PMC:6019327 / 89232-90370
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6019327","sourcedb":"PMC","sourceid":"6019327","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6019327","text":"Following AF ablation, hypertension has been shown to be an independent predictor of recurrence.268,328,329,330 Conversely, patients with pharmacologically controlled hypertension could have similar risk of AF recurrence postablation as those without hypertension.279 Pooled analysis of two small studies demonstrated that renal artery denervation resulted in both sustained lowering of BP and reduction in AF recurrence postablation.127,331 However, the antiarrhythmic effect of renal denervation is not well established, and whether it is mediated by remodeling of the hypertension-associated atrial substrate or decrease in neurohormonal activation remains uncertain.129 Whereas upstream therapy with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers might be effective for primary prevention of AF in patients with systolic LV dysfunction or left ventricular hypertrophy,332 their effect on secondary prevention postablation of AF is uncertain. Numerous, mostly retrospective, studies have shown that modulation of the renin-angiotensin-aldosterone system does not improve ablation outcome.289,290,291,333,334","tracks":[{"project":"2_test","denotations":[{"id":"28506916-20500237-29307467","span":{"begin":96,"end":99},"obj":"20500237"},{"id":"28506916-20500237-29307467","span":{"begin":96,"end":99},"obj":"20500237"},{"id":"28506916-17395676-29307468","span":{"begin":100,"end":103},"obj":"17395676"},{"id":"28506916-17395676-29307468","span":{"begin":100,"end":103},"obj":"17395676"},{"id":"28506916-19889688-29307469","span":{"begin":104,"end":107},"obj":"19889688"},{"id":"28506916-19889688-29307469","span":{"begin":104,"end":107},"obj":"19889688"},{"id":"28506916-29759360-45816356","span":{"begin":108,"end":111},"obj":"29759360"},{"id":"28506916-29759360-45816356","span":{"begin":108,"end":111},"obj":"29759360"},{"id":"28506916-21444879-29307470","span":{"begin":264,"end":267},"obj":"21444879"},{"id":"28506916-21444879-29307470","span":{"begin":264,"end":267},"obj":"21444879"},{"id":"28506916-22958958-29307471","span":{"begin":434,"end":437},"obj":"22958958"},{"id":"28506916-22958958-29307471","span":{"begin":434,"end":437},"obj":"22958958"},{"id":"28506916-24691452-29307472","span":{"begin":438,"end":441},"obj":"24691452"},{"id":"28506916-24691452-29307472","span":{"begin":438,"end":441},"obj":"24691452"},{"id":"28506916-27720832-29307473","span":{"begin":670,"end":673},"obj":"27720832"},{"id":"28506916-27720832-29307473","span":{"begin":670,"end":673},"obj":"27720832"},{"id":"28506916-15936615-29307474","span":{"begin":900,"end":903},"obj":"15936615"},{"id":"28506916-15936615-29307474","span":{"begin":900,"end":903},"obj":"15936615"},{"id":"28506916-20022814-29307475","span":{"begin":1119,"end":1122},"obj":"20022814"},{"id":"28506916-20022814-29307475","span":{"begin":1119,"end":1122},"obj":"20022814"},{"id":"28506916-20689107-29307476","span":{"begin":1123,"end":1126},"obj":"20689107"},{"id":"28506916-20689107-29307476","span":{"begin":1123,"end":1126},"obj":"20689107"},{"id":"28506916-20064822-29307477","span":{"begin":1127,"end":1130},"obj":"20064822"},{"id":"28506916-20064822-29307477","span":{"begin":1127,"end":1130},"obj":"20064822"},{"id":"28506916-17593228-29307478","span":{"begin":1131,"end":1134},"obj":"17593228"},{"id":"28506916-17593228-29307478","span":{"begin":1131,"end":1134},"obj":"17593228"},{"id":"28506916-20682557-29307479","span":{"begin":1135,"end":1138},"obj":"20682557"},{"id":"28506916-20682557-29307479","span":{"begin":1135,"end":1138},"obj":"20682557"},{"id":"T47959","span":{"begin":96,"end":99},"obj":"20500237"},{"id":"T53042","span":{"begin":96,"end":99},"obj":"20500237"},{"id":"T5689","span":{"begin":100,"end":103},"obj":"17395676"},{"id":"T72165","span":{"begin":100,"end":103},"obj":"17395676"},{"id":"T77878","span":{"begin":104,"end":107},