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PMC:7019868 / 17447-23718 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
341 2808-2818 Chemical denotes iPEDVPT-P5
419 4903-4910 Chemical denotes iPEDVPT
315 104-108 Species denotes PEDV Tax:28295
316 244-248 Species denotes PEDV Tax:28295
317 162-169 Chemical denotes iPEDVPT
318 440-447 Chemical denotes iPEDVPT
319 497-504 Chemical denotes iPEDVPT
320 736-743 Chemical denotes iPEDVPT
321 744-746 Chemical denotes P5 MESH:C016883
322 751-758 Chemical denotes iPEDVPT
323 980-990 Chemical denotes iPEDVPT-P5
328 1145-1149 Species denotes PEDV Tax:28295
329 1236-1242 Species denotes stocks Tax:3724
330 1338-1342 Species denotes PEDV Tax:28295
331 1172-1186 Disease denotes giant syncytia MESH:D005870
342 2823-2830 Chemical denotes iPEDVPT
343 2831-2834 Chemical denotes P96
344 2914-2921 Chemical denotes iPEDVPT
345 2930-2937 Chemical denotes iPEDVPT
346 3016-3023 Chemical denotes iPEDVPT
347 3071-3078 Chemical denotes iPEDVPT
348 3157-3164 Chemical denotes iPEDVPT
349 3172-3179 Chemical denotes iPEDVPT
374 3875-3878 Species denotes pig Tax:9823
375 4463-4467 Species denotes PEDV Tax:28295
376 3489-3496 Chemical denotes iPEDVPT
377 3501-3508 Chemical denotes iPEDVPT
378 3517-3524 Chemical denotes iPEDVPT
379 3530-3537 Chemical denotes iPEDVPT
380 4149-4159 Chemical denotes iPEDVPT-P5
381 4172-4179 Chemical denotes iPEDVPT
382 4194-4201 Chemical denotes iPEDVPT
383 4352-4355 Chemical denotes DPI
384 4363-4366 Chemical denotes DPI
385 4392-4402 Chemical denotes iPEDVPT-P5
386 4415-4426 Chemical denotes iPEDVPT-P96
387 4427-4429 Chemical denotes 5S
388 4692-4702 Chemical denotes iPEDVPT-P5
389 4717-4728 Chemical denotes iPEDVPT-P96
390 4729-4731 Chemical denotes 5S
391 4739-4742 Chemical denotes DPI
392 4777-4780 Chemical denotes DPI
393 3952-3960 Disease denotes diarrhea MESH:D003967
394 4260-4268 Disease denotes diarrhea MESH:D003967
395 4270-4278 Disease denotes anorexia MESH:D000855
396 4476-4492 Disease denotes villous blunting MESH:D018253
397 4497-4504 Disease denotes atrophy MESH:D001284
417 4814-4824 Chemical denotes iPEDVPT-P5
418 4833-4840 Chemical denotes iPEDVPT
420 4911-4914 Chemical denotes P96
421 5051-5058 Chemical denotes iPEDVPT
422 5071-5078 Chemical denotes iPEDVPT
423 5247-5257 Chemical denotes iPEDVPT-P5
424 5258-5261 Chemical denotes 96S
425 5354-5365 Chemical denotes iPEDVPT-P96
426 5493-5500 Chemical denotes iPEDVPT
427 5563-5570 Chemical denotes iPEDVPT
428 5588-5595 Chemical denotes iPEDVPT
429 5683-5690 Chemical denotes iPEDVPT
430 5722-5733 Chemical denotes iPEDVPT-P96
431 5902-5912 Chemical denotes iPEDVPT-P5
432 5136-5151 Disease denotes villous atrophy MESH:C564019
433 5172-5203 Disease denotes conspicuous villous hyperplasia MESH:D018253
434 5322-5337 Disease denotes villous atrophy MESH:C564019
435 5628-5639 Disease denotes weight gain MESH:D015430
437 5984-5988 Species denotes PEDV Tax:28295

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T87 312-316 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T88 557-561 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T89 810-820 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T90 1286-1291 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T91 1380-1387 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T92 1637-1642 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T93 1780-1784 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T94 2013-2017 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T95 2123-2127 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T96 2212-2217 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T97 2402-2406 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T98 2559-2563 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T99 2647-2652 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T100 2883-2888 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T101 3144-3148 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T102 3264-3269 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T103 3312-3316 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T104 3401-3405 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T105 3938-3941 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T106 4111-4115 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T107 4512-4519 Body_part denotes jejunum http://purl.org/sig/ont/fma/fma7207
T108 4552-4557 Body_part denotes ileum http://purl.org/sig/ont/fma/fma7208
T109 4587-4595 Body_part denotes duodenum http://purl.org/sig/ont/fma/fma7206
T110 4870-4874 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T111 5159-5166 Body_part denotes jejunum http://purl.org/sig/ont/fma/fma7207
T112 5341-5348 Body_part denotes jejunum http://purl.org/sig/ont/fma/fma7207
T113 5783-5787 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T114 6013-6021 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T115 6091-6102 Body_part denotes enterocytes http://purl.org/sig/ont/fma/fma62122
T116 6162-6184 Body_part denotes mesenteric lymph nodes http://purl.org/sig/ont/fma/fma277405

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T18 4512-4519 Body_part denotes jejunum http://purl.obolibrary.org/obo/UBERON_0002115
T19 4552-4557 Body_part denotes ileum http://purl.obolibrary.org/obo/UBERON_0002116
T20 4587-4595 Body_part denotes duodenum http://purl.obolibrary.org/obo/UBERON_0002114
T21 5159-5166 Body_part denotes jejunum http://purl.obolibrary.org/obo/UBERON_0002115
T22 5341-5348 Body_part denotes jejunum http://purl.obolibrary.org/obo/UBERON_0002115
T23 6162-6184 Body_part denotes mesenteric lymph nodes http://purl.obolibrary.org/obo/UBERON_0002509
T24 6173-6178 Body_part denotes lymph http://purl.obolibrary.org/obo/UBERON_0002391

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T20 1736-1745 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T21 2311-2320 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T22 2792-2801 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T23 3952-3960 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T24 4260-4268 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T25 5192-5203 Disease denotes hyperplasia http://purl.obolibrary.org/obo/MONDO_0005043

