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LitCovid-PubTator

LitCovid-PD-FMA-UBERON

LitCovid-PD-UBERON

LitCovid-PD-HP

{"project":"LitCovid-PD-HP","denotations":[{"id":"T15","span":{"begin":89,"end":98},"obj":"Phenotype"},{"id":"T16","span":{"begin":588,"end":597},"obj":"Phenotype"},{"id":"T17","span":{"begin":775,"end":784},"obj":"Phenotype"},{"id":"T18","span":{"begin":984,"end":993},"obj":"Phenotype"}],"attributes":[{"id":"A15","pred":"hp_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/HP_0030731"},{"id":"A16","pred":"hp_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/HP_0030731"},{"id":"A17","pred":"hp_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/HP_0030731"},{"id":"A18","pred":"hp_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/HP_0030731"}],"text":"Public bulk RNA-seq dataset analysis\nNA-seq profile data of 13 organs including 695 para-carcinoma normal tissues as control from public TCGA were obtained for our analysis, and Fig. 1a showed that ACE2 could be expressed in various organs, the mean expression of different organs could be found in Table 1. According to the mean expression of ACE2, the mucosa of oral cavity could express ACE2, and the results were validated by the data of normal tissues from the FANTOM5 CAGE dataset (Fig. 1b).\nFig. 1 Bulk RNA-seq analysis of public datasets. a Violin plot of ACE2 expression in para-carcinoma normal tissues from TCGA, colored by organs. b Bar plot of ACE2 expression in normal tissues from FANTOM5 CAGE dataset, colored by organs. c Bar plot of ACE2 expression of para-carcinoma normal tissues from TCGA in different oral sites, colored by oral sites; d Boxplot of ACE2 in two kinds of oral sites from TCGA, colored by oral sites\nTable 1 Sample size and ACE2 expression of para-carcinoma normal tissues in different organs\nSample size ACE2 mean expression Standard deviation of expression\nIntestine 51 9.50 1.183\nKidney 129 9.20 2.410\nStomach 35 8.25 3.715\nBile duct 9 7.23 1.163\nLiver 50 6.86 1.351\nOral cavity 32 6.23 1.271\nLung 110 5.83 0.710\nThyroid 59 5.65 0.646\nEsophagus 11 5.31 1.552\nBladder 19 5.10 1.809\nBreast 113 4.61 0.961\nUterus 25 4.37 1.125\nProstate 52 4.35 1.905\nTo investigate the ACE2 expression on mucosa of oral cavity, we looked into the ACE2 expression in different oral sites. According to the site information provided by the TCGA, among the 32 adjacent normal tissues, 13 tissues located in the oral tongue, 2 tissues located in the base of tongue, 3 tissues located in the floor of mouse, and 14 tissues did not definite the site and were just put into the category of oral cavity. The mean expression distribution of different sites was shown in Fig. 1c. When we combined the base of tongue, floor of mouth and oral cavity as other sites, and compared them with oral tongue, we found the obvious tendency that the mean expression of ACE2 was higher in oral tongue (13 tissues) than others (19 tissues) (Fig. 1d), while may due to the limitation of the sample size, the p value was not significant (P = 0.062)."}

