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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7014668","sourcedb":"PMC","sourceid":"7014668","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7014668","text":"It is important to note that our estimates are based on a number of key assumptions that cannot yet be informed directly by evidence from the ongoing 2019-nCoV outbreak. The current outbreak has spread rapidly and early evidence suggests that the average disease severity is lower than that of SARS. This may also suggest a substantial proportion of asymptomatic cases. A recent analysis of a family transmission cluster is based on a small sample size but one in six infections was asymptomatic [11]; this is a major impediment for the effectiveness of syndromic screening. However, if asymptomatic cases were not infectious they would not pose a risk for seeding infection chains on arrival. To allow easy adaptation of our results as new insight becomes available in the coming weeks, we developed a free interactive online tool, available at 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