PMC:6141714 / 49498-52421 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6141714","sourcedb":"PMC","sourceid":"6141714","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6141714","text":"References Autoimmune disease Source of hMSC Variables Experimental model Clinical and laboratory effects Mechanism proposed\n(164) Type I diabetes mellitus Bone marrow None Mice ↓Disease onset↓Insulitis in the pancreas ↑Tregs in the pancreas\n(74) Type I diabetes mellitus Adipose tissue Administration of adipose tissue-derived MSCs overexpressing betatrophin Administration of adipose tissue-derived MSCs alone Mice ↓Hyperglycemia↓Weight loss Effectiveness of adipose tissue-derived MSCs overexpressing betatrophin \u003e Effectiveness of adipose tissue-derived MSCs alone ↑Islet proliferation↑Ngn3 transcription factor↑Pax6 transcription factor↑Islet production of insulin↑β-cells ratio↑IL-4↑IL-10↑IL-13↓TNF-α↓NADP-cytochrome P450 reductase↑XIAP in the islets↑Bcl-xL in the islets↑Bcl-2 in the islets↓Caspase-3 in the islets↓Apoptotic cells\n(75) Type I diabetes mellitus Umbilical cord stroma None Mice ↑Survival rates↓Blood glucose↑Serum insulin levels↑Glucose tolerance↑C-peptide↓Insulitis ↓Th1 cells↓Th17 cells↑Tregs↓Dendritic cells↓IFN-γ in the serum↓IL-1β in the serum↓TNF-α in the serum↓CCL2 in the serum↓IL-17 in the serum↑IL-4 in the serum↑IL-10 in the serum↑TGF-β1↑Intact islets↑Insulin-producing cells devided from the differentiation of umbilical cord stroma-derived MSCs\n(76) Type I diabetes mellitus Umbilical cord stroma Administration of umbilical cord-derived MSCs before the onset of type I diabetes Mice ↓Disease onset↑Fasting C-peptide↓Insulitis ↑CD4+CD25+Foxp3+ Tregs↓IL-2↓IFN-γ↓TNF- α↑Islet β-cells\nTreatment of type I diabetes with umbilical cord-derived MSCs after the onset of the disease ↓Fasting plasma glucose↓Fed blood glucose↑Fasting C-peptide↓Insulitis\n(77) Type I diabetes mellitus Bone marrow None Mice ↓Hyperglycemia↓Area under the glycemia curve↓Fasting glycemia↑Serum insulin ↑Islet β-cells function↓CD3+ cells↓Islet infiltration↑Larger pancreatic islets↓IL-2 in the pancreas↓IFN-γ in the pancreas↓IL-4 in the pancreas\n(79) Type I diabetes mellitus Bone marrow None Mice ↓Hyperglycemia↑Insulin production↑Human insulin in mice↑C-peptide production ↑Nestin↑Pdx1 transcription factor↑Ngn3 transcription factor↑Pax4 transcription factor↑NeuroD1 transcription factor↑Nkx2.2 transcription factor↑Nkx6.1 transcription factor↑PCSK1 gene↑Insulin gene↑Glucagon gene↑PCSK1 gene↑PP gene\n(80) Type I diabetes mellitus Bone marrow None Mice ↓Hyperglycemia↑Insulin levels ↓Fas in human islets↓MiR-375 in human islets↓PBMC activation↓PBMC proliferation↓IL-2↓IFN-γ↓IL-2 receptor↑HGF↑IL-10↑VEGF↑PGE-2↑TGF-β↑Treg function↓Islet β-cells apoptosis↑Islet β-cells function against inflammatory cytokines↓Immune reaction against transplanted islets after humanization of mice\n(78) Type I diabetes mellitus Umbilical cord stroma None Humans ↓Post-prandial plasma glucose↓Hemoglobin HbA1c↑Fasting C peptide↑C-peptide/glucose ratio ↑Islet β-cells 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