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PMC:7033706 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3 32-41 Disease denotes pneumonia MESH:D011014
2 12-23 Species denotes coronavirus Tax:11118
9 292-300 Species denotes patients Tax:9606
10 517-522 Species denotes human Tax:9606
11 565-582 Species denotes novel coronavirus Tax:2697049
12 584-593 Species denotes 2019-nCoV Tax:2697049
13 217-226 Disease denotes pneumonia MESH:D011014
25 746-755 Species denotes 2019-nCoV Tax:2697049
26 820-828 Species denotes patients Tax:9606
27 975-990 Species denotes new-coronavirus Tax:2697049
28 1056-1064 Species denotes patients Tax:9606
29 1143-1152 Species denotes 2019-nCoV Tax:2697049
30 1251-1259 Species denotes patients Tax:9606
31 1319-1324 Species denotes human Tax:9606
32 1328-1333 Species denotes human Tax:9606
33 1350-1359 Species denotes 2019-nCoV Tax:2697049
34 1403-1418 Species denotes new-coronavirus Tax:2697049
35 1241-1250 Disease denotes pneumonia MESH:D011014
46 2505-2510 Gene denotes spike Gene:43740568
47 2995-2996 Gene denotes S Gene:43740568
48 2749-2750 Gene denotes S Gene:43740568
49 2562-2563 Gene denotes S Gene:43740568
50 2495-2504 Species denotes 2019-nCoV Tax:2697049
51 2572-2581 Species denotes 2019-nCoV Tax:2697049
52 2630-2638 Species denotes SARS-CoV Tax:694009
53 2649-2662 Species denotes coronaviruses Tax:11118
54 2762-2771 Species denotes 2019-nCoV Tax:2697049
55 2985-2994 Species denotes 2019-nCoV Tax:2697049
69 1530-1539 Species denotes 2019-nCoV Tax:2697049
70 1661-1665 Species denotes nCoV Tax:2697049
71 1694-1719 Species denotes bat SARS-like coronavirus Tax:1508227
72 1822-1830 Species denotes SARS-CoV Tax:694009
73 1864-1873 Species denotes 2019-nCoV Tax:2697049
74 1890-1905 Species denotes betacoronavirus Tax:694002
75 1984-1992 Species denotes SARS-CoV Tax:694009
76 2021-2024 Species denotes CoV Tax:11118
77 2062-2076 Species denotes horseshoe bats Tax:49442
78 2196-2200 Species denotes rats Tax:10116
79 2292-2301 Species denotes 2019-nCoV Tax:2697049
80 1584-1592 CellLine denotes MN908947 CVCL:U508
81 1758-1768 CellLine denotes MG772934.1 CVCL:8732
101 5041-5045 Gene denotes SC-1 Gene:6941
102 5437-5441 Gene denotes SC-1 Gene:6941
103 5301-5302 Gene denotes S Gene:43740568
104 3993-3994 Gene denotes S Gene:43740568
105 3099-3116 Species denotes novel coronavirus Tax:2697049
106 3506-3525 Species denotes novel coronaviruses Tax:2697049
107 3538-3544 Species denotes humans Tax:9606
108 3629-3638 Species denotes 2019-nCoV Tax:2697049
109 3744-3755 Species denotes coronavirus Tax:11118
110 3933-3942 Species denotes 2019-nCoV Tax:2697049
111 3983-3992 Species denotes 2019-nCoV Tax:2697049
112 4026-4034 Species denotes SARS-CoV Tax:694009
113 4054-4058 Species denotes CoVs Tax:11118
114 5021-5029 Species denotes SARS-CoV Tax:694009
115 5291-5300 Species denotes 2019-nCoV Tax:2697049
116 5345-5353 Species denotes SARS-CoV Tax:694009
117 3170-3197 Disease denotes respiratory virus infection
118 3718-3727 Disease denotes pneumonia MESH:D011014
119 5491-5510 Disease denotes 2019-nCoV infection MESH:C000657245
135 5814-5818 Gene denotes DPP4 Gene:1803
136 5559-5562 Species denotes CoV Tax:11118
137 5632-5637 Species denotes human Tax:9606
138 5638-5651 Species denotes coronaviruses Tax:11118
139 5663-5671 Species denotes SARS-CoV Tax:694009
140 5676-5684 Species denotes MERS-CoV Tax:1335626
141 5703-5707 Species denotes CoVs Tax:11118
142 5808-5813 Species denotes human Tax:9606
143 5819-5834 Species denotes transgenic mice Tax:10090
144 6089-6098 Species denotes 2019-nCoV Tax:2697049
145 6118-6131 Species denotes coronaviruses Tax:11118
146 5614-5623 Disease denotes infection MESH:D007239
147 5845-5858 Disease denotes CoV infection MESH:D018352
148 5929-5948 Disease denotes 2019-nCoV infection MESH:C000657245
149 6076-6085 Disease denotes infection MESH:D007239
163 6598-6599 Gene denotes S Gene:43740568
164 6580-6581 Gene denotes S Gene:43740568
165 6159-6167 Species denotes SARS-CoV Tax:694009
166 6172-6180 Species denotes MERS-CoV Tax:1335626
167 6323-6331 Species denotes SARS-CoV Tax:694009
168 6428-6436 Species denotes MERS-CoV Tax:1335626
169 6570-6579 Species denotes 2019-nCoV Tax:2697049
170 6613-6624 Species denotes coronavirus Tax:11118
171 6655-6664 Species denotes 2019-nCoV Tax:2697049
172 6719-6730 Species denotes coronavirus Tax:11118
173 6737-6746 Species denotes 2019-nCoV Tax:2697049
174 6336-6355 Disease denotes MERS-CoV infections MESH:D018352
175 6535-6548 Disease denotes CoV infection MESH:D018352
183 7023-7024 Gene denotes S Gene:43740568
184 6817-6825 Species denotes SARS-CoV Tax:694009
185 6830-6838 Species denotes MERS-CoV Tax:1335626
186 7013-7022 Species denotes 2019-nCoV Tax:2697049
187 7078-7087 Species denotes 2019-nCoV Tax:2697049
188 7180-7188 Species denotes SARS-CoV Tax:694009
189 7196-7204 Species denotes MERS-CoV Tax:1335626
199 7653-7661 Species denotes SARS-CoV Tax:694009
200 7734-7738 Species denotes CoVs Tax:11118
201 7755-7758 Species denotes CoV Tax:11118
202 7775-7778 Species denotes CoV Tax:11118
203 7839-7848 Species denotes 2019-nCoV Tax:2697049
204 7524-7532 Species denotes SARS-CoV Tax:694009
205 7436-7455 Disease denotes 2019-nCoV infection MESH:C000657245
206 7613-7632 Disease denotes 2019-nCoV infection MESH:C000657245
207 7968-7987 Disease denotes 2019-nCoV infection MESH:C000657245
210 8139-8140 Gene denotes S Gene:43740568
211 8129-8138 Species denotes 2019-nCoV Tax:2697049

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 1639-1643 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T2 2511-2518 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T3 2527-2531 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T4 2564-2568 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T5 2751-2758 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T6 2941-2952 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T7 3894-3898 Body_part denotes iris http://purl.org/sig/ont/fma/fma58235
