PMC:549712 / 49725-50443
Annnotations
craft-sa-dev
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T14603 | 0-6 | NN | denotes | Bruce4 |
| T14604 | 10-15 | NNS | denotes | cells |
| T14605 | 7-9 | NN | denotes | ES |
| T14606 | 21-32 | VBN | denotes | transfected |
| T14607 | 16-20 | VBD | denotes | were |
| T14608 | 33-37 | IN | denotes | with |
| T14609 | 38-42 | NN | denotes | KpnI |
| T14610 | 43-53 | VBN | denotes | linearized |
| T14611 | 42-43 | HYPH | denotes | - |
| T14612 | 64-70 | NN | denotes | vector |
| T14613 | 54-63 | NN | denotes | targeting |
| T14614 | 71-74 | CC | denotes | and |
| T14615 | 75-83 | VBN | denotes | selected |
| T14616 | 84-88 | IN | denotes | with |
| T14617 | 89-93 | NN | denotes | G418 |
| T14618 | 93-94 | . | denotes | . |
| T14619 | 94-240 | sentence | denotes | ES-cell clones resistant to G418 were isolated and analyzed by Southern blot analysis for homologous recombination events within the Ptdsr locus. |
| T14620 | 95-97 | NN | denotes | ES |
| T14621 | 98-102 | NN | denotes | cell |
| T14622 | 97-98 | HYPH | denotes | - |
| T14623 | 103-109 | NNS | denotes | clones |
| T14624 | 133-141 | VBN | denotes | isolated |
| T14625 | 110-119 | JJ | denotes | resistant |
| T14626 | 120-122 | IN | denotes | to |
| T14627 | 123-127 | NN | denotes | G418 |
| T14628 | 128-132 | VBD | denotes | were |
| T14629 | 142-145 | CC | denotes | and |
| T14630 | 146-154 | VBN | denotes | analyzed |
| T14631 | 155-157 | IN | denotes | by |
| T14632 | 158-166 | NNP | denotes | Southern |
| T14633 | 167-171 | NN | denotes | blot |
| T14634 | 172-180 | NN | denotes | analysis |
| T14635 | 181-184 | IN | denotes | for |
| T14636 | 185-195 | JJ | denotes | homologous |
| T14637 | 210-216 | NNS | denotes | events |
| T14638 | 196-209 | NN | denotes | recombination |
| T14639 | 217-223 | IN | denotes | within |
| T14640 | 224-227 | DT | denotes | the |
| T14641 | 234-239 | NN | denotes | locus |
| T14642 | 228-233 | NN | denotes | Ptdsr |
| T14643 | 239-240 | . | denotes | . |
| T14644 | 240-451 | sentence | denotes | Chimeric mice were produced by microinjection of two independent homologous recombinant (Ptdsr+/-) ES cells into BALB/c blastocysts and transfer to pseudopregnant foster mothers followed by development to term. |
| T14645 | 241-249 | JJ | denotes | Chimeric |
| T14646 | 250-254 | NNS | denotes | mice |
| T14647 | 260-268 | VBN | denotes | produced |
| T14648 | 255-259 | VBD | denotes | were |
| T14649 | 269-271 | IN | denotes | by |
| T14650 | 272-286 | NN | denotes | microinjection |
| T14651 | 287-289 | IN | denotes | of |
| T14652 | 290-293 | CD | denotes | two |
| T14653 | 343-348 | NNS | denotes | cells |
| T14654 | 294-305 | JJ | denotes | independent |
| T14655 | 306-316 | JJ | denotes | homologous |
| T14656 | 317-328 | JJ | denotes | recombinant |
| T14657 | 329-330 | -LRB- | denotes | ( |
| T14658 | 330-335 | NN | denotes | Ptdsr |
| T14659 | 335-336 | SYM | denotes | + |
| T14660 | 336-337 | HYPH | denotes | / |
| T14661 | 337-338 | SYM | denotes | - |
| T14662 | 338-339 | -RRB- | denotes | ) |
| T14663 | 340-342 | NN | denotes | ES |
| T14664 | 349-353 | IN | denotes | into |
| T14665 | 354-358 | NN | denotes | BALB |
