PMC:7039956 / 6912-8240 JSONTXT

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    LitCovid-PubTator

    {"project":"LitCovid-PubTator","denotations":[{"id":"185","span":{"begin":1124,"end":1128},"obj":"Gene"},{"id":"186","span":{"begin":1158,"end":1162},"obj":"Gene"},{"id":"187","span":{"begin":1220,"end":1224},"obj":"Gene"},{"id":"188","span":{"begin":1313,"end":1317},"obj":"Gene"},{"id":"189","span":{"begin":1205,"end":1211},"obj":"Gene"},{"id":"217","span":{"begin":159,"end":163},"obj":"Gene"},{"id":"218","span":{"begin":360,"end":363},"obj":"Gene"},{"id":"219","span":{"begin":365,"end":370},"obj":"Gene"},{"id":"220","span":{"begin":376,"end":381},"obj":"Gene"},{"id":"221","span":{"begin":420,"end":423},"obj":"Gene"},{"id":"222","span":{"begin":425,"end":429},"obj":"Gene"},{"id":"223","span":{"begin":431,"end":437},"obj":"Gene"},{"id":"224","span":{"begin":439,"end":442},"obj":"Gene"},{"id":"225","span":{"begin":444,"end":450},"obj":"Gene"},{"id":"226","span":{"begin":452,"end":458},"obj":"Gene"},{"id":"227","span":{"begin":493,"end":496},"obj":"Gene"},{"id":"228","span":{"begin":498,"end":502},"obj":"Gene"},{"id":"229","span":{"begin":504,"end":508},"obj":"Gene"},{"id":"230","span":{"begin":514,"end":518},"obj":"Gene"},{"id":"231","span":{"begin":557,"end":562},"obj":"Gene"},{"id":"232","span":{"begin":564,"end":569},"obj":"Gene"},{"id":"233","span":{"begin":581,"end":587},"obj":"Gene"},{"id":"234","span":{"begin":625,"end":629},"obj":"Gene"},{"id":"235","span":{"begin":631,"end":636},"obj":"Gene"},{"id":"236","span":{"begin":638,"end":644},"obj":"Gene"},{"id":"237","span":{"begin":646,"end":651},"obj":"Gene"},{"id":"238","span":{"begin":686,"end":692},"obj":"Gene"},{"id":"239","span":{"begin":694,"end":699},"obj":"Gene"},{"id":"240","span":{"begin":705,"end":710},"obj":"Gene"},{"id":"241","span":{"begin":758,"end":764},"obj":"Gene"},{"id":"242","span":{"begin":766,"end":769},"obj":"Gene"},{"id":"243","span":{"begin":775,"end":778},"obj":"Gene"}],"attributes":[{"id":"A185","pred":"tao:has_database_id","subj":"185","obj":"Gene:59272"},{"id":"A186","pred":"tao:has_database_id","subj":"186","obj":"Gene:59272"},{"id":"A187","pred":"tao:has_database_id","subj":"187","obj":"Gene:59272"},{"id":"A188","pred":"tao:has_database_id","subj":"188","obj":"Gene:59272"},{"id":"A217","pred":"tao:has_database_id","subj":"217","obj":"Gene:59272"},{"id":"A218","pred":"tao:has_database_id","subj":"218","obj":"Gene:104444"},{"id":"A219","pred":"tao:has_database_id","subj":"219","obj":"Gene:16687"},{"id":"A220","pred":"tao:has_database_id","subj":"220","obj":"Gene:16661"},{"id":"A221","pred":"tao:has_database_id","subj":"221","obj":"Gene:14089"},{"id":"A222","pred":"tao:has_database_id","subj":"222","obj":"Gene:14726"},{"id":"A223","pred":"tao:has_database_id","subj":"223","obj":"Gene:12843"},{"id":"A224","pred":"tao:has_database_id","subj":"224","obj":"Gene:13179"},{"id":"A225","pred":"tao:has_database_id","subj":"225","obj":"Gene:1281"},{"id":"A226","pred":"tao:has_database_id","subj":"226","obj":"Gene:1291"},{"id":"A227","pred":"tao:has_database_id","subj":"227","obj":"Gene:914"},{"id":"A228","pred":"tao:has_database_id","subj":"228","obj":"Gene:915"},{"id":"A229","pred":"tao:has_database_id","subj":"229","obj":"Gene:916"},{"id":"A230","pred":"tao:has_database_id","subj":"230","obj":"Gene:917"},{"id":"A231","pred":"tao:has_database_id","subj":"231","obj":"Gene:9332"},{"id":"A232","pred":"tao:has_database_id","subj":"232","obj":"Gene:1436"},{"id":"A233","pred":"tao:has_database_id","subj":"233","obj":"Gene:2212"},{"id":"A234","pred":"tao:has_database_id","subj":"234","obj":"Gene:1215"},{"id":"A235","pred":"tao:has_database_id","subj":"235","obj":"Gene:2206"},{"id":"A236","pred":"tao:has_database_id","subj":"236","obj":"Gene:100503895"},{"id":"A237","pred":"tao:has_database_id","subj":"237","obj":"Gene:17229"},{"id":"A238","pred":"tao:has_database_id","subj":"238","obj":"Gene:75345"},{"id":"A239","pred":"tao:has_database_id","subj":"239","obj":"Gene:329693"},{"id":"A240","pred":"tao:has_database_id","subj":"240","obj":"Gene:12518"},{"id":"A241","pred":"tao:has_database_id","subj":"241","obj":"Gene:18613"},{"id":"A242","pred":"tao:has_database_id","subj":"242","obj":"Gene:22371"},{"id":"A243","pred":"tao:has_database_id","subj":"243","obj":"Gene:13805"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Single cell RNA-seq was utilized for four oral tissues, and the data was analyzed to confirm the above results and assess the cell type-specific expression of ACE2. After the data preprocessing (shown in section “Materials and methods”), 22 969 cells were acquired and 7 cell types were identified (Fig. 2a), including epithelial cells (marker genes including SFN, KRT6A, and KRT10), fibroblasts (marker genes including FAP, PDPN, COL1A2, DCN, COL3A1, COL6A1), T cells (marker genes including CD2, CD3D, CD3E, and CD3G), macrophages (marker genes including CD163, CSF1R, CD68, and FCGR2A), mast cells (marker genes including CMA1, MS4A2, TPSAB1, TPSB2), B cells (marker genes including SLAMF7, FCRL5, and CD79A) and endothelial cells (marker genes including PECAM1, VWF, and ENG). The heatmap of main cell markers across the cell types can be found in Fig. 2b.\nFig. 2 Single cell RNA-seq analysis of oral tissues from independent dataset. a Seven-cell types were identified by the cell markers; cells were clustered by UMAP method. b Heatmap of cell markers for identifying cell types. c Scatter plots of all the cells with ACE2 expression. d Violin plot of ACE2 expression across different oral sites. e Violin plot of ACE2 expression across different cell types. f Scatter plots of tongue epithelial cells with ACE2 expression"}

