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PMC:7039956 / 4622-6865 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
147 564-568 Gene denotes ACE2 Gene:59272
148 657-661 Gene denotes ACE2 Gene:59272
149 751-755 Gene denotes ACE2 Gene:59272
150 871-875 Gene denotes ACE2 Gene:59272
151 704-708 Gene denotes CAGE Gene:168400
152 583-597 Disease denotes para-carcinoma MESH:D002277
153 770-784 Disease denotes para-carcinoma MESH:D002277
155 1041-1045 Gene denotes ACE2 Gene:59272
158 960-964 Gene denotes ACE2 Gene:59272
159 979-993 Disease denotes para-carcinoma MESH:D002277
165 198-202 Gene denotes ACE2 Gene:59272
166 344-348 Gene denotes ACE2 Gene:59272
167 390-394 Gene denotes ACE2 Gene:59272
168 474-478 Gene denotes CAGE Gene:168400
169 84-98 Disease denotes para-carcinoma MESH:D002277
175 1405-1409 Gene denotes ACE2 Gene:59272
176 1466-1470 Gene denotes ACE2 Gene:59272
177 2067-2071 Gene denotes ACE2 Gene:59272
178 1715-1720 Species denotes mouse Tax:10090
179 1935-1940 Disease denotes mouth MESH:D009059

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T68 12-15 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T69 106-113 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T70 354-360 Body_part denotes mucosa http://purl.org/sig/ont/fma/fma85355
T71 364-375 Body_part denotes oral cavity http://purl.org/sig/ont/fma/fma20292
T72 449-456 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T73 510-513 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T74 605-612 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T75 683-690 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T76 792-799 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T77 1001-1008 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T78 1095-1104 Body_part denotes Intestine http://purl.org/sig/ont/fma/fma7199
T79 1119-1125 Body_part denotes Kidney http://purl.org/sig/ont/fma/fma7203
T80 1141-1148 Body_part denotes Stomach http://purl.org/sig/ont/fma/fma7148
T81 1163-1172 Body_part denotes Bile duct http://purl.org/sig/ont/fma/fma9706
T82 1163-1167 Body_part denotes Bile http://purl.org/sig/ont/fma/fma62971
T83 1186-1191 Body_part denotes Liver http://purl.org/sig/ont/fma/fma7197
T84 1206-1217 Body_part denotes Oral cavity http://purl.org/sig/ont/fma/fma20292
T85 1232-1236 Body_part denotes Lung http://purl.org/sig/ont/fma/fma7195
T86 1252-1259 Body_part denotes Thyroid http://purl.org/sig/ont/fma/fma9603
T87 1274-1283 Body_part denotes Esophagus http://purl.org/sig/ont/fma/fma7131
T88 1298-1305 Body_part denotes Bladder http://purl.org/sig/ont/fma/fma15900
T89 1320-1326 Body_part denotes Breast http://purl.org/sig/ont/fma/fma9601
T90 1342-1348 Body_part denotes Uterus http://purl.org/sig/ont/fma/fma17558
T91 1363-1371 Body_part denotes Prostate http://purl.org/sig/ont/fma/fma9600
T92 1424-1430 Body_part denotes mucosa http://purl.org/sig/ont/fma/fma85355
T93 1434-1445 Body_part denotes oral cavity http://purl.org/sig/ont/fma/fma20292
T94 1592-1599 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T95 1604-1611 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T96 1632-1638 Body_part denotes tongue http://purl.org/sig/ont/fma/fma54640
T97 1642-1649 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T98 1665-1679 Body_part denotes base of tongue http://purl.org/sig/ont/fma/fma54645
T99 1683-1690 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T100 1729-1736 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T101 1802-1813 Body_part denotes oral cavity http://purl.org/sig/ont/fma/fma20292
T102 1910-1924 Body_part denotes base of tongue http://purl.org/sig/ont/fma/fma54645
T103 1926-1940 Body_part denotes floor of mouth http://purl.org/sig/ont/fma/fma86592
T104 1945-1956 Body_part denotes oral cavity http://purl.org/sig/ont/fma/fma20292
T105 2001-2007 Body_part denotes tongue http://purl.org/sig/ont/fma/fma54640
T106 2091-2097 Body_part denotes tongue http://purl.org/sig/ont/fma/fma54640
T107 2102-2109 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T108 2127-2134 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T26 63-69 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T27 233-239 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T28 274-280 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T29 354-360 Body_part denotes mucosa http://purl.obolibrary.org/obo/UBERON_0000344
T30 364-375 Body_part denotes oral cavity http://purl.obolibrary.org/obo/UBERON_0000167
T31 635-641 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T32 729-735 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T33 1022-1028 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T34 1095-1104 Body_part denotes Intestine http://purl.obolibrary.org/obo/UBERON_0000160
T35 1119-1125 Body_part denotes Kidney http://purl.obolibrary.org/obo/UBERON_0002113
T36 1141-1148 Body_part denotes Stomach http://purl.obolibrary.org/obo/UBERON_0000945
T37 1163-1172 Body_part denotes Bile duct http://purl.obolibrary.org/obo/UBERON_0002394
T38 1168-1172 Body_part denotes duct http://purl.obolibrary.org/obo/UBERON_0000058
T39 1186-1191 Body_part denotes Liver http://purl.obolibrary.org/obo/UBERON_0002107
T40 1206-1217 Body_part denotes Oral cavity http://purl.obolibrary.org/obo/UBERON_0000167
T41 1232-1236 Body_part denotes Lung http://purl.obolibrary.org/obo/UBERON_0002048
T42 1252-1259 Body_part denotes Thyroid http://purl.obolibrary.org/obo/UBERON_0002046
T43 1274-1283 Body_part denotes Esophagus http://purl.obolibrary.org/obo/UBERON_0001043
T44 1298-1305 Body_part denotes Bladder http://purl.obolibrary.org/obo/UBERON_0001255
T45 1320-1326 Body_part denotes Breast http://purl.obolibrary.org/obo/UBERON_0000310
T46 1342-1348 Body_part denotes Uterus http://purl.obolibrary.org/obo/UBERON_0000995
T47 1424-1430 Body_part denotes mucosa http://purl.obolibrary.org/obo/UBERON_0000344
T48 1434-1445 Body_part denotes oral cavity http://purl.obolibrary.org/obo/UBERON_0000167
T49 1632-1638 Body_part denotes tongue http://purl.obolibrary.org/obo/UBERON_0001723
T50 1673-1679 Body_part denotes tongue http://purl.obolibrary.org/obo/UBERON_0001723
T51 1802-1813 Body_part denotes oral cavity http://purl.obolibrary.org/obo/UBERON_0000167
T52 1918-1924 Body_part denotes tongue http://purl.obolibrary.org/obo/UBERON_0001723
T53 1935-1940 Body_part denotes mouth http://purl.obolibrary.org/obo/UBERON_0000165
T54 1945-1956 Body_part denotes oral cavity http://purl.obolibrary.org/obo/UBERON_0000167
T55 2001-2007 Body_part denotes tongue http://purl.obolibrary.org/obo/UBERON_0001723
T56 2091-2097 Body_part denotes tongue http://purl.obolibrary.org/obo/UBERON_0001723

