PMC:6562565 / 40962-41391
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6562565","sourcedb":"PMC","sourceid":"6562565","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6562565","text":"CTLA-4 ICB \u0026 CD73 inhibition ➣ anti-CTLA-4mAbs:\n9H10 (389)\nUC10-4F10 (382)\n➣ CD73 pharmacologic inhibitor:\nAPCP (389)\n➣ anti-CD73mAb:\nTY/23 (382) ➣ Breast: 4T1.2 (382)\n➣ Melanoma: B16F10 (389)\n➣ Colon: MC38 (382)\n➣ Prostate: RM-1 (382) ➣ Primary tumor expansion rate ↓ (382, 389)\nCD8+ \u003e\u003e CD4+ T cells (382)\n➣ Survival ↑ (382) ↑ CD8+, CD4+ T cells (389)↑ Tumor-specific CD8+ T cells (382)↑ IFN-γ, T-bet mRNA (382)↑ IFN-γ (389)","divisions":[{"label":"td","span":{"begin":0,"end":28}},{"label":"td","span":{"begin":30,"end":146}},{"label":"p","span":{"begin":30,"end":48}},{"label":"p","span":{"begin":49,"end":59}},{"label":"p","span":{"begin":60,"end":75}},{"label":"p","span":{"begin":76,"end":107}},{"label":"p","span":{"begin":108,"end":118}},{"label":"p","span":{"begin":119,"end":134}},{"label":"p","span":{"begin":135,"end":146}},{"label":"td","span":{"begin":148,"end":237}},{"label":"p","span":{"begin":148,"end":169}},{"label":"p","span":{"begin":170,"end":194}},{"label":"p","span":{"begin":195,"end":214}},{"label":"p","span":{"begin":215,"end":237}},{"label":"td","span":{"begin":239,"end":328}},{"label":"p","span":{"begin":239,"end":282}},{"label":"p","span":{"begin":283,"end":309}},{"label":"p","span":{"begin":310,"end":328}}],"tracks":[{"project":"MyTest","denotations":[{"id":"31244820-24660106-35366078","span":{"begin":55,"end":58},"obj":"24660106"},{"id":"31244820-23983257-35366079","span":{"begin":71,"end":74},"obj":"23983257"},{"id":"31244820-24660106-35366080","span":{"begin":114,"end":117},"obj":"24660106"},{"id":"31244820-24660106-35366081","span":{"begin":190,"end":193},"obj":"24660106"},{"id":"31244820-23983257-35366082","span":{"begin":210,"end":213},"obj":"23983257"},{"id":"31244820-24660106-35366083","span":{"begin":278,"end":281},"obj":"24660106"},{"id":"31244820-24660106-35366086","span":{"begin":352,"end":355},"obj":"24660106"},{"id":"31244820-23983257-35366087","span":{"begin":387,"end":390},"obj":"23983257"},{"id":"31244820-23983257-35366088","span":{"begin":412,"end":415},"obj":"23983257"},{"id":"31244820-24660106-35366089","span":{"begin":425,"end":428},"obj":"24660106"},{"id":"31244820-24660106-35366078","span":{"begin":55,"end":58},"obj":"24660106"},{"id":"31244820-24660106-35366081","span":{"begin":190,"end":193},"obj":"24660106"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"31244820-24660106-35366078","pred":"source","obj":"MyTest"},{"subj":"31244820-23983257-35366079","pred":"source","obj":"MyTest"},{"subj":"31244820-24660106-35366080","pred":"source","obj":"MyTest"},{"subj":"31244820-24660106-35366081","pred":"source","obj":"MyTest"},{"subj":"31244820-23983257-35366082","pred":"source","obj":"MyTest"},{"subj":"31244820-24660106-35366083","pred":"source","obj":"MyTest"},{"subj":"31244820-24660106-35366086","pred":"source","obj":"MyTest"},{"subj":"31244820-23983257-35366087","pred":"source","obj":"MyTest"},{"subj":"31244820-23983257-35366088","pred":"source","obj":"MyTest"},{"subj":"31244820-24660106-35366089","pred":"source","obj":"MyTest"},{"subj":"31244820-24660106-35366078","pred":"source","obj":"MyTest"},{"subj":"31244820-24660106-35366081","pred":"source","obj":"MyTest"}]},{"project":"TEST0","denotations":[{"id":"31244820-6-13-3850226","span":{"begin":55,"end":58},"obj":"[\"24660106\", \"24660106\"]"},{"id":"31244820-11-18-3850227","span":{"begin":71,"end":74},"obj":"[\"23983257\"]"},{"id":"31244820-6-13-3850228","span":{"begin":114