    LitCovid-PD-FMA-UBERON

    {"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T112","span":{"begin":7,"end":11},"obj":"Body_part"},{"id":"T113","span":{"begin":12,"end":15},"obj":"Body_part"},{"id":"T114","span":{"begin":47,"end":54},"obj":"Body_part"},{"id":"T115","span":{"begin":126,"end":130},"obj":"Body_part"},{"id":"T116","span":{"begin":245,"end":250},"obj":"Body_part"},{"id":"T117","span":{"begin":271,"end":275},"obj":"Body_part"},{"id":"T118","span":{"begin":319,"end":335},"obj":"Body_part"},{"id":"T119","span":{"begin":330,"end":335},"obj":"Body_part"},{"id":"T120","span":{"begin":384,"end":395},"obj":"Body_part"},{"id":"T121","span":{"begin":463,"end":468},"obj":"Body_part"},{"id":"T122","span":{"begin":521,"end":532},"obj":"Body_part"},{"id":"T123","span":{"begin":590,"end":600},"obj":"Body_part"},{"id":"T124","span":{"begin":595,"end":600},"obj":"Body_part"},{"id":"T125","span":{"begin":656,"end":661},"obj":"Body_part"},{"id":"T126","span":{"begin":716,"end":733},"obj":"Body_part"},{"id":"T127","span":{"begin":728,"end":733},"obj":"Body_part"},{"id":"T128","span":{"begin":801,"end":805},"obj":"Body_part"},{"id":"T129","span":{"begin":825,"end":829},"obj":"Body_part"},{"id":"T130","span":{"begin":875,"end":879},"obj":"Body_part"},{"id":"T131","span":{"begin":880,"end":883},"obj":"Body_part"},{"id":"T132","span":{"begin":905,"end":912},"obj":"Body_part"},{"id":"T133","span":{"begin":947,"end":951},"obj":"Body_part"},{"id":"T134","span":{"begin":981,"end":985},"obj":"Body_part"},{"id":"T135","span":{"begin":995,"end":1000},"obj":"Body_part"},{"id":"T136","span":{"begin":1045,"end":1049},"obj":"Body_part"},{"id":"T137","span":{"begin":1074,"end":1078},"obj":"Body_part"},{"id":"T138","span":{"begin":1113,"end":1118},"obj":"Body_part"},{"id":"T139","span":{"begin":1253,"end":1257},"obj":"Body_part"},{"id":"T140","span":{"begin":1284,"end":1290},"obj":"Body_part"},{"id":"T141","span":{"begin":1291,"end":1307},"obj":"Body_part"},{"id":"T142","span":{"begin":1302,"end":1307},"obj":"Body_part"}],"attributes":[{"id":"A112","pred":"fma_id","subj":"T112","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A113","pred":"fma_id","subj":"T113","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A114","pred":"fma_id","subj":"T114","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A115","pred":"fma_id","subj":"T115","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A116","pred":"fma_id","subj":"T116","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A117","pred":"fma_id","subj":"T117","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A118","pred":"fma_id","subj":"T118","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A119","pred":"fma_id","subj":"T119","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A120","pred":"fma_id","subj":"T120","obj":"http://purl.org/sig/ont/fma/fma63877"},{"id":"A121","pred":"fma_id","subj":"T121","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A122","pred":"fma_id","subj":"T122","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A123","pred":"fma_id","subj":"T123","obj":"http://purl.org/sig/ont/fma/fma66784"},{"id":"A124","pred":"fma_id","subj":"T124","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A125","pred":"fma_id","subj":"T125","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A126","pred":"fma_id","subj":"T126","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A127","pred":"fma_id","subj":"T127","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A128","pred":"fma_id","subj":"T128","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A129","pred":"fma_id","subj":"T129","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A130","pred":"fma_id","subj":"T130","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A131","pred":"fma_id","subj":"T131","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A132","pred":"fma_id","subj