| T14666 | 359-360 | NN | denotes | c |
| T14667 | 358-359 | HYPH | denotes | / |
| T14668 | 361-372 | NNS | denotes | blastocysts |
| T14669 | 373-376 | CC | denotes | and |
| T14670 | 377-385 | NN | denotes | transfer |
| T14671 | 386-388 | IN | denotes | to |
| T14672 | 389-403 | JJ | denotes | pseudopregnant |
| T14673 | 411-418 | NNS | denotes | mothers |
| T14674 | 404-410 | JJ | denotes | foster |
| T14675 | 419-427 | VBN | denotes | followed |
| T14676 | 428-430 | IN | denotes | by |
| T14677 | 431-442 | NN | denotes | development |
| T14678 | 443-445 | IN | denotes | to |
| T14679 | 446-450 | NN | denotes | term |
| T14680 | 450-451 | . | denotes | . |
| T14681 | 451-500 | sentence | denotes | Chimeric males were mated with C57BL/6J females. |
| T14682 | 452-460 | JJ | denotes | Chimeric |
| T14683 | 461-466 | NNS | denotes | males |
| T14684 | 472-477 | VBN | denotes | mated |
| T14685 | 467-471 | VBD | denotes | were |
| T14686 | 478-482 | IN | denotes | with |
| T14687 | 483-488 | NN | denotes | C57BL |
| T14688 | 489-491 | NN | denotes | 6J |
| T14689 | 488-489 | HYPH | denotes | / |
| T14690 | 492-499 | NNS | denotes | females |
| T14691 | 499-500 | . | denotes | . |
| T14692 | 500-585 | sentence | denotes | From the two selected ES-cell clones, one successfully contributed to the germ-line. |
| T14693 | 501-505 | IN | denotes | From |
| T14694 | 556-567 | VBD | denotes | contributed |
| T14695 | 506-509 | DT | denotes | the |
| T14696 | 531-537 | NNS | denotes | clones |
| T14697 | 510-513 | CD | denotes | two |
| T14698 | 514-522 | VBN | denotes | selected |
| T14699 | 523-525 | NN | denotes | ES |
| T14700 | 526-530 | NN | denotes | cell |
| T14701 | 525-526 | HYPH | denotes | - |
| T14702 | 537-539 | , | denotes | , |
| T14703 | 539-542 | CD | denotes | one |
| T14704 | 543-555 | RB | denotes | successfully |
| T14705 | 568-570 | IN | denotes | to |
| T14706 | 571-574 | DT | denotes | the |
| T14707 | 580-584 | NN | denotes | line |
| T14708 | 575-579 | NN | denotes | germ |
| T14709 | 579-580 | HYPH | denotes | - |
| T14710 | 584-585 | . | denotes | . |
| T14711 | 585-718 | sentence | denotes | Germ-line transmission of the mutant allele was verified by PCR and Southern blot of genomic DNA from black coat-color F1 offspring. |
| T14712 | 586-590 | NN | denotes | Germ |
| T14713 | 591-595 | NN | denotes | line |
| T14714 | 590-591 | HYPH | denotes | - |
| T14715 | 596-608 | NN | denotes | transmission |
| T14716 | 634-642 | VBN | denotes | verified |
| T14717 | 609-611 | IN | denotes | of |
| T14718 | 612-615 | DT | denotes | the |
| T14719 | 623-629 | NN | denotes | allele |
| T14720 | 616-622 | JJ | denotes | mutant |
| T14721 | 630-633 | VBD | denotes | was |
| T14722 | 643-645 | IN | denotes | by |
| T14723 | 646-649 | NN | denotes | PCR |
| T14724 | 650-653 | CC | denotes | and |
| T14725 | 654-662 | NNP | denotes | Southern |
| T14726 | 663-667 | NN | denotes | blot |
| T14727 | 668-670 | IN | denotes | of |
| T14728 | 671-678 | JJ | denotes | genomic |
| T14729 | 679-682 | NN | denotes | DNA |
| T14730 | 683-687 | IN | denotes | from |
| T14731 | 688-693 | JJ | denotes | black |
| T14732 | 699-704 | NN | denotes | color |