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T176 74-75 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T177 141-142 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T178 155-160 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T179 257-259 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T180 312-316 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T181 429-431 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T182 469-476 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T183 557-561 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T184 583-585 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T185 643-650 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T186 788-789 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T187 1061-1062 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T188 1110-1112 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T189 1221-1228 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T190 1270-1277 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T191 1281-1285 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T192 1281-1285 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T193 1286-1291 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T194 1313-1315 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T195 1552-1559 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T196 1632-1636 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T197 1632-1636 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T198 1637-1642 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T199 1685-1692 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T200 1726-1728 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T201 1747-1754 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes Viruses
T202 1780-1784 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T203 1873-1882 http://purl.obolibrary.org/obo/CL_0000228 denotes syncytium
T204 1994-2001 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T205 2013-2017 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T206 2102-2109 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T207 2123-2127 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T208 2196-2203 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T209 2207-2211 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T210 2207-2211 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T211 2212-2217 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T212 2293-2294 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T213 2402-2406 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T214 2526-2533 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T215 2559-2563 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T216 2617-2622 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T217 2642-2646 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T218 2642-2646 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T219 2647-2652 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T220 2727-2734 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T221 2878-2882 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T222 2878-2882 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T223 2883-2888 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T224 3144-3148 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T225 3218-3219 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T226 3259-3263 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T227 3259-3263 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T228 3264-3269 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T229 3312-3316 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T230 3348-3350 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T231 3401-3405 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T232 3428-3430 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T233 3472-3475 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T234 3545-3552 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T235 3714-3721 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T236 3812-3819 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T237 4088-4095 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T238 4111-4115 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T239 4293-4301 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T240 4327-4331 http://purl.obolibrary.org/obo/CLO_0001757 denotes at 1
T241 4512-4519 http://purl.obolibrary.org/obo/UBERON_0002115 denotes jejunum
T242 4528-4529 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T243 4552-4557 http://purl.obolibrary.org/obo/UBERON_0002116 denotes ileum
T244 4845-4852 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T245 4870-4874 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T246 4924-4925 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T247 5042-5049 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T248 5112-5113 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T249 5159-5166 http://purl.obolibrary.org/obo/UBERON_0002115 denotes jejunum
T250 5341-5348 http://purl.obolibrary.org/obo/UBERON_0002115 denotes jejunum
T251 5531-5532 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T252 5783-5787 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T253 5813-5815 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T254 6044-6051 http://purl.obolibrary.org/obo/SO_0000418 denotes signals
T255 6162-6184 http://purl.obolibrary.org/obo/UBERON_0002509 denotes mesenteric lymph nodes
T256 6263-6270 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T102 810-820 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T103 1313-1315 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T104 1380-1387 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T105 1862-1868 Chemical denotes nuclei http://purl.obolibrary.org/obo/CHEBI_33252
T106 1939-1945 Chemical denotes nuclei http://purl.obolibrary.org/obo/CHEBI_33252
T107 3562-3564 Chemical denotes PI http://purl.obolibrary.org/obo/CHEBI_28874|http://purl.obolibrary.org/obo/CHEBI_53806|http://purl.obolibrary.org/obo/CHEBI_61484|http://purl.obolibrary.org/obo/CHEBI_74790
T111 4007-4012 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T112 4703-4708 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T113 4732-4737 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T39 1613-1619 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T40 1701-1710 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T41 2274-2280 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T42 2496-2502 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T43 3126-3134 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange
T44 3852-3866 http://purl.obolibrary.org/obo/GO_0019076 denotes viral shedding
T45 4312-4326 http://purl.obolibrary.org/obo/GO_0019076 denotes viral shedding
T46 4970-4984 http://purl.obolibrary.org/obo/GO_0019076 denotes viral shedding
T47 5438-5452 http://purl.obolibrary.org/obo/GO_0019076 denotes viral shedding
T48 5749-5758 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T49 5749-5758 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T50 5885-5894 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T51 5885-5894 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T127 0-2 Sentence denotes 3.