"obj":"19889688"},{"id":"T20302","span":{"begin":104,"end":107},"obj":"19889688"},{"id":"T26786","span":{"begin":108,"end":111},"obj":"29759360"},{"id":"T38306","span":{"begin":108,"end":111},"obj":"29759360"},{"id":"T47487","span":{"begin":264,"end":267},"obj":"21444879"},{"id":"T81848","span":{"begin":264,"end":267},"obj":"21444879"},{"id":"T23627","span":{"begin":434,"end":437},"obj":"22958958"},{"id":"T19322","span":{"begin":434,"end":437},"obj":"22958958"},{"id":"T26735","span":{"begin":438,"end":441},"obj":"24691452"},{"id":"T15958","span":{"begin":438,"end":441},"obj":"24691452"},{"id":"T82156","span":{"begin":670,"end":673},"obj":"27720832"},{"id":"T50006","span":{"begin":670,"end":673},"obj":"27720832"},{"id":"T77783","span":{"begin":900,"end":903},"obj":"15936615"},{"id":"T41583","span":{"begin":900,"end":903},"obj":"15936615"},{"id":"T75004","span":{"begin":1119,"end":1122},"obj":"20022814"},{"id":"T67443","span":{"begin":1119,"end":1122},"obj":"20022814"},{"id":"T74219","span":{"begin":1123,"end":1126},"obj":"20689107"},{"id":"T89568","span":{"begin":1123,"end":1126},"obj":"20689107"},{"id":"T31045","span":{"begin":1127,"end":1130},"obj":"20064822"},{"id":"T8329","span":{"begin":1127,"end":1130},"obj":"20064822"},{"id":"T82905","span":{"begin":1131,"end":1134},"obj":"17593228"},{"id":"T12573","span":{"begin":1131,"end":1134},"obj":"17593228"},{"id":"T55401","span":{"begin":1135,"end":1138},"obj":"20682557"},{"id":"T31283","span":{"begin":1135,"end":1138},"obj":"20682557"},{"id":"T92409","span":{"begin":96,"end":99},"obj":"20500237"},{"id":"T99325","span":{"begin":96,"end":99},"obj":"20500237"},{"id":"T89771","span":{"begin":100,"end":103},"obj":"17395676"},{"id":"T10151","span":{"begin":100,"end":103},"obj":"17395676"},{"id":"T28789","span":{"begin":104,"end":107},"obj":"19889688"},{"id":"T21848","span":{"begin":104,"end":107},"obj":"19889688"},{"id":"T68826","span":{"begin":108,"end":111},"obj":"29759360"},{"id":"T22891","span":{"begin":108,"end":111},"obj":"29759360"},{"id":"T18125","span":{"begin":264,"end":267},"obj":"21444879"},{"id":"T75112","span":{"begin":264,"end":267},"obj":"21444879"},{"id":"T64498","span":{"begin":434,"end":437},"obj":"22958958"},{"id":"T68643","span":{"begin":434,"end":437},"obj":"22958958"},{"id":"T90898","span":{"begin":438,"end":441},"obj":"24691452"},{"id":"T70236","span":{"begin":438,"end":441},"obj":"24691452"},{"id":"T65143","span":{"begin":670,"end":673},"obj":"27720832"},{"id":"T34821","span":{"begin":670,"end":673},"obj":"27720832"},{"id":"T55263","span":{"begin":900,"end":903},"obj":"15936615"},{"id":"T65278","span":{"begin":900,"end":903},"obj":"15936615"},{"id":"T57785","span":{"begin":1119,"end":1122},"obj":"20022814"},{"id":"T44873","span":{"begin":1119,"end":1122},"obj":"20022814"},{"id":"T32197","span":{"begin":1123,"end":1126},"obj":"20689107"},{"id":"T13868","span":{"begin":1123,"end":1126},"obj":"20689107"},{"id":"T12083","span":{"begin":1127,"end":1130},"obj":"20064822"},{"id":"T47849","span":{"begin":1127,"end":1130},"obj":"20064822"},{"id":"T581","span":{"begin":1131,"end":1134},"obj":"17593228"},{"id":"T71533","span":{"begin":1131,"end":1134},"obj":"17593228"},{"id":"T20023","span":{"begin":1135,"end":1138},"obj":"20682557"},{"id":"T42062","span":{"begin":1135,"end":1138},"obj":"20682557"}],"attributes":[{"subj":"28506916-20500237-29307467","pred":"source","obj":"2_test"},{"subj":"28506916-20500237-29307467","pred":"source","obj":"2_test"},{"subj":"28506916-17395676-29307468","pred":"source","obj":"2_test"},{"subj":"28506916-17395676-29307468","pred":"source","obj":"2_test"},{"subj":"28506916-19889688-29307469","pred":"source","obj":"2_test"},{"subj":"28506916-19889688-29307469","pred":"source","obj":"2_test"},{"subj":"28506916-29759360-45816356","pred":"source","obj":"2_test"},{"subj":"28506916-29759360-45816356","pred":"source","obj":"2_test"},{"subj":"28506916-21444879-29307470","pred":"source","obj":"2_test"},{"subj":"28506916-21444879-29307470","pred":"source","obj":"2_test"},{"subj