T45 | 7295-7300 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T46 | 7392-7397 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T47 | 7726-7736 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
T48 | 7793-7794 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T49 | 7813-7818 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T50 | 8175-8176 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T51 | 8662-8663 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T52 | 8673-8676 | http://purl.obolibrary.org/obo/CLO_0009946 | denotes | kon |
T53 | 8691-8695 | http://purl.obolibrary.org/obo/CLO_0007875 | denotes | Ms−1 |
T54 | 8691-8695 | http://purl.obolibrary.org/obo/CLO_0050048 | denotes | Ms−1 |
T55 | 8691-8695 | http://purl.obolibrary.org/obo/CLO_0052410 | denotes | Ms−1 |
T56 | 8731-8734 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | s−1 |
T57 | 8767-8771 | http://purl.obolibrary.org/obo/CLO_0001692 | denotes | a KD |
T58 | 8829-8834 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T59 | 8829-8834 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
T60 | 8838-8839 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T61 | 9048-9053 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T62 | 9121-9129 | http://purl.obolibrary.org/obo/CLO_0007225 | denotes | labelled |
T63 | 9182-9187 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T64 | 9238-9242 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | test |
T65 | 9697-9698 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T66 | 9799-9800 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T67 | 10292-10299 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
T68 | 10303-10304 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T69 | 10468-10469 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T70 | 10570-10573 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T1 | 47-54 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T2 | 404-413 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T3 | 630-637 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T4 | 894-896 | Chemical | denotes | KD | http://purl.obolibrary.org/obo/CHEBI_73601 |
T5 | 913-920 | Chemical | denotes | epitope | http://purl.obolibrary.org/obo/CHEBI_53000 |
T6 | 1393-1400 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T7 | 2112-2121 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T8 | 2455-2457 | Chemical | denotes | SL | http://purl.obolibrary.org/obo/CHEBI_74815 |
T9 | 2638-2645 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T10 | 2666-2668 | Chemical | denotes | SL | http://purl.obolibrary.org/obo/CHEBI_74815 |
T11 | 2707-2719 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
T12 | 2826-2837 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
T13 | 2897-2907 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
T14 | 2897-2902 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
T15 | 2903-2907 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
T16 | 2970-2977 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T17 | 3880-3884 | Chemical | denotes | salt | http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710 |
T19 | 3909-3911 | Chemical | denotes | VL | http://purl.obolibrary.org/obo/CHEBI_75013 |
T20 | 4047-4049 | Chemical | denotes | VL | http://purl.obolibrary.org/obo/CHEBI_75013 |
T21 | 4308-4312 | Chemical | denotes | salt | http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710 |
T23 | 4371-4375 | Chemical | denotes | R162 | http://purl.obolibrary.org/obo/CHEBI_85885 |
T24 | 4737-4744 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T25 | 4921-4933 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
T26 | 4943-4950 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T27 | 5017-5021 | Chemical | denotes | MEGA | http://purl.obolibrary.org/obo/CHEBI_6617 |
T28 | 5230-5237 | Chemical | denotes | Protein | http://purl.obolibrary.org/obo/CHEBI_16541 |
