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PMC:7029759 / 13232-15165 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
281 44-51 Species denotes patient Tax:9606
291 166-174 Species denotes patients Tax:9606
292 218-226 Species denotes patients Tax:9606
293 268-276 Species denotes Patients Tax:9606
294 389-398 Species denotes 2019-nCoV Tax:2697049
295 514-522 Species denotes patients Tax:9606
296 562-571 Species denotes 2019-nCoV Tax:2697049
297 291-306 Disease denotes viral infection MESH:D001102
298 495-504 Disease denotes infection MESH:D007239
299 537-546 Disease denotes infection MESH:D007239
307 598-606 Species denotes Patients Tax:9606
308 630-639 Species denotes 2019-nCoV Tax:2697049
309 719-727 Species denotes patients Tax:9606
310 1000-1005 Species denotes Ebola Tax:1570291
311 1006-1014 Species denotes patients Tax:9606
312 710-718 Disease denotes infected MESH:D007239
313 1126-1134 Disease denotes infected MESH:D007239
322 1171-1179 Species denotes patients Tax:9606
323 1265-1274 Species denotes 2019-nCoV Tax:2697049
324 1368-1376 Species denotes patients Tax:9606
325 1546-1554 Species denotes patients Tax:9606
326 1616-1623 Species denotes patient Tax:9606
327 1798-1805 Species denotes patient Tax:9606
328 1838-1845 Species denotes patient Tax:9606
329 1193-1202 Disease denotes infection MESH:D007239

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T247 8-16 GO:0042571 denotes antibody
T246 157-162 UBERON:0001977 denotes serum
T245 203-208 NCBITaxon:10239 denotes virus
T244 231-239 GO:0006936 denotes contract
T243 244-249 NCBITaxon:10239 denotes virus
T242 291-296 NCBITaxon:10239 denotes viral
T241 333-341 GO:0042571 denotes antibody
T240 342-348 UBERON:0002405;GO:0006955 denotes immune
T239 349-357 GO:0006955 denotes response
T238 371-376 NCBITaxon:10239 denotes viral
T237 377-385 CHEBI:59132;CHEBI:59132 denotes antigens
T236 389-398 SP_7 denotes 2019-nCoV
T235 425-435 GO:0042571 denotes antibodies
T234 463-468 NCBITaxon:10239 denotes virus
T233 562-571 SP_7 denotes 2019-nCoV
T232 572-582 GO:0042571 denotes antibodies
T231 630-639 SP_7 denotes 2019-nCoV
T230 658-664 UBERON:0001969 denotes plasma
T229 680-686 UBERON:0001969 denotes plasma
T228 743-749 UBERON:0001969 denotes plasma
T227 803-809 UBERON:0001969 denotes plasma
T226 1033-1038 UBERON:0001977 denotes serum
T225 1252-1260 UBERON:0001977 denotes antisera
T224 1265-1274 SP_7 denotes 2019-nCoV
T223 1300-1308 UBERON:0001977 denotes antisera
T222 1572-1578 UBERON:0001969 denotes plasma
T221 1624-1628 UBERON:0001977 denotes sera
T220 1806-1810 UBERON:0001977 denotes sera
T219 1908-1919 GO:0065007 denotes controlling

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T62 8-16 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T63 157-162 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T64 333-341 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T65 658-664 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T66 680-686 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T67 743-749 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T68 803-809 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T69 1033-1038 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T70 1572-1578 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T6 157-162 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T7 1033-1038 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T35 122-132 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T36 291-306 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T37 297-306 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T38 495-504 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T39 537-546 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T40 1000-1005 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T41 1193-1202 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T112 57-58 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T113 203-208 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T114 244-249 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T115 264-266 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T116 320-321 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T117 463-468 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T118 658-664 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T119 680-686 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T120 743-749 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T121 803-809 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T122 1280-1281 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T123 1340-1341 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T124 1572-1578 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T53 377-385 Chemical denotes antigens http://purl.obolibrary.org/obo/CHEBI_59132
T54 1566-1571 Chemical denotes donor http://purl.obolibrary.org/obo/CHEBI_17891
T55 1682-1691 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T56 1743-1751 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T7 291-306 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T8 342-357 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T9 1409-1415 http://purl.obolibrary.org/obo/GO_0040007 denotes growth

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T83 0-56 Sentence denotes Passive antibody transfer from convalescent patient sera
T84 57-267 Sentence denotes A simple but potentially very effective tool that can be used in infectious outbreaks is to use the serum of patients who have recovered from the virus to treat patients who contract the virus in the future 36.
T85 268-399 Sentence denotes Patients with resolved viral infection will develop a polyclonal antibody immune response to different viral antigens of 2019-nCoV.
T86 400-597 Sentence denotes Some of these polyclonal antibodies will likely neutralize the virus and prevent new rounds of infection, and the patients with resolved infection should produce 2019-nCoV antibodies in high titer.
T87 598-731 Sentence denotes Patients with resolved cases of 2019-nCoV can simply donate plasma, and then this plasma can be transfused into infected patients 37.
T88 732-935 Sentence denotes Given that plasma donation is well established, and the transfusion of plasma is also routine medical care, this proposal does not need any new science or medical approvals in order to be put into place.
T89 936-1138 Sentence denotes Indeed, the same rationale was used in the treatment of several Ebola patients with convalescent serum during the outbreak in 2014–2015, including two American healthcare workers who became infected 38.
T90 1139-1377 Sentence denotes As the outbreak continues, more patients who survived infection will become available to serve as donors to make antisera for 2019-nCoV, and a sizeable stock of antisera could be developed to serve as a treatment for the sickest patients.
T91 1378-1592 Sentence denotes Unfortunately, the exponential growth of the outbreak would work against this strategy, since the growing number of cases would likely outstrip the ability of previous patients to provide donor plasma as treatment.
T92 1593-1724 Sentence denotes Moreover, convalescent patient sera would have significant variability in the potency of antiviral effect, making it less ideal 37.
T93 1725-1933 Sentence denotes While transfusion medicine services should certainly pursue convalescent patient sera as an option right now for patient treatment, it is ultimately limited in its effective scope of controlling the outbreak.