PMC:6610326 / 35449-36476 JSONTXT

{"project":"2_test","denotations":[{"id":"31316328-8209258-38515499","span":{"begin":255,"end":259},"obj":"8209258"},{"id":"31316328-9419057-38515500","span":{"begin":318,"end":322},"obj":"9419057"},{"id":"31316328-7605627-38515501","span":{"begin":382,"end":386},"obj":"7605627"},{"id":"31316328-9052802-38515502","span":{"begin":457,"end":461},"obj":"9052802"},{"id":"31316328-19833869-38515503","span":{"begin":541,"end":545},"obj":"19833869"},{"id":"31316328-26197969-38515504","span":{"begin":617,"end":621},"obj":"26197969"},{"id":"31316328-30625319-38515506","span":{"begin":706,"end":710},"obj":"30625319"},{"id":"31316328-30625319-38515507","span":{"begin":773,"end":777},"obj":"30625319"},{"id":"31316328-23449777-38515508","span":{"begin":833,"end":837},"obj":"23449777"},{"id":"31316328-26842965-38515509","span":{"begin":896,"end":900},"obj":"26842965"},{"id":"31316328-26842965-38515510","span":{"begin":959,"end":963},"obj":"26842965"},{"id":"31316328-26842965-38515511","span":{"begin":1023,"end":1027},"obj":"26842965"}],"text":"Table 5 SOD1, TDP-43 and FUS mouse models of ALS.\nMouse models Promotor CNS over-expression (fold) Survival (months) Inclusions Motor Phenotype MN loss Denervation References\nSOD1 G93A hSOD1 17 3.5–4.5 SOD1(+) Yes Yes Yes Gurney et al., 1994\ns-G93A hSOD1 8–10 8.3 hyaline Yes Yes Yes Gurney, 1997\nG37R hSOD1 4–12 5 SOD1(+) Yes Yes Yes Wong et al., 1995\nG85R hSOD1 0.2–1 8.5 SOD1(+) Ub(+) Yes Yes Yes Bruijn et al., 1997\nTDP-43 A315T PrP 3 5 TDP-43(–) Ub(+) Yes Yes Yes Wegorzewska et al., 2009\nrNLS8 NEFH – 2.6 off Dox TDP-43(+) Yes Yes Yes Walker et al., 2015; Spiller et al., 2016a\nM337VKNOCK-IN – No 24.5 No No No Yes Ebstein et al., 2019\nG298SKNOCK-IN – No 24.5 No No Yes Yes Ebstein et al., 2019\nTDP-43 KO – – ns No Yes Yes Yes Iguchi et al., 2013\nFUS hFUSWT MAPT 2.6 No No No Yes Sharma et al., 2016\nhFUSR521C MAPT 4 12 No No Yes Yes Sharma et al., 2016\nhFUSP525L MAPT 4 12 No Yes Yes Yes Sharma et al., 2016"}

{"project":"0_colil","denotations":[{"id":"31316328-8209258-630956","span":{"begin":255,"end":259},"obj":"8209258"},{"id":"31316328-9419057-630957","span":{"begin":318,"end":322},"obj":"9419057"},{"id":"31316328-7605627-630958","span":{"begin":382,"end":386},"obj":"7605627"},{"id":"31316328-9052802-630959","span":{"begin":457,"end":461},"obj":"9052802"},{"id":"31316328-19833869-630960","span":{"begin":541,"end":545},"obj":"19833869"},{"id":"31316328-26197969-630961","span":{"begin":617,"end":621},"obj":"26197969"},{"id":"31316328-30625319-630963","span":{"begin":706,"end":710},"obj":"30625319"},{"id":"31316328-30625319-630964","span":{"begin":773,"end":777},"obj":"30625319"},{"id":"31316328-23449777-630965","span":{"begin":833,"end":837},"obj":"23449777"},{"id":"31316328-26842965-630966","span":{"begin":896,"end":900},"obj":"26842965"},{"id":"31316328-26842965-630967","span":{"begin":959,"end":963},"obj":"26842965"},{"id":"31316328-26842965-630968","span":{"begin":1023,"end":1027},"obj":"26842965"}],"text":"Table 5 SOD1, TDP-43 and FUS mouse models of ALS.\nMouse models Promotor CNS over-expression (fold) Survival (months) Inclusions Motor Phenotype MN loss Denervation References\nSOD1 G93A hSOD1 17 3.5–4.5 SOD1(+) Yes Yes Yes Gurney et al., 1994\ns-G93A hSOD1 8–10 8.3 hyaline Yes Yes Yes Gurney, 1997\nG37R hSOD1 4–12 5 SOD1(+) Yes Yes Yes Wong et al., 1995\nG85R hSOD1 0.2–1 8.5 SOD1(+) Ub(+) Yes Yes Yes Bruijn et al., 1997\nTDP-43 A315T PrP 3 5 TDP-43(–) Ub(+) Yes Yes Yes Wegorzewska et al., 2009\nrNLS8 NEFH – 2.6 off Dox TDP-43(+) Yes Yes Yes Walker et al., 2015; Spiller et al., 2016a\nM337VKNOCK-IN – No 24.5 No No No Yes Ebstein et al., 2019\nG298SKNOCK-IN – No 24.5 No No Yes Yes Ebstein et al., 2019\nTDP-43 KO – – ns No Yes Yes Yes Iguchi et al., 2013\nFUS hFUSWT MAPT 2.6 No No No Yes Sharma et al., 2016\nhFUSR521C MAPT 4 12 No No Yes Yes Sharma et al., 2016\nhFUSP525L MAPT 4 12 No Yes Yes Yes Sharma et al., 2016"}