PMC:7029449 / 2989-4343
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7029449","sourcedb":"PMC","sourceid":"7029449","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7029449","text":"In an analysis of the first 425 confirmed cases of infection, 73% of cases with illness onset between 12 and 22 January reported no exposure to either a wet market or another person with symptoms of a respiratory illness [2]. The lack of reported exposure to another ill person could be attributed to lack of awareness or recall bias, but China’s health minister publicly warned that pre-symptomatic transmission could be occurring [6]. Determining the extent to which asymptomatic or pre-symptomatic transmission might be occurring is an urgent priority, because it has direct implications for public health and hospital infection control. Data on viral shedding dynamics could help in assessing duration of infectiousness. For severe acute respiratory syndrome-related coronavirus (SARS-CoV), infectivity peaked at around 10 days after illness onset [7], consistent with the peak in viral load at around that time [8]. This allowed control of the SARS epidemic through prompt detection of cases and strict isolation. For influenza virus infections, virus shedding is highest on the day of illness onset and relatively higher from shortly before symptom onset until a few days after onset [9]. To date, transmission patterns of 2019-nCoV appear more similar to influenza, with contagiousness occurring around the time of symptom onset, rather than 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