| T14733 | 694-698 | NN | denotes | coat |
| T14734 | 698-699 | HYPH | denotes | - |
| T14735 | 708-717 | NN | denotes | offspring |
| T14736 | 705-707 | NN | denotes | F1 |
| T14737 | 717-718 | . | denotes | . |
| R8752 | T14603 | T14604 | compound | Bruce4,cells |
| R8753 | T14604 | T14606 | nsubjpass | cells,transfected |
| R8754 | T14605 | T14604 | compound | ES,cells |
| R8755 | T14607 | T14606 | auxpass | were,transfected |
| R8756 | T14608 | T14606 | prep | with,transfected |
| R8757 | T14609 | T14610 | npadvmod | KpnI,linearized |
| R8758 | T14610 | T14612 | amod | linearized,vector |
| R8759 | T14611 | T14610 | punct | -,linearized |
| R8760 | T14612 | T14608 | pobj | vector,with |
| R8761 | T14613 | T14612 | compound | targeting,vector |
| R8762 | T14614 | T14606 | cc | and,transfected |
| R8763 | T14615 | T14606 | conj | selected,transfected |
| R8764 | T14616 | T14615 | prep | with,selected |
| R8765 | T14617 | T14616 | pobj | G418,with |
| R8766 | T14618 | T14606 | punct | .,transfected |
| R8767 | T14620 | T14621 | compound | ES,cell |
| R8768 | T14621 | T14623 | compound | cell,clones |
| R8769 | T14622 | T14621 | punct | -,cell |
| R8770 | T14623 | T14624 | nsubjpass | clones,isolated |
| R8771 | T14625 | T14623 | amod | resistant,clones |
| R8772 | T14626 | T14625 | prep | to,resistant |
| R8773 | T14627 | T14626 | pobj | G418,to |
| R8774 | T14628 | T14624 | auxpass | were,isolated |
| R8775 | T14629 | T14624 | cc | and,isolated |
| R8776 | T14630 | T14624 | conj | analyzed,isolated |
| R8777 | T14631 | T14630 | prep | by,analyzed |
| R8778 | T14632 | T14633 | compound | Southern,blot |
| R8779 | T14633 | T14634 | compound | blot,analysis |
| R8780 | T14634 | T14631 | pobj | analysis,by |
| R8781 | T14635 | T14630 | prep | for,analyzed |
| R8782 | T14636 | T14637 | amod | homologous,events |
| R8783 | T14637 | T14635 | pobj | events,for |
| R8784 | T14638 | T14637 | compound | recombination,events |
| R8785 | T14639 | T14637 | prep | within,events |
| R8786 | T14640 | T14641 | det | the,locus |
| R8787 | T14641 | T14639 | pobj | locus,within |
| R8788 | T14642 | T14641 | compound | Ptdsr,locus |
| R8789 | T14643 | T14624 | punct | .,isolated |
| R8790 | T14645 | T14646 | amod | Chimeric,mice |
| R8791 | T14646 | T14647 | nsubjpass | mice,produced |
| R8792 | T14648 | T14647 | auxpass | were,produced |
| R8793 | T14649 | T14647 | prep | by,produced |
| R8794 | T14650 | T14649 | pobj | microinjection,by |
| R8795 | T14651 | T14650 | prep | of,microinjection |
| R8796 | T14652 | T14653 | nummod | two,cells |
| R8797 | T14653 | T14651 | pobj | cells,of |
| R8798 | T14654 | T14653 | amod | independent,cells |
| R8799 | T14655 | T14653 | amod | homologous,cells |
| R8800 | T14656 | T14653 | amod | recombinant,cells |
| R8801 | T14657 | T14658 | punct | (,Ptdsr |
| R8802 | T14658 | T14653 | parataxis | Ptdsr,cells |
| R8803 | T14659 | T14658 | punct | +,Ptdsr |
| R8804 | T14660 | T14658 | punct | /,Ptdsr |
| R8805 | T14661 | T14658 | punct | -,Ptdsr |
| R8806 | T14662 | T14658 | punct | ),Ptdsr |
| R8807 | T14663 | T14653 | compound | ES,cells |
| R8808 | T14664 | T14650 | prep | into,microinjection |
| R8809 | T14665 | T14666 | compound | BALB,c |
