PMC:6650341 / 16812-18039
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6650341","sourcedb":"PMC","sourceid":"6650341","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6650341","text":"The mitochondrion, which is one of the most important sources of ROS, has been extensively associated with oxidative stress and hypertension8,12,13,145,228. ROS-induced hypertension could involve the mitochondria in the brain72 and in the kidney354,355,356. Cytochrome P450 genes are important sources of ROS in the mitochondria, endoplasmic reticulum, and plasma membrane. P450 proteins are a family of hemoproteins that catalyze the oxygenation of a wide variety of compounds and, in general, is the terminal oxidase enzyme in the electron transfer chain in the mitochondria95. The efficiency of electron transfer depends on many conditions. For example, SNPs in the gene encoding Cytochrome P450 affect the regulation of ROS production and the redox balance357,358. SNPs in the cytochrome P450 gene family have also been associated with high blood pressure in several different populations 96,98,360,361 but protective in a North Americans 97. CYP-epoxygenase decreases renal sodium transport, in part, by inhibition of ENaC activity in the cortical collecting duct362. 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