T29 | 6004-6011 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T30 | 6399-6407 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
T31 | 6494-6498 | Chemical | denotes | salt | http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710 |
T33 | 6522-6530 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
T34 | 6568-6576 | Chemical | denotes | arginine | http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29016|http://purl.obolibrary.org/obo/CHEBI_32696 |
T37 | 6603-6613 | Chemical | denotes | asparagine | http://purl.obolibrary.org/obo/CHEBI_22653 |
T38 | 6787-6793 | Chemical | denotes | lysine | http://purl.obolibrary.org/obo/CHEBI_18019|http://purl.obolibrary.org/obo/CHEBI_25094 |
T40 | 6833-6839 | Chemical | denotes | valine | http://purl.obolibrary.org/obo/CHEBI_27266 |
T41 | 6885-6889 | Chemical | denotes | salt | http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710 |
T43 | 6992-6999 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T44 | 7269-7271 | Chemical | denotes | KD | http://purl.obolibrary.org/obo/CHEBI_73601 |
T45 | 7379-7386 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T46 | 7544-7551 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T47 | 8769-8771 | Chemical | denotes | KD | http://purl.obolibrary.org/obo/CHEBI_73601 |
T48 | 8940-8947 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T49 | 9196-9204 | Chemical | denotes | solution | http://purl.obolibrary.org/obo/CHEBI_75958 |
T50 | 9495-9502 | Chemical | denotes | epitope | http://purl.obolibrary.org/obo/CHEBI_53000 |
T51 | 10036-10043 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
T52 | 10415-10422 | Chemical | denotes | mixture | http://purl.obolibrary.org/obo/CHEBI_60004 |
T53 | 10909-10918 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-111 | Sentence | denotes | Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody |
T2 | 112-142 | Sentence | denotes | Emerging Microbes & Infections |
T3 | 143-145 | Sentence | denotes | X. |
T4 | 146-157 | Sentence | denotes | Tian et al. |
T5 | 159-167 | Sentence | denotes | Abstract |
T6 | 168-176 | Sentence | denotes | ABSTRACT |
T7 | 177-362 | Sentence | denotes | The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health. |
T8 | 363-435 | Sentence | denotes | Currently, however, there is no specific antiviral treatment or vaccine. |
T9 | 436-758 | Sentence | denotes | Considering the relatively high identity of receptor-binding domain (RBD) in 2019-nCoV and SARS-CoV, it is urgent to assess the cross-reactivity of anti-SARS CoV antibodies with 2019-nCoV spike protein, which could have important implications for rapid development of vaccines and therapeutic antibodies against 2019-nCoV. |
T10 | 759-908 | Sentence | denotes | Here, we report for the first time that a SARS-CoV-specific human monoclonal antibody, CR3022, could bind potently with 2019-nCoV RBD (KD of 6.3 nM). |
T11 | 909-996 | Sentence | denotes | The epitope of CR3022 does not overlap with the ACE2 binding site within 2019-nCoV RBD. |
T12 | 997-1214 | Sentence | denotes | These results suggest that CR3022 may have the potential to be developed as candidate therapeutics, alone or in combination with other neutralizing antibodies, for the prevention and treatment of 2019-nCoV infections. |
T13 | 1215-1659 | Sentence | denotes | Interestingly, some of the most potent SARS-CoV-specific neutralizing antibodies (e.g. m396, CR3014) that target the ACE2 binding site of SARS-CoV failed to bind 2019-nCoV spike protein, implying that the difference in the RBD of SARS-CoV and 2019-nCoV has a critical impact for the cross-reactivity of neutralizing antibodies, and that it is still necessary to develop novel monoclonal antibodies that could bind specifically to 2019-nCoV RBD. |
T14 | 1661-1789 | Sentence | denotes | Very recently, a novel coronavirus which was temporarily named “2019 novel coronavirus (2019-nCoV)” emerged in Wuhan, China [1]. |
