PMC:5917310 / 16814-17924 JSONTXT

{"project":"TEST0","denotations":[{"id":"29542385-186-192-13672","span":{"begin":186,"end":188},"obj":"[\"23222858\"]"},{"id":"29542385-189-195-13673","span":{"begin":189,"end":191},"obj":"[\"18422434\"]"},{"id":"29542385-152-158-13674","span":{"begin":647,"end":649},"obj":"[\"26445858\"]"},{"id":"29542385-237-243-13675","span":{"begin":993,"end":995},"obj":"[\"15325835\"]"},{"id":"29542385-108-114-13676","span":{"begin":1106,"end":1108},"obj":"[\"7499817\"]"}],"text":"We found an average S. aureus nasal colonization rate of 19.3%, which is comparable to previously described colonization rates in the general population in Europe and the United States [21,22]. The low prevalence of MRSA isolates, 10 (1.3%) was also found to be consistent with studies from Europe. We observed a positive association between previous dispensation of any antibiotics and isolation of MRSA, but caution is needed as MRSA was only isolated in 1.3% of the individuals in our study. This is consistent with previous hospital studies where antibiotic surgical prophylaxis increases nasal carriage of antibiotic-resistant staphylococci [23]. Evidence seems to indicate that the endogenous microflora of the patient may be critical since clinical studies have found that S. aureus skin colonisation increases the risk of a subsequent infection by three-fold, and up to 80% of cases of staphylococcal bacteraemia are caused by strains identical to those in the patient’s nasal cavity [24]. Furthermore, patient colonisation with S. aureus is associated with a 2–9-fold increased risk of infection [25]."}

{"project":"0_colil","denotations":[{"id":"29542385-23222858-13672","span":{"begin":186,"end":188},"obj":"23222858"},{"id":"29542385-18422434-13673","span":{"begin":189,"end":191},"obj":"18422434"},{"id":"29542385-26445858-13674","span":{"begin":647,"end":649},"obj":"26445858"},{"id":"29542385-15325835-13675","span":{"begin":993,"end":995},"obj":"15325835"},{"id":"29542385-7499817-13676","span":{"begin":1106,"end":1108},"obj":"7499817"}],"text":"We found an average S. aureus nasal colonization rate of 19.3%, which is comparable to previously described colonization rates in the general population in Europe and the United States [21,22]. The low prevalence of MRSA isolates, 10 (1.3%) was also found to be consistent with studies from Europe. We observed a positive association between previous dispensation of any antibiotics and isolation of MRSA, but caution is needed as MRSA was only isolated in 1.3% of the individuals in our study. This is consistent with previous hospital studies where antibiotic surgical prophylaxis increases nasal carriage of antibiotic-resistant staphylococci [23]. Evidence seems to indicate that the endogenous microflora of the patient may be critical since clinical studies have found that S. aureus skin colonisation increases the risk of a subsequent infection by three-fold, and up to 80% of cases of staphylococcal bacteraemia are caused by strains identical to those in the patient’s nasal cavity [24]. Furthermore, patient colonisation with S. aureus is associated with a 2–9-fold increased risk of infection [25]."}

{"project":"MyTest","denotations":[{"id":"29542385-23222858-29034982","span":{"begin":186,"end":188},"obj":"23222858"},{"id":"29542385-18422434-29034983","span":{"begin":189,"end":191},"obj":"18422434"},{"id":"29542385-26445858-29034984","span":{"begin":647,"end":649},"obj":"26445858"},{"id":"29542385-15325835-29034985","span":{"begin":993,"end":995},"obj":"15325835"},{"id":"29542385-7499817-29034986","span":{"begin":1106,"end":1108},"obj":"7499817"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"We found an average S. aureus nasal colonization rate of 19.3%, which is comparable to previously described colonization rates in the general population in Europe and the United States [21,22]. The low prevalence of MRSA isolates, 10 (1.3%) was also found to be consistent with studies from Europe. We observed a positive association between previous dispensation of any antibiotics and isolation of MRSA, but caution is needed as MRSA was only isolated in 1.3% of the individuals in our study. This is consistent with previous hospital studies where antibiotic surgical prophylaxis increases nasal carriage of antibiotic-resistant staphylococci [23]. Evidence seems to indicate that the endogenous microflora of the patient may be critical since clinical studies have found that S. aureus skin colonisation increases the risk of a subsequent infection by three-fold, and up to 80% of cases of staphylococcal bacteraemia are caused by strains identical to those in the patient’s nasal cavity [24]. Furthermore, patient colonisation with S. aureus is associated with a 2–9-fold increased risk of infection [25]."}

{"project":"2_test","denotations":[{"id":"29542385-23222858-29034982","span":{"begin":186,"end":188},"obj":"23222858"},{"id":"29542385-18422434-29034983","span":{"begin":189,"end":191},"obj":"18422434"},{"id":"29542385-26445858-29034984","span":{"begin":647,"end":649},"obj":"26445858"},{"id":"29542385-15325835-29034985","span":{"begin":993,"end":995},"obj":"15325835"},{"id":"29542385-7499817-29034986","span":{"begin":1106,"end":1108},"obj":"7499817"}],"text":"We found an average S. aureus nasal colonization rate of 19.3%, which is comparable to previously described colonization rates in the general population in Europe and the United States [21,22]. The low prevalence of MRSA isolates, 10 (1.3%) was also found to be consistent with studies from Europe. We observed a positive association between previous dispensation of any antibiotics and isolation of MRSA, but caution is needed as MRSA was only isolated in 1.3% of the individuals in our study. This is consistent with previous hospital studies where antibiotic surgical prophylaxis increases nasal carriage of antibiotic-resistant staphylococci [23]. Evidence seems to indicate that the endogenous microflora of the patient may be critical since clinical studies have found that S. aureus skin colonisation increases the risk of a subsequent infection by three-fold, and up to 80% of cases of staphylococcal bacteraemia are caused by strains identical to those in the patient’s nasal cavity [24]. Furthermore, patient colonisation with S. aureus is associated with a 2–9-fold increased risk of infection [25]."}