CTLA-4 ICB & CD73 inhibition  ➣ anti-CTLA-4mAbs:
9H10 (389)
UC10-4F10 (382)
➣ CD73 pharmacologic inhibitor:
APCP (389)
➣ anti-CD73mAb:
TY/23 (382)  ➣ Breast: 4T1.2 (382)
➣ Melanoma: B16F10 (389)
➣ Colon: MC38 (382)
➣ Prostate: RM-1 (382)  ➣ Primary tumor expansion rate ↓ (382, 389)
CD8+ >> CD4+ T cells (382)
➣ Survival ↑ (382)  ↑ CD8+, CD4+ T cells (389)↑ Tumor-specific CD8+ T cells (382)↑ IFN-γ, T-bet mRNA (382)↑ IFN-γ (389)