PMC:5985360 / 7033-7864 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/5985360","sourcedb":"PMC","sourceid":"5985360","source_url":"https://www.ncbi.nlm.nih.gov/pmc/5985360","text":"Let the genotype frequencies of the sickle homozygote, heterozygote, and wild-type homozygote be p2, 2pq, and q2, respectively. Let the corresponding relative fitnesses be 0, 1+s, and 1, respectively.2 Then, at equilibrium, s=(p/1−2p). For each of the five continental African samples in the 1000 Genomes Project Phase 3 release version 5a, we estimated the effective population size Ne on the basis of the heterozygosities of all single-nucleotide polymorphisms (i.e., diallelic, triallelic, and quadrallelic) by assuming a mutation rate of 0.97×10−8 mutations per site per generation.34 We then took the harmonic mean of the five Ne estimates. Assuming one initial copy of the mutant allele, we simulated 1,000 generations under a combination of random genetic drift and balancing selection. We repeated this process 1,000 times.","tracks":[{"project":"2_test","denotations":[{"id":"29526279-12364370-2046643","span":{"begin":200,"end":201},"obj":"12364370"},{"id":"29526279-20981092-2046644","span":{"begin":586,"end":588},"obj":"20981092"}],"attributes":[{"subj":"29526279-12364370-2046643","pred":"source","obj":"2_test"},{"subj":"29526279-20981092-2046644","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ece793","default":true}]}]}}