T15 | 1790-2067 | Sentence | denotes | As of 1 February 2020, 2019-nCoV has resulted in a total of 11,821 laboratory-confirmed human infections in China, including 259 deaths, and 132 exported cases in 23 countries outside of China (https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports). |
T16 | 2068-2160 | Sentence | denotes | Currently, there is no vaccine or effective antiviral treatment against 2019-nCoV infection. |
T17 | 2161-2217 | Sentence | denotes | Based on the phylogenetic analysis (GISAID accession no. |
T18 | 2218-2477 | Sentence | denotes | EPI_ISL_402124) [2], 2019-nCoV belongs to lineage B betacoronavirus and shares high sequence identity with that of bat or human severe acute respiratory syndrome coronavirus-related coronavirus (SARSr-CoV) and bat SARS-like coronavirus (SL-CoV) (Figure 1(a)). |
T19 | 2478-2603 | Sentence | denotes | In previous studies, a number of potent monoclonal antibodies against SARS coronavirus (SARS-CoV) have been identified [3–7]. |
T20 | 2604-2869 | Sentence | denotes | These antibodies target the spike protein (S) of SARS-CoV and SL-CoVs, which is a type I transmembrane glycoprotein and mediates the entrance to human respiratory epithelial cells by interacting with cell surface receptor angiotensin-converting enzyme 2 (ACE2) [8]. |
T21 | 2870-3033 | Sentence | denotes | More specifically, the 193 amino acid length (N318-V510) receptor binding domain (RBD) within the S protein is the critical target for neutralizing antibodies [9]. |
T22 | 3034-3252 | Sentence | denotes | Some of the antibodies recognize different epitopes on RBD; e.g. the SARS-CoV neutralizing antibodies CR3014 and CR3022 bound noncompetitively to the SARS-CoV RBD and neutralized the virus in a synergistic fashion [5]. |
T23 | 3253-3502 | Sentence | denotes | We predicted the conformation of 2019-nCoV RBD as well as its complex structures with several neutralizing antibodies, and found that the modelling results support the interactions between 2019-nCoV RBD and certain SARS-CoV antibodies (Figure 1(b)). |
T24 | 3503-3606 | Sentence | denotes | This could be due to the relatively high identity (73%) of RBD in 2019-nCoV and SARS-CoV (Figure 1(c)). |
T25 | 3607-3819 | Sentence | denotes | For instance, residues in RBD of SARS-CoV that make polar interactions with a neutralizing antibody m396 as indicated by the complex crystal structure [10] are invariably conserved in 2019-nCoV RBD (Figure 1(d)). |
T26 | 3820-3912 | Sentence | denotes | In the structure of SARS-CoV-RBD-m396, R395 in RBD formed a salt bridge with D95 of m396-VL. |
T27 | 3913-4051 | Sentence | denotes | Concordantly, the electrostatic interaction was also observed in the model of 2019-nCoV-RBD-m396, forming by R408 (RBD) and D95 (m396-VL). |
T28 | 4052-4168 | Sentence | denotes | This analysis suggests that some SARS-CoV-specific monoclonal antibodies may be effective in neutralizing 2019-nCoV. |
T29 | 4169-4410 | Sentence | denotes | In contrast, the interactions between antibody F26G19 [11] or 80R [12] and the RBD in 2019-nCoV decreased significantly due to the lack of salt bridges formed by R426-D56 in SARS-CoV-RBD-F26G19 or D480-R162 in SARS-CoV-RBD-80R, respectively. |
T30 | 4411-4614 | Sentence | denotes | Furthermore, while most of the 80R-binding residues on the RBD of SARS-CoV are not conserved on RBD of 2019-nCoV (Figure 1(c)), it is unlikely that the antibody 80R could effectively recognize 2019-nCoV. |
T31 | 4615-4865 | Sentence | denotes | Therefore, it is urgent to experimentally determine the cross-reactivity of anti-SARS-CoV antibodies with 2019-nCoV spike protein, which could have important implications for rapid development of vaccines and therapeutic antibodies against 2019-nCoV. |
