PMC:6141714 / 115857-116664 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6141714","sourcedb":"PMC","sourceid":"6141714","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6141714","text":"References Autoimmune disease Source of hMSC Variables Experimental model Clinical and laboratory effects Mechanism proposed\n(119) Idiopathic pulmonary fibrosis Bone marrow Umbilical cord None Mice ↑Survival rates↓Pulmonary inflammation and fibrosis Effectiveness bone marrow-derived MSCs \u003e effectiveness umbilical cord-derived MSCs ↓CD3+CD56+ NKT cells↓CD3+CD8+ T cell induction↑CD3+CD4+ T cells↑CD4+CD25+CD127(low/−)/foxp3+ Tregs↓IFN-γ↓TNF-α↓IL-6↓IL-8↓CCL2↓α-SMA activation↑TGF-β1↑CXCL10\n(120) Idiopathic pulmonary fibrosis Adipose tissue None Mice ↑Survival rates↓Ashcroft's modified score for lung fibrosis↓Lung weight↓Lung pathology↓Collagen deposition in the lungs ↓IL-2↓IL-1β↓TNF-α↓TGF-β↓bFGF↓CTGF↓COL3a1↓CoL1a1↓Matrix metalloproteinases↓Tissue inhibitor of metalloproteinases","divisions":[{"label":"tr","span":{"begin":0,"end":136}},{"label":"th","span":{"begin":0,"end":11}},{"label":"th","span":{"begin":12,"end":31}},{"label":"th","span":{"begin":33,"end":48}},{"label":"th","span":{"begin":50,"end":60}},{"label":"th","span":{"begin":62,"end":81}},{"label":"th","span":{"begin":83,"end":115}},{"label":"th","span":{"begin":117,"end":136}},{"label":"tr","span":{"begin":137,"end":507}},{"label":"td","span":{"begin":137,"end":142}},{"label":"td","span":{"begin":144,"end":173}},{"label":"td","span":{"begin":175,"end":201}},{"label":"td","span":{"begin":203,"end":207}},{"label":"td","span":{"begin":209,"end":213}},{"label":"td","span":{"begin":215,"end":349}},{"label":"td","span":{"begin":351,"end":507}},{"label":"td","span":{"begin":508,"end":513}},{"label":"td","span":{"begin":515,"end":544}},{"label":"td","span":{"begin":546,"end":560}},{"label":"td","span":{"begin":562,"end":566}},{"label":"td","span":{"begin":568,"end":572}},{"label":"td","span":{"begin":574,"end":693}}],"tracks":[{"project":"MyTest","denotations":[{"id":"30254638-27107963-35421690","span":{"begin":138,"end":141},"obj":"27107963"},{"id":"30254638-27871152-35421691","span":{"begin":509,"end":512},"obj":"27871152"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"30254638-27107963-35421690","pred":"source","obj":"MyTest"},{"subj":"30254638-27871152-35421691","pred":"source","obj":"MyTest"}]},{"project":"2_test","denotations":[{"id":"30254638-27107963-35421690","span":{"begin":138,"end":141},"obj":"27107963"},{"id":"30254638-27871152-35421691","span":{"begin":509,"end":512},"obj":"27871152"}],"attributes":[{"subj":"30254638-27107963-35421690","pred":"source","obj":"2_test"},{"subj":"30254638-27871152-35421691","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"MyTest","color":"#ec9793","default":true},{"id":"2_test","color":"#93a8ec"}]}]}}