T8 3995-4002 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T9 4363-4367 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T10 4723-4736 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T11 4723-4727 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T12 4850-4868 Body_part denotes cellular membranes http://purl.org/sig/ont/fma/fma63841
T13 4918-4922 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T14 4970-4974 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T15 5032-5039 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T16 5087-5094 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T17 5218-5225 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T18 5275-5279 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T19 5408-5419 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T20 6395-6402 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T21 6443-6453 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T22 6957-6964 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T23 8141-8145 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 3894-3898 Body_part denotes iris http://purl.obolibrary.org/obo/UBERON_0001769
T2 4942-4946 Body_part denotes pore http://purl.obolibrary.org/obo/UBERON_0008915

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p5527s40 5164-5178 MPA denotes 6-HB formation

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 32-41 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T2 217-226 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T3 1241-1250 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T4 1698-1702 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T5 1822-1830 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 1984-1992 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 2630-2638 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 2793-2796 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T10 3182-3197 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T11 3188-3197 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T12 3718-3727 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T13 4026-4034 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T14 4233-4236 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T16 5021-5029 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T17 5345-5353 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T18 5491-5510 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T19 5501-5510 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T20 5614-5623 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T21 5663-5671 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T22 5849-5858 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T23 5929-5948 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T24 5939-5948 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T25 6076-6085 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T26 6159-6167 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T27 6323-6331 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T28 6345-6355 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T29 6539-6548 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T30 6817-6825 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T31 7166-7169 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T33 7180-7188 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T34 7436-7455 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T35 7446-7455 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T36 7524-7532 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T37 7613-7632 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T38 7623-7632 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T39 7653-7661 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T40 7968-7987 Disease denotes 2019-nCoV infection http://purl.obolibrary.org/obo/MONDO_0100096
T41 7978-7987 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 316-317 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 385-392 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T3 413-417 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T4 442-449 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T5 507-513 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T6 517-522 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T7 563-564 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 672-673 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T9 864-866 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T10 1319-1324 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T11 1328-1333 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T12 1639-1643 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T13 1694-1697 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T14 1727-1730 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T15 1914-1915 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T16 1921-1924 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T17 1944-1947 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T18 1963-1966 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T19 2014-2017 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T20 2072-2076 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T21 2247-2251 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T22 2261-2268 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T23 2325-2329 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T24 2338-2345 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T25 2390-2393 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T26 2527-2531 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T27 2534-2535 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T28 2564-2568 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T29 2596-2599 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T30 2613-2616 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T31 2695-2696 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T32 2777-2783 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T33 2784-2791 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T34 2858-2865 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T35 2937-2939 http://purl.obolibrary.org/obo/PR_000005794 denotes CP
