PMC:7039956 / 9452-10180 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"289","span":{"begin":116,"end":120},"obj":"Gene"},{"id":"290","span":{"begin":292,"end":296},"obj":"Gene"},{"id":"291","span":{"begin":391,"end":395},"obj":"Gene"},{"id":"292","span":{"begin":520,"end":524},"obj":"Gene"},{"id":"293","span":{"begin":706,"end":725},"obj":"Disease"}],"attributes":[{"id":"A289","pred":"tao:has_database_id","subj":"289","obj":"Gene:59272"},{"id":"A290","pred":"tao:has_database_id","subj":"290","obj":"Gene:59272"},{"id":"A291","pred":"tao:has_database_id","subj":"291","obj":"Gene:59272"},{"id":"A292","pred":"tao:has_database_id","subj":"292","obj":"Gene:59272"},{"id":"A293","pred":"tao:has_database_id","subj":"293","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In this study, the analysis of public bulk-seq RNA datasets showed that the mucosa of oral cavity could express the ACE2 and was higher in tongue than other oral sites. The results of this study were consistent with the study of Zou et al.10 in general, many organs with higher expression of ACE2 than lung, such as intestine, heart, and kidney. According to the study of Zhao et al.11, the ACE2 expression in lung is concentrated in a small population of type II alveolar cells (AT2), that may cause the relatively low ACE2 expression of lung in bulk-seq RNA datasets analysis. Even though, the result of Zou et al. indicated that the respiratory tract should also be considered as a vulnerable target to 2019-nCoV infection10."}

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