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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6218602","sourcedb":"PMC","sourceid":"6218602","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6218602","text":"Surgical modalities that can precisely target particular regions of focal and well-localized dysconnectivity in the brain are currently being tested as a more circuit-specific approach to precision medicine in schizophrenia. Deep brain stimulation (DBS) has been a well-established targeted therapeutic approach that has been used to improve the treatment-resistant symptoms of Parkinson's disease, obsessive-compulsive disorder and treatment refractory depression (199–202).","tracks":[{"project":"2_test","denotations":[{"id":"30425662-25867121-41865530","span":{"begin":466,"end":469},"obj":"25867121"},{"id":"30425662-23123071-41865530","span":{"begin":466,"end":469},"obj":"23123071"},{"id":"30425662-19759530-41865530","span":{"begin":466,"end":469},"obj":"19759530"},{"id":"30425662-22721950-41865530","span":{"begin":466,"end":469},"obj":"22721950"}],"attributes":[{"subj":"30425662-25867121-41865530","pred":"source","obj":"2_test"},{"subj":"30425662-23123071-41865530","pred":"source","obj":"2_test"},{"subj":"30425662-19759530-41865530","pred":"source","obj":"2_test"},{"subj":"30425662-22721950-41865530","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#c493ec","default":true}]}]}}