T36 3182-3187 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T37 3538-3544 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T38 3558-3565 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T39 3588-3594 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T40 3738-3739 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T41 3740-3743 http://purl.obolibrary.org/obo/NCBITaxon_9596 denotes pan
T42 4047-4050 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T43 4111-4113 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T44 4118-4120 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T45 4118-4120 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T46 4166-4168 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T47 4242-4243 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T48 4363-4367 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T49 4444-4445 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T50 4510-4512 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T51 4510-4512 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T52 4563-4570 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T53 4633-4635 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T54 4657-4659 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T55 4657-4659 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T56 4723-4727 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T57 4728-4736 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T58 4803-4805 http://purl.obolibrary.org/obo/CLO_0003622 denotes HB
T59 4859-4868 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T60 4918-4922 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T61 4970-4974 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T62 4980-4981 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T63 4982-4989 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T64 5041-5045 http://purl.obolibrary.org/obo/CLO_0008956 denotes SC-1
T65 5041-5045 http://purl.obolibrary.org/obo/CLO_0008957 denotes SC-1
T66 5041-5045 http://purl.obolibrary.org/obo/CLO_0008958 denotes SC-1
T67 5041-5045 http://purl.obolibrary.org/obo/CLO_0050606 denotes SC-1
T68 5118-5120 http://purl.obolibrary.org/obo/CLO_0003622 denotes HB
T69 5166-5168 http://purl.obolibrary.org/obo/CLO_0003622 denotes HB
T70 5275-5279 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T71 5376-5377 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T72 5437-5441 http://purl.obolibrary.org/obo/CLO_0008956 denotes SC-1
T73 5437-5441 http://purl.obolibrary.org/obo/CLO_0008957 denotes SC-1
T74 5437-5441 http://purl.obolibrary.org/obo/CLO_0008958 denotes SC-1
T75 5437-5441 http://purl.obolibrary.org/obo/CLO_0050606 denotes SC-1
T76 5442-5449 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T77 5553-5554 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T78 5555-5558 http://purl.obolibrary.org/obo/NCBITaxon_9596 denotes pan
T79 5585-5592 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T80 5632-5637 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T81 5696-5699 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T82 5743-5750 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T83 5788-5795 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T84 5808-5813 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T85 5986-5993 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T86 5997-5998 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T87 6443-6462 http://purl.obolibrary.org/obo/CHEBI_33708 denotes amino acid residues
T88 6443-6462 http://purl.obolibrary.org/obo/PR_000036907 denotes amino acid residues
T89 6711-6713 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T90 6717-6718 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T91 6941-6943 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T92 7050-7051 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T93 7174-7176 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T94 7174-7176 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T95 7596-7604 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T96 7727-7730 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T97 7740-7751 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes such as bat
T98 7768-7771 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T99 8019-8022 http://purl.obolibrary.org/obo/CLO_0001926 denotes Ben
T100 8141-8145 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 1731-1733 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T2 1948-1950 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T3 1967-1969 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T4 2018-2020 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T5 2511-2518 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T6 2600-2602 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T7 2617-2619 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T8 2751-2758 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T9 2773-2775 Chemical denotes SP http://purl.obolibrary.org/obo/CHEBI_74820