T32 | 4866-4967 | Sentence | denotes | Figure 1. (a) Phylogenetic analysis of 2019-nCoV spike glycoprotein from its protein BLAST sequences. |
T33 | 4968-5836 | Sentence | denotes | The neighbour-joining tree was constructed using MEGA X, tested by bootstrap method of 2000 replicates, and edited by the online tool of iTOL (v5). (b) The simulated model of 2019-nCoV RBD binding to SARS-CoV-RBD-specific antibodies (m396, 80R, and F26G19). (c) Protein sequence alignment of 2019-nCoV and SARS-CoV RBD, showing the predominant residues that contribute to interactions with ACE2 or SARS-CoV-specific antibodies. (d) The comparison of the complex structures of SARS-CoV-RBD and SARS-CoV-RBD-specific antibodies (shown in the first row) and models of 2019-nCoV-RBD and SARS-CoV-RBD-specific antibodies (shown in the second row). (e) Binding of monoclonal antibodies to 2019-nCoV RBD determined by ELISA. (f) Binding profiles of 2019-nCoV RBD to ACE2 and antibodies, and (g) competition of CR3022 and ACE2 with 2019-nCoV RBD measured by BLI in OctetRED96. |
T34 | 5837-5942 | Sentence | denotes | Binding kinetics was evaluated using a 1:1 Langmuir binding model by ForteBio Data Analysis 7.0 software. |
T35 | 5943-6012 | Sentence | denotes | In this study, we first expressed and purified 2019-nCoV RBD protein. |
T36 | 6013-6121 | Sentence | denotes | We also predicted the conformations of 2019-nCoV RBD and its complex with the putative receptor, human ACE2. |
T37 | 6122-6295 | Sentence | denotes | Comparison of the interaction between the complex of ACE2 [13] and SARS-CoV RBD and homology model of ACE2 and 2019-nCoV RBD revealed similar binding modes (data not shown). |
T38 | 6296-6433 | Sentence | denotes | In both complexes, β5–β6 loop and β6–β7 loop form extensive contact, including at least seven pairs of hydrogen bonds, with the receptor. |
T39 | 6434-6554 | Sentence | denotes | Notably, R426 on the forth α helix in SARS-CoV RBD builds a salt bridge with E329 and a hydrogen bond with Q325 on ACE2. |
T40 | 6555-6769 | Sentence | denotes | However, the arginine (R426 in SARS-CoV RBD) to asparagine (N439) mutation in 2019-nCoV RBD abolished the strong polar interactions, which may induce a decrease in the binding affinity between RBD and the receptor. |
T41 | 6770-6953 | Sentence | denotes | Interestingly, a lysine (K417 in 2019-nCoV RBD) replacement of valine (V404 in SARS-CoV RBD) on β6 formed an extra salt bridge with D30 on ACE2, which may recover the binding ability. |
T42 | 6954-7075 | Sentence | denotes | These data indicate that the RBD in S protein of 2019-nCoV may bind to ACE2 with a similar affinity as SARS-CoV RBD does. |
T43 | 7076-7243 | Sentence | denotes | Indeed, we measured the binding of 2019-nCoV RBD to human ACE2 by the biolayer interferometry binding (BLI) assay, and found that 2019-nCoV RBD bound potently to ACE2. |
T44 | 7244-7416 | Sentence | denotes | The calculated affinity (KD) of 2019-nCoV RBD with human ACE2 was 15.2 nM (Figure 1(f)), which is comparable to that of SARS-CoV spike protein with human ACE2 (15 nM) [14]. |
T45 | 7417-7570 | Sentence | denotes | These results indicate that ACE2 could be the potential receptor for the new coronavirus, and that the expressed 2019-nCoV RBD protein is functional [2]. |
T46 | 7571-7953 | Sentence | denotes | Next, we expressed and purified several representative SARS-CoV-specific antibodies which have been reported to target RBD and possess potent neutralizing activities, including m396 [3], CR3014 [4], CR3022 [5], as well as a MERS-CoV-specific human monoclonal antibody m336 developed by our laboratory [15], and measured their binding ability to 2019-nCoV RBD by ELISA (Figure 1(e)). |
T47 | 7954-8053 | Sentence | denotes | Surprisingly, we found that most of these antibodies did not show evident binding to 2019-nCoV RBD. |
T48 | 8054-8129 | Sentence | denotes | To confirm this result, we further measured the binding kinetics using BLI. |
