PMC:7033263 / 2808-4539 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7033263","sourcedb":"PMC","sourceid":"7033263","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7033263","text":"2019-nCoV features\nCoronaviruses are enveloped, positive-sense, single stranded RNA viruses that are distributed broadly among humans, other mammals, and birds, which cause respiratory, enteric, hepatic, and neurologic diseases [5]. Six coronavirus species are known to cause human disease. Four viruses including hCoV-229E, OC43, NL63, and HKU1 are prevalent and typically cause mild respiratory diseases [6]. The two novel fatal coronaviruses emerge periodically in different areas, severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012. Given the high prevalence and wide distribution of coronaviruses, the genetic diversity and frequent recombination of genomes, and increasing human and animal activities, novel coronaviruses are likely to emerge periodically in humans owing to frequent cross-species infections and occasional spillover events [7, 8].\nAs Zhu et al. reported that the identified 2019-nCoV genome has been sequenced are phylogenetically the closest to certain beta-coronaviruses detected in bats, belonging to the sarbecovirus subgenus of coronaviridae family [1], and these results in conjunction with other reports show that it is 75–80% identical to the SARS-CoV [9, 10] and 40% identical to the MERS-CoV. It can be propagated in the same cells for growing SARS-CoV and MERS-CoV. Notably, 2019-nCoV grows better in primary human airway epithelial cells than in standard tissue-culture cells, unlike SARS-CoV or MERS-CoV. It appears that 2019-nCoV uses the same cellular receptor hACE2 (human angiotensin-converting enzyme 2) as SARS-CoV [11], it seems the transmission may develop after signs of lower respiratory tract 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