| R8810 | T14666 | T14668 | compound | c,blastocysts |
| R8811 | T14667 | T14666 | punct | /,c |
| R8812 | T14668 | T14664 | pobj | blastocysts,into |
| R8813 | T14669 | T14650 | cc | and,microinjection |
| R8814 | T14670 | T14650 | conj | transfer,microinjection |
| R8815 | T14671 | T14670 | prep | to,transfer |
| R8816 | T14672 | T14673 | amod | pseudopregnant,mothers |
| R8817 | T14673 | T14671 | pobj | mothers,to |
| R8818 | T14674 | T14673 | amod | foster,mothers |
| R8819 | T14675 | T14650 | acl | followed,microinjection |
| R8820 | T14676 | T14675 | agent | by,followed |
| R8821 | T14677 | T14676 | pobj | development,by |
| R8822 | T14678 | T14677 | prep | to,development |
| R8823 | T14679 | T14678 | pobj | term,to |
| R8824 | T14680 | T14647 | punct | .,produced |
| R8825 | T14682 | T14683 | amod | Chimeric,males |
| R8826 | T14683 | T14684 | nsubjpass | males,mated |
| R8827 | T14685 | T14684 | auxpass | were,mated |
| R8828 | T14686 | T14684 | prep | with,mated |
| R8829 | T14687 | T14688 | compound | C57BL,6J |
| R8830 | T14688 | T14690 | compound | 6J,females |
| R8831 | T14689 | T14688 | punct | /,6J |
| R8832 | T14690 | T14686 | pobj | females,with |
| R8833 | T14691 | T14684 | punct | .,mated |
| R8834 | T14693 | T14694 | prep | From,contributed |
| R8835 | T14695 | T14696 | det | the,clones |
| R8836 | T14696 | T14693 | pobj | clones,From |
| R8837 | T14697 | T14696 | nummod | two,clones |
| R8838 | T14698 | T14696 | amod | selected,clones |
| R8839 | T14699 | T14700 | compound | ES,cell |
| R8840 | T14700 | T14696 | compound | cell,clones |
| R8841 | T14701 | T14700 | punct | -,cell |
| R8842 | T14702 | T14694 | punct | ", ",contributed |
| R8843 | T14703 | T14694 | nsubj | one,contributed |
| R8844 | T14704 | T14694 | advmod | successfully,contributed |
| R8845 | T14705 | T14694 | prep | to,contributed |
| R8846 | T14706 | T14707 | det | the,line |
| R8847 | T14707 | T14705 | pobj | line,to |
| R8848 | T14708 | T14707 | compound | germ,line |
| R8849 | T14709 | T14707 | punct | -,line |
| R8850 | T14710 | T14694 | punct | .,contributed |
| R8851 | T14712 | T14713 | compound | Germ,line |
| R8852 | T14713 | T14715 | compound | line,transmission |
| R8853 | T14714 | T14713 | punct | -,line |
| R8854 | T14715 | T14716 | nsubjpass | transmission,verified |
| R8855 | T14717 | T14715 | prep | of,transmission |
| R8856 | T14718 | T14719 | det | the,allele |
| R8857 | T14719 | T14717 | pobj | allele,of |
| R8858 | T14720 | T14719 | amod | mutant,allele |
| R8859 | T14721 | T14716 | auxpass | was,verified |
| R8860 | T14722 | T14716 | prep | by,verified |
| R8861 | T14723 | T14722 | pobj | PCR,by |
| R8862 | T14724 | T14723 | cc | and,PCR |
| R8863 | T14725 | T14726 | compound | Southern,blot |
| R8864 | T14726 | T14723 | conj | blot,PCR |
| R8865 | T14727 | T14723 | prep | of,PCR |
| R8866 | T14728 | T14729 | amod | genomic,DNA |
| R8867 | T14729 | T14727 | pobj | DNA,of |
| R8868 | T14730 | T14729 | prep | from,DNA |
| R8869 | T14731 | T14732 | amod | black,color |
| R8870 | T14732 | T14735 | compound | color,offspring |
| R8871 | T14733 | T14732 | compound | coat,color |
| R8872 | T14734 | T14732 | punct | -,color |
| R8873 | T14735 | T14730 | pobj | offspring,from |
