PMC:6650341 / 5770-6441 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6650341","sourcedb":"PMC","sourceid":"6650341","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6650341","text":"1.4 Renin-angiotensin system:\nThe development and progression of hypertension due to increased production of ROS have been related to renal vasoconstriction caused by an increase in renal afferent nerve activity and myogenic response and secretion of vasoconstrictor hormones, such as angiotensin II, endothelin-1, and thromboxane29. Angiotensin II increases ROS production, inflammation, and renal tubular ion and water transport, and decreases dopamine receptor expression and function, resulting in hypertension4,5,8,15–17,29–34 . 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