":"T132","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A133","pred":"fma_id","subj":"T133","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A134","pred":"fma_id","subj":"T134","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A135","pred":"fma_id","subj":"T135","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A136","pred":"fma_id","subj":"T136","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A137","pred":"fma_id","subj":"T137","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A138","pred":"fma_id","subj":"T138","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A139","pred":"fma_id","subj":"T139","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A140","pred":"fma_id","subj":"T140","obj":"http://purl.org/sig/ont/fma/fma54640"},{"id":"A141","pred":"fma_id","subj":"T141","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A142","pred":"fma_id","subj":"T142","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Single cell RNA-seq was utilized for four oral tissues, and the data was analyzed to confirm the above results and assess the cell type-specific expression of ACE2. After the data preprocessing (shown in section “Materials and methods”), 22 969 cells were acquired and 7 cell types were identified (Fig. 2a), including epithelial cells (marker genes including SFN, KRT6A, and KRT10), fibroblasts (marker genes including FAP, PDPN, COL1A2, DCN, COL3A1, COL6A1), T cells (marker genes including CD2, CD3D, CD3E, and CD3G), macrophages (marker genes including CD163, CSF1R, CD68, and FCGR2A), mast cells (marker genes including CMA1, MS4A2, TPSAB1, TPSB2), B cells (marker genes including SLAMF7, FCRL5, and CD79A) and endothelial cells (marker genes including PECAM1, VWF, and ENG). The heatmap of main cell markers across the cell types can be found in Fig. 2b.\nFig. 2 Single cell RNA-seq analysis of oral tissues from independent dataset. a Seven-cell types were identified by the cell markers; cells were clustered by UMAP method. b Heatmap of cell markers for identifying cell types. c Scatter plots of all the cells with ACE2 expression. d Violin plot of ACE2 expression across different oral sites. e Violin plot of ACE2 expression across different cell types. f Scatter plots of tongue epithelial cells with ACE2 expression"}

    LitCovid-PD-UBERON

    {"project":"LitCovid-PD-UBERON","denotations":[{"id":"T57","span":{"begin":1284,"end":1290},"obj":"Body_part"}],"attributes":[{"id":"A57","pred":"uberon_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/UBERON_0001723"}],"text":"Single cell RNA-seq was utilized for four oral tissues, and the data was analyzed to confirm the above results and assess the cell type-specific expression of ACE2. After the data preprocessing (shown in section “Materials and methods”), 22 969 cells were acquired and 7 cell types were identified (Fig. 2a), including epithelial cells (marker genes including SFN, KRT6A, and KRT10), fibroblasts (marker genes including FAP, PDPN, COL1A2, DCN, COL3A1, COL6A1), T cells (marker genes including CD2, CD3D, CD3E, and CD3G), macrophages (marker genes including CD163, CSF1R, CD68, and FCGR2A), mast cells (marker genes including CMA1, MS4A2, TPSAB1, TPSB2), B cells (marker genes including SLAMF7, FCRL5, and CD79A) and endothelial cells (marker genes including PECAM1, VWF, and ENG). The heatmap of main cell markers across the cell types can be found in Fig. 2b.\nFig. 2 Single cell RNA-seq analysis of oral tissues from independent dataset. a Seven-cell types were identified by the cell markers; cells were clustered by UMAP method. b Heatmap of cell markers for identifying cell types. c Scatter plots of all the cells with ACE2 expression. d Violin plot of ACE2 expression across different oral sites. e Violin plot of ACE2 expression across different cell types. f Scatter plots of tongue epithelial cells with ACE2 expression"}

