PMC:6599329 / 24337-25254 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6599329","sourcedb":"PMC","sourceid":"6599329","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6599329","text":"Aggregation substance was already proved to have a role in Enterococcal biofilm formation [3, 36]. Adhesion lipoproteins are surface-associated lipoproteins involved in Enterococcal adherence, colonization and virulence [37] and are directly linked to biofilm formation as in agreement with our findings. Fibronectin/fibrinogen binding proteins also showed more than tenfold increase in biofilm stages and were suggested to have a significant role in E. faecalis associated urinary tract infections in a murine model [38] and endocarditis in rats [39]. Fibronectin binding protein mutants of community-associated MRSA losses the ability for fibronectin binding thereby preventing the establishment of biofilm in host tissue [40]. These proteins were assumed to be associated with bacterial aggregation and involve in primary attachment to a surface and hence can be considered as a suitable biofilm inhibiting target.","tracks":[{"project":"2_test","denotations":[{"id":"31253082-21209892-12221380","span":{"begin":91,"end":92},"obj":"21209892"},{"id":"31253082-25431047-12221381","span":{"begin":94,"end":96},"obj":"25431047"},{"id":"31253082-21903750-12221382","span":{"begin":221,"end":223},"obj":"21903750"},{"id":"31253082-22782954-12221383","span":{"begin":518,"end":520},"obj":"22782954"},{"id":"31253082-26351286-12221384","span":{"begin":548,"end":550},"obj":"26351286"},{"id":"31253082-24628034-12221385","span":{"begin":725,"end":727},"obj":"24628034"}],"attributes":[{"subj":"31253082-21209892-12221380","pred":"source","obj":"2_test"},{"subj":"31253082-25431047-12221381","pred":"source","obj":"2_test"},{"subj":"31253082-21903750-12221382","pred":"source","obj":"2_test"},{"subj":"31253082-22782954-12221383","pred":"source","obj":"2_test"},{"subj":"31253082-26351286-12221384","pred":"source","obj":"2_test"},{"subj":"31253082-24628034-12221385","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#a1ec93","default":true}]}]}}