T10 2784-2791 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T11 2847-2849 Chemical denotes FP http://purl.obolibrary.org/obo/CHEBI_74750
T12 2858-2865 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T13 2911-2913 Chemical denotes TM http://purl.obolibrary.org/obo/CHEBI_55460|http://purl.obolibrary.org/obo/CHEBI_74861
T15 2937-2939 Chemical denotes CP http://purl.obolibrary.org/obo/CHEBI_3380|http://purl.obolibrary.org/obo/CHEBI_73461
T17 3054-3064 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T18 3407-3419 Chemical denotes nucleic acid http://purl.obolibrary.org/obo/CHEBI_33696
T19 3415-3419 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T20 3995-4002 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T21 4051-4053 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T22 4118-4120 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T23 4510-4512 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T24 4563-4570 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T25 4572-4574 Chemical denotes FP http://purl.obolibrary.org/obo/CHEBI_74750
T26 4657-4659 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T27 4706-4708 Chemical denotes FP http://purl.obolibrary.org/obo/CHEBI_74750
T28 4982-4989 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T29 5032-5039 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T30 5041-5045 Chemical denotes SC-1 http://purl.obolibrary.org/obo/CHEBI_136542
T31 5087-5094 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T32 5218-5225 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T33 5408-5419 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T34 5408-5413 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T35 5414-5419 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T36 5437-5441 Chemical denotes SC-1 http://purl.obolibrary.org/obo/CHEBI_136542
T37 5442-5449 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T38 5570-5579 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T39 5585-5592 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T40 5700-5702 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T41 5724-5735 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T42 5743-5750 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T43 5788-5795 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T44 5986-5993 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T45 6044-6055 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T46 6395-6402 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T47 6443-6453 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T48 6443-6448 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T49 6449-6453 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T50 6957-6964 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T51 7174-7176 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T52 7731-7733 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T53 7752-7754 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T54 7772-7774 Chemical denotes SL http://purl.obolibrary.org/obo/CHEBI_74815
T55 8019-8022 Chemical denotes Ben http://purl.obolibrary.org/obo/CHEBI_33783

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 32-41 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T2 217-226 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T3 1241-1250 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T4 3718-3727 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 3209-3230 http://purl.obolibrary.org/obo/GO_0001171 denotes reverse transcription
T2 3217-3230 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T3 3255-3276 http://purl.obolibrary.org/obo/GO_0001171 denotes reverse transcription
T4 3263-3276 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T5 3292-3313 http://purl.obolibrary.org/obo/GO_0001171 denotes reverse transcription
T6 3300-3313 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T7 5169-5178 http://purl.obolibrary.org/obo/GO_0009058 denotes formation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-130 Sentence denotes An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies
T2 131-163 Sentence denotes Emerging Microbes and Infections
T3 164-166 Sentence denotes S.
T4 167-179 Sentence denotes Jiang et al.
T5 181-523 Sentence denotes In December of 2019, an outbreak of pneumonia caused by an unknown aetiology occurred in Wuhan, China and most patients were linked to a single seafood market, which reportedly sold seafood and some live animals, including poultry, bats, marmots and other wild animals, suggesting that the pathogen may be transmitted from an animal to human.
T6 524-613 Sentence denotes The pathogen was soon identified to be a novel coronavirus, 2019-nCoV denoted by WHO [1].
T7 614-805 Sentence denotes On 19 January 2020, Wuhan Health Commission reported that a total 198 cases in the 25–89-year-old range were confirmed positive for 2019-nCoV, including 25 being discharged and 3 having died.
T8 806-1038 Sentence denotes Among the 170 patients under treatment in hospitals, 126, 35, and 9 are in mild, severe, and critical condition, respectively (http://www.thatsmags.com/china/post/30618/new-coronavirus-spreads-to-over-130-in-china-death-toll-rises).
T9 1039-1153 Sentence denotes In addition, two patients in Thailand, one in Japan, and one in South Korea, were detected positive for 2019-nCoV.
T10 1154-1466 Sentence denotes They did not visit the specific seafood market, but might have close contact with some pneumonia patients during their trip in Wuhan, raising the concern of limited human-to-human transmission of 2019-nCoV (http://www.thatsmags.com/china/post/30618/new-coronavirus-spreads-to-over-130-in-china-death-toll-rises).
