PMC:7036338 / 4972-6944 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7036338","sourcedb":"PMC","sourceid":"7036338","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7036338","text":"Patient 2 was a 55-year-old Korean man, who had been working at Wuhan, China, arrived in Korea via Shanghai on January 22, 2020. The detailed exposure history and a clinical course of this patient is described in Supplementary Data 1. Briefly, he did not have any significant exposure history and developed sore throat and intermittent myalgia since January 10 which was controlled by nonsteroidal anti-inflammatory agent. He was tested on January 23, 2020, confirmed with SARS-CoV-2 infection next day and hospitalized on the same day. Therefore, his admission day (January 24) was considered to be the day 15 of symptom onset. His CXR on day 15 showed infiltration and chest HRCT on day 16 showed bilateral ground-glass opacity (Supplementary Fig. 3A). The viral load kinetics are shown in Fig. 1B (viral RNA copies) and Supplementary Fig. 2 (reverse Ct value). In this patient, the initial test was performed on day 14 of symptom onset and SARS-CoV-2 was detected in both URT and LRT specimens. However, the initial viral loads were relatively lower (49,047 copies/mL for URT and 391,243 copies/mL for LRT) than those of Patient 1 (46,971,053 copies/mL for URT and 9,171,220 copies/mL for LRT) in whom the test was performed on day 2 of symptom onset. SARS-CoV-2 was detected a few more times during hospitalization from both URT and LRT specimens at low levels. As he had just mild cough with little or no sputum, LRT specimens were available only a few times. From D18 (URT specimen) and D20 (LRT specimen), rRT-PCR became undetectable for two consecutive days, respectively. On day 25, RdRp (Ct value of 36.69) and E (Ct value of 33.18) genes was detected again from the URT sample of day 25, it was interpreted as negative due to high Ct value of RdRp gene. From his plasma and stool specimens, only E genes were once detected on day 17 and it was also interpreted as negative result. His CXR improved from day 19 and he was discharged on day 27 (February 5, 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