| R8874 | T14736 | T14735 | compound | F1,offspring |
| R8875 | T14737 | T14716 | punct | .,verified |
craft-ca-core-ex-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T14397 | 7-15 | CL:0002322 | denotes | ES cells |
| T14398 | 10-15 | CL_GO_EXT:cell | denotes | cells |
| T14399 | 21-32 | GO:0009294 | denotes | transfected |
| T14400 | 43-53 | SO_EXT:sequence_linearization | denotes | linearized |
| T14401 | 54-70 | SO_EXT:0001644 | denotes | targeting vector |
| T14402 | 89-93 | CHEBI:42768 | denotes | G418 |
| T14403 | 95-102 | CL:0002322 | denotes | ES-cell |
| T14404 | 98-102 | CL_GO_EXT:cell | denotes | cell |
| T14405 | 103-109 | SO_EXT:sequence_cloned_entity | denotes | clones |
| T14406 | 123-127 | CHEBI:42768 | denotes | G418 |
| T14407 | 196-209 | GO_SO_EXT:sequence_rearrangement_process | denotes | recombination |
| T14408 | 228-233 | PR_EXT:000009218 | denotes | Ptdsr |
| T14409 | 250-254 | NCBITaxon:10088 | denotes | mice |
| T14410 | 317-328 | GO_SO_EXT:sequence_rearrangement_process | denotes | recombinant |
| T14411 | 330-335 | PR_EXT:000009218 | denotes | Ptdsr |
| T14412 | 335-336 | SO_EXT:normal_or_wild_type_or_present | denotes | + |
| T14413 | 337-338 | SO_EXT:sequence_nullness_or_absence | denotes | - |
| T14414 | 340-348 | CL:0002322 | denotes | ES cells |
| T14415 | 343-348 | CL_GO_EXT:cell | denotes | cells |
| T14416 | 361-372 | UBERON:0000358 | denotes | blastocysts |
| T14417 | 377-385 | GO_EXT:biological_movement_or_translocation_process | denotes | transfer |
| T14418 | 461-466 | PATO_UBERON_EXT:male_or_bearer_of_maleness | denotes | males |
| T14419 | 472-477 | GO:0007618 | denotes | mated |
| T14420 | 492-499 | PATO_UBERON_EXT:female_or_bearer_of_femaleness | denotes | females |
| T14421 | 523-530 | CL:0002322 | denotes | ES-cell |
| T14422 | 526-530 | CL_GO_EXT:cell | denotes | cell |
| T14423 | 531-537 | SO_EXT:sequence_cloned_entity | denotes | clones |
| T14424 | 616-622 | SO_EXT:sequence_altered_entity_or_alteration_process | denotes | mutant |
| T14425 | 623-629 | SO_EXT:0001023 | denotes | allele |
| T14426 | 671-682 | SO_EXT:genomic_DNA | denotes | genomic DNA |
| T14427 | 679-682 | CHEBI_SO_EXT:DNA | denotes | DNA |
| T14428 | 694-698 | UBERON:0010166 | denotes | coat |
craft-ca-core-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T14327 | 7-15 | CL:0002322 | denotes | ES cells |
| T14328 | 21-32 | GO:0009294 | denotes | transfected |
| T14329 | 54-70 | SO:0001644 | denotes | targeting vector |
| T14330 | 89-93 | CHEBI:42768 | denotes | G418 |
| T14331 | 95-102 | CL:0002322 | denotes | ES-cell |
| T14332 | 123-127 | CHEBI:42768 | denotes | G418 |
| T14333 | 228-233 | PR:000009218 | denotes | Ptdsr |
| T14334 | 250-254 | NCBITaxon:10088 | denotes | mice |
| T14335 | 330-335 | PR:000009218 | denotes | Ptdsr |
| T14336 | 340-348 | CL:0002322 | denotes | ES cells |
| T14337 | 361-372 | UBERON:0000358 | denotes | blastocysts |
| T14338 | 472-477 | GO:0007618 | denotes | mated |
| T14339 | 523-530 | CL:0002322 | denotes | ES-cell |
| T14340 | 623-629 | SO:0001023 | denotes | allele |
| T14341 | 671-678 | SO:0001026 | denotes | genomic |
| T14342 | 694-698 | UBERON:0010166 | denotes | coat |