PMC:7019868 / 1663-3217
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7019868","sourcedb":"PMC","sourceid":"7019868","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7019868","text":"Porcine epidemic diarrhea virus (PEDV) is an enveloped, positive-sense and single stranded RNA virus belonging to the genus Alphacoronavirus. PEDV is the causative agent of porcine epidemic diarrhea (PED), a historic, highly contagious enteric swine disease characterized by diarrhea, dehydration and poor growth performance in pigs at all ages [1,2]. PED was first identified in 1971 in the United Kingdom, and subsequently became an endemic disease in the Europe and most Asian countries with a low mortality rate and limited economic losses [1]. For decades, the disease was controlled through the use of live attenuated vaccines (LAVs) derived from the PEDV prototypes, CV777- or DR13. Unfortunately, in late 2010, a new highly virulent PEDV strain emerged in China and quickly spread worldwide, including Taiwan [3,4]. Moreover, the conventional LAV failed to induce protection against this new virulent PEDV strain, consequently resulting in nearly 100% mortality amongst neonatal piglets and leading to substantial economic impacts on swine markets in the affected regions [5]. Phylogenetic analysis categorizes PEDV into two genogroups [2]. Genogroup I consists primarily of the historic, low-virulent PEDV strains that appeared around 1970, whereas genogroup II is composed of the highly virulent PEDV strains, which emerged after 2010s. Both genogroups can be further divided into two subgroups each, namely G1a, G1b, G2a and G2b though a recent phylogenetic study identified a novel recombinant PEDV strain classified into a new G1c clade [6].","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"60","span":{"begin":0,"end":31},"obj":"Species"},{"id":"61","span":{"begin":33,"end":37},"obj":"Species"},{"id":"62","span":{"begin":142,"end":146},"obj":"Species"},{"id":"63","span":{"begin":244,"end":249},"obj":"Species"},{"id":"64","span":{"begin":657,"end":661},"obj":"Species"},{"id":"65","span":{"begin":741,"end":745},"obj":"Species"},{"id":"66","span":{"begin":909,"end":913},"obj":"Species"},{"id":"67","span":{"begin":1042,"end":1047},"obj":"Species"},{"id":"68","span":{"begin":1119,"end":1123},"obj":"Species"},{"id":"69","span":{"begin":1210,"end":1214},"obj":"Species"},{"id":"70","span":{"begin":1306,"end":1310},"obj":"Species"},{"id":"71","span":{"begin":1506,"end":1510},"obj":"Species"},{"id":"72","span":{"begin":173,"end":180},"obj":"Species"},{"id":"73","span":{"begin":181,"end":198},"obj":"Disease"},{"id":"74","span":{"begin":275,"end":283},"obj":"Disease"},{"id":"75","span":{"begin":285,"end":296},"obj":"Disease"}],"attributes":[{"id":"A60","pred":"tao:has_database_id","subj":"60","obj":"Tax:28295"},{"id":"A61","pred":"tao:has_database_id","subj":"61","obj":"Tax:28295"},{"id":"A62","pred":"tao:has_database_id","subj":"62","obj":"Tax:28295"},{"id":"A63","pred":"tao:has_database_id","subj":"63","obj":"Tax:9823"},{"id":"A64","pred":"tao:has_database_id","subj":"64","obj":"Tax:28295"},{"id":"A65","pred":"tao:has_database_id","subj":"65","obj":"Tax:28295"},{"id":"A66","pred":"tao:has_database_id","subj":"66","obj":"Tax:28295"},{"id":"A67","pred":"tao:has_database_id","subj":"67","obj":"Tax:9823"},{"id":"A68","pred":"tao:has_database_id","subj":"68","obj":"Tax:28295"},{"id":"A69","pred":"tao:has_database_id","subj":"69","obj":"Tax:28295"},{"id":"A70","pred":"tao:has_database_id","subj":"70","obj":"Tax:28295"},{"id":"A71","pred":"tao:has_database_id","subj":"71","obj":"Tax:28295"},{"id":"A72","pred":"tao:has_database_id","subj":"72","obj":"Tax:1586324"},{"id":"A73","pred":"tao:has_database_id","subj":"73","obj":"MESH:D003967"},{"id":"A74","pred":"tao:has_database_id","subj":"74","obj":"MESH:D003967"},{"id":"A75","pred":"tao:has_database_id","subj":"75","obj":"MESH:D003681"},{"subj":"60","pred":"source","obj":"LitCovid-PubTator"},{"subj":"61","pred":"source","obj":"LitCovid-PubTator"},{"subj":"62","pred":"source","obj":"LitCovid-PubTator"},{"subj":"63","pred":"source","obj":"LitCovid-PubTator"},{"subj":"64","pred":"source","obj":"LitCovid-PubTator"},{"subj":"65","pred":"source","obj":"LitCovid-PubTator"},{"subj":"66","pred":"source","obj":"LitCovid-PubTator"},{"subj":"67","pred":"source","obj":"LitCovid-PubTator"},{"subj":"68","pred":"source","obj":"LitCovid-PubTator"},{"subj":"69","pred":"source","obj":"LitCovid-PubTator"},{"subj":"70","pred":"source","obj":"LitCovid-PubTator"},{"subj":"71","pred":"source","obj":"LitCovid-PubTator"},{"subj":"72","pred":"source","obj":"LitCovid-PubTator"},{"subj":"73","pred":"source","obj":"LitCovid-PubTator"},{"subj":"74","pred":"source","obj":"LitCovid-PubTator"},{"subj":"75","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T10","span":{"begin":91,"end":94},"obj":"Body_part"}],"attributes":[{