PMC:6582309 / 17505-19133
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6582309","sourcedb":"PMC","sourceid":"6582309","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6582309","text":"Brain region Pathology Cognitive decline References\nPrefrontal cortex Aβ Executive function, behavioral changes [cognitive performance, loss of previously learned behaviors (e.g., house soiling)], motor skills, attention, emotions and impulse control (fearfulness, aggression, stereotypic pacing or circling) Bosch et al.,2012\nFrontal cortex Aβ Changes in executive functions (inhibitory control and complex working memory) Ishihara et al., 1991; Schmidt et al., 2015; Smolek et al.,2016\nParietal cortex Aβ Sensory association, learning and memory Yu et al., 2011; Nešić et al.,2017\nEntorhinal cortex Aβ, NFTs* Visual learning, memory Schmidt et al., 2015; Smolek et al.,2016\nOccipital cortex Aβ Learning and memory (visual association area, visual cortex) Martin et al.,2011\nTemporal cortex Aβ, NFTs* Visual memory (facial recognition), emotions Smolek et al.,2016\nHippocampus Aβ, NFTs* Changes in sleep–wake cycles, appetite control, complex working memory Colle et al., 2000; Pugliese et al., 2006; Yu et al., 2011; Schmidt et al., 2015; Smolek et al.,2016\nCerebral cortex (not further specified) Aβ Disorientation, decrease in social interactions, changes in sleep–wake cycles, loss of prior housetraining, increased anxiety, changes in level of activity Colle et al., 2000; Pugliese et al., 2006; Yu et al.,2011\nCerebral capillaries and arteries Aβ - CAA Lower perceptual speed and episodic memory Ishihara et al., 1991; Colle et al., 2000; Yu et al.,2011\nMeningeal blood vessels Aβ - CAA Ishihara et al., 1991; Borràs et al., 1999; Colle et al., 2000; Yu et al., 2011; Nešić et 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