,"end":117},"obj":"[\"24660106\"]"},{"id":"31244820-20-27-3850229","span":{"begin":190,"end":193},"obj":"[\"24660106\", \"24660106\"]"},{"id":"31244820-15-22-3850230","span":{"begin":210,"end":213},"obj":"[\"23983257\"]"},{"id":"31244820-39-46-3850231","span":{"begin":278,"end":281},"obj":"[\"24660106\"]"},{"id":"31244820-22-29-3850234","span":{"begin":352,"end":355},"obj":"[\"24660106\"]"},{"id":"31244820-57-64-3850235","span":{"begin":387,"end":390},"obj":"[\"23983257\"]"},{"id":"31244820-82-89-3850236","span":{"begin":412,"end":415},"obj":"[\"23983257\"]"},{"id":"31244820-95-102-3850237","span":{"begin":425,"end":428},"obj":"[\"24660106\"]"},{"id":"31244820-6-13-3850226","span":{"begin":55,"end":58},"obj":"[\"24660106\", \"24660106\"]"},{"id":"31244820-20-27-3850229","span":{"begin":190,"end":193},"obj":"[\"24660106\", \"24660106\"]"}],"attributes":[{"subj":"31244820-6-13-3850226","pred":"source","obj":"TEST0"},{"subj":"31244820-11-18-3850227","pred":"source","obj":"TEST0"},{"subj":"31244820-6-13-3850228","pred":"source","obj":"TEST0"},{"subj":"31244820-20-27-3850229","pred":"source","obj":"TEST0"},{"subj":"31244820-15-22-3850230","pred":"source","obj":"TEST0"},{"subj":"31244820-39-46-3850231","pred":"source","obj":"TEST0"},{"subj":"31244820-22-29-3850234","pred":"source","obj":"TEST0"},{"subj":"31244820-57-64-3850235","pred":"source","obj":"TEST0"},{"subj":"31244820-82-89-3850236","pred":"source","obj":"TEST0"},{"subj":"31244820-95-102-3850237","pred":"source","obj":"TEST0"},{"subj":"31244820-6-13-3850226","pred":"source","obj":"TEST0"},{"subj":"31244820-20-27-3850229","pred":"source","obj":"TEST0"}]},{"project":"2_test","denotations":[{"id":"31244820-24660106-35366078","span":{"begin":55,"end":58},"obj":"24660106"},{"id":"31244820-23983257-35366079","span":{"begin":71,"end":74},"obj":"23983257"},{"id":"31244820-24660106-35366080","span":{"begin":114,"end":117},"obj":"24660106"},{"id":"31244820-24660106-35366081","span":{"begin":190,"end":193},"obj":"24660106"},{"id":"31244820-23983257-35366082","span":{"begin":210,"end":213},"obj":"23983257"},{"id":"31244820-24660106-35366083","span":{"begin":278,"end":281},"obj":"24660106"},{"id":"31244820-24660106-35366086","span":{"begin":352,"end":355},"obj":"24660106"},{"id":"31244820-23983257-35366087","span":{"begin":387,"end":390},"obj":"23983257"},{"id":"31244820-23983257-35366088","span":{"begin":412,"end":415},"obj":"23983257"},{"id":"31244820-24660106-35366089","span":{"begin":425,"end":428},"obj":"24660106"},{"id":"31244820-24660106-35366078","span":{"begin":55,"end":58},"obj":"24660106"},{"id":"31244820-24660106-35366081","span":{"begin":190,"end":193},"obj":"24660106"}],"attributes":[{"subj":"31244820-24660106-35366078","pred":"source","obj":"2_test"},{"subj":"31244820-23983257-35366079","pred":"source","obj":"2_test"},{"subj":"31244820-24660106-35366080","pred":"source","obj":"2_test"},{"subj":"31244820-24660106-35366081","pred":"source","obj":"2_test"},{"subj":"31244820-23983257-35366082","pred":"source","obj":"2_test"},{"subj":"31244820-24660106-35366083","pred":"source","obj":"2_test"},{"subj":"31244820-24660106-35366086","pred":"source","obj":"2_test"},{"subj":"31244820-23983257-35366087","pred":"source","obj":"2_test"},{"subj":"31244820-23983257-35366088","pred":"source","obj":"2_test"},{"subj":"31244820-24660106-35366089","pred":"source","obj":"2_test"},{"subj":"31244820-24660106-35366078","pred":"source","obj":"2_test"},{"subj":"31244820-24660106-35366081","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"MyTest","color":"#c193ec","default":true},{"id":"TEST0","color":"#93eca7"},{"id":"2_test","color":"#ec9398"}]}]}}