":"28506916-22958958-29307471","pred":"source","obj":"2_test"},{"subj":"28506916-22958958-29307471","pred":"source","obj":"2_test"},{"subj":"28506916-24691452-29307472","pred":"source","obj":"2_test"},{"subj":"28506916-24691452-29307472","pred":"source","obj":"2_test"},{"subj":"28506916-27720832-29307473","pred":"source","obj":"2_test"},{"subj":"28506916-27720832-29307473","pred":"source","obj":"2_test"},{"subj":"28506916-15936615-29307474","pred":"source","obj":"2_test"},{"subj":"28506916-15936615-29307474","pred":"source","obj":"2_test"},{"subj":"28506916-20022814-29307475","pred":"source","obj":"2_test"},{"subj":"28506916-20022814-29307475","pred":"source","obj":"2_test"},{"subj":"28506916-20689107-29307476","pred":"source","obj":"2_test"},{"subj":"28506916-20689107-29307476","pred":"source","obj":"2_test"},{"subj":"28506916-20064822-29307477","pred":"source","obj":"2_test"},{"subj":"28506916-20064822-29307477","pred":"source","obj":"2_test"},{"subj":"28506916-17593228-29307478","pred":"source","obj":"2_test"},{"subj":"28506916-17593228-29307478","pred":"source","obj":"2_test"},{"subj":"28506916-20682557-29307479","pred":"source","obj":"2_test"},{"subj":"28506916-20682557-29307479","pred":"source","obj":"2_test"},{"subj":"T47959","pred":"source","obj":"2_test"},{"subj":"T53042","pred":"source","obj":"2_test"},{"subj":"T5689","pred":"source","obj":"2_test"},{"subj":"T72165","pred":"source","obj":"2_test"},{"subj":"T77878","pred":"source","obj":"2_test"},{"subj":"T20302","pred":"source","obj":"2_test"},{"subj":"T26786","pred":"source","obj":"2_test"},{"subj":"T38306","pred":"source","obj":"2_test"},{"subj":"T47487","pred":"source","obj":"2_test"},{"subj":"T81848","pred":"source","obj":"2_test"},{"subj":"T23627","pred":"source","obj":"2_test"},{"subj":"T19322","pred":"source","obj":"2_test"},{"subj":"T26735","pred":"source","obj":"2_test"},{"subj":"T15958","pred":"source","obj":"2_test"},{"subj":"T82156","pred":"source","obj":"2_test"},{"subj":"T50006","pred":"source","obj":"2_test"},{"subj":"T77783","pred":"source","obj":"2_test"},{"subj":"T41583","pred":"source","obj":"2_test"},{"subj":"T75004","pred":"source","obj":"2_test"},{"subj":"T67443","pred":"source","obj":"2_test"},{"subj":"T74219","pred":"source","obj":"2_test"},{"subj":"T89568","pred":"source","obj":"2_test"},{"subj":"T31045","pred":"source","obj":"2_test"},{"subj":"T8329","pred":"source","obj":"2_test"},{"subj":"T82905","pred":"source","obj":"2_test"},{"subj":"T12573","pred":"source","obj":"2_test"},{"subj":"T55401","pred":"source","obj":"2_test"},{"subj":"T31283","pred":"source","obj":"2_test"},{"subj":"T92409","pred":"source","obj":"2_test"},{"subj":"T99325","pred":"source","obj":"2_test"},{"subj":"T89771","pred":"source","obj":"2_test"},{"subj":"T10151","pred":"source","obj":"2_test"},{"subj":"T28789","pred":"source","obj":"2_test"},{"subj":"T21848","pred":"source","obj":"2_test"},{"subj":"T68826","pred":"source","obj":"2_test"},{"subj":"T22891","pred":"source","obj":"2_test"},{"subj":"T18125","pred":"source","obj":"2_test"},{"subj":"T75112","pred":"source","obj":"2_test"},{"subj":"T64498","pred":"source","obj":"2_test"},{"subj":"T68643","pred":"source","obj":"2_test"},{"subj":"T90898","pred":"source","obj":"2_test"},{"subj":"T70236","pred":"source","obj":"2_test"},{"subj":"T65143","pred":"source","obj":"2_test"},{"subj":"T34821","pred":"source","obj":"2_test"},{"subj":"T55263","pred":"source","obj":"2_test"},{"subj":"T65278","pred":"source","obj":"2_test"},{"subj":"T57785","pred":"source","obj":"2_test"},{"subj":"T44873","pred":"source","obj":"2_test"},{"subj":"T32197","pred":"source","obj":"2_test"},{"subj":"T13868","pred":"source","obj":"2_test"},{"subj":"T12083","pred":"source","obj":"2_test"},{"subj":"T47849","pred":"source","obj":"2_test"},{"subj":"T581","pred":"source","obj":"2_test"},{"subj":"T71533","pred":"source","obj":"2_test"},{"subj":"T20023","pred":"source","obj":"2_test"},{"subj":"T42062","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#cb93ec","default":true}]}]}}