PMC:6019327 / 346456-347492
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6019327","sourcedb":"PMC","sourceid":"6019327","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6019327","text":"Colchicine\nColchicine, an anti-inflammatory agent, has been used post-AF ablation both to reduce pericarditis-related pain, but also to reduce AF. Colchicine has been shown to reduce postoperative AF following cardiac surgery,983,984 and has also been studied following AF ablation. The first major study was a prospective randomized trial in 161 patients undergoing ablation of PAF. Patients were randomized to receive colchicine 0.5 mg bid or placebo.985 At 3 months of follow-up, AF recurred in 34% of the placebo patients vs 16% of the patients treated with colchicine. Colchicine led to a reduction in C-reactive protein and IL-6. A subsequent randomized study of 233 patients with PAF demonstrated a long-term recurrence rate of 31% among the patients treated with colchicine vs 49% among the placebo patients.986 A survey of the writing group members shows that 6% of the members routinely administer colchicine for 1–3 months postablation. Ninety-four percent of the writing group members do not routinely administer colchicine.","divisions":[{"label":"title","span":{"begin":0,"end":10}}],"tracks":[{"project":"2_test","denotations":[{"id":"28506916-24240932-29308711","span":{"begin":226,"end":229},"obj":"24240932"},{"id":"28506916-24240932-29308711","span":{"begin":226,"end":229},"obj":"24240932"},{"id":"28506916-22090167-29308712","span":{"begin":230,"end":233},"obj":"22090167"},{"id":"28506916-22090167-29308712","span":{"begin":230,"end":233},"obj":"22090167"},{"id":"28506916-23040570-45814893","span":{"begin":453,"end":456},"obj":"23040570"},{"id":"28506916-23040570-45814893","span":{"begin":453,"end":456},"obj":"23040570"},{"id":"28506916-24508207-45814894","span":{"begin":816,"end":819},"obj":"24508207"},{"id":"28506916-24508207-45814894","span":{"begin":816,"end":819},"obj":"24508207"},{"id":"T77612","span":{"begin":226,"end":229},"obj":"24240932"},{"id":"T98510","span":{"begin":226,"end":229},"obj":"24240932"},{"id":"T93841","span":{"begin":230,"end":233},"obj":"22090167"},{"id":"T28061","span":{"begin":230,"end":233},"obj":"22090167"},{"id":"T69281","span":{"begin":453,"end":456},"obj":"23040570"},{"id":"T55704","span":{"begin":453,"end":456},"obj":"23040570"},{"id":"T61687","span":{"begin":816,"end":819},"obj":"24508207"},{"id":"T88622","span":{"begin":816,"end":819},"obj":"24508207"},{"id":"T9892","span":{"begin":226,"end":229},"obj":"24240932"},{"id":"T94859","span":{"begin":226,"end":229},"obj":"24240932"},{"id":"T64349","span":{"begin":230,"end":233},"obj":"22090167"},{"id":"T71883","span":{"begin":230,"end":233},"obj":"22090167"},{"id":"T20064","span":{"begin":453,"end":456},"obj":"23040570"},{"id":"T48399","span":{"begin":453,"end":456},"obj":"23040570"},{"id":"T91334","span":{"begin":816,"end":819},"obj":"24508207"},{"id":"T56931","span":{"begin":816,"end":819},"obj":"24508207"}],"attributes":[{"subj":"28506916-24240932-29308711","pred":"source","obj":"2_test"},{"subj":"28506916-24240932-29308711","pred":"source","obj":"2_test"},{"subj":"28506916-22090167-29308712","pred":"source","obj":"2_test"},{"subj":"28506916-22090167-29308712","pred":"source","obj":"2_test"},{"subj":"28506916-23040570-45814893","pred":"source","obj":"2_test"},{"subj":"28506916-23040570-45814893","pred":"source","obj":"2_test"},{"subj":"28506916-24508207-45814894","pred":"source","obj":"2_test"},{"subj":"28506916-24508207-45814894","pred":"source","obj":"2_test"},{"subj":"T77612","pred":"source","obj":"2_test"},{"subj":"T98510","pred":"source","obj":"2_test"},{"subj":"T93841","pred":"source","obj":"2_test"},{"subj":"T28061","pred":"source","obj":"2_test"},{"subj":"T69281","pred":"source","obj":"2_test"},{"subj":"T55704","pred":"source","obj":"2_test"},{"subj":"T61687","pred":"source","obj":"2_test"},{"subj":"T88622","pred":"source","obj":"2_test"},{"subj":"T9892","pred":"source","obj":"2_test"},{"subj":"T94859","pred":"source","obj":"2_test"},{"subj":"T64349","pred":"source","obj":"2_test"},{"subj":"T71883","pred":"source","obj":"2_test"},{"subj":"T20064","pred":"source","obj":"2_test"},{"subj":"T48399","pred":"source","obj":"2_test"},{"subj":"T91334","pred":"source","obj":"2_test"},{"subj":"T56931","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93adec","default":true}]}]}}