    LitCovid-PD-MONDO

    {"project":"LitCovid-PD-MONDO","denotations":[{"id":"T28","span":{"begin":420,"end":423},"obj":"Disease"},{"id":"T29","span":{"begin":498,"end":502},"obj":"Disease"}],"attributes":[{"id":"A28","pred":"mondo_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/MONDO_0021055"},{"id":"A29","pred":"mondo_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/MONDO_0014280"}],"text":"Single cell RNA-seq was utilized for four oral tissues, and the data was analyzed to confirm the above results and assess the cell type-specific expression of ACE2. After the data preprocessing (shown in section “Materials and methods”), 22 969 cells were acquired and 7 cell types were identified (Fig. 2a), including epithelial cells (marker genes including SFN, KRT6A, and KRT10), fibroblasts (marker genes including FAP, PDPN, COL1A2, DCN, COL3A1, COL6A1), T cells (marker genes including CD2, CD3D, CD3E, and CD3G), macrophages (marker genes including CD163, CSF1R, CD68, and FCGR2A), mast cells (marker genes including CMA1, MS4A2, TPSAB1, TPSB2), B cells (marker genes including SLAMF7, FCRL5, and CD79A) and endothelial cells (marker genes including PECAM1, VWF, and ENG). The heatmap of main cell markers across the cell types can be found in Fig. 2b.\nFig. 2 Single cell RNA-seq analysis of oral tissues from independent dataset. a Seven-cell types were identified by the cell markers; cells were clustered by UMAP method. b Heatmap of cell markers for identifying cell types. c Scatter plots of all the cells with ACE2 expression. d Violin plot of ACE2 expression across different oral sites. e Violin plot of ACE2 expression across different cell types. f Scatter plots of tongue epithelial cells with ACE2 expression"}

    LitCovid-PD-CLO

    {"project":"LitCovid-PD-CLO","denotations":[{"id":"T123","span":{"begin":7,"end":11},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T124","span":{"begin":126,"end":135},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T125","span":{"begin":238,"end":240},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T126","span":{"begin":245,"end":250},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T127","span":{"begin":271,"end":281},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T128","span":{"begin":304,"end":306},"obj":"http://purl.obolibrary.org/obo/CLO_0001236"},{"id":"T129","span":{"begin":319,"end":329},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T130","span":{"begin":330,"end":335},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T131","span":{"begin":344,"end":349},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T132","span":{"begin":384,"end":395},"obj":"http://purl.obolibrary.org/obo/CL_0000057"},{"id":"T133","span":{"begin":404,"end":409},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T134","span":{"begin":461,"end":468},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T135","span":{"begin":477,"end":482},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T136","span":{"begin":541,"end":546},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T137","span":{"begin":564,"end":569},"obj":"http://purl.obolibrary.org/obo/PR_000002062"},{"id":"T138","span":{"begin":571,"end":575},"obj":"http://purl.obolibrary.org/obo/PR_000002064"},{"id":"T139","span":{"begin":595,"end":600},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T140","span":{"begin":609,"end":614},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T141","span":{"begin":654,"end":661},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T142","span":{"begin":670,"end":675},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T143","span":{"begin":716,"end":733},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T144","span":{"begin":742,"end":747},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T145","span":{"begin":801,"end":805},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T146","span":{"begin":825,"end":835},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T147","span":{"begin":875,"end":879},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T148","span":{"begin":939,"end":940},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T149","span":{"begin":947,"end":957},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T150","span":{"begin":981,"end":985},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T151","span":{"begin":995,"end":1000},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T152","span":{"begin":1032,"end":1033},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T153","span":{"begin":1045,"end":1049},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T154","span":{"begin":1074,"end":1084},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T155","span":{"begin":1113,"end":1118},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T156","span":{"begin":1253,"end":1263},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T157","span":{"begin":1284,"end":1290},"obj":"http://purl.obolibrary.org/obo/UBERON_0001723"},{"id":"T158","span":{"begin":1291,"end":1301},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T159","span":{"begin":1302,"end":1307},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Single cell RNA-seq was utilized for four oral tissues, and the data was analyzed to confirm the above results and assess the cell type-specific expression of ACE2. After the data preprocessing (shown in section “Materials and methods”), 22 969 cells were acquired and 7 cell types were identified (Fig. 2a), including epithelial cells (marker genes including SFN, KRT6A, and KRT10), fibroblasts (marker genes including FAP, PDPN, COL1A2, DCN, COL3A1, COL6A1), T cells (marker genes including CD2, CD3D, CD3E, and CD3G), macrophages (marker genes including CD163, CSF1R, CD68, and FCGR2A), mast cells (marker genes including CMA1, MS4A2, TPSAB1, TPSB2), B cells (marker genes including SLAMF7, FCRL5, and CD79A) and endothelial cells (marker genes including PECAM1, VWF, and ENG). The heatmap of main cell markers across the cell types can be found in Fig. 2b.\nFig. 2 Single cell RNA-seq analysis of oral tissues from independent dataset. a Seven-cell types were identified by the cell markers; cells were clustered by UMAP method. b Heatmap of cell markers for identifying cell types. c Scatter plots of all the cells with ACE2 expression. d Violin plot of ACE2 expression across different oral sites. e Violin plot of ACE2 expression across different cell types. f Scatter plots of tongue epithelial cells with ACE2 expression"}

