PMC:6610326 / 35449-36476 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6610326","sourcedb":"PMC","sourceid":"6610326","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6610326","text":"Table 5 SOD1, TDP-43 and FUS mouse models of ALS.\nMouse models Promotor CNS over-expression (fold) Survival (months) Inclusions Motor Phenotype MN loss Denervation References\nSOD1 G93A hSOD1 17 3.5–4.5 SOD1(+) Yes Yes Yes Gurney et al., 1994\ns-G93A hSOD1 8–10 8.3 hyaline Yes Yes Yes Gurney, 1997\nG37R hSOD1 4–12 5 SOD1(+) Yes Yes Yes Wong et al., 1995\nG85R hSOD1 0.2–1 8.5 SOD1(+) Ub(+) Yes Yes Yes Bruijn et al., 1997\nTDP-43 A315T PrP 3 5 TDP-43(–) Ub(+) Yes Yes Yes Wegorzewska et al., 2009\nrNLS8 NEFH – 2.6 off Dox TDP-43(+) Yes Yes Yes Walker et al., 2015; Spiller et al., 2016a\nM337VKNOCK-IN – No 24.5 No No No Yes Ebstein et al., 2019\nG298SKNOCK-IN – No 24.5 No No Yes Yes Ebstein et al., 2019\nTDP-43 KO – – ns No Yes Yes Yes Iguchi et al., 2013\nFUS hFUSWT MAPT 2.6 No No No Yes Sharma et al., 2016\nhFUSR521C MAPT 4 12 No No Yes Yes Sharma et al., 2016\nhFUSP525L MAPT 4 12 No Yes Yes Yes Sharma et al., 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