PMC:6967083 / 5519-6282 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6967083","sourcedb":"PMC","sourceid":"6967083","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6967083","text":"The GFAP variant, when expressed in older ages, causes neuronal loss in the brain especially in the brain stem [5]. In some reports, neuronal loss in basal ganglia are found in adult-onset GFAP variant [6–8], that presence of striatonigral neuronal loss on FP-CIT PET with GFAP variant was first described in this case. An unusual pattern of dopamine depletion with a rostrocaudal gradient in the putamen and caudate nucleus were seen, unlike in patients with PD which shows preferential depletion in posterior putamen with relative sparing of caudate nucleus [9]. The atypical dopamine depletion pattern has not been described or investigated in other Alexander disease patients in the literature and that it could also relate to the interaction of co-pathology.","tracks":[{"project":"AxD_symptoms","denotations":[{"id":"T22","span":{"begin":55,"end":68},"obj":"Phenotype"},{"id":"T23","span":{"begin":133,"end":163},"obj":"Phenotype"},{"id":"T24","span":{"begin":240,"end":253},"obj":"Phenotype"}],"attributes":[{"id":"A22","pred":"hp_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/HP_0002529"},{"id":"A23","pred":"hp_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/HP_0200147"},{"id":"A24","pred":"hp_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/HP_0002529"},{"subj":"T22","pred":"source","obj":"AxD_symptoms"},{"subj":"T23","pred":"source","obj":"AxD_symptoms"},{"subj":"T24","pred":"source","obj":"AxD_symptoms"}]},{"project":"2_test","denotations":[{"id":"31952467-29740945-12806211","span":{"begin":112,"end":113},"obj":"29740945"},{"id":"31952467-23706596-12806212","span":{"begin":203,"end":204},"obj":"23706596"},{"id":"31952467-22323779-12806213","span":{"begin":561,"end":562},"obj":"22323779"}],"attributes":[{"subj":"31952467-29740945-12806211","pred":"source","obj":"2_test"},{"subj":"31952467-23706596-12806212","pred":"source","obj":"2_test"},{"subj":"31952467-22323779-12806213","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"AxD_symptoms","color":"#ec93e7","default":true},{"id":"2_test","color":"#93ecd7"}]}]}}