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T24","span":{"begin":89,"end":98},"obj":"Disease"},{"id":"T25","span":{"begin":588,"end":597},"obj":"Disease"},{"id":"T26","span":{"begin":775,"end":784},"obj":"Disease"},{"id":"T27","span":{"begin":984,"end":993},"obj":"Disease"}],"attributes":[{"id":"A24","pred":"mondo_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/MONDO_0004993"},{"id":"A25","pred":"mondo_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/MONDO_0004993"},{"id":"A26","pred":"mondo_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/MONDO_0004993"},{"id":"A27","pred":"mondo_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/MONDO_0004993"}],"text":"Public bulk RNA-seq dataset analysis\nNA-seq profile data of 13 organs including 695 para-carcinoma normal tissues as control from public TCGA were obtained for our analysis, and Fig. 1a showed that ACE2 could be expressed in various organs, the mean expression of different organs could be found in Table 1. According to the mean expression of ACE2, the mucosa of oral cavity could express ACE2, and the results were validated by the data of normal tissues from the FANTOM5 CAGE dataset (Fig. 1b).\nFig. 1 Bulk RNA-seq analysis of public datasets. a Violin plot of ACE2 expression in para-carcinoma normal tissues from TCGA, colored by organs. b Bar plot of ACE2 expression in normal tissues from FANTOM5 CAGE dataset, colored by organs. c Bar plot of ACE2 expression of para-carcinoma normal tissues from TCGA in different oral sites, colored by oral sites; d Boxplot of ACE2 in two kinds of oral sites from TCGA, colored by oral sites\nTable 1 Sample size and ACE2 expression of para-carcinoma normal tissues in different organs\nSample size ACE2 mean expression Standard deviation of expression\nIntestine 51 9.50 1.183\nKidney 129 9.20 2.410\nStomach 35 8.25 3.715\nBile duct 9 7.23 1.163\nLiver 50 6.86 1.351\nOral cavity 32 6.23 1.271\nLung 110 5.83 0.710\nThyroid 59 5.65 0.646\nEsophagus 11 5.31 1.552\nBladder 19 5.10 1.809\nBreast 113 4.61 0.961\nUterus 25 4.37 1.125\nProstate 52 4.35 1.905\nTo investigate the ACE2 expression on mucosa of oral cavity, we looked into the ACE2 expression in different oral sites. According to the site information provided by the TCGA, among the 32 adjacent normal tissues, 13 tissues located in the oral tongue, 2 tissues located in the base of tongue, 3 tissues located in the floor of mouse, and 14 tissues did not definite the site and were just put into the category of oral cavity. The mean expression distribution of different sites was shown in Fig. 1c. When we combined the base of tongue, floor of mouth and oral cavity as other sites, and compared them with oral tongue, we found the obvious tendency that the mean expression of ACE2 was higher in oral tongue (13 tissues) than others (19 tissues) (Fig. 1d), while may due to the limitation of the sample size, the p value was not significant (P = 0.062)."}