T11 1467-1583 Sentence denotes Research scientists have released the full genomic sequence of 2019-nCoV, such as Wuhan-Hu-1 (GenBank, accession no.
T12 1584-1594 Sentence denotes MN908947).
T13 1595-1757 Sentence denotes The phylogenetic analysis revealed that the gene sequence of 2016-nCoV is 89% identical to that of bat SARS-like coronavirus ZXC21 (bat-SL-CoVZXC21, accession no.
T14 1758-2008 Sentence denotes MG772934.1) and ZC45 (MG772933.1), and 82% identical to that of SARS-CoV Tor2 (JX163927), suggesting that 2019-nCoV also belongs to betacoronavirus Lineage B, but has closer homology to bat-SL-CoVZC45 and bat-SL-CoVZXC21 than SARS-CoV [2] (Figure 1).
T15 2009-2219 Sentence denotes Both bat-SL-CoV ZC45 and ZXC21 were found in Chinese horseshoe bats (Rhinolopus sinicus) in Zhoushan city of Zhejiang Province, China between 2015 and 2017 [3], which can infect suckling rats and cause disease.
T16 2220-2446 Sentence denotes Given that there were some bats and live animals in the seafood market, 2019-nCoV may be originated from bats or live animals exposure to the materials contaminated with bat droppings in the seafood market or surrounding area.
T17 2447-2456 Sentence denotes Figure 1.
T18 2457-2772 Sentence denotes Analysis of the functional domains in 2019-nCoV spike protein and its gene. (A) Phylogenetic analysis of S gene of 2019-nCoV (Wuhan-Hu-1), bat-SL-CoVZXC21, bat-SL-CoVZXC45, SARS-CoV and other coronaviruses using Neighbor-Joining method. (B) The representative scheme of functional domains in S protein of 2019-nCoV.
T19 2773-3065 Sentence denotes SP, signal peptide; NTD, N-terminal domain; RBD, receptor-binding domain; FP, fusion peptide, HR1, heptad repeat 1; HR2, heptad repeat 2; TM, transmembrane domain; CP, cytoplasmic domain. (C) The target sites in 2019-nCoV S for development of vaccines, antibodies and fusion/entry inhibitors.
T20 3066-3466 Sentence denotes The rapid identification of this novel coronavirus is attributed to recent advances in the detection of respiratory virus infection, including reverse transcription PCR (RT-PCR), real-time reverse transcription PCR (rRT-PCR), reverse transcription loop-mediated isothermal amplification (RT-LAMP), and real-time RT-LAMP as well as multiplex nucleic acid amplification and microarray-based assays [4].
T21 3467-3639 Sentence denotes These methods are useful for detecting novel coronaviruses not only in humans, but also in animals for identification of animal reservoir or intermediate host of 2019-nCoV.
T22 3640-3970 Sentence denotes WHO recommended that if there is no clue about the putative pathogen from the pneumonia outbreak, a pan-coronavirus assay should be used for amplification followed by sequencing of the amplicon for characterization and confirmation (https://apps.who.int/iris/bitstream/handle/10665/330374/WHO-2019-nCoV-laboratory-2020.1-eng.pdf).
T23 3971-4165 Sentence denotes By aligning 2019-nCoV S protein sequence with those of SARS-CoV and several bat-SL-CoVs, we predicted that the cleavage site for generating S1 and S2 subunits is located at R694/S695 (Figure 1).
T24 4166-4368 Sentence denotes S1 subunit contains two functional domains, the N-terminal domain (NTD) and a receptor-binding domain (RBD), both of which are responsible for the binding of the virion to the receptor on the host cell.
T25 4369-4509 Sentence denotes They also contain several conformational neutralizing epitopes, serving as a target for developing neutralizing antibodies and vaccines [5].
T26 4510-4608 Sentence denotes S2 subunit contains three functional domains, fusion peptide (FP), and heptad repeat (HR) 1 and 2.
T27 4609-4869 Sentence denotes After binding of RBD in S1 to the receptor, the S2 subunit changes conformation by inserting the FP into the host cell membrane and association between HR1 and HR2 to form six-helical bundle (6-HB), resulting in the fusion between viral and cellular membranes.
T28 4870-4979 Sentence denotes The viral genetic materials enter into the host cell through the fusion pore for replication in the cell [5].
