PMC:6019327 / 89232-90370 JSONTXT

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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6019327","sourcedb":"PMC","sourceid":"6019327","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6019327","text":"Following AF ablation, hypertension has been shown to be an independent predictor of recurrence.268,328,329,330 Conversely, patients with pharmacologically controlled hypertension could have similar risk of AF recurrence postablation as those without hypertension.279 Pooled analysis of two small studies demonstrated that renal artery denervation resulted in both sustained lowering of BP and reduction in AF recurrence postablation.127,331 However, the antiarrhythmic effect of renal denervation is not well established, and whether it is mediated by remodeling of the hypertension-associated atrial substrate or decrease in neurohormonal activation remains uncertain.129 Whereas upstream therapy with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers might be effective for primary prevention of AF in patients with systolic LV dysfunction or left ventricular hypertrophy,332 their effect on secondary prevention postablation of AF is uncertain. Numerous, mostly retrospective, studies have shown that modulation of the renin-angiotensin-aldosterone system does not improve ablation 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