T49 | 8130-8194 | Sentence | denotes | An irrelevant anti-CD40 antibody was used as a negative control. |
T50 | 8195-8356 | Sentence | denotes | Similarly, the antibody m396, which was predicted to bind 2019-nCoV RBD (Figure 1(d)), only showed slight binding at the highest measured concentration (2.0 µM). |
T51 | 8357-8506 | Sentence | denotes | Further studies are needed to solve the high-resolution structure of 2019-nCoV RBD and understand why it could not be recognized by these antibodies. |
T52 | 8507-8649 | Sentence | denotes | Notably, one SARS-CoV-specific antibody, CR3022, was found to bind potently with 2019-nCoV RBD as determined by ELISA and BLI (Figure 1(e,f)). |
T53 | 8650-8796 | Sentence | denotes | It followed a fast-on (kon of 1.84 × 105 Ms−1) and slow-off (koff of 1.16 × 10−3 s−1) binding kinetics, resulting in a KD of 6.3 nM (Figure 1(f)). |
T54 | 8797-8952 | Sentence | denotes | This antibody was isolated from blood of a convalescent SARS patient and did not compete with the antibody CR3014 for binding to recombinant S protein [5]. |
T55 | 8953-9092 | Sentence | denotes | To further elucidate the binding epitopes of CR3022, we measured the competition of CR3022 and human ACE2 for the binding to 2019-nCoV RBD. |
T56 | 9093-9278 | Sentence | denotes | The streptavidin biosensors labelled with biotinylated 2019-nCoV RBD were saturated with human ACE2 in solution, followed by the addition of the test antibodies in the presence of ACE2. |
T57 | 9279-9396 | Sentence | denotes | As shown in Figure 1(g), the antibody CR3022 did not show any competition with ACE2 for the binding to 2019-nCoV RBD. |
T58 | 9397-9569 | Sentence | denotes | These results suggest that CR3022, distinct from the other two SARS-CoV antibodies, recognizes an epitope that does not overlap with the ACE2 binding site of 2019-nCoV RBD. |
T59 | 9570-9666 | Sentence | denotes | The RBD of 2019-nCoV differs largely from the SARS-CoV at the C-terminus residues (Figure 1(c)). |
T60 | 9667-9868 | Sentence | denotes | Our results implied that such a difference did not result in drastic changes in the capability to engage the ACE2 receptor, but had a critical impact on the cross-reactivity of neutralizing antibodies. |
T61 | 9869-10162 | Sentence | denotes | Some of the most potent SARS-CoV-specific neutralizing antibodies (e.g. m396, CR3014) that target the receptor binding site of SARS-CoV failed to bind 2019-nCoV spike protein, indicating that it is necessary to develop novel monoclonal antibodies that could bind specifically to 2019-nCoV RBD. |
T62 | 10163-10397 | Sentence | denotes | Interestingly, it was reported that the antibody CR3022 completely neutralized both the wild-type SARS-CoV and the CR3014 escape viruses at a concentration of 23.5 μg/ml, and that no escape variants could be generated with CR3022 [5]. |
T63 | 10398-10535 | Sentence | denotes | Furthermore, the mixture of CR3022 and CR3014 neutralized SARS-CoV in a synergistic fashion by recognizing different epitopes on RBD [5]. |
T64 | 10536-10748 | Sentence | denotes | These results suggest that CR3022 has the potential to be developed as candidate therapeutics, alone or in combination with other neutralizing antibodies, for the prevention and treatment of 2019-nCoV infections. |
T65 | 10749-10945 | Sentence | denotes | We expect more cross-reactive antibodies against 2019-nCoV and SARS-CoV or other coronaviruses to be identified soon, facilitating the development of effective antiviral therapeutics and vaccines. |
T66 | 10947-10969 | Sentence | denotes | Supplementary Material |
T67 | 10970-10991 | Sentence | denotes | Supplemental Material |
T68 | 10993-11013 | Sentence | denotes | Disclosure statement |
T69 | 11014-11078 | Sentence | denotes | No potential conflict of interest was reported by the author(s). |
T70 | 11080-11085 | Sentence | denotes | ORCID |