    LitCovid-PD-CHEBI

    {"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T13","span":{"begin":420,"end":423},"obj":"Chemical"}],"attributes":[{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_73617"}],"text":"Single cell RNA-seq was utilized for four oral tissues, and the data was analyzed to confirm the above results and assess the cell type-specific expression of ACE2. After the data preprocessing (shown in section “Materials and methods”), 22 969 cells were acquired and 7 cell types were identified (Fig. 2a), including epithelial cells (marker genes including SFN, KRT6A, and KRT10), fibroblasts (marker genes including FAP, PDPN, COL1A2, DCN, COL3A1, COL6A1), T cells (marker genes including CD2, CD3D, CD3E, and CD3G), macrophages (marker genes including CD163, CSF1R, CD68, and FCGR2A), mast cells (marker genes including CMA1, MS4A2, TPSAB1, TPSB2), B cells (marker genes including SLAMF7, FCRL5, and CD79A) and endothelial cells (marker genes including PECAM1, VWF, and ENG). The heatmap of main cell markers across the cell types can be found in Fig. 2b.\nFig. 2 Single cell RNA-seq analysis of oral tissues from independent dataset. a Seven-cell types were identified by the cell markers; cells were clustered by UMAP method. b Heatmap of cell markers for identifying cell types. c Scatter plots of all the cells with ACE2 expression. d Violin plot of ACE2 expression across different oral sites. e Violin plot of ACE2 expression across different cell types. f Scatter plots of tongue epithelial cells with ACE2 expression"}

    LitCovid-sentences

    {"project":"LitCovid-sentences","denotations":[{"id":"T54","span":{"begin":0,"end":164},"obj":"Sentence"},{"id":"T55","span":{"begin":165,"end":780},"obj":"Sentence"},{"id":"T56","span":{"begin":781,"end":860},"obj":"Sentence"},{"id":"T57","span":{"begin":861,"end":1328},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Single cell RNA-seq was utilized for four oral tissues, and the data was analyzed to confirm the above results and assess the cell type-specific expression of ACE2. After the data preprocessing (shown in section “Materials and methods”), 22 969 cells were acquired and 7 cell types were identified (Fig. 2a), including epithelial cells (marker genes including SFN, KRT6A, and KRT10), fibroblasts (marker genes including FAP, PDPN, COL1A2, DCN, COL3A1, COL6A1), T cells (marker genes including CD2, CD3D, CD3E, and CD3G), macrophages (marker genes including CD163, CSF1R, CD68, and FCGR2A), mast cells (marker genes including CMA1, MS4A2, TPSAB1, TPSB2), B cells (marker genes including SLAMF7, FCRL5, and CD79A) and endothelial cells (marker genes including PECAM1, VWF, and ENG). The heatmap of main cell markers across the cell types can be found in Fig. 2b.\nFig. 2 Single cell RNA-seq analysis of oral tissues from independent dataset. a Seven-cell types were identified by the cell markers; cells were clustered by UMAP method. b Heatmap of cell markers for identifying cell types. c Scatter plots of all the cells with ACE2 expression. d Violin plot of ACE2 expression across different oral sites. e Violin plot of ACE2 expression across different cell types. f Scatter plots of tongue epithelial cells with ACE2 expression"}