PMC:7033720 / 7254-9688 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7033720","sourcedb":"PMC","sourceid":"7033720","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7033720","text":"On 2nd January 2020, samples were collected from two unusual pneumonia patients from Zhongnan Hospital of Wuhan University. Patient 1 was a 39-year-old male staff at Huanan Seafood Market who experienced fever (up to 37.7°C) and aggravated cough with frothy white sputum for 5 days before admitted to the hospital on 25th December 2019. Patient 2 was a 21-year-old female who developed an intermittent febrile cough, chills, fever (up to 40°C), and frothy white sputum after having a contact with Huanan Seafood Market staff on 22nd December 2019. She was admitted on 28th December after unsuccessful outpatient treatment. The results of clinical laboratory test on the first day of hospitalization are listed in Table 1. Chest CT scan of both patients showed patchy pulmonary opacities below the pleura in the bilateral lung field (Figure S1), which suggests viral infections may occur in both lungs. However, the subsequent routine anti-viral and anti-infection treatment did not alleviate their symptoms. On 31st December 2019, patient 1 had more severe symptoms, including poor mental states, shortness of breath, and 86% SpO2 without oxygen inhalation. A CT re-examination showed mild pleural effusion in the left lung, an increase in the density of ground-glass opacities, and an extension of the patchy area. The patient later experienced Type I respiratory failure on the same day. On 2nd January 2020, both patients were transferred to Wuhan Infectious Diseases Hospital for continuing treatment. To the date this manuscript was prepared, patient 1 and patient 2 were later discharged from the hospital in stable condition on 12th January and 11th January 2020, respectively.\nTable 1. Clinical laboratory test on the first day of hospitalization.\nItems Case 1 Case 2 Normal range of lab test\nWBC, ×109/L 5.23 2.89 3.5–9.5\nNeutrophils, ×109/L/L 3.58 1.92 1.8–6.3\nT lymphocyte, ×109/L 1.32 0.46 1.1–3.2\nHb, g/L 138.6 127.5 115–150\nPlatelet, ×109/L 170 117 125–350\nAlbumin, g/L 65.9 47 40–55\nAST, U/L 92 33 7–45\nALT, U/L 30 30 13–45\nCK, U/L 36 35 \u003c171\nCK-MB, U/L 11 10 0–25\nLDH, U/L 313 247 110–245\nUREA, mmol/L 2.81 2.7 2.8–7.60\nCREA, μmol/L 73.9 57.2 49–90\nDefinition of abbreviations: ALT = alanine aminotransferase; AST = aspartate aminotransferase; CK = creatine kinase; CK-MB = creatinine kinase–MB isoenzyme; CREA = creatinine; UREA = Urea nitrogen; Hb = haemoglobin; LDH = lactate dehydrogenase; WBC = white blood 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