T71 | 11086-11134 | Sentence | denotes | Zhengli Shi http://orcid.org/0000-0001-8089-163X |
T72 | 11135-11183 | Sentence | denotes | Shibo Jiang http://orcid.org/0000-0001-8283-7135 |
T73 | 11184-11233 | Sentence | denotes | Tianlei Ying http://orcid.org/0000-0002-9597-2843 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
3 | 18-40 | Species | denotes | 2019 novel coronavirus | Tax:2697049 |
4 | 60-76 | Species | denotes | SARS coronavirus | Tax:694009 |
5 | 86-91 | Species | denotes | human | Tax:9606 |
34 | 957-961 | Gene | denotes | ACE2 | Gene:59272 |
35 | 1332-1336 | Gene | denotes | ACE2 | Gene:59272 |
36 | 198-220 | Species | denotes | 2019 novel coronavirus | Tax:2697049 |
37 | 222-231 | Species | denotes | 2019-nCoV | Tax:2697049 |
38 | 282-287 | Species | denotes | human | Tax:9606 |
39 | 349-354 | Species | denotes | human | Tax:9606 |
40 | 513-522 | Species | denotes | 2019-nCoV | Tax:2697049 |
41 | 527-535 | Species | denotes | SARS-CoV | Tax:694009 |
42 | 614-623 | Species | denotes | 2019-nCoV | Tax:2697049 |
43 | 748-757 | Species | denotes | 2019-nCoV | Tax:2697049 |
44 | 801-809 | Species | denotes | SARS-CoV | Tax:694009 |
45 | 879-888 | Species | denotes | 2019-nCoV | Tax:2697049 |
46 | 982-991 | Species | denotes | 2019-nCoV | Tax:2697049 |
47 | 1254-1262 | Species | denotes | SARS-CoV | Tax:694009 |
48 | 1353-1361 | Species | denotes | SARS-CoV | Tax:694009 |
49 | 1377-1386 | Species | denotes | 2019-nCoV | Tax:2697049 |
50 | 1445-1453 | Species | denotes | SARS-CoV | Tax:694009 |
51 | 1458-1467 | Species | denotes | 2019-nCoV | Tax:2697049 |
52 | 1645-1654 | Species | denotes | 2019-nCoV | Tax:2697049 |
53 | 589-597 | Species | denotes | SARS CoV | Tax:694009 |
54 | 819-824 | Species | denotes | human | Tax:9606 |
55 | 846-852 | Chemical | denotes | CR3022 | |
56 | 924-930 | Chemical | denotes | CR3022 | |
57 | 1024-1030 | Chemical | denotes | CR3022 | |
58 | 1308-1314 | Chemical | denotes | CR3014 | |
59 | 288-298 | Disease | denotes | infections | MESH:D007239 |
60 | 314-320 | Disease | denotes | deaths | MESH:D003643 |
61 | 1193-1213 | Disease | denotes | 2019-nCoV infections | MESH:C000657245 |
71 | 1678-1695 | Species | denotes | novel coronavirus | Tax:2697049 |
72 | 1725-1747 | Species | denotes | 2019 novel coronavirus | Tax:2697049 |
73 | 1749-1758 | Species | denotes | 2019-nCoV | Tax:2697049 |
74 | 1813-1822 | Species | denotes | 2019-nCoV | Tax:2697049 |
75 | 1878-1883 | Species | denotes | human | Tax:9606 |
76 | 1884-1894 | Disease | denotes | infections | MESH:D007239 |
77 | 1919-1925 | Disease | denotes | deaths | MESH:D003643 |
78 | 2031-2047 | Disease | denotes | coronavirus-2019 | MESH:C000657245 |
79 | 2140-2159 | Disease | denotes | 2019-nCoV infection | MESH:C000657245 |
97 | 5358-5362 | Gene | denotes | ACE2 | Gene:59272 |
98 | 5727-5731 | Gene | denotes | ACE2 | Gene:59272 |
99 | 5782-5786 | Gene | denotes | ACE2 | Gene:59272 |
100 | 4905-4914 | Species | denotes | 2019-nCoV | Tax:2697049 |
101 | 5143-5152 | Species | denotes | 2019-nCoV | Tax:2697049 |
102 | 5168-5176 | Species | denotes | SARS-CoV | Tax:694009 |
103 | 5260-5269 | Species | denotes | 2019-nCoV | Tax:2697049 |
104 | 5274-5282 | Species | denotes | SARS-CoV | Tax:694009 |
105 | 5444-5452 | Species | denotes | SARS-CoV | Tax:694009 |
106 | 5461-5469 | Species | denotes | SARS-CoV | Tax:694009 |
107 | 5533-5542 | Species | denotes | 2019-nCoV | Tax:2697049 |
108 | 5551-5559 | Species | denotes | SARS-CoV | Tax:694009 |
109 | 5651-5660 | Species | denotes | 2019-nCoV | Tax:2697049 |
110 | 5710-5719 | Species | denotes | 2019-nCoV | Tax:2697049 |
111 | 5792-5801 | Species | denotes | 2019-nCoV | Tax:2697049 |
112 | 5366-5374 | Species | denotes | SARS-CoV | Tax:694009 |
113 | 5771-5777 | Chemical | denotes | CR3022 | |
153 | 2826-2857 | Gene | denotes | angiotensin-converting enzyme 2 | Gene:59272 |
154 | 2859-2863 | Gene | denotes | ACE2 | Gene:59272 |
