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PMC:7029759 / 31865-33636 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
851 32-36 Gene denotes ACE2 Gene:59272
852 97-101 Gene denotes ACE2 Gene:59272
853 254-258 Gene denotes ACE2 Gene:59272
854 393-397 Gene denotes ACE2 Gene:59272
855 563-567 Gene denotes ACE2 Gene:59272
856 657-661 Gene denotes ACE2 Gene:59272
857 889-893 Gene denotes ACE2 Gene:59272
858 999-1003 Gene denotes ACE2 Gene:59272
859 1123-1127 Gene denotes ACE2 Gene:59272
860 1227-1231 Gene denotes ACE2 Gene:59272
861 1293-1297 Gene denotes ACE2 Gene:59272
862 1460-1471 Gene denotes Fc receptor
863 1473-1477 Gene denotes CD16 Gene:2214
864 1753-1757 Gene denotes ACE2 Gene:59272
865 808-809 Gene denotes S Gene:43740568
866 436-444 Species denotes patients Tax:9606
867 472-480 Species denotes patients Tax:9606
868 539-548 Species denotes 2019-nCoV Tax:2697049
869 549-557 Species denotes patients Tax:9606
870 798-807 Species denotes 2019-nCoV Tax:2697049
871 1433-1442 Species denotes 2019-nCoV Tax:2697049
872 949-958 Chemical denotes histidine MESH:D006639
873 486-497 Disease denotes lung injury MESH:D055370
874 789-793 Disease denotes SARS MESH:D045169
875 1093-1097 Disease denotes SARS MESH:D045169
876 1244-1255 Disease denotes lung injury MESH:D055370
877 1556-1560 Disease denotes MERS MESH:D018352

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T439 32-36 G_3;PG_10;PR:000003622 denotes ACE2
T438 83-96 GO:0005576 denotes extracellular
T437 97-101 G_3;PG_10;PR:000003622 denotes ACE2
T436 197-203 SO:0000417 denotes domain
T435 240-253 GO:0005576 denotes extracellular
T434 254-258 G_3;PG_10;PR:000003622 denotes ACE2
T433 271-279 GO:0032941 denotes secreted
T432 283-290 UBERON:0000479 denotes tissues
T431 319-332 GO:0005576 denotes extracellular
T430 333-339 SO:0000417 denotes domain
T429 393-397 G_3;PG_10;PR:000003622 denotes ACE2
T428 486-490 UBERON:0002048 denotes lung
T427 539-548 SP_7 denotes 2019-nCoV
T426 563-567 G_3;PG_10;PR:000003622 denotes ACE2
T425 657-661 G_3;PG_10;PR:000003622 denotes ACE2
T424 789-793 SP_10 denotes SARS
T423 798-807 SP_7 denotes 2019-nCoV
T422 808-817 PG_1 denotes S protein
T421 889-893 G_3;PG_10;PR:000003622 denotes ACE2
T420 999-1003 G_3;PG_10;PR:000003622 denotes ACE2
T419 1004-1017 GO:0005576 denotes extracellular
T418 1018-1024 SO:0000417 denotes domain
T417 1093-1097 PR:000014459;SP_10;PG_9 denotes SARS
T416 1098-1099 PG_9;PG_1;PR:000005292 denotes S
T415 1100-1107 PG_1;PR:000005292 denotes protein
T414 1123-1127 G_3;PG_10;PR:000003622 denotes ACE2
T413 1227-1231 G_3;PG_10;PR:000003622 denotes ACE2
T412 1244-1248 UBERON:0002048 denotes lung
T411 1293-1297 G_3;PG_10;PR:000003622 denotes ACE2
T410 1390-1398 GO:0042571 denotes antibody
T409 1433-1442 SP_7 denotes 2019-nCoV
T408 1473-1477 PR:000001483 denotes CD16
T407 1542-1552 GO:0042571 denotes antibodies
T406 1556-1560 SP_9 denotes MERS
T405 1753-1757 G_3;PG_10;PR:000003622 denotes ACE2

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T205 136-140 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T206 283-290 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T207 398-405 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T208 486-490 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T209 639-649 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T210 810-817 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T211 910-917 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T212 949-958 Body_part denotes histidine http://purl.org/sig/ont/fma/fma82755
T213 1100-1107 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T214 1207-1214 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T215 1244-1248 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T216 1390-1398 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T217 1488-1493 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T20 486-490 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T21 1244-1248 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p4596s33 1025-1034 NegReg denotes abolished
p4596s34 1035-1044 Enzyme denotes peptidase
p4596s35 1045-1053 MPA denotes activity
p4596s39 1068-1072 MPA denotes high
p4596s40 1073-1081 MPA denotes affinity
p4596s41 1082-1089 Interaction denotes binding

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T116 491-497 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T117 789-793 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T118 1093-1097 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T119 1249-1255 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T330 37-39 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T331 173-174 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T332 194-196 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T333 448-449 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T334 486-490 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T335 486-490 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T336 501-502 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T337 568-570 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T338 672-680 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T339 1045-1053 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T340 1244-1248 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T341 1244-1248 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T342 1305-1313 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T343 1460-1462 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc
T344 1488-1493 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T345 1501-1504 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T346 1758-1760 http://purl.obolibrary.org/obo/CLO_0052676 denotes Fc

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T142 398-405 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T143 509-511 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T144 639-649 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T145 639-644 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T146 645-649 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T147 810-817 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T148 910-917 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T149 949-958 Chemical denotes histidine http://purl.obolibrary.org/obo/CHEBI_27570
T150 1100-1107 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T151 1207-1214 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T20 662-680 http://purl.obolibrary.org/obo/GO_0008233 denotes peptidase activity
T21 1035-1053 http://purl.obolibrary.org/obo/GO_0008233 denotes peptidase activity

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T200 0-223 Sentence denotes One potential limitation of the ACE2-Fc strategy is that the increase in levels of extracellular ACE2 could have unknown effects on the body, particularly when elevated for a prolonged time via Fc domain extended half-life.
T201 224-370 Sentence denotes Small levels of extracellular ACE2 are already secreted by tissues, so the circulation of this extracellular domain would not be unprecedented 72.
T202 371-591 Sentence denotes Moreover, recombinant ACE2 protein was well-tolerated by healthy patients in a phase I trial, and by patients with lung injury in a phase II trial, suggesting treating 2019-nCoV patients with ACE2-Fc will also tolerated.
T203 592-818 Sentence denotes If investigators are still concerned, critical amino acid(s) for ACE2 peptidase activity could be mutated to abolish the native function of this sequence, while retaining high affinity binding for SARS and 2019-nCoV S protein.
T204 819-1111 Sentence denotes Indeed, this possibility was previously investigated in generating an ACE2 and IgG1 fusion protein, which showed that mutation of histidine residues at position 374 and 378 of the ACE2 extracellular domain abolished peptidase activity, but retained high affinity binding to SARS S protein 56.
T205 1112-1331 Sentence denotes Of course, ACE2 peptidase mutation would eliminate the beneficial effects from the recombinant protein delivery of ACE2 in treating lung injury, so it is recommended that retaining ACE2 enzyme activity be pursued first.
T206 1332-1564 Sentence denotes Another potential concern is that receptor binding via an antibody format could inadvertently direct 2019-nCoV toward infecting Fc receptor (CD16) positive cells, which has been shown in vitro for neutralizing antibodies in MERS 73.
T207 1565-1667 Sentence denotes It’s unclear what clinical significance this would have, and to what extent this would happen in vivo.
T208 1668-1771 Sentence denotes Ultimately, clinical trials will be needed to delineate any specific side effects of ACE2-Fc treatment.