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T15 89-98 Phenotype denotes carcinoma http://purl.obolibrary.org/obo/HP_0030731
T16 588-597 Phenotype denotes carcinoma http://purl.obolibrary.org/obo/HP_0030731
T17 775-784 Phenotype denotes carcinoma http://purl.obolibrary.org/obo/HP_0030731
T18 984-993 Phenotype denotes carcinoma http://purl.obolibrary.org/obo/HP_0030731

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T24 89-98 Disease denotes carcinoma http://purl.obolibrary.org/obo/MONDO_0004993
T25 588-597 Disease denotes carcinoma http://purl.obolibrary.org/obo/MONDO_0004993
T26 775-784 Disease denotes carcinoma http://purl.obolibrary.org/obo/MONDO_0004993
T27 984-993 Disease denotes carcinoma http://purl.obolibrary.org/obo/MONDO_0004993

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T78 63-69 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T79 233-239 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T80 274-280 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T81 354-360 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa
T82 364-375 http://purl.obolibrary.org/obo/UBERON_0000167 denotes oral cavity
T83 364-375 http://www.ebi.ac.uk/efo/EFO_0000825 denotes oral cavity
T84 547-548 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T85 635-641 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T86 643-644 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T87 729-735 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T88 1022-1028 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T89 1095-1104 http://purl.obolibrary.org/obo/UBERON_0000160 denotes Intestine
T90 1095-1104 http://www.ebi.ac.uk/efo/EFO_0000834 denotes Intestine
T91 1119-1125 http://purl.obolibrary.org/obo/UBERON_0002113 denotes Kidney
T92 1119-1125 http://www.ebi.ac.uk/efo/EFO_0000927 denotes Kidney
T93 1119-1125 http://www.ebi.ac.uk/efo/EFO_0000929 denotes Kidney
T94 1149-1151 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T95 1163-1172 http://purl.obolibrary.org/obo/UBERON_0002394 denotes Bile duct
T96 1186-1191 http://purl.obolibrary.org/obo/UBERON_0002107 denotes Liver
T97 1186-1191 http://www.ebi.ac.uk/efo/EFO_0000887 denotes Liver
T98 1206-1217 http://purl.obolibrary.org/obo/UBERON_0000167 denotes Oral cavity
T99 1206-1217 http://www.ebi.ac.uk/efo/EFO_0000825 denotes Oral cavity
T100 1232-1236 http://purl.obolibrary.org/obo/UBERON_0002048 denotes Lung
T101 1232-1236 http://www.ebi.ac.uk/efo/EFO_0000934 denotes Lung
T102 1274-1283 http://purl.obolibrary.org/obo/UBERON_0001043 denotes Esophagus
T103 1284-1286 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T104 1320-1326 http://purl.obolibrary.org/obo/UBERON_0000310 denotes Breast
T105 1342-1348 http://purl.obolibrary.org/obo/UBERON_0000995 denotes Uterus
T106 1342-1348 http://www.ebi.ac.uk/efo/EFO_0000975 denotes Uterus
T107 1372-1374 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T108 1424-1430 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa
T109 1434-1445 http://purl.obolibrary.org/obo/UBERON_0000167 denotes oral cavity
T110 1434-1445 http://www.ebi.ac.uk/efo/EFO_0000825 denotes oral cavity
T111 1632-1638 http://purl.obolibrary.org/obo/UBERON_0001723 denotes tongue
T112 1673-1679 http://purl.obolibrary.org/obo/UBERON_0001723 denotes tongue
T113 1715-1720 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T114 1802-1813 http://purl.obolibrary.org/obo/UBERON_0000167 denotes oral cavity
T115 1802-1813 http://www.ebi.ac.uk/efo/EFO_0000825 denotes oral cavity
T116 1918-1924 http://purl.obolibrary.org/obo/UBERON_0001723 denotes tongue
T117 1935-1940 http://www.ebi.ac.uk/efo/EFO_0000825 denotes mouth
T118 1945-1956 http://purl.obolibrary.org/obo/UBERON_0000167 denotes oral cavity
T119 1945-1956 http://www.ebi.ac.uk/efo/EFO_0000825 denotes oral cavity
T120 2001-2007 http://purl.obolibrary.org/obo/UBERON_0001723 denotes tongue
T121 2091-2097 http://purl.obolibrary.org/obo/UBERON_0001723 denotes tongue