155 | 2239-2248 | Species | denotes | 2019-nCoV | Tax:2697049 |
156 | 2270-2285 | Species | denotes | betacoronavirus | Tax:694002 |
157 | 2340-2345 | Species | denotes | human | Tax:9606 |
158 | 2346-2391 | Species | denotes | severe acute respiratory syndrome coronavirus | Tax:694009 |
159 | 2400-2411 | Species | denotes | coronavirus | Tax:11118 |
160 | 2413-2422 | Species | denotes | SARSr-CoV | Tax:694009 |
161 | 2428-2453 | Species | denotes | bat SARS-like coronavirus | Tax:1508227 |
162 | 2458-2461 | Species | denotes | CoV | Tax:11118 |
163 | 2548-2564 | Species | denotes | SARS coronavirus | Tax:694009 |
164 | 2566-2574 | Species | denotes | SARS-CoV | Tax:694009 |
165 | 2653-2661 | Species | denotes | SARS-CoV | Tax:694009 |
166 | 2669-2673 | Species | denotes | CoVs | Tax:11118 |
167 | 2749-2754 | Species | denotes | human | Tax:9606 |
168 | 3184-3192 | Species | denotes | SARS-CoV | Tax:694009 |
169 | 3286-3295 | Species | denotes | 2019-nCoV | Tax:2697049 |
170 | 3442-3451 | Species | denotes | 2019-nCoV | Tax:2697049 |
171 | 3569-3578 | Species | denotes | 2019-nCoV | Tax:2697049 |
172 | 3583-3591 | Species | denotes | SARS-CoV | Tax:694009 |
173 | 3640-3648 | Species | denotes | SARS-CoV | Tax:694009 |
174 | 3791-3800 | Species | denotes | 2019-nCoV | Tax:2697049 |
175 | 3840-3848 | Species | denotes | SARS-CoV | Tax:694009 |
176 | 3991-4000 | Species | denotes | 2019-nCoV | Tax:2697049 |
177 | 4158-4167 | Species | denotes | 2019-nCoV | Tax:2697049 |
178 | 4255-4264 | Species | denotes | 2019-nCoV | Tax:2697049 |
179 | 4343-4351 | Species | denotes | SARS-CoV | Tax:694009 |
180 | 4379-4387 | Species | denotes | SARS-CoV | Tax:694009 |
181 | 4477-4485 | Species | denotes | SARS-CoV | Tax:694009 |
182 | 4514-4523 | Species | denotes | 2019-nCoV | Tax:2697049 |
183 | 4604-4613 | Species | denotes | 2019-nCoV | Tax:2697049 |
184 | 4721-4730 | Species | denotes | 2019-nCoV | Tax:2697049 |
185 | 4855-4864 | Species | denotes | 2019-nCoV | Tax:2697049 |
186 | 3103-3111 | Species | denotes | SARS-CoV | Tax:694009 |
187 | 3468-3476 | Species | denotes | SARS-CoV | Tax:694009 |
188 | 4085-4093 | Species | denotes | SARS-CoV | Tax:694009 |
189 | 4696-4704 | Species | denotes | SARS-CoV | Tax:694009 |
190 | 3136-3142 | Chemical | denotes | CR3014 | |
191 | 3147-3153 | Chemical | denotes | CR3022 | |
234 | 6116-6120 | Gene | denotes | ACE2 | Gene:59272 |
235 | 6175-6179 | Gene | denotes | ACE2 | Gene:59272 |
236 | 6224-6228 | Gene | denotes | ACE2 | Gene:59272 |
237 | 6549-6553 | Gene | denotes | ACE2 | Gene:59272 |
238 | 6909-6913 | Gene | denotes | ACE2 | Gene:59272 |
239 | 7025-7029 | Gene | denotes | ACE2 | Gene:59272 |
240 | 7134-7138 | Gene | denotes | ACE2 | Gene:59272 |
241 | 7238-7242 | Gene | denotes | ACE2 | Gene:59272 |
242 | 7301-7305 | Gene | denotes | ACE2 | Gene:59272 |
243 | 7398-7402 | Gene | denotes | ACE2 | Gene:59272 |
244 | 7445-7449 | Gene | denotes | ACE2 | Gene:59272 |
245 | 5990-5999 | Species | denotes | 2019-nCoV | Tax:2697049 |
246 | 6052-6061 | Species | denotes | 2019-nCoV | Tax:2697049 |
247 | 6110-6115 | Species | denotes | human | Tax:9606 |
248 | 6189-6197 | Species | denotes | SARS-CoV | Tax:694009 |
249 | 6233-6242 | Species | denotes | 2019-nCoV | Tax:2697049 |
250 | 6472-6480 | Species | denotes | SARS-CoV | Tax:694009 |
251 | 6586-6594 | Species | denotes | SARS-CoV | Tax:694009 |
252 | 6633-6642 | Species | denotes | 2019-nCoV | Tax:2697049 |
253 | 6803-6812 | Species | denotes | 2019-nCoV | Tax:2697049 |
254 | 6849-6857 | Species | denotes | SARS-CoV | Tax:694009 |
255 | 7003-7012 | Species | denotes | 2019-nCoV | Tax:2697049 |
256 | 7057-7065 | Species | denotes | SARS-CoV | Tax:694009 |
257 | 7111-7120 | Species | denotes | 2019-nCoV | Tax:2697049 |
258 | 7128-7133 | Species | denotes | human | Tax:9606 |
259 | 7206-7215 | Species | denotes | 2019-nCoV | Tax:2697049 |
