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PMC:7040011 / 5018-6563 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T18 68-74 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T19 237-244 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T20 1083-1090 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T21 1214-1220 Body_part denotes intron http://purl.org/sig/ont/fma/fma84121
T22 1229-1233 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T23 1458-1462 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T2 68-74 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T28 935-937 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T29 956-958 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T30 1229-1233 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T31 1235-1238 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T32 1458-1462 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T18 706-708 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T19 976-978 Chemical denotes AF http://purl.obolibrary.org/obo/CHEBI_73807
T20 1112-1114 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T38 0-145 Sentence denotes To analyze the distribution of eQTLs for ACE2, we used the Genotype Tissue Expression (GTEx) database (https://www.gtexportal.org/home/datasets).
T39 146-443 Sentence denotes We found 15 unique eQTL variants (14 SNPs and 1 INDELs) for ACE2 with q value ≤ 0.05 in 20 tissues from the GTEx database (rs112171234, rs12010448, rs143695310, rs1996225, rs200781818, rs2158082, rs4060, rs4646127, rs4830974, rs4830983, rs5936011, rs5936029, rs6629110, rs6632704, and rs75979613).
T40 444-518 Sentence denotes The AFs of the 15 eQTL variants were compared among different populations.
T41 519-710 Sentence denotes Notably, our results showed most of the 15 eQTL variants had much higher AFs in the ChinaMAP dataset and EAS populations compared to European populations (Fig. 1c and Supplementary Table S3).
T42 711-944 Sentence denotes The AFs of the top 6 common variants (rs4646127, rs2158082, rs5936011, rs6629110, rs4830983, and rs5936029) were higher than 95% in EAS populations, whereas the AFs of these variants in European populations were much lower (52%–65%).
T43 945-1116 Sentence denotes All of the 11 common variants (AF > 0.05) and 1 rare variant (rs143695310) in the 15 eQTLs are associated with high expression of ACE2 in tissues (Supplementary Table S3).
T44 1117-1315 Sentence denotes For instance, the eQTL variant rs4646127 (log allelic fold change = 0.314), which locates in the intron of ACE2 gene, has the highest AFs in both of the ChinaMAP (0.997) and EAS (0.994) populations.
T45 1316-1410 Sentence denotes Comparatively, the AFs of rs4646127 in EUR (0.651) and AMR (0.754) populations are much lower.
T46 1411-1545 Sentence denotes These findings suggested the genotypes of ACE2 gene polymorphism may be associated higher expression levels of ACE2 in EAS population.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
219 1522-1526 Gene denotes ACE2 Gene:59272
220 1453-1457 Gene denotes ACE2 Gene:59272
221 1224-1228 Gene denotes ACE2 Gene:59272
222 1075-1079 Gene denotes ACE2 Gene:59272
223 206-210 Gene denotes ACE2 Gene:59272
224 41-45 Gene denotes ACE2 Gene:59272
225 1519-1521 Gene denotes of Gene:6688
226 1450-1452 Gene denotes of Gene:6688
227 1263-1265 Gene denotes of Gene:6688
228 1221-1223 Gene denotes of Gene:6688
229 876-878 Gene denotes of Gene:6688
230 719-721 Gene denotes of Gene:6688
231 552-554 Gene denotes of Gene:6688
232 452-454 Gene denotes of Gene:6688
233 28-30 Gene denotes of Gene:6688
234 1530-1533 Chemical denotes EAS
235 976-978 Disease denotes AF MESH:D001281
236 269-280 Mutation denotes rs112171234 rs112171234
237 282-292 Mutation denotes rs12010448 rs12010448
238 1007-1018 Mutation denotes rs143695310 rs143695310
239 307-316 Mutation denotes rs1996225 rs1996225
240 318-329 Mutation denotes rs200781818 rs200781818
241 760-769 Mutation denotes rs2158082 rs2158082
242 342-348 Mutation denotes rs4060 rs4060
243 1342-1351 Mutation denotes rs4646127 rs4646127
244 361-370 Mutation denotes rs4830974 rs4830974
245 793-802 Mutation denotes rs4830983 rs4830983
246 771-780 Mutation denotes rs5936011 rs5936011
247 808-817 Mutation denotes rs5936029 rs5936029
248 782-791 Mutation denotes rs6629110 rs6629110
249 416-425 Mutation denotes rs6632704 rs6632704
250 431-441 Mutation denotes rs75979613 rs75979613
251 1148-1157 Mutation denotes rs4646127 rs4646127
252 331-340 Mutation denotes rs2158082 rs2158082
253 383-392 Mutation denotes rs5936011 rs5936011
254 405-414 Mutation denotes rs6629110 rs6629110
255 372-381 Mutation denotes rs4830983 rs4830983
256 394-403 Mutation denotes rs5936029 rs5936029
257 294-305 Mutation denotes rs143695310 rs143695310
258 749-758 Mutation denotes rs4646127 rs4646127
259 350-359 Mutation denotes rs4646127 rs4646127