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T9 37-39 Chemical denotes NA http://purl.obolibrary.org/obo/CHEBI_33696
T10 1252-1259 Chemical denotes Thyroid http://purl.obolibrary.org/obo/CHEBI_9584
T11 1665-1669 Chemical denotes base http://purl.obolibrary.org/obo/CHEBI_22695
T12 1910-1914 Chemical denotes base http://purl.obolibrary.org/obo/CHEBI_22695

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T30 0-36 Sentence denotes Public bulk RNA-seq dataset analysis
T31 37-307 Sentence denotes NA-seq profile data of 13 organs including 695 para-carcinoma normal tissues as control from public TCGA were obtained for our analysis, and Fig. 1a showed that ACE2 could be expressed in various organs, the mean expression of different organs could be found in Table 1.
T32 308-497 Sentence denotes According to the mean expression of ACE2, the mucosa of oral cavity could express ACE2, and the results were validated by the data of normal tissues from the FANTOM5 CAGE dataset (Fig. 1b).
T33 498-935 Sentence denotes Fig. 1 Bulk RNA-seq analysis of public datasets. a Violin plot of ACE2 expression in para-carcinoma normal tissues from TCGA, colored by organs. b Bar plot of ACE2 expression in normal tissues from FANTOM5 CAGE dataset, colored by organs. c Bar plot of ACE2 expression of para-carcinoma normal tissues from TCGA in different oral sites, colored by oral sites; d Boxplot of ACE2 in two kinds of oral sites from TCGA, colored by oral sites
T34 936-1028 Sentence denotes Table 1 Sample size and ACE2 expression of para-carcinoma normal tissues in different organs
T35 1029-1094 Sentence denotes Sample size ACE2 mean expression Standard deviation of expression
T36 1095-1118 Sentence denotes Intestine 51 9.50 1.183
T37 1119-1140 Sentence denotes Kidney 129 9.20 2.410
T38 1141-1162 Sentence denotes Stomach 35 8.25 3.715
T39 1163-1185 Sentence denotes Bile duct 9 7.23 1.163
T40 1186-1205 Sentence denotes Liver 50 6.86 1.351
T41 1206-1231 Sentence denotes Oral cavity 32 6.23 1.271
T42 1232-1251 Sentence denotes Lung 110 5.83 0.710
T43 1252-1273 Sentence denotes Thyroid 59 5.65 0.646
T44 1274-1297 Sentence denotes Esophagus 11 5.31 1.552
T45 1298-1319 Sentence denotes Bladder 19 5.10 1.809
T46 1320-1341 Sentence denotes Breast 113 4.61 0.961
T47 1342-1362 Sentence denotes Uterus 25 4.37 1.125
T48 1363-1385 Sentence denotes Prostate 52 4.35 1.905
T49 1386-1506 Sentence denotes To investigate the ACE2 expression on mucosa of oral cavity, we looked into the ACE2 expression in different oral sites.
T50 1507-1814 Sentence denotes According to the site information provided by the TCGA, among the 32 adjacent normal tissues, 13 tissues located in the oral tongue, 2 tissues located in the base of tongue, 3 tissues located in the floor of mouse, and 14 tissues did not definite the site and were just put into the category of oral cavity.
T51 1815-1888 Sentence denotes The mean expression distribution of different sites was shown in Fig. 1c.
T52 1889-2243 Sentence denotes When we combined the base of tongue, floor of mouth and oral cavity as other sites, and compared them with oral tongue, we found the obvious tendency that the mean expression of ACE2 was higher in oral tongue (13 tissues) than others (19 tissues) (Fig. 1d), while may due to the limitation of the sample size, the p value was not significant (P = 0.062).