260 | 7276-7285 | Species | denotes | 2019-nCoV | Tax:2697049 |
261 | 7295-7300 | Species | denotes | human | Tax:9606 |
262 | 7364-7372 | Species | denotes | SARS-CoV | Tax:694009 |
263 | 7392-7397 | Species | denotes | human | Tax:9606 |
264 | 7490-7505 | Species | denotes | new coronavirus | Tax:2697049 |
265 | 7530-7539 | Species | denotes | 2019-nCoV | Tax:2697049 |
266 | 6399-6407 | Chemical | denotes | hydrogen | MESH:D006859 |
267 | 6511-6515 | Chemical | denotes | E329 | |
268 | 6522-6530 | Chemical | denotes | hydrogen | MESH:D006859 |
269 | 6541-6545 | Chemical | denotes | Q325 | |
270 | 6568-6576 | Chemical | denotes | arginine | MESH:D001120 |
271 | 6603-6613 | Chemical | denotes | asparagine | MESH:D001216 |
272 | 6787-6793 | Chemical | denotes | lysine | MESH:D008239 |
273 | 6795-6799 | Chemical | denotes | K417 | |
274 | 6833-6839 | Chemical | denotes | valine | MESH:D014633 |
275 | 6902-6905 | Chemical | denotes | D30 | MESH:C005496 |
286 | 8149-8153 | Gene | denotes | CD40 | Gene:958 |
287 | 7795-7803 | Species | denotes | MERS-CoV | Tax:1335626 |
288 | 7916-7925 | Species | denotes | 2019-nCoV | Tax:2697049 |
289 | 8039-8048 | Species | denotes | 2019-nCoV | Tax:2697049 |
290 | 8253-8262 | Species | denotes | 2019-nCoV | Tax:2697049 |
291 | 8426-8435 | Species | denotes | 2019-nCoV | Tax:2697049 |
292 | 7626-7634 | Species | denotes | SARS-CoV | Tax:694009 |
293 | 7813-7818 | Species | denotes | human | Tax:9606 |
294 | 7758-7764 | Chemical | denotes | CR3014 | |
295 | 7770-7776 | Chemical | denotes | CR3022 | |
317 | 9054-9058 | Gene | denotes | ACE2 | Gene:59272 |
318 | 9188-9192 | Gene | denotes | ACE2 | Gene:59272 |
319 | 9273-9277 | Gene | denotes | ACE2 | Gene:59272 |
320 | 9358-9362 | Gene | denotes | ACE2 | Gene:59272 |
321 | 9534-9538 | Gene | denotes | ACE2 | Gene:59272 |
322 | 8588-8597 | Species | denotes | 2019-nCoV | Tax:2697049 |
323 | 8858-8865 | Species | denotes | patient | Tax:9606 |
324 | 9048-9053 | Species | denotes | human | Tax:9606 |
325 | 9078-9087 | Species | denotes | 2019-nCoV | Tax:2697049 |
326 | 9148-9157 | Species | denotes | 2019-nCoV | Tax:2697049 |
327 | 9182-9187 | Species | denotes | human | Tax:9606 |
328 | 9382-9391 | Species | denotes | 2019-nCoV | Tax:2697049 |
329 | 9555-9564 | Species | denotes | 2019-nCoV | Tax:2697049 |
330 | 8520-8528 | Species | denotes | SARS-CoV | Tax:694009 |
331 | 9460-9468 | Species | denotes | SARS-CoV | Tax:694009 |
332 | 8548-8554 | Chemical | denotes | CR3022 | |
333 | 8904-8910 | Chemical | denotes | CR3014 | |
334 | 8998-9004 | Chemical | denotes | CR3022 | |
335 | 9037-9043 | Chemical | denotes | CR3022 | |
336 | 9317-9323 | Chemical | denotes | CR3022 | |
337 | 9424-9430 | Chemical | denotes | CR3022 | |
357 | 9776-9780 | Gene | denotes | ACE2 | Gene:59272 |
358 | 9581-9590 | Species | denotes | 2019-nCoV | Tax:2697049 |
359 | 9616-9624 | Species | denotes | SARS-CoV | Tax:694009 |
360 | 9893-9901 | Species | denotes | SARS-CoV | Tax:694009 |
361 | 9996-10004 | Species | denotes | SARS-CoV | Tax:694009 |
362 | 10020-10029 | Species | denotes | 2019-nCoV | Tax:2697049 |
363 | 10148-10157 | Species | denotes | 2019-nCoV | Tax:2697049 |
364 | 10261-10269 | Species | denotes | SARS-CoV | Tax:694009 |
365 | 10456-10464 | Species | denotes | SARS-CoV | Tax:694009 |
366 | 10798-10807 | Species | denotes | 2019-nCoV | Tax:2697049 |
367 | 10812-10820 | Species | denotes | SARS-CoV | Tax:694009 |
368 | 10830-10843 | Species | denotes | coronaviruses | Tax:11118 |
369 | 10212-10218 | Chemical | denotes | CR3022 | |
370 | 10278-10284 | Chemical | denotes | CR3014 | |
371 | 10386-10392 | Chemical | denotes | CR3022 | |
372 | 10426-10432 | Chemical | denotes | CR3022 | |
373 | 10437-10443 | Chemical | denotes | CR3014 | |
374 | 10563-10569 | Chemical | denotes | CR3022 | |
375 | 10727-10747 | Disease | denotes | 2019-nCoV infections | MESH:C000657245 |