T128 3-10 Sentence denotes Results
T129 12-16 Sentence denotes 3.1.
T130 17-46 Sentence denotes Recovery of recombinant PEDVs
T131 47-284 Sentence denotes We have recently developed a reverse genetic platform of PEDV and have successfully generated a recombinant virus, iPEDVPT-P96, which is phenotypically comparable to its parental attenuated Taiwan PEDV-Pintung 52 strain, PEDVPT-P96 [19].
T132 285-587 Sentence denotes To study the role of the S gene in the attenuation mechanism of PEDVPT-P96, we further generated the recombinant, highly virulent Taiwan PEDVPT 52 strain, iPEDVPT-P5, and two chimeric viruses (iPEDVPT-P5-96S and iPEDVPT-P96-5S) by replacing the complete sequence of the S gene reciprocally (Figure S1).
T133 588-704 Sentence denotes In general, the approach to rescue the new recombinant viruses were virtually the same as published previously [19].
T134 705-940 Sentence denotes However, for the generation of iPEDVPT-P5 and iPEDVPT-P5-96S, we split the plasmid B to two fragments at nucleotide position of 9654 according to Hou et al. [23] in order to compensate for the instability caused by the toxic sequences.
T135 941-1103 Sentence denotes The in vitro and in vivo properties of iPEDVPT-P5 were confirmed similarly to those of the parental PEDVPT-P5 strain in a seven-day-old conventional piglet model.
T136 1104-1229 Sentence denotes At 24–48 h post-electroporation, typical PEDV cytopathic effects of giant syncytia were observed for all recombinant viruses.
T137 1230-1450 Sentence denotes Viral stocks were prepared by passaging viruses in Vero cells one additional time (P1), and the presence of PEDV was confirmed by detection of PEDV S protein by immunofluorescence assay (Figure 1A) and sequence analyses.
T138 1452-1456 Sentence denotes 3.2.
T139 1457-1503 Sentence denotes In Vitro Characterization of Recombinant PEDVs
T140 1504-1668 Sentence denotes The in vitro characteristics of the recombinant viruses were compared by evaluation of the size of syncytia, growth kinetics in Vero cells, and plaque morphologies.
T141 1669-1746 Sentence denotes All recombinant viruses induced formation of syncytia by 18 h post-infection.
T142 1747-1981 Sentence denotes Viruses carrying the identical S gene exhibited similar fusogenic ability as suggested by the comparable number of nuclei per syncytium; representative micrographs used to count the number of nuclei in syncytia are shown in Figure 1A.
T143 1982-2164 Sentence denotes Remarkably, viruses carrying S gene derived from iPEDVPT-P96, induced 3.5 to 4 times larger syncytia than the other two viruses containing S gene derived from iPEDVPT-P5 (Figure 1B).
T144 2165-2356 Sentence denotes Replication of all recombinant viruses in Vero cells were examined by performing both one-step and multistep growth kinetics at a multiplicity of infection (MOI) of 1 and 0.001, respectively.
T145 2357-2665 Sentence denotes Interestingly, although replacement of the S gene resulted in an alteration of the replication kinetics and efficiency, leading to similar growth curve patterns between viruses carrying the identical S gene sequence, it did not fully reverse the capability of virus yield, at least in Vero cells (Figure 1C).
T146 2666-2778 Sentence denotes We observed that plaque morphologies of the four recombinant viruses correlated to the results of syncytia size.
T147 2779-3095 Sentence denotes At 72 h post-infection, both iPEDVPT-P5 and iPEDVPT-P96-5S induced barely visible viral plaques in Vero cells macroscopically, whereas iPEDVPT-P96 and iPEDVPT-5-96S generated distinct and comparable viral plaques with the plaque size of iPEDVPT-P5-96S being slightly smaller than that of the iPEDVPT-P96 (Figure 1D).
