PMC:6650341 / 22075-22929 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6650341","sourcedb":"PMC","sourceid":"6650341","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6650341","text":"Catalase (CAT) catalyzes the conversion of H2O2 to water and oxygen. SNPs in the CAT gene promoter region, CAT-844 AA and CAT-262 CT or TT, have been associated with essential hypertension among Chinese157, smoking Russians154, Greeks155, but not African-Americans and Caucasians156. However, CAT haplotype [−844G,−89A,−20T] relative to the CAT haplotype [−844A,−89T,−20C] was predictive of a decrease in diastolic blood pressure after bariatric surgery in a French population378. In individuals with low-level lead exposure, CAT rs769217, C\u003eT, is associated with increased blood markers of oxidative stress and hypertension379. By contrast, CAT rs1049982, −20 C\u003eT, is associated with lower blood pressure230. 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