LitCovid-PD-CLO

LitCovid-PD-CHEBI

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T9","span":{"begin":37,"end":39},"obj":"Chemical"},{"id":"T10","span":{"begin":1252,"end":1259},"obj":"Chemical"},{"id":"T11","span":{"begin":1665,"end":1669},"obj":"Chemical"},{"id":"T12","span":{"begin":1910,"end":1914},"obj":"Chemical"}],"attributes":[{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_33696"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_9584"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_22695"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_22695"}],"text":"Public bulk RNA-seq dataset analysis\nNA-seq profile data of 13 organs including 695 para-carcinoma normal tissues as control from public TCGA were obtained for our analysis, and Fig. 1a showed that ACE2 could be expressed in various organs, the mean expression of different organs could be found in Table 1. According to the mean expression of ACE2, the mucosa of oral cavity could express ACE2, and the results were validated by the data of normal tissues from the FANTOM5 CAGE dataset (Fig. 1b).\nFig. 1 Bulk RNA-seq analysis of public datasets. a Violin plot of ACE2 expression in para-carcinoma normal tissues from TCGA, colored by organs. b Bar plot of ACE2 expression in normal tissues from FANTOM5 CAGE dataset, colored by organs. c Bar plot of ACE2 expression of para-carcinoma normal tissues from TCGA in different oral sites, colored by oral sites; d Boxplot of ACE2 in two kinds of oral sites from TCGA, colored by oral sites\nTable 1 Sample size and ACE2 expression of para-carcinoma normal tissues in different organs\nSample size ACE2 mean expression Standard deviation of expression\nIntestine 51 9.50 1.183\nKidney 129 9.20 2.410\nStomach 35 8.25 3.715\nBile duct 9 7.23 1.163\nLiver 50 6.86 1.351\nOral cavity 32 6.23 1.271\nLung 110 5.83 0.710\nThyroid 59 5.65 0.646\nEsophagus 11 5.31 1.552\nBladder 19 5.10 1.809\nBreast 113 4.61 0.961\nUterus 25 4.37 1.125\nProstate 52 4.35 1.905\nTo investigate the ACE2 expression on mucosa of oral cavity, we looked into the ACE2 expression in different oral sites. According to the site information provided by the TCGA, among the 32 adjacent normal tissues, 13 tissues located in the oral tongue, 2 tissues located in the base of tongue, 3 tissues located in the floor of mouse, and 14 tissues did not definite the site and were just put into the category of oral cavity. The mean expression distribution of different sites was shown in Fig. 1c. When we combined the base of tongue, floor of mouth and oral cavity as other sites, and compared them with oral tongue, we found the obvious tendency that the mean expression of ACE2 was higher in oral tongue (13 tissues) than others (19 tissues) (Fig. 1d), while may due to the limitation of the sample size, the p value was not significant (P = 0.062)."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T30","span":{"begin":0,"end":36},"obj":"Sentence"},{"id":"T31","span":{"begin":37,"end":307},"obj":"Sentence"},{"id":"T32","span":{"begin":308,"end":497},"obj":"Sentence"},{"id":"T33","span":{"begin":498,"end":935},"obj":"Sentence"},{"id":"T34","span":{"begin":936,"end":1028},"obj":"Sentence"},{"id":"T35","span":{"begin":1029,"end":1094},"obj":"Sentence"},{"id":"T36","span":{"begin":1095,"end":1118},"obj":"Sentence"},{"id":"T37","span":{"begin":1119,"end":1140},"obj":"Sentence"},{"id":"T38","span":{"begin":1141,"end":1162},"obj":"Sentence"},{"id":"T39","span":{"begin":1163,"end":1185},"obj":"Sentence"},{"id":"T40","span":{"begin":1186,"end":1205},"obj":"Sentence"},{"id":"T41","span":{"begin":1206,"end":1231},"obj":"Sentence"},{"id":"T42","span":{"begin":1232,"end":1251},"obj":"Sentence"},{"id":"T43","span":{"begin":1252,"end":1273},"obj":"Sentence"},{"id":"T44","span":{"begin":1274,"end":1297},"obj":"Sentence"},{"id":"T45","span":{"begin":1298,"end":1319},"obj":"Sentence"},{"id":"T46","span":{"begin":1320,"end":1341},"obj":"Sentence"},{"id":"T47","span":{"begin":1342,"end":1362},"obj":"Sentence"},{"id":"T48","span":{"begin":1363,"end":1385},"obj":"Sentence"},{"id":"T49","span":{"begin":1386,"end":1506},"obj":"Sentence"},{"id":"T50","span":{"begin":1507,"end":1814},"obj":"Sentence"},{"id":"T51","span":{"begin":1815,"end":1888},"obj":"Sentence"},{"id":"T52","span":{"begin":1889,"end":2243},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Public bulk RNA-seq dataset analysis\nNA-seq profile data of 13 organs including 695 para-carcinoma normal tissues as control from public TCGA were obtained for our analysis, and Fig. 1a showed that ACE2 could be expressed in various organs, the mean expression of different organs could be found in Table 1. According to the mean expression of ACE2, the mucosa of oral cavity could express ACE2, and the results were validated by the data of normal tissues from the FANTOM5 CAGE dataset (Fig. 1b).\nFig. 1 Bulk RNA-seq analysis of public datasets. a Violin plot of ACE2 expression in para-carcinoma normal tissues from TCGA, colored by organs. b Bar plot of ACE2 expression in normal tissues from FANTOM5 CAGE dataset, colored by organs. c Bar plot of ACE2 expression of para-carcinoma normal tissues from TCGA in different oral sites, colored by oral sites; d Boxplot of ACE2 in two kinds of oral sites from TCGA, colored by oral sites\nTable 1 Sample size and ACE2 expression of para-carcinoma normal tissues in different organs\nSample size ACE2 mean expression Standard deviation of expression\nIntestine 51 9.50 1.183\nKidney 129 9.20 2.410\nStomach 35 8.25 3.715\nBile duct 9 7.23 1.163\nLiver 50 6.86 1.351\nOral cavity 32 6.23 1.271\nLung 110 5.83 0.710\nThyroid 59 5.65 0.646\nEsophagus 11 5.31 1.552\nBladder 19 5.10 1.809\nBreast 113 4.61 0.961\nUterus 25 4.37 1.125\nProstate 52 4.35 1.905\nTo investigate the ACE2 expression on mucosa of oral cavity, we looked into the ACE2 expression in different oral sites. According to the site information provided by the TCGA, among the 32 adjacent normal tissues, 13 tissues located in the oral tongue, 2 tissues located in the base of tongue, 3 tissues located in the floor of mouse, and 14 tissues did not definite the site and were just put into the category of oral cavity. The mean expression distribution of different sites was shown in Fig. 1c. When we combined the base of tongue, floor of mouth and oral cavity as other sites, and compared them with oral tongue, we found the obvious tendency that the mean expression of ACE2 was higher in oral tongue (13 tissues) than others (19 tissues) (Fig. 1d), while may due to the limitation of the sample size, the p value was not significant (P = 0.062)."}

PMC:7039956 / 4622-6865 JSONTXT

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PMC:7039956 / 4622-6865 JSON TXT