Brain region   Pathology   Cognitive decline   References
Prefrontal cortex  Aβ  Executive function, behavioral changes [cognitive performance, loss of previously learned behaviors (e.g., house soiling)], motor skills, attention, emotions and impulse control (fearfulness, aggression, stereotypic pacing or circling)  Bosch et al.,2012
Frontal cortex  Aβ  Changes in executive functions (inhibitory control and complex working memory)  Ishihara et al., 1991; Schmidt et al., 2015; Smolek et al.,2016
Parietal cortex  Aβ  Sensory association, learning and memory  Yu et al., 2011; Nešić et al.,2017
Entorhinal cortex  Aβ, NFTs*  Visual learning, memory  Schmidt et al., 2015; Smolek et al.,2016
Occipital cortex  Aβ  Learning and memory (visual association area, visual cortex)  Martin et al.,2011
Temporal cortex  Aβ, NFTs*  Visual memory (facial recognition), emotions  Smolek et al.,2016
Hippocampus  Aβ, NFTs*  Changes in sleep–wake cycles, appetite control, complex working memory  Colle et al., 2000; Pugliese et al., 2006; Yu et al., 2011; Schmidt et al., 2015; Smolek et al.,2016
Cerebral cortex (not further specified)  Aβ  Disorientation, decrease in social interactions, changes in sleep–wake cycles, loss of prior housetraining, increased anxiety, changes in level of activity  Colle et al., 2000; Pugliese et al., 2006; Yu et al.,2011
Cerebral capillaries and arteries  Aβ - CAA  Lower perceptual speed and episodic memory  Ishihara et al., 1991; Colle et al., 2000; Yu et al.,2011
Meningeal blood vessels  Aβ - CAA   Ishihara et al., 1991; Borràs et al., 1999; Colle et al., 2000; Yu et al., 2011; Nešić et al.,2017