T148 3096-3270 Sentence denotes These data suggested that the exchange of the S gene between iPEDVPT-P5 and iPEDVPT-P96 affected the fusogenicity and, to a lesser extent, replication kinetics in Vero cells.
T149 3272-3276 Sentence denotes 3.3.
T150 3277-3357 Sentence denotes Investigation of the Role of Spike Gene on the Pathogenicity of PEDVPT 52 strain
T151 3358-3644 Sentence denotes To evaluate the pathogenicity related to S gene replacement in PEDVPT 52 strain, we orally inoculated 2 mL of 5 × 102 TCID50/mL of iPEDVPT-P5, iPEDVPT-P5-96S, iPEDVPT-P96, iPEDVPT-P96-5S viruses and with PI medium in seven-day-old crossbred piglets assigned in the corresponding groups.
T152 3645-3771 Sentence denotes Parameters used to assess the pathogenicity of different recombinant viruses were summarized in Table 2 and shown in Figure 2.
T153 3772-3928 Sentence denotes The target sequences of the recombinant viruses at the time point of peak fecal viral shedding in each pig was confirmed identical to the original inoculum.
T154 3929-4051 Sentence denotes No viral RNA shedding, diarrhea or mortality was detected in the mock-treated group during the entire experimental course.
T155 4052-4357 Sentence denotes Piglets inoculated with recombinant viruses carrying the S gene derived from the highly virulent iPEDVPT-P5, namely the iPEDVPT-P5 itself and iPEDVPT-P96-5S, had an early onset of clinical symptoms including diarrhea, anorexia and decreased activity, and peak viral shedding at 1 d post-inoculation (DPI).
T156 4358-4624 Sentence denotes At 3 DPI, piglets inoculated with iPEDVPT-P5 (n = 3) and iPEDVPT-P96-5S (n = 3) both exhibited extensive PEDV-induced villous blunting and atrophy in the jejunum and, to a lesser extent, in the ileum; histological changes in the duodenum were not obvious (Figure 3).
T157 4625-4781 Sentence denotes Mortality rates of both groups were comparable, reaching 50% at 2 (iPEDVPT-P5 group) and 5 (iPEDVPT-P96-5S group) DPI and ultimately exceeded 80% by 10 DPI.
T158 4782-4985 Sentence denotes In comparison, inoculation with iPEDVPT-P5-96S and iPEDVPT-P96 viruses containing the S gene derived from the attenuated iPEDVPT-P96, induced a delayed onset of clinical symptoms and peak viral shedding.
T159 4986-5237 Sentence denotes Histological evaluation of piglets inoculated with both viruses (iPEDVPT-P96, n = 3; iPEDVPT-P5-96S, n = 3) at 3 DPI revealed a much milder degree of villous atrophy in the jejunum with conspicuous villous hyperplasia compared to the other two groups.
T160 5238-5393 Sentence denotes Notably, iPEDVPT-P5-96S-treated piglets exhibited statistically significant severer villous atrophy in jejunum than iPEDVPT-P96-treated piglets (Figure 3).
T161 5394-5695 Sentence denotes Despite the similar pattern and severity of viral shedding and clinical symptoms, inoculation with iPEDVPT-P5-96S eventually resulted in a higher mortality rate (40% in iPEDVPT-P96 and 80 % and iPEDVPT-P5-96S) and lower average daily weight gain by 10 DPI than those upon inoculation with iPEDVPT-P96.
T162 5696-5913 Sentence denotes These data suggested that iPEDVPT-P96 fully regained virulence by replacement of the S gene from the virulent PEDVPT 52 strains and the complementary approach can only partially reduce the virulence of the iPEDVPT-P5.
T163 5914-6185 Sentence denotes In agreement with the previous study, immunohistochemistry using anti-PEDV nucleocapsid monoclonal antibody demonstrated positive signals predominantly in the jejunal and ileal enterocytes at the top of villi (Figure 4) but occasionally within the mesenteric lymph nodes.
T164 6186-6271 Sentence denotes No difference in the viral distribution was identified among the recombinant viruses.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T13 3952-3960 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T14 4260-4268 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T15 4270-4278 Phenotype denotes anorexia http://purl.obolibrary.org/obo/HP_0002039
T16 5136-5151 Phenotype denotes villous atrophy http://purl.obolibrary.org/obo/HP_0011473
T17 5322-5337 Phenotype denotes villous atrophy http://purl.obolibrary.org/obo/HP_0011473
T18 5628-5639 Phenotype denotes weight gain http://purl.obolibrary.org/obo/HP_0004324

2_test

Id Subject Object Predicate Lexical cue
31905842-28490591-144353228 863-865 28490591 denotes 23