PMC:6707402 / 25309-27404 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6707402","sourcedb":"PMC","sourceid":"6707402","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6707402","text":"Other reactions\nOnly one study in this review administered DMSO as eye-drops 114. In this study, two patients experienced severe conjunctival hyperemia due to allergic reactions, and 25% of patients experienced a stinging sensation when eye-drops were applied 114. Other studies performed eye examinations to determine whether DMSO caused changes in the lens; however, no such cases were observed 2, 45.\nHyponatremia occurred in six patients after they received large doses of DMSO as treatment for cranial hypertension 62. This adverse reaction was not reported in other studies ( Table 8).\nTable 8. Other adverse reactions observed per number of patients.\nAdverse reaction Studies Total patients, n Patients with reaction, n (%) (min%–max%) †\nFever [ 27, 71, 73, 77, 101] 547 44 (8) (2–19) [ 27] - [ 77]\nChills [ 27, 33, 70, 71, 81, 85, 101] 852 60 (7) (1–31) [ 101] - [ 71]\nDizziness [ 2, 46, 55, 85, 101] 885 18 (2) (1–15) [ 55] - [ 2]\nWeakness [ 33, 45, 46] 293 19 (6) (1–29) [ 46] - [ 45]\nSedation [ 2] 78 34 (44)\nHyponatremia [ 62] 6 6 (100)\n†Incidences of the adverse reactions have been calculated for all the individual studies. (%, min-max) are the lowest and highest observed incidence of an adverse reaction observed in the group of studies included. Very few cases of serious adverse reactions associated with DMSO have been described 18, 36, 51, 59.\nOverall, most studies administered DMSO intravenously or transdermally ( Table 9)\nTable 9. Way of administration of DMSO in included studies.\nAdministration Number of studies References\nIntravenous 49 [ 7, 16, 18, 23, 25, 26, 33, 34, 36, 39– 41, 46– 48, 51, 53, 54, 56, 59, 61, 62, 65, 68, 70– 74, 77, 80, 81, 84– 87, 90, 91, 94, 98– 102, 104, 110, 115, 117, 118]\nTransdermal 48 [ 2, 4, 6, 17, 19– 22, 24, 28– 32, 37, 42, 44, 45, 50, 52, 55, 57, 58, 63, 64, 66, 67, 69, 72, 75, 76, 78, 79, 82– 84, 88, 89, 93, 95, 96, 106– 109, 111– 113]\nIntravesical 7 [ 8, 35, 38, 43, 49, 97, 105]\nOral 2 [ 9, 60]\nEye-drops 1 [ 114]\nLocal injection 1 [ 92]\nIntra-articular 1 [ 103]\nRectal 1 [ 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