T29 4980-5284 Sentence denotes A peptide derived from the HR2 domain of SARS-CoV S protein (SC-1) can interact with HR1 region in viral S protein to form heterologous 6-HB, resulting in the inhibition of homologous 6-HB formation between HR1 and HR2 domains in viral S protein and thus blocking the viral fusion with the host cell [6].
T30 5285-5511 Sentence denotes Since 2019-nCoV S-HR2 sequence is 100% identical to that of SARS-CoV, while there are only a few mutations of non-critical amino acids in S-HR1 region, SC-1 peptide is expected to be also effective against 2019-nCoV infection.
T31 5512-5712 Sentence denotes We have recently designed and engineered a pan-CoV fusion inhibitor, EK1 peptide, which could inhibit infection of five human coronaviruses, including SARS-CoV and MERS-CoV, and three bat-SL-CoVs [7].
T32 5713-5949 Sentence denotes Intranasal application of EK1 peptide before or after viral challenge, EK1 peptide can protect human DPP4-transgenic mice from MERS-CoV infection, suggesting its potential prophylactic and therapeutic effect against 2019-nCoV infection.
T33 5950-6146 Sentence denotes Once confirmed, we will develop EK1 peptide as a t prophylactic or therapeutic for intranasal application to prevent or treat infection by 2019-nCoV and other emerging coronaviruses in the future.
T34 6147-6411 Sentence denotes The RBDs of SARS-CoV and MERS-CoV contain multiple conformation-dependent neutralizing epitopes that induce more potent neutralizing antibodies and protective efficacy against SARS-CoV and MERS-CoV infections, respectively, than other regions in S protein [5,8,9].
T35 6412-6674 Sentence denotes Modification of MERS-CoV S-RBD amino acid residues based on the structure design could improve its protection against MERS-CoV infection [9], suggesting that 2019-nCoV S-RBD or modified S-RBD of other coronavirus may be applied for developing 2019-nCoV vaccines.
T36 6675-6793 Sentence denotes Of course, the RBD-containing S and S1 of a coronavirus, e.g. 2019-nCoV, can also be used for vaccine development [8].
T37 6794-6997 Sentence denotes The recently developed SARS-CoV and MERS-CoV neutralizing monoclonal antibodies (mAbs) and nanobodies with protective efficacy are specific to the S1 subunit of S protein, particularly the RBD [5,89–10].
T38 6998-7106 Sentence denotes Therefore, the 2019-nCoV S-RBD is anticipated to be a key target for developing 2019-nCoV neutralizing mAbs.
T39 7107-7331 Sentence denotes The neutralizing mAbs targeting non-RBD regions, including NTD and S2 of SARS-CoV and/or MERS-CoV S could also be identified [5,8,11,12], although their neutralizing potency is generally lower than that of RBD-specific mAbs.
T40 7332-7456 Sentence denotes It may take several months or even years for researching and developing neutralizing antibodies against 2019-nCoV infection.
T41 7457-7633 Sentence denotes One of the rapid approaches is to evaluate the currently available SARS-CoV neutralizing antibodies with cross-neutralizing and protection activity against 2019-nCoV infection.
T42 7634-7849 Sentence denotes We have shown that SARS-CoV S-RBD-specific neutralizing mAbs and sera could cross-neutralize bat-SL-CoVs, such as bat-SL-CoV-W1V1 and bat-SL-CoV-SHC014 [13], suggesting that they may also cross-neutralize 2019-nCoV.
T43 7850-7988 Sentence denotes Once identified, these cross-neutralizing antibodies can be promptly developed for urgent prevention and treatment of 2019-nCoV infection.
T44 7990-8006 Sentence denotes Acknowledgements
T45 8007-8146 Sentence denotes We thank Dr Ben Hu at Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China for phylogenetic analysis of 2019-nCoV S gene.
T46 8148-8168 Sentence denotes Disclosure statement
T47 8169-8233 Sentence denotes No potential conflict of interest was reported by the author(s).
T48 8235-8240 Sentence denotes ORCID
T49 8241-8289 Sentence denotes Shibo Jiang http://orcid.org/0000-0001-8283-7135
T50 8290-8337 Sentence denotes Lanying Du http://orcid.org/0000-0001-5955-1294
T51 8338-8386 Sentence denotes Zhengli Shi http://orcid.org/0000-0001-8089-163X