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma67095"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T5","span":{"begin":17,"end":25},"obj":"Disease"},{"id":"T6","span":{"begin":190,"end":198},"obj":"Disease"},{"id":"T7","span":{"begin":244,"end":257},"obj":"Disease"},{"id":"T8","span":{"begin":275,"end":283},"obj":"Disease"}],"attributes":[{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0024990"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T20","span":{"begin":26,"end":31},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T21","span":{"begin":95,"end":100},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T22","span":{"begin":206,"end":207},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T23","span":{"begin":495,"end":496},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T24","span":{"begin":719,"end":720},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T25","span":{"begin":1423,"end":1426},"obj":"http://purl.obolibrary.org/obo/CLO_0003423"},{"id":"T26","span":{"begin":1447,"end":1448},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T27","span":{"begin":1486,"end":1487},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T28","span":{"begin":1534,"end":1535},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T20","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T2","span":{"begin":1268,"end":1270},"obj":"Chemical"}],"attributes":[{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T12","span":{"begin":306,"end":312},"obj":"http://purl.obolibrary.org/obo/GO_0040007"}],"attributes":[{"subj":"T12","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T13","span":{"begin":0,"end":141},"obj":"Sentence"},{"id":"T14","span":{"begin":142,"end":351},"obj":"Sentence"},{"id":"T15","span":{"begin":352,"end":548},"obj":"Sentence"},{"id":"T16","span":{"begin":549,"end":689},"obj":"Sentence"},{"id":"T17","span":{"begin":690,"end":823},"obj":"Sentence"},{"id":"T18","span":{"begin":824,"end":1084},"obj":"Sentence"},{"id":"T19","span":{"begin":1085,"end":1148},"obj":"Sentence"},{"id":"T20","span":{"begin":1149,"end":1346},"obj":"Sentence"},{"id":"T21","span":{"begin":1347,"end":1554},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T13","pred":"source","obj":"LitCovid-sentences"},{"subj":"T14","pred":"source","obj":"LitCovid-sentences"},{"subj":"T15","pred":"source","obj":"LitCovid-sentences"},{"subj":"T16","pred":"source","obj":"LitCovid-sentences"},{"subj":"T17","pred":"source","obj":"LitCovid-sentences"},{"subj":"T18","pred":"source","obj":"LitCovid-sentences"},{"subj":"T19","pred":"source","obj":"LitCovid-sentences"},{"subj":"T20","pred":"source","obj":"LitCovid-sentences"},{"subj":"T21","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T5","span":{"begin":17,"end":25},"obj":"Phenotype"},{"id":"T6","span":{"begin":190,"end":198},"obj":"Phenotype"},{"id":"T7","span":{"begin":275,"end":283},"obj":"Phenotype"},{"id":"T8","span":{"begin":285,"end":296},"obj":"Phenotype"},{"id":"T9","span":{"begin":301,"end":312},"obj":"Phenotype"}],"attributes":[{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0002014"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0002014"},{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0002014"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0001944"},{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0001510"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"2_test","denotations":[{"id":"31905842-83132-144353208","span":{"begin":346,"end":347},"obj":"83132"},{"id":"31905842-26689811-144353209","span":{"begin":348,"end":349},"obj":"26689811"},{"id":"31905842-83132-144353210","span":{"begin":545,"end":546},"obj":"83132"},{"id":"31905842-22840964-144353211","span":{"begin":818,"end":819},"obj":"22840964"},{"id":"31905842-25903998-144353212","span":{"begin":820,"end":821},"obj":"25903998"},{"id":"31905842-26641031-144353213","span":{"begin":1081,"end":1082},"obj":"26641031"},{"id":"31905842-26689811-144353214","span":{"begin":1145,"end":1146},"obj":"26689811"}],"attributes":[{"subj":"31905842-83132-144353208","pred":"source","obj":"2_test"},{"subj":"31905842-26689811-144353209","pred":"source","obj":"2_test"},{"subj":"31905842-83132-144353210","pred":"source","obj":"2_test"},{"subj":"31905842-22840964-144353211","pred":"source","obj":"2_test"},{"subj":"31905842-25903998-144353212","pred":"source","obj":"2_test"},{"subj":"31905842-26641031-144353213","pred":"source","obj":"2_test"},{"subj":"31905842-26689811-144353214","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#a893ec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#97ec93"},{"id":"LitCovid-PD-MONDO","color":"#ec93b1"},{"id":"LitCovid-PD-CLO","color":"#93cbec"},{"id":"LitCovid-PD-CHEBI","color":"#e5ec93"},{"id":"LitCovid-PD-GO-BP","color":"#d993ec"},{"id":"LitCovid-sentences","color":"#93ecbf"},{"id":"LitCovid-PD-HP","color":"#eca593"},{"id":"2_test","color":"#939bec"}]}]}}