PMC:7040011 / 5018-6563
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T18 | 68-74 | Body_part | denotes | Tissue | http://purl.org/sig/ont/fma/fma9637 |
T19 | 237-244 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
T20 | 1083-1090 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
T21 | 1214-1220 | Body_part | denotes | intron | http://purl.org/sig/ont/fma/fma84121 |
T22 | 1229-1233 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
T23 | 1458-1462 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T2 | 68-74 | Body_part | denotes | Tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T28 | 935-937 | http://purl.obolibrary.org/obo/CLO_0001407 | denotes | 52 |
T29 | 956-958 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
T30 | 1229-1233 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
T31 | 1235-1238 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T32 | 1458-1462 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T18 | 706-708 | Chemical | denotes | S3 | http://purl.obolibrary.org/obo/CHEBI_29388 |
T19 | 976-978 | Chemical | denotes | AF | http://purl.obolibrary.org/obo/CHEBI_73807 |
T20 | 1112-1114 | Chemical | denotes | S3 | http://purl.obolibrary.org/obo/CHEBI_29388 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T38 | 0-145 | Sentence | denotes | To analyze the distribution of eQTLs for ACE2, we used the Genotype Tissue Expression (GTEx) database (https://www.gtexportal.org/home/datasets). |
T39 | 146-443 | Sentence | denotes | We found 15 unique eQTL variants (14 SNPs and 1 INDELs) for ACE2 with q value ≤ 0.05 in 20 tissues from the GTEx database (rs112171234, rs12010448, rs143695310, rs1996225, rs200781818, rs2158082, rs4060, rs4646127, rs4830974, rs4830983, rs5936011, rs5936029, rs6629110, rs6632704, and rs75979613). |
T40 | 444-518 | Sentence | denotes | The AFs of the 15 eQTL variants were compared among different populations. |
T41 | 519-710 | Sentence | denotes | Notably, our results showed most of the 15 eQTL variants had much higher AFs in the ChinaMAP dataset and EAS populations compared to European populations (Fig. 1c and Supplementary Table S3). |
T42 | 711-944 | Sentence | denotes | The AFs of the top 6 common variants (rs4646127, rs2158082, rs5936011, rs6629110, rs4830983, and rs5936029) were higher than 95% in EAS populations, whereas the AFs of these variants in European populations were much lower (52%–65%). |
T43 | 945-1116 | Sentence | denotes | All of the 11 common variants (AF > 0.05) and 1 rare variant (rs143695310) in the 15 eQTLs are associated with high expression of ACE2 in tissues (Supplementary Table S3). |
T44 | 1117-1315 | Sentence | denotes | For instance, the eQTL variant rs4646127 (log allelic fold change = 0.314), which locates in the intron of ACE2 gene, has the highest AFs in both of the ChinaMAP (0.997) and EAS (0.994) populations. |
T45 | 1316-1410 | Sentence | denotes | Comparatively, the AFs of rs4646127 in EUR (0.651) and AMR (0.754) populations are much lower. |
T46 | 1411-1545 | Sentence | denotes | These findings suggested the genotypes of ACE2 gene polymorphism may be associated higher expression levels of ACE2 in EAS population. |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id | tao:has_standard_notation |
---|---|---|---|---|---|---|
219 | 1522-1526 | Gene | denotes | ACE2 | Gene:59272 | |
220 | 1453-1457 | Gene | denotes | ACE2 | Gene:59272 | |
221 | 1224-1228 | Gene | denotes | ACE2 | Gene:59272 | |
222 | 1075-1079 | Gene | denotes | ACE2 | Gene:59272 | |
223 | 206-210 | Gene | denotes | ACE2 | Gene:59272 | |
224 | 41-45 | Gene | denotes | ACE2 | Gene:59272 | |
225 | 1519-1521 | Gene | denotes | of | Gene:6688 | |
226 | 1450-1452 | Gene | denotes | of | Gene:6688 | |
227 | 1263-1265 | Gene | denotes | of | Gene:6688 | |
228 | 1221-1223 | Gene | denotes | of | Gene:6688 | |
229 | 876-878 | Gene | denotes | of | Gene:6688 | |
230 | 719-721 | Gene | denotes | of | Gene:6688 | |
231 | 552-554 | Gene | denotes | of | Gene:6688 | |
232 | 452-454 | Gene | denotes | of | Gene:6688 | |
233 | 28-30 | Gene | denotes | of | Gene:6688 | |
234 | 1530-1533 | Chemical | denotes | EAS | ||
235 | 976-978 | Disease | denotes | AF | MESH:D001281 | |
236 | 269-280 | Mutation | denotes | rs112171234 | rs112171234 | |
237 | 282-292 | Mutation | denotes | rs12010448 | rs12010448 | |
238 | 1007-1018 | Mutation | denotes | rs143695310 | rs143695310 | |
239 | 307-316 | Mutation | denotes | rs1996225 | rs1996225 | |
240 | 318-329 | Mutation | denotes | rs200781818 | rs200781818 | |
241 | 760-769 | Mutation | denotes | rs2158082 | rs2158082 | |
242 | 342-348 | Mutation | denotes | rs4060 | rs4060 | |
243 | 1342-1351 | Mutation | denotes | rs4646127 | rs4646127 | |
244 | 361-370 | Mutation | denotes | rs4830974 | rs4830974 | |
245 | 793-802 | Mutation | denotes | rs4830983 | rs4830983 | |
246 | 771-780 | Mutation | denotes | rs5936011 | rs5936011 | |
247 | 808-817 | Mutation | denotes | rs5936029 | rs5936029 | |
248 | 782-791 | Mutation | denotes | rs6629110 | rs6629110 | |
249 | 416-425 | Mutation | denotes | rs6632704 | rs6632704 | |
250 | 431-441 | Mutation | denotes | rs75979613 | rs75979613 | |
251 | 1148-1157 | Mutation | denotes | rs4646127 | rs4646127 | |
252 | 331-340 | Mutation | denotes | rs2158082 | rs2158082 | |
253 | 383-392 | Mutation | denotes | rs5936011 | rs5936011 | |
254 | 405-414 | Mutation | denotes | rs6629110 | rs6629110 | |
255 | 372-381 | Mutation | denotes | rs4830983 | rs4830983 | |
256 | 394-403 | Mutation | denotes | rs5936029 | rs5936029 | |
257 | 294-305 | Mutation | denotes | rs143695310 | rs143695310 | |
258 | 749-758 | Mutation | denotes | rs4646127 | rs4646127 | |
259 | 350-359 | Mutation | denotes | rs4646127 | rs4646127 |